1. Tokyo Medical & Dental University

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    1. Mentioned In 128 Articles

    2. Plaque morphology assessed by optical coherence tomography in the culprit lesions of the first episode of acute myocardial infarction in patients with low low-density lipoprotein cholesterol level

      Plaque morphology assessed by optical coherence tomography in the culprit lesions of the first episode of acute myocardial infarction in patients with low low-density lipoprotein cholesterol level
      Background There remains a residual risk for acute myocardial infarction (AMI) even with low low-density lipoprotein cholesterol (LDL-C) levels. This study aimed to characterize the culprit lesion morphology of AMI by optical coherence tomography (OCT) in patients with low LDL-C. Methods Four-hundred and nine culprit lesions of 409 patients with their first presentation of AMI imaged by OCT were investigated. OCT analysis included the presence of plaque rupture and thin-capped ...
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    3. ULTRA-WIDEFIELD OPTICAL COHERENCE TOMOGRAPHY FOR RETINAL DETACHMENT WITH PROLIFERATIVE VITREORETINOPATHY

      ULTRA-WIDEFIELD OPTICAL COHERENCE TOMOGRAPHY FOR RETINAL DETACHMENT WITH PROLIFERATIVE VITREORETINOPATHY
      Purpose: To evaluate the efficacy of using preoperative and postoperative ultra-widefield optical coherence tomography ) images in the treatment of proliferative vitreoretinopathy . Methods: The preoperative and postoperative images of a 62-year-old man with proliferative vitreoretinopathy accompanied by a rhegmatogenous retinal detachment were analyzed. Patient: At the initial examination, the vision was 20/400. It was difficult to obtain clear images of the fundus by color fundus photography because of synechia iridis ...
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    4. Subclinical Calcified Nodules in Saphenous Vein Graft on High-Resolution Coronary Angioscopy

      Subclinical Calcified Nodules in Saphenous Vein Graft on High-Resolution Coronary Angioscopy
      Long-term patency of saphenous vein graft (SVG) remains challenging.1 A 75-year-old man on hemodialysis had undergone coronary artery bypass grafting (CABG) 11 years earlier. At the current presentation he underwent percutaneous coronary intervention (PCI) for SVG failure to the diagonal branch (Figure A). Intravascular ultrasound (IVUS) and optical coherence tomography (OCT) showed convex calcifications at the severe proximal anastomotic stenosis (Figure B,C) and tandem stenotic sites (Figure D ...
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    5. Optical coherence tomography‐defined plaque vulnerability in relation to functional stenosis severity stratified by fractional flow reserve and quantitative flow ratio

      Optical coherence tomography‐defined plaque vulnerability in relation to functional stenosis severity stratified by fractional flow reserve and quantitative flow ratio
      Objectives We sought to investigate that the quantitative flow ratio (QFR) might be associated with optical coherence tomography (OCT)‐defined plaque vulnerability. Background Both functional stenosis severity and plaque instability are related to adverse clinical outcomes in patients with coronary artery disease. Recent studies have shown an association between physiological stenosis severity and the presence of thin‐cap fibroatheroma (TCFA). Measurement of QFR is a novel method for rapid computational ...
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    6. Evaluation of Crack Formation and Propagation with Ultrasonic Root-End Preparation and Obturation Using a Digital Microscope and Optical Coherence Tomography

      Evaluation of Crack Formation and Propagation with Ultrasonic Root-End Preparation and Obturation Using a Digital Microscope and Optical Coherence Tomography
      Objective . This study is aimed at determining (1) the effect of root-end resection, ultrasonic root-end preparation, and root-end filling on the incidence of crack formation and propagation by using a digital microscope (DM) and optical coherence tomography (OCT) and (2) the performance of OCT on the detection of cracks by comparing with microcomputed tomography (micro-CT) as a reference standard. Methodology . Thirty extracted lower incisors were endodontically treated and subjected to ...
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    7. Impact of lesion angle on optical coherence tomography findings and clinical outcomes after drug-eluting stent implantation in curved vessels

      Impact of lesion angle on optical coherence tomography findings and clinical outcomes after drug-eluting stent implantation in curved vessels
      Tortuous coronary lesions are associated with adverse outcomes after implantation of bare metal or first-generation drug-eluting stents (DESs). We investigated the impact of lesion angle on vessel wall injuries and stent apposition as assessed by optical coherence tomography (OCT) after second- and newer-generation DES implantation. We investigated 95 de novo lesions treated with a single DES (62 platinum-chromium everolimus-eluting stents and 33 bioresorbable-polymer sirolimus-eluting stents). Post-intervention OCT findings were compared ...
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    8. Swept-source optical coherence tomographic observation on prevalence and variations of cemento-enamel junction morphology

      Swept-source optical coherence tomographic observation on prevalence and variations of cemento-enamel junction morphology
      To investigate the prevalence of different patterns of cemento-enamel junction (CEJ) morphology under swept-source optical coherence tomography (SS-OCT). One hundred extracted human teeth were used consisting of incisors, premolars, and molars. Each sample was observed for every 500 m circumferentially along CEJ and OCT images of the pattern were noted. Microscopic observations were done for the representative sample using confocal laser scanning microscope (CLSM) and transmission electron microscope (TEM). The ...
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    9. Detection of Simulated Periradicular Lesions in Porcine Bone by Optical Coherence Tomography

