1. Thomas E. Milner

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    1. Mentioned In 90 Articles

    2. Optical coherence tomography image-guided smart laser knife for surgery

      Optical coherence tomography image-guided smart laser knife for surgery
      Background and Objective Surgical oncology can benefit from specialized tools that enhance imaging and enable precise cutting and removal of tissue without damage to adjacent structures. The combination of high-resolution, fast optical coherence tomography (OCT) co-aligned with a nanosecond pulsed thulium (Tm) laser offers advantages over conventional surgical laser systems. Tm lasers provide superior beam quality, high volumetric tissue removal rates with minimal residual thermal footprint in tissue, enabling a ...
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    3. Apparatus and methods for identifying and evaluating bright spot indications observed through optical coherence tomography

      Apparatus and methods for identifying and evaluating bright spot indications observed through optical coherence tomography
      Exemplary embodiments of the present disclosure include apparatus and methods for identifying bright spot indications observed through optical coherence tomography. The indications can be evaluated, for example, to link risk factors or other conditions to clinically relevant outcomes
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    4. Scattering angle resolved optical coherence tomography for in vivo murine retinal imaging

      Scattering angle resolved optical coherence tomography for in vivo murine retinal imaging
      Optical coherence tomography (OCT) retinal imaging contributes to understanding central nervous system (CNS) diseases because the eye is an anatomical window to the brain with direct optical access to nonmylenated retinal ganglion cells. However, many CNS diseases are associated with neuronal changes beyond the resolution of standard OCT retinal imaging systems. Though studies have shown the utility of scattering angle resolved (SAR) OCT for particle sizing and detecting disease states ...
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    5. System and method for interlacing differing coherence length sweeps to improve OCT image quality

      System and method for interlacing differing coherence length sweeps to improve OCT image quality
      A system and method for sweeping electromagnetic radiation over a first coherence length and a second length over a range of wavelengths to generate an image. Electromagnetic radiation having a first coherence length is generated and swept over a range of wavelengths. Electromagnetic radiation having a second coherence length is generated and swept over a range of wavelengths. The electromagnetic radiation is splitting through a reference path and a sample ...
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    6. Polarization-sensitive spectral interferometry as a function of depth for tissue identification

      Polarization-sensitive spectral interferometry as a function of depth for tissue identification
      A polarization sensitive spectral interferometer apparatus and method for analyzing a sample by optical energy reflected from the sample. The polarization sensitive spectral interferometer apparatus and method determines polarization properties of the sample by optical energy reflected from the sample. The method for analyzing a sample with a spectral interferometer identifies the tissue type of the sample by the polarization properties as a function of depth from the sample.
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    7. Diagnosis of Thin-Capped Fibroatheromas in Intravascular Optical Coherence Tomography Images Effects of Light Scattering

      Diagnosis of Thin-Capped Fibroatheromas in Intravascular Optical Coherence Tomography Images Effects of Light Scattering
      Background Intravascular optical coherence tomography (IVOCT) images are recorded by detecting light backscattered within coronary arteries. We hypothesize that nonthin-capped fibroatheroma (TCFA) causes may scatter light to create the false appearance of IVOCT TCFA. Methods and Results Ten human cadaver hearts were imaged with IVOCT (n=14 coronary arteries). IVOCT and histological TCFA images were coregistered and compared. Of 21 IVOCT TCFAs (fibrous cap 65 m, lipid arc 1 quadrant ...
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    8. Effect of image registration on longitudinal analysis of retinal nerve fiber layer thickness of non-human primates using Optical Coherence Tomography (OCT)

      Effect of image registration on longitudinal analysis of retinal nerve fiber layer thickness of non-human primates using Optical Coherence Tomography (OCT)
      Background In this paper we determined the benefits of image registration on estimating longitudinal retinal nerve fiber layer thickness (RNFLT) changes. Methods RNFLT maps around the optic nerve head (ONH) of healthy primate eyes were measured using Optical Coherence Tomography (OCT) weekly for 30 weeks. One automatic algorithm based on mutual information (MI) and the other semi-automatic algorithm based on log-polar transform cross-correlation using manually segmented blood vessels (LPCC_MSBV), were ...
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    9. Fourier optics analysis of phase-mask-based path-length-multiplexed optical coherence tomography

