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1. Mentioned In 92 Articles
2. Longitudinal assessment of optic nerve head changes using optical coherence tomography in a primate microbead model of ocular hypertension
  
  Explore Nature Publishing Group Sep 10 2020 Ophthalmology
  
  In humans, the longitudinal characterisation of early optic nerve head (ONH) damage in ocular hypertension (OHT) is difficult as patients with glaucoma usually have structural ONH damage at the time of diagnosis. Previous studies assessed glaucomatous ONH cupping by measuring the anterior lamina cribrosa depth (LCD) and minimal rim width (MRW) using optical coherence tomography (OCT). In this study, we induced OHT by repeated intracameral microbead injections in 16 cynomolgus ...
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  Mentions: Singapore Eye Research Institute National University of Singapore Tin Aung
3. Effect of Pharmacological Pupil Dilatation on Angle Configuration in Untreated Primary Angle Closure Suspects: A Swept Source Anterior Segment Optical Coherence Tomography Study
  
  Explore LWW Online Apr 7 2020 Ophthalmology
  
  Precis: Angle closure worsens with pharmacological dilatation in about 50.0% of the subjects diagnosed as primary angle closure suspects. Purpose: To evaluate the changes in angle configuration with swept source anterior segment optical coherence tomography before and after pharmacological pupil dilatation in untreated primary angle closure suspects. Patients Methods: 106 subjects over the age of 50 years and diagnosed as primary angle closure suspects were included in this cross-sectional ...
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  Mentions: Singapore Eye Research Institute National University of Singapore Tomey Corporation
4. Evaluation of meridional scans for angle closure assessment with anterior segment swept-source optical coherence tomography
  
  Explore BJO Online Mar 12 2020 Ophthalmology
  
  Background/aims As swept-source optical coherence tomography (SS-OCT) simultaneously obtains 128 meridional scans, it is important to identify which scans are playing the main role in classifying gonioscopic angle closure to simplify the analysis. We aimed to evaluate the diagnostic performance of every meridional scan in its ability to detect gonioscopic angle closure. Methods Observational study with 2027 phakic subjects consecutively recruited from a community polyclinic. Gonioscopy and SS-OCT were ...
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  Mentions: Singapore Eye Research Institute Harvard University National University of Singapore
5. Towards Label-Free 3D Segmentation of Optical Coherence Tomography Images of the Optic Nerve Head Using Deep Learning
  
  Explore arxiv.org Mar 1 2020 Ophthalmology
  
  Since the introduction of optical coherence tomography (OCT), it has been possible to study the complex 3D morphological changes of the optic nerve head (ONH) tissues that occur along with the progression of glaucoma. Although several deep learning (DL) techniques have been recently proposed for the automated extraction (segmentation) and quantification of these morphological changes, the device-specific nature and the difficulty in preparing manual segmentations (training data) limit their clinical ...
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  Mentions: Duke University Medical University of Vienna Singapore Eye Research Institute
6. NTU and SERI launch joint laboratory to develop advanced ocular imaging technologies
  
  Explore Optical Coherence Tomography News Jan 7 2020 Ophthalmology , Partnership
  
  ...ecord in translational research excellence, which supports Singapore's vibrant research ecosystem.” Professor Aung Tin, Executive Director, Singapore Eye Research Institute, said, “We hope that this new lab between SNEC-...
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  Mentions: Imperial College London Singapore Eye Research Institute Nanyang Technological University
7. Anterior Segment Optical Coherence Tomography: Is There a Clinical Role in the Management of Primary Angle Closure Disease?
  
  Explore LWW Online Jan 1 2020 Ophthalmology
  
  Primary angle closure disease (PACD) covers a spectrum that includes primary angle closure suspect, primary angle closure, primary angle closure glaucoma, and acute primary angle closure. Accumulating evidence suggests that the pathogenesis of PACD is complex, with multiple contributory factors including variations in the anatomic or biometric characteristics of the angle segment structures. Advances in anterior segment optical coherence tomography technology have further enhanced our understanding of the risk factors ...
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  Mentions: Singapore Eye Research Institute National University of Singapore Tin Aung
8. Recent advances in anterior chamber angle imaging
  
  Explore Nature Publishing Group Nov 4 2019 Ophthalmology
  
  Differentiating the two main forms of primary glaucoma (open-angle and closed-angle glaucoma) depends on the correct assessment of the anterior chamber angle (ACA). This assessment will determine the management plan and prognosis for the disease. The standard method of examining the angle has been, for many years, slit-lamp gonioscopy. This method, although clinically still useful, is less robust for patient follow up and clinical research, given its low reproducibility. Several ...
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  Mentions: Singapore Eye Research Institute Tomey Corporation Mani Baskaran
9. DeshadowGAN: A Deep Learning Approach to Remove Shadows from Optical Coherence Tomography Images
  
  Explore arxiv.org Oct 14 2019 Ophthalmology
  
  Purpose: To remove retinal shadows from optical coherence tomography (OCT) images of the optic nerve head (ONH). Methods: 2328 OCT images acquired through the center of the ONH using a Spectralis OCT machine for both eyes of 13 subjects were used to train a generative adversarial network (GAN) using a custom loss function.Image quality was assessed qualitatively (for artifacts) and quantitatively using the intralayer contrast a measure of shadow ...
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  Mentions: Cardiff University Nanyang Technological University National University of Singapore
10. A Deep Learning Approach to Denoise Optical Coherence Tomography Images of the Optic Nerve Head
  
