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Thomas Jefferson University
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Mentioned In 97 Articles
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Retinal Optical Coherence Tomography Metrics are Unchanged in Verubecestat Alzheimer's Disease Clinical Trial but Correlate with Baseline Regional Brain Atrophy
Background: We performed exploratory analyses of retinal thickness data from a clinical trial of the APP cleaving enzyme (BACE) inhibitor verubecestat in patients with Alzheimer's disease (AD). Objective: To evaluate: 1) possible retinal thickness changes following BACE inhibition; and 2) possible association between retinal thickness and brain atrophy. Methods: Retinal thickness was measured using spectral-domain optical coherence tomography in a 78-week randomized placebo-controlled trial of verubecestat in 1,785 ...Read Full ArticleMentions: Thomas Jefferson University -
A pilot exploration using optical coherence tomography angiography analysis of capillary vascular density and foveal avascular zone for the diagnosis of uveal melanoma
Dear Editor, Choroidal melanoma is a rare malignancy, and in one study from the United Kingdom, up to 30% of patients referred by the general ophthalmologist to an ocular oncology center were misdiagnosed. [1] Later, the mnemonic To find small ocular melanoma using helpful hints daily [2] was established to aid in the detection of this malignancy at an early point. With the rapid advancements in ocular imaging technology, quantifiable ...Read Full Article -
Overhead Mounted Optical Coherence Tomography in Childhood Glaucoma Evaluation
Prcis: Overhead mounted spectral-domain optical coherence tomography enables high quality imaging of the optic nerve and macula in childhood glaucoma and is particularly useful when standard tabletop optical coherence tomography has failed or is not possible. Purpose: Tabletop optical coherence tomography, integral to adult glaucoma management, can be limited in childhood glaucoma patients due to young age, poor cooperation, and/or technical challenges. To address these imaging difficulties, we determined ...Read Full Article -
Wide-Field (15 × 9 mm) Swept-Source Optical Coherence Tomography Angiography Following Plaque Radiotherapy of Choroidal Melanoma: An Analysis of 105 eyes
Purpose: The aim of this study was to evaluate retinal microvascular abnormalities following plaque radiotherapy of choroidal melanoma (CM) using wide-field swept-source optical coherence tomography angiography (OCTA). Design: Single-centre retrospective review. Methods: Retrospective case series of 105 CM patients treated with I-125 plaque radiotherapy and imaged with wide-field (15 9 mm) SS-OCTA from March 2018 to August 2018 at the Ocular Oncology Service, Wills Eye Hospital (Philadelphia, PA). Results: At ...Read Full Article -
SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY FEATURES OF VITREORETINAL LYMPHOMA IN 55 EYES
Purpose: To evaluate spectral domain optical coherence tomography (SD- OCT ) features of vitreoretinal lymphoma (VRL). Methods: Review of records and SD- OCT images of vitreoretinal lymphoma evaluated at Ocular Oncology Service, Wills Eye Hospital between July 1, 2000, and April 1, 2019. Results: There were 55 eyes of 32 patients included. At presentation, SD- OCT features included vitreous opacities (n = 36, 65%), preretinal deposits (n = 7, 13%), intraretinal deposits (n ...Read Full Article -
Utility of Optical Coherence Tomography (OCT) in Centers For Medicare and Medicaid Services (CMS)-defined Severe Glaucoma Patients
Precis: Patients with Centers For Medicare and Medicaid Services (CMS)-defined severe glaucoma often have clinically useful remaining retinal nerve fiber layer (RNFL), suggesting that structurally based rather than functionally based criteria would be more appropriate to use as guidelines for the utilization of optical coherence tomography (OCT) imaging. Purpose: RNFL OCT in glaucomatous eyes with advanced structural damage can reach a floor after which there is no further detectable ...Read Full ArticleMentions: Thomas Jefferson University -
Optical Coherence Tomography Monitoring in a Patient With Retinoblastoma
A 17-month-old girl with group B retinoblastoma in her right eye developed recurrence of a parafoveal tumor ( Figure , A) after 6 cycles of intravenous chemotherapy. Despite treatment with indocyanine greenenhanced transpupillary thermotherapy, optical coherence tomography (vertical orientation) demonstrated continued tumor growth toward the foveola. The patient was subsequently treated with 2 cycles of intra-arterial chemotherapy, after which complete tumor regression to a flat scar was documented clinically and by optical ...Read Full Article -
OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY DETECTS SUBCLINICAL RADIAL PERIPAPILLARY CAPILLARY DENSITY REDUCTION AFTER PLAQUE RADIOTHERAPY FOR CHOROIDAL MELANOMA
Purpose: To evaluate radial peripapillary capillary density (RPCD) in irradiated eyes without radiation papillopathy clinically. Methods: Patients treated with plaque radiotherapy for unilateral choroidal melanoma without radiation papillopathy clinically received optical coherence tomography and optical coherence tomography angiography imaging at 12- to 24-month follow-up. Comparison of RPCD globally and meridian closest to plaque and meridian farthest to plaque of irradiated versus nonirradiated eyes was performed. Results: Mean age was 55 ...Read Full Article -
Utility of Optical Coherence Tomography (OCT) in Centers for Medicare and Medicaid Services (CMS) Defined Severe Glaucoma Patients
Prcis: Patients with CMS defined severe glaucoma often have clinically useful remaining RNFL, suggesting that structurally-based rather than functionally-based criteria would be more appropriate to use as guidelines for the utilization of OCT imaging. Purpose: RNFL OCT in glaucomatous eyes with advanced structural damage can reach a floor after which there is no further detectable thinning of RNFL. Insurers are considering limiting coverage for OCT in severe stage glaucoma defined ...Read Full ArticleMentions: Thomas Jefferson University -
Jefferson and Wills Eye Launch World's First Center Focused on Connections Between the Eye and the Brain
...ry careers, and discovering new treatments to define the future of care. Jefferson (Philadelphia University + Thomas Jefferson University), home of Sidney Kimmel Medical College, dates back to 1824 and today comprises 10...Read Full ArticleMentions: Thomas Jefferson University -
Peripapillary versus macular combined hamartoma of the retina and retinal pigment epithelium: Imaging characteristics
Purpose To compare clinical, optical coherence tomography (OCT), and fundus autofluorescence (FAF) characteristics of peripapillary versus (vs.) macular variants of combined hamartoma of the retina and retinal pigment epithelium (combined hamartoma). Design Retrospective observational, comparative case series Methods:Setting Multicentre collaborative study Study Population 50 eyes with a clinical diagnosis of combined hamartoma Observational Analysis A comparative analysis of color fundus photographs (CFPs), OCT and FAF was performed for peripapillary ...Read Full Article -
Optical Coherence Tomography to Assess Anatomic Changes in Recipients of Electronic Retinal Implants Getting Closer to the Promised Land of Sight for All
They came to Bethsaida. Some people brought a blind man to him and begged him to touch him. 23 He took the blind man by the hand and led him out of the village; and when he had put saliva on his eyes and laid his hands on him, he asked him, Can you see anything? 24 And the man looked up and said, I can see people, but they ...Read Full ArticleMentions: Thomas Jefferson University -
Microvascular Capillary Plexus Findings of Commotio Retinae on Optical Coherence Tomography Angiography
Optical coherence tomography (OCT) and histopathology features of commotio retinae (CR) have been established, but alterations of the microvascular macular capillary plexus on OCT angiography (OCTA) has not been previously studied. We present a 46-year-old man who sustained a tennis ball injury to the right eye with visual acuity reduction to 20/30 and grey-white deep macular discoloration, suggestive of CR. Spectral-domain OCT (SD-OCT) showed increased reflectivity and thickness of ...Read Full Article -
Optical coherence tomography of iris mammillations
A 10-year-old girl presented with blurred vision of 2 months. Uncorrected visual acuity was 20/20 in both eyes (OU). Refraction revealed 0.75 diopters of astigmatism OU. Visual blur was related to a moderate convergence insufficiency. The superior 90% of the left iris was darkly pigmented and velvety in consistency with regularly spaced protuberances (mammillations) (figure 1).Read Full Article
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About Thomas Jefferson University
Thomas Jefferson University is an independent medical school, health professions and medical research institution. Founded in 1824, it is located in Center City, Philadelphia, Pennsylvania. The university takes an active role in medical research. It began as Jefferson Medical College in 1824. On July 1, 1969 the institution officially became Thomas Jefferson University. The university is made up of three colleges: Jefferson Medical College, Jefferson College of Graduate Studies, Jefferson College of Health Professions".