1. Thomas E. Milner

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    1. Mentioned In 100 Articles

    2. Apparatus and methods for optical coherence tomography and two-photon luminescence imaging

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      Apparatus and methods for optical coherence tomography and two-photon luminescence imaging
      Exemplary embodiments of the present disclosure include a combined catheter-based optical coherence tomography-two-photon luminescence (OCT-TPL) imaging system. Exemplary embodiments further include methods to detect, and further characterize the distribution of cellular components (e.g., macrophage, collagen/elastin fiber, lipid droplet) in thin-cap fibroatheromas with high spatial resolution in vivo.
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      Mentions: Thomas E. Milner Marc D. Feldman University of Texas at Austin

    3. Assessment of Vascular Patency and Inflammation with Intravascular Optical Coherence Tomography in Patients with Superficial Femoral Artery Disease Treated with Zilver PTX Stents

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      Assessment of Vascular Patency and Inflammation with Intravascular Optical Coherence Tomography in Patients with Superficial Femoral Artery Disease Treated with Zilver PTX Stents
      Purpose Zilver PTX nitinol self-expanding drug-eluting stent with paclitaxel coating is effective for treatment of superficial femoral artery (SFA) disease. However, as with any stent, it induces a measure of vascular inflammatory response. The current clinical trial (NCT02734836) aimed to assess vascular patency, remodeling, and inflammatory markers with intravascular optical coherence tomography (OCT) in patients with SFA disease treated with Zilver PTX stents. Methods Serial OCT examinations were performed in ...
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      Mentions: Leiden University Thomas E. Milner Marc D. Feldman

    4. Laser brain cancer surgery in a xenograft model guided by optical coherence tomography

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      Laser brain cancer surgery in a xenograft model guided by optical coherence tomography
      Higher precision surgical devices are needed for tumor resections near critical brain structures. The goal of this study is to demonstrate feasibility of a system capable of precise and bloodless tumor ablation. An image-guided laser surgical system is presented for excision of brain tumors in vivo in a murine xenograft model. The system combines optical coherence tomography (OCT) guidance with surgical lasers for high-precision tumor ablation (Er:YAG) and microcirculation ...
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      Mentions: Thomas E. Milner Marc D. Feldman University of Texas at Austin

    5. Scattering-Angle-Resolved Optical Coherence Tomography of a Hypoxic Mouse Retina Model

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      Scattering-Angle-Resolved Optical Coherence Tomography of a Hypoxic Mouse Retina Model
      Several studies have noted a correlation between retinal degeneration and traumatic encephalopathy (TE) making the retina a leading candidate for detection and assessment. Scattering-angle-resolved optical coherence tomography (SAR-OCT) is a candidate imaging modality to detect sub-resolution changes in retinal microstructure. SAR-OCT images of murine retinas that experience a hypoxic insult euthanasia by isoflurane overdoseare presented. A total of 4 SAR-OCT measurement parameters are reported in 6 longitudinal experiments: blood flow ...
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      Mentions: Thomas E. Milner University of Texas at Austin

    6. OCT-IVUS catheter for concurrent luminal imaging

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      OCT-IVUS catheter for concurrent luminal imaging
      The invention relates to an apparatus for in vivo imaging. More specifically, the present invention relates to a catheter that incorporates an Optical Coherence Tomography (OCT) system and an Intravascular Ultrasound ("IVUS) system for concurrent imaging of luminal systems, such as imaging the vasculature system, including, without limitation, cardiac vasculature, peripheral vasculature and neural vasculature.
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      Mentions: Thomas E. Milner Paul Castella University of Texas at Austin

    7. Design Considerations for Murine Retinal Imaging Using Scattering Angle Resolved Optical Coherence Tomography

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      Design Considerations for Murine Retinal Imaging Using Scattering Angle Resolved Optical Coherence Tomography
      Optical coherence tomography (OCT), an optical imaging approach enabling cross-sectional analysis of turbid samples, is routinely used for retinal imaging in human and animal models of diseases affecting the retina. Scattering angle resolved (SAR-)OCT has previously been demonstrated as offering additional contrast in human studies, but no SAR-OCT system has been reported in detail for imaging the retinas of mice. An optical model of a mouse eye was designed ...
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      Mentions: Thomas E. Milner University of Texas at Austin

