1. The Chinese University of Hong Kong

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    1. Mentioned In 95 Articles

    2. Layered Neointimal Pattern Secondary to Intraluminal Clot Organization in an Optical Coherence Tomography Longitudinal Study

      Layered Neointimal Pattern Secondary to Intraluminal Clot Organization in an Optical Coherence Tomography Longitudinal Study
      We present a case of follow-up optical coherence tomography (OCT) in a patient with non-obstructive intraluminal clot protrusion treated with medical therapy. The follow-up OCT scan showed layered neointimal changes similar to images observed in stent failure. A 37-year-old male presented with self-aborted anterior ST-elevation myocardial infarction. Urgent coronary angiogram showed thrombotic lesion in the proximal left anterior descending (LAD) artery (Figure 1). Multiple passes of aspiration thrombectomy retrieved a ...
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    3. Effect of optic disc–fovea distance on the normative classifications of macular inner retinal layers as assessed with OCT in healthy subjects

      Effect of optic disc–fovea distance on the normative classifications of macular inner retinal layers as assessed with OCT in healthy subjects
      Purpose To determine the influence of the optic discfovea distance (DFD) on the normative classifications based on thickness measurements of macular inner retinal layers with spectral-domain optical coherence tomography (OCT) in healthy subjects. Methods A total of 182 eyes from 182 healthy subjects were included (mean (SD) spherical equivalent 0.8 (1.9) dioptres). We performed macula and optic disc imaging with the Topcon 3D OCT 2000. The thickness of ...
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    4. Spectral Domain-Optical Coherence Tomography Measurements in Alzheimer’s Disease: A Systematic Review and Meta-analysis

      Spectral Domain-Optical Coherence Tomography Measurements in Alzheimer’s Disease: A Systematic Review and Meta-analysis
      Topic Optical coherence tomography (OCT) is a non-invasive tool to measure specific retinal layers in the eye. The relationship of retinal spectral domain-OCT (SD-OCT) measurements with Alzheimers Disease (AD) and mild cognitive impairment (MCI) remains unclear. Hence, we conducted a systematic review and meta-analysis to examine the SD-OCT measurements in AD and MCI. Clinical Relevance Current methods of diagnosing early AD are expensive and invasive. Retinal measurements of SD-OCT, which ...
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    5. Quantitative retinal microvasculature in children using swept-source optical coherence tomography: the Hong Kong Children Eye Study

      Quantitative retinal microvasculature in children using swept-source optical coherence tomography: the Hong Kong Children Eye Study
      Aims To evaluate the distributions of quantitative optical coherence tomography angiography (OCT-A) metrics and its associated factors in children. Methods 1059 children aged 68 years were recruited from the Hong Kong Children Eye Study. All the participants underwent OCT-A with a swept-source OCT. Retinal microvasculature on superficial capillary plexus was assessed and quantified by a customised automated image analysis programme. Univariable and multiple linear regression analyses were performed to determine ...
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    6. Relationship between Optical Intensity on Optical Coherence Tomography and Retinal Ischemia in Branch Retinal Vein Occlusion

      Relationship between Optical Intensity on Optical Coherence Tomography and Retinal Ischemia in Branch Retinal Vein Occlusion
      Branch retinal vein occlusion (BRVO) may be complicated with retinal ischemia in some cases. The purpose of the current study is to investigate the relationship between optical intensity on optical coherence tomography (OCT) and retinal ischemia in BRVO. Twenty-seven eyes diagnosed with BRVO without macular edema were classified into two groups based on the presence or absence of retinal ischemia. The optical intensity of inner retinal layers and photoreceptor inner ...
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    7. The Role of Optical Coherence Tomography in the Acute Management of Neuro-Ophthalmic Diseases

      The Role of Optical Coherence Tomography in the Acute Management of Neuro-Ophthalmic Diseases
      Optical coherence tomography (OCT) can provide highspeed and high-resolution images of the anatomical structures of the optic nerve head and macula. However, in neuro-ophthalmic conditions that present acutely, structural changes lag functional deficits, and the role of OCT in the acute setting has been challenged. This review aims to summarize the recent literature and evidence supporting the use of OCT in the acute management of some common neuro-ophthalmic scenarios, including ...
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    8. Relationship of intercapillary area with visual acuity in diabetes mellitus: an optical coherence tomography angiography study

      Relationship of intercapillary area with visual acuity in diabetes mellitus: an optical coherence tomography angiography study
      Aim To examine the correlation of best-corrected visual acuity (BCVA) with intercapillary area (ICA) measured from optical coherence tomography angiography (OCT-A) in patients with diabetes, and to compare the strength of associations between BCVA with ICA and other OCT-A metrics. Methods A cross-sectional study involved 447 eyes from 299 patients with diabetes. All participants underwent OCT-A with a swept-source OCT (Triton DRI-OCT, Topcon, Tokyo, Japan). An automated customised MATLAB programme ...
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    9. Optical Coherence Tomography Angiography Compared With Optical Coherence Tomography Macular Measurements for Detection of Glaucoma

      Optical Coherence Tomography Angiography Compared With Optical Coherence Tomography Macular Measurements for Detection of Glaucoma
      Importance Whether optical coherence tomography angiography (OCT-A) outperforms OCT to detect glaucoma remains inconclusive. Objective To compare (1) the diagnostic performance for detection of glaucoma and (2) the structure-function association between inner macular vessel density and inner macular thickness. Design, Setting, and Participants This cross-sectional study included 115 patients with glaucoma and 35 healthy individuals for measurements of retinal thickness and retinal vessel density, segmented between the anterior boundary of ...
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    10. Repeatability, interocular correlation and agreement of quantitative swept-source optical coherence tomography angiography macular metrics in healthy subjects

