1. Texas A&M University

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    1. Mentioned In 71 Articles

    2. Rapid lipid-laden plaque identification in intravascular optical coherence tomography imaging based on time-series deep learning

      Rapid lipid-laden plaque identification in intravascular optical coherence tomography imaging based on time-series deep learning
      Significance Coronary heart disease has the highest rate of death and morbidity in the Western world. Atherosclerosis is an asymptomatic condition that is considered the primary cause of cardiovascular diseases. The accumulation of low-density lipoprotein triggers an inflammatory process in focal areas of arteries, which leads to the formation of plaques. Lipid-laden plaques containing a necrotic core may eventually rupture, causing heart attack and stroke. Lately, intravascular optical coherence tomography ...
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    3. Vector of motion measurements in the living cochlea using a 3D OCT vibrometry system

      Vector of motion measurements in the living cochlea using a 3D OCT vibrometry system
      Optical coherence tomography (OCT) has become an important tool for measuring the vibratory response of the living cochlea. It stands alone in its capacity to measure the intricate motion of the hearing organ through the surrounding otic capsule bone. Nevertheless, as an extension of phase-sensitive OCT, it is only capable of measuring motion along the optical axis. Hence, measurements are 1-D. To overcome this limitation and provide a measure of ...
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    4. Electronic device for automatic calibration of swept-source optical coherence tomography systems

      Electronic device for automatic calibration of swept-source optical coherence tomography systems
      A circuit for generating a swept source optical coherence tomography (SS-OCT) imaging calibration clock. The circuit comprises a first photodetector configured to convert an SS-OCT optical calibration signal to an SS-OCT electrical calibration signal, a first analog-to-digital converter (ADC) coupled to the first photodetector and configured to convert the SS-OCT electrical calibration signal to a sequence of SS-OCT calibration signal digital values, a processing unit coupled to the first ADC ...
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    5. Extreme Raman red shift: ultrafast multimode nonlinear space-time dynamics, pulse compression, and broadly tunable frequency conversion

      Extreme Raman red shift: ultrafast multimode nonlinear space-time dynamics, pulse compression, and broadly tunable frequency conversion
      Ultrashort high-energy pulses at wavelengths longer than 1m are now desirable for a vast variety of applications in ultrafast and strong-field physics. To date, the main answer to the wavelength tunability for energetic, broadband pulses still relies on optical parametric amplification (OPA), which often requires multiple and complex stages, may feature imperfect beam quality, and has limited conversion efficiency into one of the amplified waves. In this work, we present ...
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    6. Dual-modality optical coherence tomography and frequency-domain fluorescence lifetime imaging microscope system for intravascular imaging

      Dual-modality optical coherence tomography and frequency-domain fluorescence lifetime imaging microscope system for intravascular imaging
      Significance: Detailed biochemical and morphological imaging of the plaque burdened coronary arteries holds the promise of improved understanding of atherosclerosis plaque development, ultimately leading to better diagnostics and therapies. Aim: Development of a dual-modality intravascular catheter supporting swept-source optical coherence tomography (OCT) and frequency-domain fluorescence lifetime imaging (FD-FLIM) of endogenous fluorophores with UV excitation. Approach: We instituted a refined approach to endoscope development that combines simulation in a commercial ray ...
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    7. Methylene blue-filled biodegradable polymer particles as a contrast agent for optical coherence tomography

      Methylene blue-filled biodegradable polymer particles as a contrast agent for optical coherence tomography
      Optical coherence tomography (OCT) images largely lack molecular information or molecular contrast. We address that issue here, reporting on the development of biodegradable micro and nano-spheres loaded with methylene blue (MB) as molecular contrast agents for OCT. MB is a constituent of FDA approved therapies and widely used as a dye in off-label clinical applications. The sequestration of MB within the polymer reduced toxicity and improved signal strength by drastically ...
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    8. Noise and sensitivity in optical coherence tomography based vibrometry

      Noise and sensitivity in optical coherence tomography based vibrometry
      There is growing interest in using the exquisite phase sensitivity of optical coherence tomography (OCT) to measure the vibratory response in organ systems such as the middle and inner ear. Using frequency domain analysis, it is possible to achieve picometer sensitivity to vibration over a wide frequency band. Here we explore the limits of the frequency domain vibratory sensitivity due to additive noise and consider the implication of phase noise ...
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    9. Picometer scale vibrometry in the human middle ear using a surgical microscope based optical coherence tomography and vibrometry system

