1. Thorlabs OCT Imaging Systems

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    1. Mentioned In 22 Articles

    2. Optical coherence tomography: A new strategy to image planarian regeneration

      Optical coherence tomography: A new strategy to image planarian regeneration

      The planarian is widely used as a model for studying tissue regeneration. In this study, we used optical coherence tomography (OCT) for the real-time, high-resolution imaging of planarian tissue regeneration. Five planaria were sliced transversely to produce 5 head and 5 tail fragments. During a 2-week regeneration period, OCT images of the planaria were acquired to analyze the signal attenuation rates, intensity ratios, and image texture features (including contrast, correlation, homogeneity, energy, and entropy) to compare the primitive and regenerated tissues. In the head and tail fragments, the signal attenuation rates of the regenerated fragments decreased from −0.2 dB ...

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    3. Visualization of Maculae and Membranous Semicircular Ducts in the Otic Capsule by Optical Coherence Tomography

      Visualization of Maculae and Membranous Semicircular Ducts in the Otic Capsule by Optical Coherence Tomography

      Objectives: (1) Show the possibility of using optical coherence tomography (OCT) to visualize the internal structure of the vestibule and semicircular canals with the bony capsule intact. (2) Study the effect of the decalcification. OCT is a nondestructive imaging modality that uses infrared light as it penetrates turbid biological tissue. Previously, OCT has been successfully used to visualize inside the cochlea in normal and abnormal inner ears. Methods: The OCT system, OCS-1300SS (Thorlabs, Inc, NJ) with a central wavelength of 1300 nm and a theoretical axial resolution of 9 µm, was employed for image acquisition. Normal and Slc26a4 mutant mice ...

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    4. Identification of vessel wall anomalies in thoracic aortic aneurysms through optical coherence tomography and gradient-based strategies

      Identification of vessel wall anomalies in thoracic aortic aneurysms through optical coherence tomography and gradient-based strategies

      Optical Coherence Tomography is a natural candidate for imaging biological structures just under tissue surface. Human thoracic aorta from aneurysms reveal elastin disorders and smooth muscle cell alterations when visualizing the media layer of the aortic wall, which is only some tens of microns in depth from surface. The resulting images require a suitable processing to enhance interesting disorder features and to use them as indicators for wall degradation, converting OCT into a hallmark for diagnosis of risk of aneurysm under intraoperative conditions. This work proposes gradient-based digital image processing approaches to conclude this risk. These techniques are believed to ...

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    5. Imaging of electro-kinetic properties of tissue using the amplitude and the phase of optical coherence tomography

      Imaging of electro-kinetic properties of tissue using the amplitude and the phase of optical coherence tomography

      The electric field induced optical changes (EIOC) measured by the optical coherence tomography (OCT) reflect the local electro-kinetic properties of the tissue. In this study we developed a method to use the phase of the complex OCT images to map EIOC in tissue samples. Switching the polarity of the electric field induced significant reversible changes in the phase of the complex OCT images. Since the resulting phase was degraded by the noise an advanced signal processing algorithm was developed to obtain the EIOC images. The developed algorithm made it possible to get structural phase images from a standard commercial OCT ...

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    6. Feature Of The Week 9/22/13: Lehigh University Researchers Investigate Space-Division Multiplexing for High-Speed Optical Coherence Tomography

      Feature Of The Week 9/22/13: Lehigh University Researchers Investigate Space-Division Multiplexing for High-Speed Optical Coherence Tomography

      High speed, high resolution and high sensitivity are desirable for optical coherence tomography (OCT). Here, we demonstrate a space-division multiplexing (SDM) technology that translates long coherence length of a commercially available wavelength tunable laser into high OCT imaging speed. We achieved an effective 800,000 A-scans/s imaging speed using a commercially available 100,000 Hz tunable vertical cavity surface-emitting laser (VCSEL) from Thorlabs Inc. A sensitivity of 94.6 dB and a roll-off of < 2 dB over ~30 mm imaging depth were measured in the prototype SDM-OCT system. An axial resolution of ~11 m in air (or ~8.3 ...

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    7. Assessment of interfacial defects at composite restorations by swept source optical coherence tomography

      Assessment of interfacial defects at composite restorations by swept source optical coherence tomography

      In clinical dental practice, it is often difficult or even impossible to detect and assess interfacial adhesive defects at adhesive restorations by means of visual inspection or other established diagnostic methods. However, nondestructive optical coherence tomography (OCT) may provide a better picture in this diagnostic scenario. The aim of this study was to evaluate the suitability of swept source OCT (SS-OCT) for the nondestructive assessment of interfacial deficiencies at composite restorations and the evaluation of cohesive defects within composite material. Ten class V composite restorations that were not adhesively luted were taken as validation objects and examined for frequency of ...

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    8. Evaluation of optical coherence tomography as a non-invasive diagnostic tool in cutaneous wound healing

      Evaluation of optical coherence tomography as a non-invasive diagnostic tool in cutaneous wound healing

      Background The monitoring of wound-healing processes is indispensable for the therapeutic effectiveness and improved care of chronic wounds. Histological sections provide the best morphological assessment of wound recovery, but cause further tissue destruction and increase the risk of infection. Therefore, it is reasonable to apply a diagnostic tool that allows a non-invasive and reliable observation of morphological changes in wound healing. Methods Optical coherence tomography (OCT) is an imaging technique for in vivo evaluation of skin diseases with a resolution close to histopathology. The aim of this study was to investigate whether OCT is suited to display the phases of ...

