1. Tokyo Medical & Dental University

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    1. Mentioned In 123 Articles

    2. Impact of lesion angle on optical coherence tomography findings and clinical outcomes after drug-eluting stent implantation in curved vessels

      Impact of lesion angle on optical coherence tomography findings and clinical outcomes after drug-eluting stent implantation in curved vessels
      Tortuous coronary lesions are associated with adverse outcomes after implantation of bare metal or first-generation drug-eluting stents (DESs). We investigated the impact of lesion angle on vessel wall injuries and stent apposition as assessed by optical coherence tomography (OCT) after second- and newer-generation DES implantation. We investigated 95 de novo lesions treated with a single DES (62 platinum-chromium everolimus-eluting stents and 33 bioresorbable-polymer sirolimus-eluting stents). Post-intervention OCT findings were compared ...
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    3. Swept-source optical coherence tomographic observation on prevalence and variations of cemento-enamel junction morphology

      Swept-source optical coherence tomographic observation on prevalence and variations of cemento-enamel junction morphology
      To investigate the prevalence of different patterns of cemento-enamel junction (CEJ) morphology under swept-source optical coherence tomography (SS-OCT). One hundred extracted human teeth were used consisting of incisors, premolars, and molars. Each sample was observed for every 500 m circumferentially along CEJ and OCT images of the pattern were noted. Microscopic observations were done for the representative sample using confocal laser scanning microscope (CLSM) and transmission electron microscope (TEM). The ...
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    4. Detection of Simulated Periradicular Lesions in Porcine Bone by Optical Coherence Tomography

      Detection of Simulated Periradicular Lesions in Porcine Bone by Optical Coherence Tomography
      Introduction The accurate detection of periradicular lesions located under a nonperforated cortical plate poses a challenge in endodontic microsurgery. Optical coherence tomography (OCT) is a noninvasive imaging method that has been successfully used in many dental applications. In this study, we investigated if spectral-domain OCT (SD-OCT) could be used to determine simulated periradicular lesions. Methods Twenty-eight cavities with different depths were prepared on bone plates obtained from 5 porcine mandibles ...
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    5. Posterior staphylomas and scleral curvature in highly myopic children and adolescents investigated by ultra-widefield optical coherence tomography

      Posterior staphylomas and scleral curvature in highly myopic children and adolescents investigated by ultra-widefield optical coherence tomography
      ...his study conformed to the tenets of the Declaration of Helsinki and were approved by the Ethics Committee of Tokyo Medical and Dental University (The approval number: M2000-2278). A signed informed consent was obtained ...
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    6. Treatment of In-Stent Restenosis by Excimer Laser Coronary Atherectomy and Drug-Coated Balloon: Serial Assessment with Optical Coherence Tomography

      Treatment of In-Stent Restenosis by Excimer Laser Coronary Atherectomy and Drug-Coated Balloon: Serial Assessment with Optical Coherence Tomography
      Objectives . We aimed to compare the results of neointimal modification before drug-coated balloon (DCB) treatment with excimer laser coronary atherectomy (ELCA) plus scoring balloon predilation versus scoring balloon alone in patients presenting with in-stent restenosis (ISR). Background . Treatment of ISR with ELCA typically results in superior acute gain by neointima debulking. However, the efficacy of combination therapy of ELCA and DCB remains unknown. Methods . A total of 42 patients (44 ...
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    7. Ultra-widefield optical coherence tomographic imaging of posterior vitreous in eyes with high myopia

      Ultra-widefield optical coherence tomographic imaging of posterior vitreous in eyes with high myopia
      Purpose To investigate the morphological changes of posterior vitreous in highly myopic (HM) eyes of patients older than 50 years. Design Retrospective, observational case series. Methods Ultra-widefield swept-source OCT (UWF-OCT) examinations were performed on 768 eyes of 448 HM patients (50- to 89-years) and 54 eyes of 52 non-HM subjects with scan width of 23 mm and depth of 5 mm. HM was defined as an axial length longer than ...
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    8. Three-dimensional assessment of proximal contact enamel using optical coherence tomography

      Three-dimensional assessment of proximal contact enamel using optical coherence tomography
      Objective The purpose of this study was to detect and investigate the association of enamel microcracks with demineralization at proximal contact areas of premolars, using 3D swept-source optical coherence tomography (SS-OCT). Methods Extracted maxillary and mandibular premolars (n = 50 each), without any visible tooth cracks, were examined for demineralization of interproximal contact areas, using the International Caries Detection and Assessment System (ICDAS). SS-OCT was used to evaluate demineralization and detect ...
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    9. Optical Coherence Tomography-based Diagnostic Criteria for Different Stages of Myopic Maculopathy

      Optical Coherence Tomography-based Diagnostic Criteria for Different Stages of Myopic Maculopathy
      Purpose To analyze the choroidal thickness (CT) of each type of myopic maculopathy, and to establish an OCT-based classification of myopic maculopathy. Design Retrospective, hospital-based, cross-sectional study. Participants Highly myopic (HM) eyes that were examined by swept-source OCT. Methods The CT was measured at the subfovea and at 3 mm nasal, temporal, superior, and inferior to the fovea. Myopic maculopathy was classified as tessellation, diffuse atrophy, patchy atrophy, and macular ...
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    10. Imaging in myopia: potential biomarkers, current challenges and future developments