    9. Understanding and improving optical coherence tomography imaging depth in selective laser sintering nylon 12 parts and powder

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      Understanding and improving optical coherence tomography imaging depth in selective laser sintering nylon 12 parts and powder
      Optical coherence tomography (OCT) has shown promise as a process sensor in selective laser sintering (SLS) due to its ability to yield depth-resolved data not attainable with conventional sensors. However, OCT images of nylon 12 powder and nylon 12 components fabricated via SLS contain artifacts that have not been previously investigated in the literature. A better understanding of light interactions with SLS powder and components is foundational for further research ...
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      Mentions: Thomas E. Milner University of Texas at Austin

    10. In situ process monitoring in selective laser sintering using optical coherence tomography

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      In situ process monitoring in selective laser sintering using optical coherence tomography
      Selective laser sintering (SLS) is an efficient process in additive manufacturing that enables rapid part production from computer-based designs. However, SLS is limited by its notable lack ofin situprocess monitoring when compared with other manufacturing processes. We report the incorporation of optical coherence tomography (OCT) into an SLS system in detail and demonstrate access to surface and subsurface features. Video frame rate cross-sectional imaging reveals areas of sintering uniformity and ...
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      Mentions: Thomas E. Milner University of Texas at Austin

    12. Optical coherence tomography image-guided smart laser knife for surgery

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      Optical coherence tomography image-guided smart laser knife for surgery
      Background and Objective Surgical oncology can benefit from specialized tools that enhance imaging and enable precise cutting and removal of tissue without damage to adjacent structures. The combination of high-resolution, fast optical coherence tomography (OCT) co-aligned with a nanosecond pulsed thulium (Tm) laser offers advantages over conventional surgical laser systems. Tm lasers provide superior beam quality, high volumetric tissue removal rates with minimal residual thermal footprint in tissue, enabling a ...
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      Mentions: Thomas E. Milner University of Texas at Austin

    13. Apparatus and methods for identifying and evaluating bright spot indications observed through optical coherence tomography

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      Apparatus and methods for identifying and evaluating bright spot indications observed through optical coherence tomography
      Exemplary embodiments of the present disclosure include apparatus and methods for identifying bright spot indications observed through optical coherence tomography. The indications can be evaluated, for example, to link risk factors or other conditions to clinically relevant outcomes
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      Mentions: Thomas E. Milner Marc D. Feldman University of Texas at Austin

    15. Scattering angle resolved optical coherence tomography for in vivo murine retinal imaging

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      Scattering angle resolved optical coherence tomography for in vivo murine retinal imaging
      Optical coherence tomography (OCT) retinal imaging contributes to understanding central nervous system (CNS) diseases because the eye is an anatomical window to the brain with direct optical access to nonmylenated retinal ganglion cells. However, many CNS diseases are associated with neuronal changes beyond the resolution of standard OCT retinal imaging systems. Though studies have shown the utility of scattering angle resolved (SAR) OCT for particle sizing and detecting disease states ...
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      Mentions: Thomas E. Milner University of Texas at Austin

    16. System and method for interlacing differing coherence length sweeps to improve OCT image quality

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      System and method for interlacing differing coherence length sweeps to improve OCT image quality
      A system and method for sweeping electromagnetic radiation over a first coherence length and a second length over a range of wavelengths to generate an image. Electromagnetic radiation having a first coherence length is generated and swept over a range of wavelengths. Electromagnetic radiation having a second coherence length is generated and swept over a range of wavelengths. The electromagnetic radiation is splitting through a reference path and a sample ...
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      Mentions: Thomas E. Milner Michael P. Minneman Insight Photonic Solutions
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  4. About Thomas E. Milner

    Thomas E. Milner

    Thomas E. Milner, Ph.D, is an Associate Professor at the University of Texas Biomedical Engineering Department, and co-founder of CardioSpectra acquired by Volcano. Research Focus: Optical-based therapeutics and diagnostic imaging, biomedical fiber sensors, infrared imaging radiometry.

  5. Related Topics

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  6. Quotes

    1. OCT is one of the most promising and exciting medical imaging technologies available today...The detail of information OCT can provide is simply astonishing and will continue to impact not only cardiology but other medical disciplines, such as ophthalmology.
      In Researchers Receive $300,000 Award to Advance Technology With Potential to Predict Heart Attacks