1. Tokyo Medical & Dental University

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    1. Mentioned In 134 Articles

    2. Prevalence, risk factors and impact of posterior staphyloma diagnosed from wide‐field optical coherence tomography in Singapore adults with high myopia

      Prevalence, risk factors and impact of posterior staphyloma diagnosed from wide‐field optical coherence tomography in Singapore adults with high myopia
      Purpose To investigate the prevalence and risk factors of posterior staphyloma using wide‐field optical coherence tomography (WF‐OCT) in adults with high myopia in Singapore. Design Population‐based cross‐sectional study. Methods Adults with spherical equivalent (SE) 5D in either eye at the first visit of Singapore Epidemiology of Eye Diseases study and Singapore Prospective Study Program study were recruited. Posterior staphyloma was diagnosed using WF‐OCT (PLEX Elite9000 ...
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    3. Effect of Pretreatment and Activation Mode on the Interfacial Adaptation of Nanoceramic Resin Inlay and Self-adhesive Resin Cementv

      Effect of Pretreatment and Activation Mode on the Interfacial Adaptation of Nanoceramic Resin Inlay and Self-adhesive Resin Cementv
      Objectives The first objective of this study was to determine if the luting material used for resin nanoceramic inlay affects interfacial adaptation. The second was to investigate whether pretreatment and the adhesive curing method before cementation affects interfacial adaptation. The final objective was to compare activation modes of luting material. Methods Class I cavities were prepared on extracted human third molars. Resin nanoceramic inlays were fabricated using Lava Ultimate CAD ...
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    4. Predictors for layered coronary plaques: an optical coherence tomography study

      Predictors for layered coronary plaques: an optical coherence tomography study
      Healed coronary plaques, morphologically characterized by a layered pattern, are signatures of previous plaque disruption and healing. Recent optical coherence tomography (OCT) studies showed that layered plaque is associated with vascular vulnerability. However, factors associated with layered plaques have not been studied. The aim of this study was to investigate predictors for layered plaque at the culprit plaques and at non-culprit plaques. Patients with coronary artery disease who underwent pre-intervention ...
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    5. Diagnosis of Occlusal Caries with Dynamic Slicing of 3D Optical Coherence Tomography Images

      Diagnosis of Occlusal Caries with Dynamic Slicing of 3D Optical Coherence Tomography Images
      Detecting the extent of occlusal caries is a clinically important but challenging task required for treatment decision making. The aim of this study was to assess the diagnostic power of 3D swept-source optical coherence tomography (OCT) for evaluation of occlusal caries in comparison with X-ray radiography. Extracted human molars not exhibiting American Dental Association (ADA) criteria advanced caries were mounted in a silicone block and digital dental radiographs were captured ...
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    6. Comprehensive In Vivo Coronary Plaque Mapping: A 3-Vessel Optical Coherence Tomography Study

      Comprehensive In Vivo Coronary Plaque Mapping: A 3-Vessel Optical Coherence Tomography Study
      Background Previous pathology studies demonstrated that thin-cap fibroatheroma (TCFA) is localized in specific segments of the epicardial coronary arteries. A detailed description of in vivo coronary plaques of various phenotypes has not been reported. Objectives We performed a comprehensive analysis on the distribution of coronary plaques with different phenotypes from our 3-vessel optical coherence tomography (OCT) database. Methods OCT images of all 3 coronary arteries in 131 patients were analyzed ...
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    7. Effect of Light Irradiation Condition on Gap Formation Under Polymeric Dental Restoration; OCT study

      Effect of Light Irradiation Condition on Gap Formation Under Polymeric Dental Restoration; OCT study
      Objective To investigate the effect of two light-curing systems; quartz tungsten-halogen (QTH) and light-emitting diode (LED), and irradiation time on interfacial gap formation of dental composite resin restorations bonded with an adhesive resin using optical coherence tomography (OCT). Materials and Methods Forty cavities were prepared in extracted human molar teeth and divided into four groups (n = 10) based on the type of light curing system QTH (LITEX 680A) and LED ...
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    8. Plaque morphology assessed by optical coherence tomography in the culprit lesions of the first episode of acute myocardial infarction in patients with low low-density lipoprotein cholesterol level

      Plaque morphology assessed by optical coherence tomography in the culprit lesions of the first episode of acute myocardial infarction in patients with low low-density lipoprotein cholesterol level
      Background There remains a residual risk for acute myocardial infarction (AMI) even with low low-density lipoprotein cholesterol (LDL-C) levels. This study aimed to characterize the culprit lesion morphology of AMI by optical coherence tomography (OCT) in patients with low LDL-C. Methods Four-hundred and nine culprit lesions of 409 patients with their first presentation of AMI imaged by OCT were investigated. OCT analysis included the presence of plaque rupture and thin-capped ...
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    9. ULTRA-WIDEFIELD OPTICAL COHERENCE TOMOGRAPHY FOR RETINAL DETACHMENT WITH PROLIFERATIVE VITREORETINOPATHY

      ULTRA-WIDEFIELD OPTICAL COHERENCE TOMOGRAPHY FOR RETINAL DETACHMENT WITH PROLIFERATIVE VITREORETINOPATHY
      Purpose: To evaluate the efficacy of using preoperative and postoperative ultra-widefield optical coherence tomography ) images in the treatment of proliferative vitreoretinopathy . Methods: The preoperative and postoperative images of a 62-year-old man with proliferative vitreoretinopathy accompanied by a rhegmatogenous retinal detachment were analyzed. Patient: At the initial examination, the vision was 20/400. It was difficult to obtain clear images of the fundus by color fundus photography because of synechia iridis ...
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    10. Subclinical Calcified Nodules in Saphenous Vein Graft on High-Resolution Coronary Angioscopy