      Fourier optics analysis of phase-mask-based path-length-multiplexed optical coherence tomography
      Imaging below fingertip surface might be a useful alternative to the traditional fingerprint sensing since the internal finger features are more reliable than the external ones. One of the most promising subsurface imaging technique is optical coherence tomography (OCT), which, however, has to acquire 3-D data even when a single en face image is required. This makes OCT inherently slow for en face imaging and produce unnecessary large data sets ...
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    10. Clinical utility of quantitative bright spots analysis in patients with acute coronary syndrome: an optical coherence tomography study

      Clinical utility of quantitative bright spots analysis in patients with acute coronary syndrome: an optical coherence tomography study
      To investigate the clinical significance of bright spots in coronary plaque detected by optical coherence tomography (OCT) in patients with coronary artery disease. We identified 112 patients [acute coronary syndromes (ACS): n = 50, stable angina pectoris (SAP): n = 62] who underwent OCT imaging of the culprit lesion. A novel OCT algorithm was applied to detect bright spots representing the juxtaposition of a variety of plaque components including macrophages. The density ...
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    11. Translating Intravascular Optical Coherence Tomography from a Research to a Clinical Tool

      Translating Intravascular Optical Coherence Tomography from a Research to a Clinical Tool
      Intravascular optical coherence tomography (IVOCT) continues to be a hot topic as a method for studying vulnerable plaque in research laboratories across the globe. It is also growing in popularity as a tool for interventional cardiologists to guide percutaneous coronary intervention (PCI). The power of IVOCT for diagnosis of thin-capped fibroatheromas (TCFAs) has yet to receive mainstream clinical attention due to the fact that clinicians still do not have a ...
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    12. Detection of plaque structure and composition using OCT combined with two-photon luminescence (TPL) imaging

      Detection of plaque structure and composition using OCT combined with two-photon luminescence (TPL) imaging
      Background and Objectives Atherosclerosis and plaque rupture leads to myocardial infarction and stroke. A novel hybrid optical coherence tomography (OCT) and two-photon luminescence (TPL) fiber-based imaging system was developed to characterize tissue constituents in the context of plaque morphology. Study Design/Materials and Methods Ex vivo coronary arteries (34 regions of interest) from three human hearts with atherosclerotic plaques were examined by OCTTPL imaging. Histological sections (4m in thickness) were ...
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    13. Group Refractive Index Measurement of Liquids Using Common-Path Swept Source Optical Coherence Tomography

      Group Refractive Index Measurement of Liquids Using Common-Path Swept Source Optical Coherence Tomography
      A fiber-optic based common-path swept source optical coherence tomography for a simple and high-resolution measurement of the group refractive indices of liquids has been investigated. The group refractive index measurement has been based on the optical length change before and after injection of liquid into a transparent glass tube. The gas-cell referenced fiber based common-path swept source optical coherence tomography instrument was utilized to obtain the group refractive indices of ...
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    14. System and method for optimization of coherence length of tunable laser sources

      System and method for optimization of coherence length of tunable laser sources
      A system and method for adjusting the coherence length of a tunable laser to optimize measurements and reduce artifacts. A tuning element of the laser system modulates, adjusts, or controls parameters associate with the tunable laser, such that the output wavelength of the tunable laser is modulated or adjusted over a wavelength range within a time interval. Modulation of the parameter has the effect of increasing a linewidth of the ...
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    15. Intravascular optical coherence tomography light scattering artifacts: merry-go-rounding, blooming, and ghost struts

      Intravascular optical coherence tomography light scattering artifacts: merry-go-rounding, blooming, and ghost struts
      We sought to elucidate the mechanisms underlying two common intravascular optical coherence tomography (IV-OCT) artifacts that occur when imaging metallic stents: merry-go-rounding (MGR), which is an increase in strut arc length (SAL), and blooming, which is an increase in the strut reflection thickness (blooming thickness). Due to uncontrollable variables that occur in vivo , we performed an in vitro assessment of MGR and blooming in stented vessel phantoms. Using Xience V ...
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  2. About Thomas E. Milner

    Thomas E. Milner

    Thomas E. Milner, Ph.D, is an Associate Professor at the University of Texas Biomedical Engineering Department, and co-founder of CardioSpectra acquired by Volcano. Research Focus: Optical-based therapeutics and diagnostic imaging, biomedical fiber sensors, infrared imaging radiometry.

  3. Quotes

    1. OCT is one of the most promising and exciting medical imaging technologies available today...The detail of information OCT can provide is simply astonishing and will continue to impact not only cardiology but other medical disciplines, such as ophthalmology.
      In Researchers Receive $300,000 Award to Advance Technology With Potential to Predict Heart Attacks