      Imaging in myopia: potential biomarkers, current challenges and future developments
      Myopia is rapidly increasing in Asia and around the world, while it is recognised that complications from high myopia may cause significant visual impairment. Thus, imaging the myopic eye is important for the diagnosis of sight-threatening complications, monitoring of disease progression and evaluation of treatments. For example, recent advances in high-resolution imaging using optical coherence tomography may delineate early myopic macula pathology, optical coherence tomography angiography may aid early choroidal ...
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    11. Optical Coherence Tomography–Defined Plaque Vulnerability in Relation to Functional Stenosis Severity and Microvascular Dysfunction

      Optical Coherence Tomography–Defined Plaque Vulnerability in Relation to Functional Stenosis Severity and Microvascular Dysfunction
      Objectives This study sought to investigate the relationship of unstable plaque features with physiological lesion severity and microvascular dysfunction . Background The functional severity of epicardial lesions and microvascular dysfunction are both related to adverse clinical outcomes. Methods We investigated 382 de novo intermediate and severe coronary lesions in 340 patients who underwent optical coherence tomography , fractional flow reserve (FFR), and index of microcirculatory resistance (IMR) examinations. Lesions were divided into ...
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    12. A non‐invasive imaging and measurement using optical coherence tomography angiography for the assessment of gingiva: An in vivo study

      A non‐invasive imaging and measurement using optical coherence tomography angiography for the assessment of gingiva: An in vivo study
      Gingiva is the soft tissue that surrounds and protects the teeth. Healthy gingiva provides an effective barrier to periodontal insults to deeper tissue, thus is an important indicator to a patients periodontal health. Current methods in assessing gingival tissue health, including visual observation and physical examination with probing on the gingiva, are qualitative and subjective. They may become cumbersome when more complex cases are involved, such as variations in gingival ...
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    13. Assessment of root caries under wet and dry conditions using swept-source optical coherence tomography (SS-OCT)

      Assessment of root caries under wet and dry conditions using swept-source optical coherence tomography (SS-OCT)
      The purpose of this study was to compare optical properties of root caries under two observing conditions using swept-source optical coherence tomography (SS-OCT). In vitro and natural root caries were observed by SS-OCT under wet and dry conditions, followed by confocal laser scanning microscope (CLSM) and transverse microradiography (TMR). Signal intensity (SI), distance between SI peaks (SI-distance) and optical lesion depth were obtained from OCT. Lesion depth was measured from ...
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    14. In vitro and clinical evaluation of optical coherence tomography for the detection of subgingival calculus and root cementum

      In vitro and clinical evaluation of optical coherence tomography for the detection of subgingival calculus and root cementum
      This study evaluated the effectiveness of swept-source optical coherence tomography (ss-OCT) for detecting calculus and root cementum during periodontal therapy. Optical coherence tomography (OCT) images were taken before and after removal of subgingival calculus from extracted teeth and compared with non-decalcified histological sections. Porcine gingival sheets of various thicknesses were applied to the root surfaces of extracted teeth with calculus and OCT images were taken. OCT images were also taken ...
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    15. Nonculprit Plaque Characteristics in Patients With Acute Coronary Syndrome Caused by Plaque Erosion vs Plaque Rupture A 3-Vessel Optical Coherence Tomography Study

      Nonculprit Plaque Characteristics in Patients With Acute Coronary Syndrome Caused by Plaque Erosion vs Plaque Rupture A 3-Vessel Optical Coherence Tomography Study
      Importance Patients with culprit plaque rupture are known to have pancoronary plaque vulnerability. However, the characteristics of nonculprit plaques in patients with acute coronary syndromes caused by plaque erosion are unknown. Objective To investigate the nonculprit plaque phenotype in patients with acute coronary syndrome according to culprit plaque pathology (erosion vs rupture) by 3-vessel optical coherence tomography imaging. Design, Setting, and Participants In this observational cohort study, between August 2010 ...
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    16. Swept-source optical coherence tomographic findings in eyes with metastatic choroidal tumor

      Swept-source optical coherence tomographic findings in eyes with metastatic choroidal tumor
      Purpose To report the swept-source optical coherence tomographic (OCT) findings in two eyes with choroidal metastases. Observations Two patients with choroidal metastasis were studied. The metastasis was from a breast cancer in Case 1 and from a lung cancer in Case 2. In Case 1, swept-source OCT showed a highly reflective solid tumor with low optical reflective tissues that had replaced the choroidal tissue. Swept-source OCT was able to image ...
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  2. About Tokyo Medical & Dental University

    Tokyo Medical & Dental University

    Tokyo Medical and Dental University is unique among medical and dental universities in Japan in that we have four divisions dedicated to graduate education and research: Medical and Dental Sciences, Health Care Sciences, the Biomedical Sciences Education Division, and the Biomedical Sciences Research Division. TMDU comprises four faculties (Medicine, Dentistry, Health Care Sciences and Oral Health Care Sciences), an undergraduate College of Liberal Arts and Sciences, two research institutes (the Institute of Biomaterials and Bioengineering and the Medical Research Institute), a university hospital attached to the Faculty of Medicine, a university hospital attached to the Faculty of Dentistry, and a dental technologist school.