1. Tohoku University

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    1. Mentioned In 28 Articles

    2. Quantitative analysis of the macula with optical coherence tomography angiography in normal Japanese subjects: The Taiwa Study

      Quantitative analysis of the macula with optical coherence tomography angiography in normal Japanese subjects: The Taiwa Study
      This study evaluated age-related changes in the superficial and deep retinal capillary plexus (SCP and DCP, respectively) and in the foveal avascular zone (FAZ). SCP and DCP perfusion density (PD) were measured in optical coherence tomography angiography (OCTA) macular scans of 145 eyes of 145 healthy Japanese subjects, and findings were compared with SCP FAZ and clinical data. We found that age was negatively correlated with SCP and DCP PD ...
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    3. Optical Coherence Tomography Assessment of Risk Factors for Visual Acuity Decline after Trabeculectomy in Patients with Advanced Open-angle Glaucoma

      Optical Coherence Tomography Assessment of Risk Factors for Visual Acuity Decline after Trabeculectomy in Patients with Advanced Open-angle Glaucoma
      Prcis: Thinning of the macular retinal nerve fiber layer and ganglion cell complex in the papillomacular bundle area contributed significantly to visual acuity decline in advanced glaucoma patients after trabeculectomy . Purpose: To identify structural parameters that could predict visual acuity (VA) decline after trabeculectomy in patients with advanced open-angle glaucoma. Patients and Methods: Retrospective review of 74 eyes of 74 patients with advanced glaucoma (defined as mean deviation (MD) 12 ...
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    4. Glaucoma Diagnosis with Machine Learning Based on Optical Coherence Tomography and Color Fundus Image

      Glaucoma Diagnosis with Machine Learning Based on Optical Coherence Tomography and Color Fundus Image
      This study aimed to develop a machine learning-based algorithm for glaucoma diagnosis in patients with open-angle glaucoma, based on three-dimensional optical coherence tomography (OCT) data and color fundus images. In this study, 208 glaucomatous and 149 healthy eyes were enrolled, and color fundus images and volumetric OCT data from the optic disc and macular area of these eyes were captured with a spectral-domain OCT (3D OCT-2000, Topcon). Thickness and deviation ...
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    5. Detection of enamel subsurface lesions by swept-source optical coherence tomography

      Detection of enamel subsurface lesions by swept-source optical coherence tomography
      This study aimed to non-destructively analyze the progression of subsurface enamel caries using swept-source optical coherence tomography (SS-OCT), a recently developed imaging analysis modality. Artificial enamel caries at various stages of demineralization were created in bovine tooth enamel using a modified lactic acid gel system. Untreated enamel served as a control. OCT images from cross-sections of enamel were collected. Mineral density, distribution, and histological changes were analyzed using an electron ...
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    6. The findings of optical coherence tomography of retinal degeneration in relation to the morphological and electroretinographic features in RPE65−/− mice

      The findings of optical coherence tomography of retinal degeneration in relation to the morphological and electroretinographic features in RPE65−/− mice
      Purpose Mutations of the gene encoding RPE65 cause Leber congenital amaurosis (LCA) retinitis pigmentosa (RP). The optical coherence tomography (OCT) is increasingly utilized to noninvasively evaluate various types of retinal diseases, including RP. The present study was conducted to characterize the OCT findings of the RPE65 / micean animal model of LCA and RPin relation to the morphological features based on histological and electron microscopic findings as well as electroretinography (ERG ...
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    7. The Spectral-Domain Optical Coherence Tomography Findings Associated with the Morphological and Electrophysiological Changes in a Rat Model of Retinal Degeneration, Rhodopsin S334ter-4 Rats

      The Spectral-Domain Optical Coherence Tomography Findings Associated with the Morphological and Electrophysiological Changes in a Rat Model of Retinal Degeneration, Rhodopsin S334ter-4 Rats
      Abstract Purpose. To characterize the spectral-domain optical coherence tomography (SD-OCT) findings of the rhodopsin S334ter transgenic rats (line 4) in relation to the morphologic and electroretinographic features. Materials and Methods. Rhodopsin S334ter transgenic rats (line 4) were employed as a model of retinal degeneration. The Sprague-Dawley (SD) rats were used as a wild-type control. SD-OCT (Micron IV; Phoenix Research Labs, Pleasanton, CA, USA) was performed on the S334ter rats (line ...
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    8. Optical coherence tomography angiography assessment of the macular capillary plexus after surgery for macula-off rhegmatogenous retinal detachment

      Optical coherence tomography angiography assessment of the macular capillary plexus after surgery for macula-off rhegmatogenous retinal detachment
      Dear Editor, Macula-involved rhegmatogenous retinal detachment (RRD) is a condition that can cause severe central visual disturbance, even after successful retinal re-attachment. Optical coherence tomography angiography (OCTA) can measure vessel density (VD) in the macular capillary plexus (MCP), both superficially (the SCP) and deeply (the DCP), and can measure the foveal avascular zone (FAZ) in these layers. Previous research used OCTA to evaluate the correlation between the FAZ and visual ...
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    9. Prediction of Surgical Outcome After Trabeculectomy for Neovascular Glaucoma with Anterior-segment Optical Coherence Tomography