  Explore Nature Publishing Group Oct 9 2019 Ophthalmology
  
  Optical coherence tomography (OCT) has become an established clinical routine for the in vivo imaging of the optic nerve head (ONH) tissues, that is crucial in the diagnosis and management of various ocular and neuro-ocular pathologies. However, the presence of speckle noise affects the quality of OCT images and its interpretation. Although recent frame-averaging techniques have shown to enhance OCT image quality, they require longer scanning durations, resulting in patient ...
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  Mentions: Medical University of Vienna Singapore Eye Research Institute Nanyang Technological University
11. Upside-down position leads to choroidal expansion and anterior chamber shallowing: OCT study
  
  Explore BJO Online Sep 13 2019 Ophthalmology
  
  Background To determine whether dynamic changes in choroidal thickness (CT) cause shallowing of the anterior chamber. Methods 34 healthy volunteers were enrolled. The participants in our study adopted the upside-down position for 1.5min, which was the model we used to study the dynamic changes in CT. Intraocular pressure (IOP) elevation, optical coherence tomography images of the choroid and anterior chamber were obtained at baseline, after being in an upside-down ...
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  Mentions: Sun Yat-Sen University Chinese Academy of Sciences Tin Aung
12. Understanding diagnostic disagreement in angle closure assessment between anterior segment optical coherence tomography and gonioscopy
  
  Explore BJO Online Sep 10 2019 Ophthalmology
  
  Background/aims Although being a more objective tool for assessment and follow-up of angle closure, reliability studies have reported a moderate diagnostic performance for anterior segment optical coherence tomography (OCT) technologies when comparing with gonioscopy as the reference standard. We aim to determine factors associated with diagnostic disagreement in angle closure when assessed by anterior segment swept source OCT (SS-OCT, CASIA SS-1000; Tomey, Nagoya, Japan) and gonioscopy. Methods Cross-sectional study ...
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  Mentions: Singapore Eye Research Institute David S. Friedman Massachusetts Eye and Ear Infirmary
13. Anterior Segment Optical Coherence Tomography Is there a Clinical Role in Management of Primary Angle Closure Disease?
  
  Explore LWW Online Sep 7 2019 Ophthalmology
  
  Primary angle-closure disease (PACD) covers a spectrum that includes primary angle-closure suspect (PACS), primary angle-closure (PAC), primary angle-closure glaucoma (PACG), as well as acute primary angle closure (APAC). Accumulating evidence suggests that the pathogenesis of PACD is complex, with multiple contributory factors including variations in the anatomical or biometric characteristics of the angle segment structures. Advances in anterior segment optical coherence tomography (ASOCT) technology have further enhanced our understanding of ...
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  Mentions: Singapore Eye Research Institute National University of Singapore Tin Aung
14. Compensation of retinal nerve fibre layer thickness as assessed using optical coherence tomography based on anatomical confounders
  
  Explore BJO Online May 28 2019 Ophthalmology
  
  Background/Aims To compensate the retinal nerve fibre layer (RNFL) thickness assessed by spectral-domain optical coherence tomography (SD-OCT) for anatomical confounders. Methods The Singapore Epidemiology of Eye Diseases is a population-based study, where 2698 eyes (1076 Chinese, 704 Malays and 918 Indians) with high-quality SD-OCT images from individuals without eye diseases were identified. Optic disc and macular cube scans were registered to determine the distance between fovea and optic disc ...
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  Mentions: Singapore Eye Research Institute The Chinese University of Hong Kong Tin Aung
15. A Deep Learning System for Automated Angle-Closure Detection in Anterior Segment Optical Coherence Tomography Images
  
  Explore American Journal of Ophthalmology Mar 5 2019 Ophthalmology
  
  Purpose Anterior segment optical coherence tomography (AS-OCT) provides an objective imaging modality for visually identifying anterior segment structures. An automated detection system could assist ophthalmologists in interpreting AS-OCT images for presence of angle closure. Design Development of an artificial intelligence automated detection system for the presence of angle closure. Methods A deep learning system for automated angle-closure detection in AS-OCT images was developed, and this was compared with another automated ...
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  Mentions: Singapore Eye Research Institute Mani Baskaran Tin Aung
16. Assessment of Circumferential Angle Closure with Swept-Source Optical Coherence Tomography: a community based study
  
  Explore American Journal of Ophthalmology Nov 28 2018 Ophthalmology
  
  Purpose To evaluate the diagnostic performance of swept-source optical coherence tomography (SS-OCT, CASIA SS-1000, Tomey Corporation, Nagoya, Japan) for angle closure detection, in comparison with gonioscopy in a community setting. Design Reliability analysis. Methods A total of 2027 phakic subjects aged 50 years, with no previous history of glaucoma, laser (including peripheral iridotomy), intraocular surgery or ocular trauma, were consecutively recruited from a community polyclinic in Singapore. Gonioscopy was performed ...
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  Mentions: Johns Hopkins University Singapore Eye Research Institute David S. Friedman
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