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    9. Application of optical coherence tomography to non-destructively characterise rind breakdown disorder of ‘Nules Clementine’ mandarins

      Application of optical coherence tomography to non-destructively characterise rind breakdown disorder of ‘Nules Clementine’ mandarins

      The feasibility of optical coherence tomography (OCT) for imaging histological changes associated with the development of a progressive rind breakdown (RBD) disorder of ‘Nules Clementine’ mandarin ( Citrus reticulate Blanco.) was investigated. The investigation utilised fruit with different levels of the disorder, carefully selected from a batch of fruit stored for eight weeks at 8 ± 0.5 °C. Images of healthy and RBD-affected intact mandarin fruit were acquired using a Thorlabs OCT system based on a broadband 930 nm source. OCT provided high resolution 2D images of fruit rind to a depth of about 1.1 mm. Immediate and non-destructive acquisition ...

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    10. In vivo microcirculation imaging of the sub surface fingertip using correlation mapping optical coherence tomography (cmOCT)

      In vivo microcirculation imaging of the sub surface fingertip using correlation mapping optical coherence tomography (cmOCT)

      We describe a novel application of correlation mapping optical coherence tomography (cmOCT) for sub-surface fingerprint biometric identification. Fingerprint biometrics including automated fingerprint identification systems, are commonly used to recognise the fingerprint, since they constitute simple, effective and valuable physical evidence. Spoofing of biometric fingerprint devices can be easily done because of the limited information obtained from the surface topography. In order to overcome this limitation a potentially more secure source of information is required for biometric identification applications. In this study, we retrieve the microcirculation map of the subsurface fingertip by use of the cmOCT technique. To increase probing depth ...

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    11. Optical Monitoring of Tumors in BALB/c Nude Mice Using Optical Coherence Tomography

      Optical Monitoring of Tumors in BALB/c Nude Mice Using Optical Coherence Tomography

      We report a method for optical monitoring of tumors in an animal model using optical coherence tomography (OCT). In a spectral domain OCT system, a superluminescent diode light source with a full width of 66 nm at half maximum and peak wavelength of 950 nm was used to take images having an axial resolution of 6.8 μ m. Cancer cells of PC-3 were cultured and inoculated into the hypodermis of auricle tissues in BALB/c nude mice. We observed tumor formation and growth at the injection region of cancer cells in vivo and obtained the images of tumor mass center ...

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    12. Assessment of transcutaneous vaccine delivery by optical coherence tomography

      Assessment of transcutaneous vaccine delivery by optical coherence tomography

      Immunization is one of the most efficient and cost-effective means for the prevention of diseases. The latest trend for inducing protective immunity is topical application of vaccines to intact skin rather than invasive administration via injection. Apart from being a non-invasive route of drug delivery, skin itself also offers advantages through the presence of cells of the immune system in both the dermis and epidermis. However, vaccine penetration through the outermost layers of skin is limited by the barrier provided by the Stratum corneum. In the current study utilizing conventional Optical Coherence Tomography (OCT) we investigate the transcutaneous delivery of ...

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    13. Feature Of The Week 07/01/12: Enhanced Optical Clearing of Skin In Vivo and OCT In-Depth Imaging

      Feature Of The Week 07/01/12: Enhanced Optical Clearing of Skin In Vivo and OCT In-Depth Imaging

      Imaging methods such as optical coherence tomography (OCT), confocal reflectance/ fluorescence microscopy, second-harmonic generation microscopy, and 2-photon microscopy are limited by the optical scattering properties of the skin to superficial depths. Optical clearing technique using high refractive index and hyperosmolarity agents can reduce the scattering of biological tissues. With this approach, better optical imaging depth and contrast have been presented and deeper optical treatment has been achieved. However, noninvasive optical clearing of skin in vivo is difficult, because the outermost layer of the skin, the stratum corneum, presents a significant barrier to topically applied OCAs. In this work, OCT imaging ...

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    14. Enhanced optical clearing of skin in vivo and optical coherence tomography in-depth imaging

      Enhanced optical clearing of skin in vivo and optical coherence tomography in-depth imaging

      The strong optical scattering of skin tissue makes it very difficult for optical coherence tomography (OCT) to achieve deep imaging in skin. Significant optical clearing of in vivo rat skin sites was achieved within 15 min by topical application of an optical clearing agent PEG-400, a chemical enhancer (thiazone or propanediol), and physical massage. Only when all three components were applied together could a 15 min treatment achieve a three fold increase in the OCT reflectance from a 300 μm depth and 31% enhancement in image depth Zthreshold.

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  2. About Thorlabs OCT Imaging Systems

    Thorlabs OCT Imaging Systems

    Thorlabs OCT Imaging Systems provides solutions for the field of Optical Coherence Tomography (OCT) imaging on the system, subsystem, and component level.