      Prediction of Surgical Outcome After Trabeculectomy for Neovascular Glaucoma with Anterior-segment Optical Coherence Tomography
      Purpose: To determine the potential of anterior-segment optical coherence tomography (AS-OCT) to predict post- trabeculectomy outcomes in NVG . Patients and Methods: We recruited fifty-five eyes of 40 NVG patients who underwent trabeculectomy . The patients were divided into success and failure groups based on the post- trabeculectomy outcome after 12 months. AS-OCT findings were compared in the success and failure groups at 1 and 2 weeks and 1, 3, 6, and ...
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    10. Evaluation of retinal nerve fiber layer defect using wide-field en-face swept-source OCT images by applying the inner limiting membrane flattening

      Evaluation of retinal nerve fiber layer defect using wide-field en-face swept-source OCT images by applying the inner limiting membrane flattening
      Purpose The assessment of retinal nerve fiber layer defects (RNFLDs) is a useful part of glaucoma care. Here, we obtained en-face images of retinal layers below the inner limiting membrane (ILM) with swept source-optical coherence tomography (SS-OCT), and measured RNFLD angle with new software. Methods This study included 105 eyes of 105 normal tension glaucoma (NTG) patients (age, 59.8 13.2). Exclusion criteria were best-corrected visual acuity 0.5 ...
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    11. EuroIntervention Automated characterisation of lipid core plaques in vivo by quantitative optical coherence tomography tissue type imaging

      EuroIntervention Automated characterisation of lipid core plaques in vivo by quantitative optical coherence tomography tissue type imaging
      Aims: Qualitative criteria for plaque tissue characterisation by OCT are well established, but quantitative methods lack systematic validation in vivo . High optical attenuation coefficient t has been associated with unstable plaque features, such as lipid core. The purpose of this study was to validate optical coherence tomography (OCT) attenuation imaging for tissue characterisation in vivo , specifically to detect lipid core in coronary atherosclerotic plaques, and to evaluate quantitatively the ability ...
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    12. Estimation of Jones matrix, birefringence and entropy using Cloude-Pottier decomposition in polarization-sensitive optical coherence tomography

      Estimation of Jones matrix, birefringence and entropy using Cloude-Pottier decomposition in polarization-sensitive optical coherence tomography
      Estimation of polarimetric parameters has been a fundamental issue to assess biological tissues that have form birefringence or polarization scrambling in polarization-sensitive optical coherence tomography (PS-OCT). We present a mathematical framework to provide a maximum likelihood estimation of the target covariance matrix and its incoherent target decomposition to estimate a Jones matrix of a dominant scattering mechanism, called Cloude-Pottier decomposition, thereby deriving the phase retardation and the optic axis of ...
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    13. Clinical Factors Associated with Lamina Cribrosa Thickness in Patients with Glaucoma, as Measured with Swept Source Optical Coherence Tomography

      Clinical Factors Associated with Lamina Cribrosa Thickness in Patients with Glaucoma, as Measured with Swept Source Optical Coherence Tomography
      Purpose To investigate the influence of various risk factors on thinning of the lamina cribrosa (LC), as measured with swept-source optical coherence tomography (SS-OCT; Topcon). Methods This retrospective study comprised 150 eyes of 150 patients: 22 normal subjects, 28 preperimetric glaucoma (PPG) patients, and 100 open-angle glaucoma patients. Average LC thickness was determined in a 3 x 3 mm cube scan of the optic disc, over which a 4 x ...
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    14. Morphologic Characteristics of Choroid in the Major Choroidal Thickening Diseases, Studied by Optical Coherence Tomography

      Morphologic Characteristics of Choroid in the Major Choroidal Thickening Diseases, Studied by Optical Coherence Tomography
      We investigated morphologic features of choroid in the choroidal thickening diseases, including central serous chorioretinopathy (CSC), polypoidal choroidal vasculopathy (PCV), and Vogt-Koyanagi-Harada disease (VKH), by a novel tomographic classification system of the choroid. This cross-sectional study involved 30 patients with active CSC, 30 patients with active PCV, and 27 patients with active VKH, and 30 normal controls. Utilizing enhanced depth imaging optical coherence tomography, we classified the morphology of the ...
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  2. About Tohoku University

    Tohoku University

    Tohoku University is located in Sendai, Miyagi in the Tōhoku Region , Japan, is a Japanese national university . It is the third oldest Imperial University in Japan and is a member of the National Seven Universities . It is considered as one of the most prestigious universities in Japan, and one of the top fifty universities in the world.  In 2009, Tohoku University had ten colleges within the university, including fifteen departments with graduate students, with a total enrollment of 17,949 students.

    Also see Tohoku University Hospital.