      Repeatability, interocular correlation and agreement of quantitative swept-source optical coherence tomography angiography macular metrics in healthy subjects
      Purpose To investigate the repeatability, interocular correlation and agreement of quantitative swept-source optical coherence tomography angiography (SS-OCTA) metrics in healthy subjects. Methods Thirty-three healthy normal subjects were enrolled. The macula was scanned four times by an SS-OCTA system using the 3mm3mm mode. The superficial capillary map images were analysed using a MATLAB program. A series of parameters were measured: foveal avascular zone (FAZ) area, FAZ perimeter, FAZ circularity, parafoveal vessel ...
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    11. Shared-hole graph search with adaptive constraints for 3D optic nerve head optical coherence tomography image segmentation

      Shared-hole graph search with adaptive constraints for 3D optic nerve head optical coherence tomography image segmentation
      Optic nerve head (ONH) is a crucial region for glaucoma detection and tracking based on spectral domain optical coherence tomography (SD-OCT) images. In this region, the existence of a hole structure makes retinal layer segmentation and analysis very challenging. To improve retinal layer segmentation, we propose a 3D method for ONH centered SD-OCT image segmentation, which is based on a modified graph search algorithm with a shared-hole and locally adaptive ...
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    12. Optical coherence tomography angiography in glaucoma: a mini-review

      Optical coherence tomography angiography in glaucoma: a mini-review
      The advent of optical coherence tomography angiography (OCT-A) provides a new opportunity to visualize the retinal vasculature in a non-invasive and dye-free manner which may help identify vascular abnormalities in glaucoma. While a reduction in retinal and optic nerve head vessel densities and blood flow indexes measured by OCT-A has been demonstrated in patients with glaucoma in many studies, it is unclear whether OCT-A provides additional information for the detection ...
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    13. Repeatability and Reproducibility of Retinal Neuronal and Axonal Measures on Spectral-domain Optical Coherence Tomography in Patients with Cognitive Impairment

      Repeatability and Reproducibility of Retinal Neuronal and Axonal Measures on Spectral-domain Optical Coherence Tomography in Patients with Cognitive Impairment
      Background: With increasing interest in determining if measurement of retinal neuronal structure with spectral-domain optical coherence tomography (SD-OCT) is useful in accessing neurodegenerative process in cognitive decline and development of dementia, it is important to evaluate whether the SD-OCT measurements are repeatable and reproducible in patients with Alzheimers disease (AD) or mild cognitive impairment (MCI). Methods: This is a retrospective cohort study. Patients with AD or MCI with no change ...
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    14. Automated framework for intraretinal cystoid macular edema segmentation in three-dimensional optical coherence tomography images with macular hole

      Automated framework for intraretinal cystoid macular edema segmentation in three-dimensional optical coherence tomography images with macular hole
      Cystoid macular edema (CME) and macular hole (MH) are the leading causes for visual loss in retinal diseases. The volume of the CMEs can be an accurate predictor for visual prognosis. This paper presents an automatic method to segment the CMEs from the abnormal retina with coexistence of MH in three-dimensional-optical coherence tomography images. The proposed framework consists of preprocessing and CMEs segmentation. The preprocessing part includes denoising, intraretinal layers ...
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    15. Determinants of Quantitative Optical Coherence Tomography Angiography Metrics in Patients with Diabetes

      Determinants of Quantitative Optical Coherence Tomography Angiography Metrics in Patients with Diabetes
      Early microvascular damage in diabetes (e.g. capillary nonperfusion and ischemia) can now be assessed and quantified with optical coherence tomography-angiography (OCT-A). The morphology of vascular tissue is indeed affected by different factors; however, there is a paucity of data examining whether OCT-A metrics are influenced by ocular, systemic and demographic variables in subjects with diabetes. We conducted an observational cross-sectional study and included 434 eyes from 286 patients with ...
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    16. Evaluation of Retinal Nerve Fiber Layer Thinning With Fourier-Domain Optical Coherence Tomography

      Evaluation of Retinal Nerve Fiber Layer Thinning With Fourier-Domain Optical Coherence Tomography
      Retinal nerve fiber layer (RNFL) defects are a defining feature of optic neuropathies and have been implicated in a few neurodegenerative disorders, including multiple sclerosis, 1 Alzheimer disease, 2 and Parkinson disease. 3 Ashina et al 4 conducted a prospective study observing 1406 children recruited from the Cophenhagen Child Cohort over 10 years. They showed that children of mothers with a history of smoking during pregnancy had a mean reduction ...
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  2. About The Chinese University of Hong Kong

    The Chinese University of Hong Kong

    The Chinese University of Hong Kong, commonly referred to as CUHK, is the second oldest university in Hong Kong; it is campus-based and also the only collegiate university in the territory. Despite its name, the Chinese University does not conduct its classes solely in Chinese. Both Chinese (Mandarin and Cantonese) and English are languages of instruction.

    The university's founders hoped that it would become the bridge that connects China and the West, and to combine tradition with modernity. The collegiate system CUHK comprises four colleges: Chung Chi College, New Asia College, United College, and Shaw College. All undergraduates are affiliated to one of them. Currently, five new colleges are to be established in the near future; namely Morningside College, S. H. Ho College, C. W. Chu College, Wu Yee Sun College and Lee Woo Sing College.

    Founded in 1963, The Chinese University of Hong Kong (CUHK) is a forward looking comprehensive research university with a global vision and a mission to combine tradition with modernity, and to bring together China and the West. CUHK teachers and students hail from all corners of the world. In 2007, we have more than 5,800 staff members, some 20,000 undergraduate and postgraduate students. Of these students, about 3,000 are from 45 countries and regions outside Hong Kong. The 100,000 alumni are connected through some 80 alumni associations both within and outside Hong Kong.