      Detection of Simulated Periradicular Lesions in Porcine Bone by Optical Coherence Tomography
      Introduction The accurate detection of periradicular lesions located under a nonperforated cortical plate poses a challenge in endodontic microsurgery. Optical coherence tomography (OCT) is a noninvasive imaging method that has been successfully used in many dental applications. In this study, we investigated if spectral-domain OCT (SD-OCT) could be used to determine simulated periradicular lesions. Methods Twenty-eight cavities with different depths were prepared on bone plates obtained from 5 porcine mandibles ...
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    10. Posterior staphylomas and scleral curvature in highly myopic children and adolescents investigated by ultra-widefield optical coherence tomography

      Posterior staphylomas and scleral curvature in highly myopic children and adolescents investigated by ultra-widefield optical coherence tomography
      ...his study conformed to the tenets of the Declaration of Helsinki and were approved by the Ethics Committee of Tokyo Medical and Dental University (The approval number: M2000-2278). A signed informed consent was obtained ...
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    11. Treatment of In-Stent Restenosis by Excimer Laser Coronary Atherectomy and Drug-Coated Balloon: Serial Assessment with Optical Coherence Tomography

      Treatment of In-Stent Restenosis by Excimer Laser Coronary Atherectomy and Drug-Coated Balloon: Serial Assessment with Optical Coherence Tomography
      Objectives . We aimed to compare the results of neointimal modification before drug-coated balloon (DCB) treatment with excimer laser coronary atherectomy (ELCA) plus scoring balloon predilation versus scoring balloon alone in patients presenting with in-stent restenosis (ISR). Background . Treatment of ISR with ELCA typically results in superior acute gain by neointima debulking. However, the efficacy of combination therapy of ELCA and DCB remains unknown. Methods . A total of 42 patients (44 ...
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    12. Ultra-widefield optical coherence tomographic imaging of posterior vitreous in eyes with high myopia

      Ultra-widefield optical coherence tomographic imaging of posterior vitreous in eyes with high myopia
      Purpose To investigate the morphological changes of posterior vitreous in highly myopic (HM) eyes of patients older than 50 years. Design Retrospective, observational case series. Methods Ultra-widefield swept-source OCT (UWF-OCT) examinations were performed on 768 eyes of 448 HM patients (50- to 89-years) and 54 eyes of 52 non-HM subjects with scan width of 23 mm and depth of 5 mm. HM was defined as an axial length longer than ...
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    13. Three-dimensional assessment of proximal contact enamel using optical coherence tomography

      Three-dimensional assessment of proximal contact enamel using optical coherence tomography
      Objective The purpose of this study was to detect and investigate the association of enamel microcracks with demineralization at proximal contact areas of premolars, using 3D swept-source optical coherence tomography (SS-OCT). Methods Extracted maxillary and mandibular premolars (n = 50 each), without any visible tooth cracks, were examined for demineralization of interproximal contact areas, using the International Caries Detection and Assessment System (ICDAS). SS-OCT was used to evaluate demineralization and detect ...
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    14. Optical Coherence Tomography-based Diagnostic Criteria for Different Stages of Myopic Maculopathy

      Optical Coherence Tomography-based Diagnostic Criteria for Different Stages of Myopic Maculopathy
      Purpose To analyze the choroidal thickness (CT) of each type of myopic maculopathy, and to establish an OCT-based classification of myopic maculopathy. Design Retrospective, hospital-based, cross-sectional study. Participants Highly myopic (HM) eyes that were examined by swept-source OCT. Methods The CT was measured at the subfovea and at 3 mm nasal, temporal, superior, and inferior to the fovea. Myopic maculopathy was classified as tessellation, diffuse atrophy, patchy atrophy, and macular ...
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    15. Imaging in myopia: potential biomarkers, current challenges and future developments

      Imaging in myopia: potential biomarkers, current challenges and future developments
      Myopia is rapidly increasing in Asia and around the world, while it is recognised that complications from high myopia may cause significant visual impairment. Thus, imaging the myopic eye is important for the diagnosis of sight-threatening complications, monitoring of disease progression and evaluation of treatments. For example, recent advances in high-resolution imaging using optical coherence tomography may delineate early myopic macula pathology, optical coherence tomography angiography may aid early choroidal ...
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    16. Optical Coherence Tomography–Defined Plaque Vulnerability in Relation to Functional Stenosis Severity and Microvascular Dysfunction

      Optical Coherence Tomography–Defined Plaque Vulnerability in Relation to Functional Stenosis Severity and Microvascular Dysfunction
      Objectives This study sought to investigate the relationship of unstable plaque features with physiological lesion severity and microvascular dysfunction . Background The functional severity of epicardial lesions and microvascular dysfunction are both related to adverse clinical outcomes. Methods We investigated 382 de novo intermediate and severe coronary lesions in 340 patients who underwent optical coherence tomography , fractional flow reserve (FFR), and index of microcirculatory resistance (IMR) examinations. Lesions were divided into ...
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  2. About Tokyo Medical & Dental University

    Tokyo Medical & Dental University

    Tokyo Medical and Dental University is unique among medical and dental universities in Japan in that we have four divisions dedicated to graduate education and research: Medical and Dental Sciences, Health Care Sciences, the Biomedical Sciences Education Division, and the Biomedical Sciences Research Division. TMDU comprises four faculties (Medicine, Dentistry, Health Care Sciences and Oral Health Care Sciences), an undergraduate College of Liberal Arts and Sciences, two research institutes (the Institute of Biomaterials and Bioengineering and the Medical Research Institute), a university hospital attached to the Faculty of Medicine, a university hospital attached to the Faculty of Dentistry, and a dental technologist school.