1. Thomas Klein

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    1. Mentioned In 34 Articles

    2. Swept source OCT system and method with phase-locked detection

      Swept source OCT system and method with phase-locked detection
      A swept source OCT system and related method are disclosed. The system comprises a control device for operating a tunable light source in response to an electronic sweep control signal such that the tunable light source carries out wave length sweeps with a repetition rate f.sub.sweep, which depends on the frequency of the sweep control signal. The system further comprises a detection device for the time-resolved detection of ...
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    3. Method for reducing the dimensionality of a spatially registered signal derived from the optical properties of a sample, and device therefor

      Method for reducing the dimensionality of a spatially registered signal derived from the optical properties of a sample, and device therefor
      At least one embodiment of the method is designed to create a two-dimensional image of a three-dimensional sample. The method comprises the following steps: provision of a wave-length-tunable light source (1) that emits primary radiation (P) with wavelengths that vary over time; sampling of location points of the sample (2) with the primary radiation (P); collection of secondary radiation (S), wherein the secondary radiation (S) is a part of the ...
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    4. Analysis of FDML lasers with meter range coherence

      Analysis of FDML lasers with meter range coherence
      FDML lasers provide sweep rates in the MHz range at wide optical bandwidths, making them ideal sources for high speed OCT. Recently, at lower speed, ultralong-range swept-source OCT has been demonstrated using a tunable vertical cavity surface emitting laser (VCSEL) and also using a Vernier-tunable laser. These sources provide relatively high sweep rates and meter range coherence lengths. In order to achieve similar coherence, we developed an extremely well dispersion ...
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    5. High-speed OCT light sources and systems [Invited]

      High-speed OCT light sources and systems [Invited]
      Imaging speed is one of the most important parameters that define the performance of optical coherence tomography (OCT) systems. During the last two decades, OCT speed has increased by over three orders of magnitude. New developments in wavelength-swept lasers have repeatedly been crucial for this development. In this review, we discuss the historical evolution and current state of the art of high-speed OCT systems, with focus on wavelength swept light ...
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    6. Flexible A-scan rate MHz OCT: computational downscaling by coherent averaging

      Flexible A-scan rate MHz OCT: computational downscaling by coherent averaging
      In order to realize fast OCT-systems with adjustable line rate, we investigate averaging of image data from an FDML based MHz-OCT-system. The line rate can be reduced in software and traded in for increased system sensitivity and image quality. We compare coherent and incoherent averaging to effectively scale down the system speed of a 3.2 MHz FDML OCT system to around 100 kHz in postprocessing. We demonstrate that coherent ...
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    7. Dynamical Fabry-Perot tuneable filter device

      Dynamical Fabry-Perot tuneable filter device
      A Fabry-Perot tuneable filter device is described with reflecting elements separated by an optical path length to form an optical resonator cavity. A first actuator means is directly or indirectly coupled with a first reflecting element. And the first actuator means is configured to modulate the optical path length between first and second reflecting elements by a modulation amplitude to thereby sweep the optical resonator cavity through a band of ...
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    8. Combined 60° Wide-Field Choroidal Thickness Maps and High-Definition En Face Vasculature Visualization Using Swept-Source Megahertz OCT at 1050 nm

      Combined 60° Wide-Field Choroidal Thickness Maps and High-Definition En Face Vasculature Visualization Using Swept-Source Megahertz OCT at 1050 nm
      Purpose : To demonstrate ultrahigh-speed swept-source optical coherence tomography (SS-OCT) at 1.68 million A-scans/s for choroidal imaging in normal and diseased eyes over a 60 field of view. To investigate and correlate wide-field three-dimensional (3D) choroidal thickness (ChT) and vascular patterns using ChT maps and coregistered high-definition en face images extracted from a single densely sampled Megahertz-OCT (MHz-OCT) dataset. Methods : High-definition, 60 wide-field 3D datasets consisting of 2088 1024 ...
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    9. Feature Of The Week 7/6/2015: Ultra-Widefield Retinal MHz-OCT Imaging With up to 100 Degrees Viewing Angle

