1. Tokyo Medical & Dental University

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    1. Mentioned In 158 Articles

    2. Optical coherence tomography in coronary atherosclerosis assessment and intervention

      Optical coherence tomography in coronary atherosclerosis assessment and intervention
      Since optical coherence tomography (OCT) was first performed in humans two decades ago, this imaging modality has been widely adopted in research on coronary atherosclerosis and adopted clinically for the optimization of percutaneous coronary intervention. In the past 10 years, substantial advances have been made in the understanding of in vivo vascular biology using OCT. Identification by OCT of culprit plaque pathology could potentially lead to a major shift in ...
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    3. Evaluation of morning glory syndrome by swept-source optical coherence tomography

      Evaluation of morning glory syndrome by swept-source optical coherence tomography
      Purpose: To investigate the deep structural abnormalities in the patients with morning glory syndrome by using swept-source optical coherence tomography (swept-source OCT). Methods: The papillary and peripapillary areas of the 4 eyes (4 patients) with morning glory syndrome were examined with a prototype swept-source OCT system with a center wavelength of 1050 nm. Particularly, the abnormalities of the lamina cribrosa as well as peripapillary sclera were evaluated. Results: The lamina ...
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    4. Predictors of Near-Infrared Spectroscopy-Detected Lipid-Rich Plaques by Optical Coherence Tomography-Defined Morphological Features in Patients With Acute Coronary Syndrome

      Predictors of Near-Infrared Spectroscopy-Detected Lipid-Rich Plaques by Optical Coherence Tomography-Defined Morphological Features in Patients With Acute Coronary Syndrome
      Background: Near-infrared spectroscopy (NIRS) provides the localization of lipid-rich components in coronary plaques. However, morphological features in NIRS-detected lipid-rich plaques (LRP) are unclear. Methods: A total of 140 de novo culprit lesions in 140 patients with the acute coronary syndrome (ACS) who underwent NIRS and optical coherence tomography (OCT) examinations for the culprit lesions at the time of percutaneous coronary interventions were investigated. We defined a NIRS-LRP as a lesion ...
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    5. Optical Coherence Tomography for Patients with Developmental Disabilities: A Preliminary Study

      Optical Coherence Tomography for Patients with Developmental Disabilities: A Preliminary Study
      Dental radiographs are essential for diagnosis and treatment planning, but are sometimes difficult to acquire for patients with developmental disabilities (PDD). Optical Coherence Tomography (OCT) is a non-ionizing imaging modality that has the potential application as an alternative to dental radiographs for PDD. This study aimed to determine the feasibility of intraoral OCT imaging for PDD. Ten participants were recruited in the Dental Education in the Care of Persons with ...
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    6. ADVANCED OCT ANALYSIS OF BIOPSY PROVEN VITREORETINAL LYMPHOMA: OCT findings in vitreo-retinal lymphoma

      ADVANCED OCT ANALYSIS OF BIOPSY PROVEN VITREORETINAL LYMPHOMA: OCT findings in vitreo-retinal lymphoma
      Importance: Although the diagnosis of vitreoretinal lymphoma (VRL) can be challenging, early detection is critical for visual prognosis. Objective: To analyze the spectrum of optical coherence tomography (OCT) findings in patients with biopsy-proven VRL and correlate these features with clinical parameters. Design: Retrospective cross-sectional study SETTING: Multicenter chart review from 13 retina, uveitis and ocular oncology clinics worldwide over an 11-year period (2008-2019). Participants: Patients with a diagnosis of biopsy-proven ...
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    7. Optical Coherence Tomography of Plaque Erosion: JACC Focus Seminar Part 2/3

      Optical Coherence Tomography of Plaque Erosion: JACC Focus Seminar Part 2/3
      Plaque erosion, a distinct histopathological and clinical entity, accounts for over 30% of acute coronary syndromes (ACS). Optical coherence tomography allows in vivo diagnosis of plaque erosion. Local flow perturbation with activation of Toll-like receptor 2 and CD8 + T cells and subsequent desquamation of endothelium and neutrophil extracellular trap formation contribute to mechanisms of plaque erosion. Compared with ACS patients with plaque rupture, those with plaque erosion are younger, have ...
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    8. Dentin anti-demineralization potential of surface reaction-type pre-reacted glass-ionomer filler containing self-adhesive resin cement

      Dentin anti-demineralization potential of surface reaction-type pre-reacted glass-ionomer filler containing self-adhesive resin cement
      Objective To investigate the anti-demineralization potential of a newly developed surface reaction-type pre-reacted glass-ionomer (S-PRG) filler containing self-adhesive resin cement against acidic attacks on the dentin surface. Materials and methods A total of 32 bovine teeth were used. Cavities were prepared on crown dentin slaps and filled with three self-adhesive resin cement: (1) S-PRG-based cement, (2) Si-based cement, and (3) RelyX cement. Specimens were then subjected to pH cycling for ...
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    9. Clinical outcomes of low-intensity area without attenuation and cholesterol crystals in non-culprit lesions assessed by optical coherence tomography

      Clinical outcomes of low-intensity area without attenuation and cholesterol crystals in non-culprit lesions assessed by optical coherence tomography
      Background and aims Pathologists have shown that intraplaque hemorrhage contributes to plaque destabilization and is frequently co-located with cholesterol crystals (CC). Optical coherence tomography (OCT)-detected low-intensity area without attenuation (LIA) may represent intraplaque hemorrhage. We aimed to examine the prevalence and impact of OCT-detected LIA + CC in untreated non-culprit lesions (NCLs) on subsequent major adverse cardiac events (MACE). Methods OCT imaged NCLs in the culprit vessel in the patients ...
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    10. Optical coherence tomography and coronary angioscopy assessment of healed coronary plaque components

