1. Thu-Mai Nguyen

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    1-14 of 14
    1. Mentioned In 14 Articles

    2. Diffuse shear wave imaging: toward passive elastography using low-frame rate spectral-domain optical coherence tomography

      Diffuse shear wave imaging: toward passive elastography using low-frame rate spectral-domain optical coherence tomography
      Optical coherence tomography (OCT) can map the stiffness of biological tissue by imaging mechanical perturbations (shear waves) propagating in the tissue. Most shear wave elastography (SWE) techniques rely on active shear sources to generate controlled displacements that are tracked at ultrafast imaging rates. Here, we propose a noise-correlation approach to retrieve stiffness information from the imaging of diffuse displacement fields using low-frame rate spectral-domain OCT. We demonstrated the method on ...
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    3. Elasticity imaging of speckle-free tissue regions with moving acoustic radiation force and phase-sensitive optical coherence tomography

      Elasticity imaging of speckle-free tissue regions with moving acoustic radiation force and phase-sensitive optical coherence tomography
      Phase-sensitive optical coherence tomography (PhS-OCT) can be utilized for quantitative shear-wave elastography using speckle tracking. However, current approaches cannot directly reconstruct elastic properties in speckle-less or speckle-free regions, for example within the crystalline lens in ophthalmology. Investigating the elasticity of the crystalline lens could improve understanding and help manage presbyopia-related pathologies that change biomechanical properties. We propose to reconstruct the elastic properties in speckle-less regions by sequentially launching shear waves ...
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    4. Moving beam shear wave reconstruction for both ultrasound and optical coherence tomography applications

      Moving beam shear wave reconstruction for both ultrasound and optical coherence tomography applications
      Shear wave elasticity imaging can quantitatively estimate a stiffness map of biological tissues based on speckle-tracking shear wave propagation. However, current approaches cannot directly reconstruct elasticity properties in speckle-less or speckle-free regions, for example within the crystalline lens in ophthalmology. We propose an imaging sequence to reconstruct the elastic properties in speckle-free regions by sequentially launching shear waves with a laterally moving acoustic radiation force, and then detecting the displacement ...
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    5. Shear wave elastography using amplitude-modulated acoustic radiation force and phase-sensitive optical coherence tomography

      Shear wave elastography using amplitude-modulated acoustic radiation force and phase-sensitive optical coherence tomography
      Investigating the elasticity of ocular tissue (cornea and intraocular lens) could help the understanding and management of pathologies related to biomechanical deficiency. In previous studies, we introduced a setup based on optical coherence tomography for shear wave elastography (SWE) with high resolution and high sensitivity. SWE determines tissue stiffness from the propagation speed of shear waves launched within tissue. We proposed acoustic radiation force to remotely induce shear waves by ...
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    6. Shear wave elastography method combining phase-sensitive optical coherence tomography and coded acoustic radiation force

      Shear wave elastography method combining phase-sensitive optical coherence tomography and coded acoustic radiation force
      We combined phase-sensitive optical coherence tomography (PhS-OCT) and acoustic radiation force (ARF) to develop a shear wave elastography (SWE) method that could be used for ophthalmic applications. SWE measures tissue stiffness from the speed of shear waves propagating through tissue. Assessing the elastic properties of the cornea and the intraocular lens can, for example, help the management of refractive surgeries (myopia or presbyopia correction). OCT is a non-contact imaging method ...
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    7. Shear wave elastography of ex vivo human corneas using phase-sensitive optical coherence tomography

      Shear wave elastography of ex vivo human corneas using phase-sensitive optical coherence tomography
      Assessing the biomechanical properties of the cornea can provide clinically valuable information in addition to structural images for better management of pathologies (e.g. glaucoma) or refractive surgeries. OCT provides a micron scale and high sensitivity that are ideal for ophthalmic applications. We propose a shear wave elastography (SWE) method for the cornea based on phase-sensitive optical coherence tomography (PhS-OCT). SWE consists in launching a propagating shear wave in tissues ...
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    8. Feature Of The Week: Feature Of The Week 1/26/14: ESPCI-ParisTech Investigates Full-Field Optical Coherence Tomograpy (FF-OCT) Shear Wave Elastography

      Feature Of The Week: Feature Of The Week 1/26/14: ESPCI-ParisTech Investigates Full-Field Optical Coherence Tomograpy (FF-OCT) Shear Wave Elastography
      Elasticity maps of tissue have proved to be particularly useful in providing complementary contrast to ultrasonic imaging, e.g., for cancer diagnosis at the millimeter scale. Optical coherence tomography (OCT) offers an endogenous contrast based on singly backscattered optical waves. Adding complementary contrast to OCT images by recording elasticity maps could also be valuable in improving OCT-based diagnosis at the microscopic scale. Static elastography has been successfully coupled with full-field ...
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    9. Shear wave pulse compression for dynamic elastography using phase-sensitive optical coherence tomography

      Shear wave pulse compression for dynamic elastography using phase-sensitive optical coherence tomography
      Assessing the biomechanical properties of soft tissue provides clinically valuable information to supplement conventional structural imaging. In the previous studies, we introduced a dynamic elastography technique based on phase-sensitive optical coherence tomography (PhS-OCT) to characterize submillimetric structures such as skin layers or ocular tissues. Here, we propose to implement a pulse compression technique for shear wave elastography. We performed shear wave pulse compression in tissue-mimicking phantoms. Using a mechanical actuator ...
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    10. 1-14 of 14
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  2. About Thu-Mai Nguyen

    Thu-Mai Nguyen was born in France in 1986. She graduated from the Ecole Superieure de Physique et Chimie Industrielles de Paris (ESPCI ParisTech), a french multidisciplinary engineering school, in 2009. She obtained her PhD degree at the Institut Langevin (Paris, France) in 2012. She is currently working at the University of Washington (Seattle, WA) as a post-doctoral fellow. Her research interests include shear wave elastography, with a focus on ophtalmic applications, and photoacoustic imaging.