      Feature Of The Week 7/6/2015: Ultra-Widefield Retinal MHz-OCT Imaging With up to 100 Degrees Viewing Angle
      We evaluate strategies to maximize the field of view (FOV) of in vivo retinal OCT imaging of human eyes and analyze the problems caused by the increased scan angle. Three imaging modes are tested: Single volume imaging with 85 FOV as well as with 100 and stitching of five 60 images to a 100 mosaic (measured as usually from the nodal point). We employ a MHz-OCT system based on a ...
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    10. Ultra-widefield retinal MHz-OCT imaging with up to 100 degrees viewing angle

      Ultra-widefield retinal MHz-OCT imaging with up to 100 degrees viewing angle
      We evaluate strategies to maximize the field of view (FOV) of in vivo retinal OCT imaging of human eyes. Three imaging modes are tested: Single volume imaging with 85 FOV as well as with 100 and stitching of five 60 images to a 100 mosaic (measured from the nodal point). We employ a MHz-OCT system based on a 1060nm Fourier domain mode locked (FDML) laser with a depth scan rate ...
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    11. A Time-Encoded Technique for fibre-based hyperspectral broadband stimulated Raman microscopy

      A Time-Encoded Technique for fibre-based hyperspectral broadband stimulated Raman microscopy
      Raman sensing and microscopy are among the most specific optical technologies to identify the chemical compounds of unknown samples, and to enable label-free biomedical imaging. Here we present a method for stimulated Raman scattering spectroscopy and imaging with a time-encoded (TICO) Raman concept. We use continuous wave, rapidly wavelength-swept probe lasers and combine them with a short-duty-cycle actively modulated pump laser. Hence, we achieve high stimulated Raman gain signal levels ...
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    12. Optores Introduces OGOP – the Optores GPU OCT Processing Library

      Optores Introduces OGOP – the Optores GPU OCT Processing Library
      Optores proudly introduces OGOP the Optores GPU OCT Processing library, an ultra-fast and highly reliable processing library for optical coherence tomography (OCT) data. Based on graphic-processing unit (GPU) optimized code, OGOP enables real-time OCT processing with sustained throughput of several gigabytes per second. The library can be licensed in editions with increasing feature sets and processing capabilities. It covers the whole OCT processing pipeline from raw data to image, and ...
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    13. High definition live 3D-OCT in vivo: design and evaluation of a 4D OCT engine with 1 GVoxel/s

      High definition live 3D-OCT in vivo: design and evaluation of a 4D OCT engine with 1 GVoxel/s
      We present a 1300 nm OCT system for volumetric real-time live OCT acquisition and visualization at 1 billion volume elements per second. All technological challenges and problems associated with such high scanning speed are discussed in detail as well as the solutions. In one configuration, the system acquires, processes and visualizes 26 volumes per second where each volume consists of 320 x 320 depth scans and each depth scan has ...
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    14. Megahertz ultra-wide-field swept-source retina optical coherence tomography compared to current existing imaging devices

      Megahertz ultra-wide-field swept-source retina optical coherence tomography compared to current existing imaging devices
      Background To investigate the image quality of wide-angle cross-sectional and reconstructed fundus images based on ultra-megahertz swept-source Fourier domain mode locking (FDML) OCT compared to current generation diagnostic devices. Methods A 1,050 nm swept-source FDML OCT system was constructed running at 1.68 MHz A-scan rate covering approximately 70 field of view. Twelve normal eyes were imaged with the device applying an isotropically dense sampling protocol (1,9001,900 ...
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    15. Multi-MHz retinal OCT

      Multi-MHz retinal OCT
      We analyze the benefits and problems of in vivo optical coherence tomography (OCT) imaging of the human retina at A-scan rates in excess of 1 MHz, using a 1050 nm Fourier-domain mode-locked (FDML) laser. Different scanning strategies enabled by MHz OCT line rates are investigated, and a simple multi-volume data processing approach is presented. In-vivo OCT of the human ocular fundus is performed at different axial scan rates of up ...
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  2. About Thomas Klein

    Thomas Klein

    Thomas Klein is a Member of the BioMolecular Optics Group at the at the Ludwig Maximilian University of Munich.