      Subclinical Calcified Nodules in Saphenous Vein Graft on High-Resolution Coronary Angioscopy
      Long-term patency of saphenous vein graft (SVG) remains challenging.1 A 75-year-old man on hemodialysis had undergone coronary artery bypass grafting (CABG) 11 years earlier. At the current presentation he underwent percutaneous coronary intervention (PCI) for SVG failure to the diagonal branch (Figure A). Intravascular ultrasound (IVUS) and optical coherence tomography (OCT) showed convex calcifications at the severe proximal anastomotic stenosis (Figure B,C) and tandem stenotic sites (Figure D ...
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    11. Optical coherence tomography‐defined plaque vulnerability in relation to functional stenosis severity stratified by fractional flow reserve and quantitative flow ratio

      Optical coherence tomography‐defined plaque vulnerability in relation to functional stenosis severity stratified by fractional flow reserve and quantitative flow ratio
      Objectives We sought to investigate that the quantitative flow ratio (QFR) might be associated with optical coherence tomography (OCT)‐defined plaque vulnerability. Background Both functional stenosis severity and plaque instability are related to adverse clinical outcomes in patients with coronary artery disease. Recent studies have shown an association between physiological stenosis severity and the presence of thin‐cap fibroatheroma (TCFA). Measurement of QFR is a novel method for rapid computational ...
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    12. Evaluation of Crack Formation and Propagation with Ultrasonic Root-End Preparation and Obturation Using a Digital Microscope and Optical Coherence Tomography

      Evaluation of Crack Formation and Propagation with Ultrasonic Root-End Preparation and Obturation Using a Digital Microscope and Optical Coherence Tomography
      Objective . This study is aimed at determining (1) the effect of root-end resection, ultrasonic root-end preparation, and root-end filling on the incidence of crack formation and propagation by using a digital microscope (DM) and optical coherence tomography (OCT) and (2) the performance of OCT on the detection of cracks by comparing with microcomputed tomography (micro-CT) as a reference standard. Methodology . Thirty extracted lower incisors were endodontically treated and subjected to ...
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    13. Impact of lesion angle on optical coherence tomography findings and clinical outcomes after drug-eluting stent implantation in curved vessels

      Impact of lesion angle on optical coherence tomography findings and clinical outcomes after drug-eluting stent implantation in curved vessels
      Tortuous coronary lesions are associated with adverse outcomes after implantation of bare metal or first-generation drug-eluting stents (DESs). We investigated the impact of lesion angle on vessel wall injuries and stent apposition as assessed by optical coherence tomography (OCT) after second- and newer-generation DES implantation. We investigated 95 de novo lesions treated with a single DES (62 platinum-chromium everolimus-eluting stents and 33 bioresorbable-polymer sirolimus-eluting stents). Post-intervention OCT findings were compared ...
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    14. Swept-source optical coherence tomographic observation on prevalence and variations of cemento-enamel junction morphology

      Swept-source optical coherence tomographic observation on prevalence and variations of cemento-enamel junction morphology
      To investigate the prevalence of different patterns of cemento-enamel junction (CEJ) morphology under swept-source optical coherence tomography (SS-OCT). One hundred extracted human teeth were used consisting of incisors, premolars, and molars. Each sample was observed for every 500 m circumferentially along CEJ and OCT images of the pattern were noted. Microscopic observations were done for the representative sample using confocal laser scanning microscope (CLSM) and transmission electron microscope (TEM). The ...
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    15. Detection of Simulated Periradicular Lesions in Porcine Bone by Optical Coherence Tomography

      Detection of Simulated Periradicular Lesions in Porcine Bone by Optical Coherence Tomography
      Introduction The accurate detection of periradicular lesions located under a nonperforated cortical plate poses a challenge in endodontic microsurgery. Optical coherence tomography (OCT) is a noninvasive imaging method that has been successfully used in many dental applications. In this study, we investigated if spectral-domain OCT (SD-OCT) could be used to determine simulated periradicular lesions. Methods Twenty-eight cavities with different depths were prepared on bone plates obtained from 5 porcine mandibles ...
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    16. Posterior staphylomas and scleral curvature in highly myopic children and adolescents investigated by ultra-widefield optical coherence tomography

      Posterior staphylomas and scleral curvature in highly myopic children and adolescents investigated by ultra-widefield optical coherence tomography
      ...his study conformed to the tenets of the Declaration of Helsinki and were approved by the Ethics Committee of Tokyo Medical and Dental University (The approval number: M2000-2278). A signed informed consent was obtained ...
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  2. About Tokyo Medical & Dental University

    Tokyo Medical & Dental University

    Tokyo Medical and Dental University is unique among medical and dental universities in Japan in that we have four divisions dedicated to graduate education and research: Medical and Dental Sciences, Health Care Sciences, the Biomedical Sciences Education Division, and the Biomedical Sciences Research Division. TMDU comprises four faculties (Medicine, Dentistry, Health Care Sciences and Oral Health Care Sciences), an undergraduate College of Liberal Arts and Sciences, two research institutes (the Institute of Biomaterials and Bioengineering and the Medical Research Institute), a university hospital attached to the Faculty of Medicine, a university hospital attached to the Faculty of Dentistry, and a dental technologist school.