      Optical coherence tomography and coronary angioscopy assessment of healed coronary plaque components
      Purpose: Histopathological or intracoronary image assessment of healed plaques (HPs) has been reported. However, the lesion characteristics of HPs remains undetermined yet. We assessed the healed plaque components in patients with coronary artery lesions using multiple imaging modalities. Methods: We enrolled 33 stable angina pectoris (SAP) patients with 36 native coronary culprit lesions with angiography severe stenosis and without severe calcification undergoing pre-intervention optical coherence tomography (OCT) and coronary angioscopy ...
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    11. Visual acuity in glaucomatous eyes correlates better with visual field parameters than with OCT parameters

      Visual acuity in glaucomatous eyes correlates better with visual field parameters than with OCT parameters
      Purpose of the study: The visual acuity is very important for glaucoma patients in their lives. The purpose of this study was to examine about the correlation of visual acuity and visual field (VF) parameters or optical coherence tomography (OCT) parameters in patients with glaucoma. Materials and methods: We evaluated 210 eyes of 210 patients (110 men and 100 women; mean age, 69.6 9.6 years) with open-angle glaucoma ...
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    12. Effect of contrast medium versus low-molecular-weight dextran for intracoronary optical coherence tomography in renal insufficiency

      Effect of contrast medium versus low-molecular-weight dextran for intracoronary optical coherence tomography in renal insufficiency
      Low-molecular-weight dextran (LMWD) is considered a safe alternative to contrast media to displace blood during optical coherence tomography (OCT) imaging, but concerns remain. The purpose of this study was to investigate whether using LMWD for OCT protects against kidney injury in patients with renal insufficiency compared with contrast media. We retrospectively identified 474 patients with renal insufficiency (estimated glomerular filtration rate 60 ml/min/1.73 m 2 ) who underwent ...
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    13. Assessment of Demineralization Inhibition Effects of Dentin Desensitizers Using Swept-Source Optical Coherence Tomography

      Assessment of Demineralization Inhibition Effects of Dentin Desensitizers Using Swept-Source Optical Coherence Tomography
      The purpose of this study was to evaluate the mechanism of action and the inhibiting effects of two types of desensitizers against dentin demineralization using pre-demineralized hypersensitivity tooth model in vitro. In this study, we confirmed that a hypersensitivity tooth model from our preliminary experiment could be prepared by immersing dentin discs in an acetic acid-based solution with pH 5.0 for three days. Dentin discs with three days of ...
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    14. Vascular Responses to First-Generation Sirolimus-Eluting Stents and Bare-Metal Stents Beyond 10 Years

      Vascular Responses to First-Generation Sirolimus-Eluting Stents and Bare-Metal Stents Beyond 10 Years
      Background: There are limited data regarding differences in vascular responses between first-generation sirolimus-eluting stents (1G-SES) and bare-metal stents (BMS) 10 years after implantation. Methods and Results: We retrospectively investigated 223 stents (105 1G-SES, 118 BMS) from 131 patients examined by optical coherence tomography (OCT) 10 years after implantation. OCT analysis included determining the presence or absence of a lipid-laden neointima, calcified neointima, macrophage accumulation, malapposition, and strut coverage. Neoatherosclerosis was ...
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    15. Low-molecular-weight dextran for optical coherence tomography may not be protective against kidney injury in patients with renal insufficiency

      Low-molecular-weight dextran for optical coherence tomography may not be protective against kidney injury in patients with renal insufficiency
      Background: Low-molecular-weight dextran (LMWD) is considered a safe alternative to contrast media for blood displacement during optical coherence tomography (OCT) imaging. Aim: To investigate whether the use of LMWD for OCT is protective against kidney injury in patients with advanced renal insufficiency. Methods: In this retrospective cohort study, we identified 421 patients with advanced renal insufficiency (estimated glomerular filtration rate 45 mL/min/1.73 m 2 ) who underwent coronary ...
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    16. Evaluation of microleakage in class-II bulk-fill composite restorations

      Evaluation of microleakage in class-II bulk-fill composite restorations
      Background/purpose Despite the clinical appeal of restoring deep class II cavities in single increment using bulk-fill resin composite, sealing of bulk-filled composite restorations is a concern. This study evaluated interfacial adaptation of bulk-fill composite restoration to axial wall and gingival floor of class II cavities using cross-polarization optical coherence tomography (CP-OCT). Materials and methods Box-shaped class II cavities were prepared in extracted molars and divided into three groups ( n ...
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    17. 1-15 of 158 1 2 3 4 ... 9 10 11 »
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  2. About Tokyo Medical & Dental University

    Tokyo Medical & Dental University

    Tokyo Medical and Dental University is unique among medical and dental universities in Japan in that we have four divisions dedicated to graduate education and research: Medical and Dental Sciences, Health Care Sciences, the Biomedical Sciences Education Division, and the Biomedical Sciences Research Division. TMDU comprises four faculties (Medicine, Dentistry, Health Care Sciences and Oral Health Care Sciences), an undergraduate College of Liberal Arts and Sciences, two research institutes (the Institute of Biomaterials and Bioengineering and the Medical Research Institute), a university hospital attached to the Faculty of Medicine, a university hospital attached to the Faculty of Dentistry, and a dental technologist school.