      Picometer scale vibrometry in the human middle ear using a surgical microscope based optical coherence tomography and vibrometry system
      We have developed a highly phase stable optical coherence tomography and vibrometry system that attaches directly to the accessory area of a surgical microscope common to both the otology clinic and operating room. Careful attention to minimizing sources of phase noise has enabled a system capable of measuring vibrations of the middle ear with a sensitivity of 5 pm in an awake human patient. The system is shown to be ...
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    10. AI-Assisted In Situ Detection of Human Glioma Infiltration Using a Novel Computational Method for Optical Coherence Tomography

      AI-Assisted In Situ Detection of Human Glioma Infiltration Using a Novel Computational Method for Optical Coherence Tomography
      Purpose: In glioma surgery, it is critical to maximize tumor resection without compromising adjacent non-cancerous brain tissue. Optical Coherence Tomography (OCT) is a non-invasive, label-free, real-time, high-resolution imaging modality that has been explored for glioma infiltration detection. Here we report a novel artificial intelligence (AI) assisted method for automated, real-time, in situ detection of glioma infiltration at high spatial resolution. Experimental Design: Volumetric OCT datasets were intraoperatively obtained from resected ...
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    11. Application of Multi-Tonal Complex with Optical Coherence Tomography Imaging System for Vibrometric Analysis of Inner-Ear Structures (Thesis)

      Application of Multi-Tonal Complex with Optical Coherence Tomography Imaging System for Vibrometric Analysis of Inner-Ear Structures (Thesis)
      Currently, research is being conducted on single tone sound transduction within the auditory portion of the inner ear, the cochlea [1]. The study of cochlear mechanics in large rodents has provided important insight into cochlear function [1]. Additionally, multi-tone stimuli can provide a new perspective in vibrometric analyses that could be used in audiometry as a measure of hearing loss for patients in terms of both magnitude and their unique ...
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    12. Data on SD-OCT image acquisition, ultrastructural features, and horizontal tissue shrinkage in the porcine retina

      Data on SD-OCT image acquisition, ultrastructural features, and horizontal tissue shrinkage in the porcine retina
      The data presented in this article are related to the research paper entitled Correlation of Spectral Domain Optical Coherence Tomography with Histology and Electron Microscopy in the Porcine Retina (Xie et al., 2018) [2]. This research data highlights our technique for retinal fundus image acquisition during spectral domain optical coherence tomography (SD-OCT) in a large animal model. Low and high magnification electron micrographs are included to demonstrate the ultrastructural features ...
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    13. Organ of Corti vibration within the intact gerbil cochlea measured by volumetric optical coherence tomography and vibrometry

      Organ of Corti vibration within the intact gerbil cochlea measured by volumetric optical coherence tomography and vibrometry
      There is indirect evidence that the mammalian cochlea in the low-frequency apical and the more commonly-studied high-frequency basal regions function in fundamentally different ways. Here, we directly tested this hypothesis by measuring sound-induced vibrations of the organ of Corti (OoC) at three turns of the gerbil cochlea using volumetric optical coherence tomography vibrometry (VOCTV), an approach that permits non-invasive imaging through the bone. In the apical turn, there was little ...
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    14. Correlation of spectral domain optical coherence tomography with histology and electron microscopy in the porcine retina

      Correlation of spectral domain optical coherence tomography with histology and electron microscopy in the porcine retina
      Spectral domain optical coherence tomography (SD-OCT) is used as a non-invasive tool for retinal morphological assessment in vivo . Information on the correlation of SD-OCT with retinal histology in the porcine retina, a model resembling the human retina, is limited. Herein, we correlated the hypo- and hyper-reflective bands on SD-OCT with histology of the lamellar architecture and cellular constituents of the porcine retina. SD-OCT images were acquired with the Heidelberg Spectralis ...
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    15. Osmotic stabilization prevents cochlear synaptopathy after blast trauma

      Osmotic stabilization prevents cochlear synaptopathy after blast trauma
      Traumatic noise causes hearing loss by damaging sensory hair cells and their auditory synapses. There are no treatments. Here, we investigated mice exposed to a blast wave approximating a roadside bomb. In vivo cochlear imaging revealed an increase in the volume of endolymph, the fluid within scala media, termed endolymphatic hydrops. Endolymphatic hydrops, hair cell loss, and cochlear synaptopathy were initiated by trauma to the mechanosensitive hair cell stereocilia and ...
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  2. About Texas A&M University

    Texas A&M University

    Texas A&M University.  From humble beginnings in 1876 as Texas' first public institution of higher learning, to a bustling 5,000-acre campus with a nationally recognized faculty, Texas A&M University is one of a select few universities with land-grant, sea-grant and space-grant designations. With an enrollment of about half men and half women, 25 percent of the freshman class are the first in their family to attend college. Here, 38,000-plus undergraduates and more than 9,000 graduate students have access to world-class research programs and award-winning faculty. Texas A&M has two branch campuses, one in Galveston, Texas, and one in the Middle Eastern country of Qatar.