1. Texas A&M University

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    1. Mentioned In 52 Articles

    2. ELHnet: a convolutional neural network for classifying cochlear endolymphatic hydrops imaged with optical coherence tomography

      ELHnet: a convolutional neural network for classifying cochlear endolymphatic hydrops imaged with optical coherence tomography
      Detection of endolymphatic hydrops is important for diagnosing Menieres disease, and can be performed non-invasively using optical coherence tomography (OCT) in animal models as well as potentially in the clinic. Here, we developed ELHnet, a convolutional neural network to classify endolymphatic hydrops in a mouse model using learned features from OCT images of mice cochleae. We trained ELHnet on 2159 training and validation images from 17 mice, using only the ...
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    3. Computer-aided detection and quantification of endolymphatic hydrops within the mouse cochlea in vivo using optical coherence tomography

      Computer-aided detection and quantification of endolymphatic hydrops within the mouse cochlea in vivo using optical coherence tomography
      Diseases that cause hearing loss and/or vertigo in humans such as Menieres disease are often studied using animal models. The volume of endolymph within the inner ear varies with these diseases. Here, we used a mouse model of increased endolymph volume, endolymphatic hydrops, to develop a computer-aided objective approach to measure endolymph volume from images collected in vivo using optical coherence tomography. The displacement of Reissners membrane from its ...
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    4. AN EFFICIENT ESTIMATION ALGORITHM FOR THE CALIBRATION OF LOW-COST SS-OCT SYSTEMS

      AN EFFICIENT ESTIMATION ALGORITHM FOR THE CALIBRATION OF LOW-COST SS-OCT SYSTEMS
      In this paper, we present a real-time instantaneous phase estimation technique for the calibration of swept source optical coherence tomography (SS-OCT) systems. The proposed algorithm is able to accurately estimate both the amplitude and phase content of a swept source signal. The results are robust in the presence of substantial noise. Furthermore, the resulting phase profile is readily unwrapped, allowing for the generation of a k-linear sampling clock by means ...
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    5. Automatic classification of atherosclerotic plaques imaged with intravascular OCT

      Automatic classification of atherosclerotic plaques imaged with intravascular OCT
      Intravascular optical coherence tomography (IV-OCT) allows evaluation of atherosclerotic plaques; however, plaque characterization is performed by visual assessment and requires a trained expert for interpretation of the large data sets. Here, we present a novel computational method for automated IV-OCT plaque characterization. This method is based on the modeling of each A-line of an IV-OCT data set as a linear combination of a number of depth profiles. After estimating these ...
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    6. Multimodal optical coherence tomography and fluorescence lifetime imaging with interleaved excitation sources for simultaneous endogenous and exogenous fluorescence

      Multimodal optical coherence tomography and fluorescence lifetime imaging with interleaved excitation sources for simultaneous endogenous and exogenous fluorescence
      Multimodal imaging probes a variety of tissue properties in a single image acquisition by merging complimentary imaging technologies. Exploiting synergies amongst the data, algorithms can be developed that lead to better tissue characterization than could be accomplished by the constituent imaging modalities taken alone. The combination of optical coherence tomography (OCT) with fluorescence lifetime imaging microscopy (FLIM) provides access to detailed tissue morphology and local biochemistry. The optical system described ...
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    7. Optical Coherence Tomography to Measure Sound-Induced Motions Within the Mouse Organ of Corti In Vivo

      Optical Coherence Tomography to Measure Sound-Induced Motions Within the Mouse Organ of Corti In Vivo
      The measurement of mechanical vibrations within the living cochlea is critical to understanding the first nonlinear steps in auditory processing, hair cell stimulation, and cochlear amplification. However, it has proven to be a challenging endeavor. This chapter describes how optical coherence tomography (OCT) can be used to measure vibrations within the tissues of the organ of Corti. These experimental measurements can be performed within the unopened cochlea of living mice ...
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    8. Automated analysis of multimodal fluorescence lifetime imaging and optical coherence tomography data for the diagnosis of oral cancer in the hamster cheek pouch model

      Automated analysis of multimodal fluorescence lifetime imaging and optical coherence tomography data for the diagnosis of oral cancer in the hamster cheek pouch model
      It is known that the progression of oral cancer is accompanied by changes in both tissue biochemistry and morphology. A multimodal imaging approach combining functional and structural imaging modalities could therefore provide a more comprehensive prognosis of oral cancer. This idea forms the central theme of the current study, wherein this premise is examined in the context of a multimodal imaging system that combines fluorescence lifetime imaging (FLIM) and optical ...
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    9. Effect of Outflow Tract Banding on Embryonic Cardiac Hemodynamics

      Effect of Outflow Tract Banding on Embryonic Cardiac Hemodynamics
      We analyzed heart wall motion and blood flow dynamics in chicken embryos using in vivo optical coherence tomography (OCT) imaging and computational fluid dynamics (CFD) embryo-specific modeling. We focused on the heart outflow tract (OFT) region of day 3 embryos, and compared normal (control) conditions to conditions after performing an OFT banding intervention, which alters hemodynamics in the embryonic heart and vasculature. We found that hemodynamics and cardiac wall motion ...
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    10. High-speed spectral calibration by complex FIR filter in phase-sensitive optical coherence tomography

      High-speed spectral calibration by complex FIR filter in phase-sensitive optical coherence tomography
      Swept-laser sources offer a number of advantages for Phase-sensitive Optical Coherence Tomography (PhOCT). However, inter- and intra-sweep variability leads to calibration errors that adversely affect phase sensitivity. While there are several approaches to overcoming this problem, our preferred method is to simply calibrate every sweep of the laser. This approach offers high accuracy and phase stability at the expense of a substantial processing burden. In this approach, the Hilbert phase ...
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    11. Phase-sensitive optical coherence tomography-based vibrometry using a highly phase-stable akinetic swept laser source

      Phase-sensitive optical coherence tomography-based vibrometry using a highly phase-stable akinetic swept laser source
      Phase-sensitive Optical Coherence Tomography (PhOCT) is an emerging tool for in vivo investigation of the vibratory function of the intact middle and inner ear. PhOCT is able to resolve micron scale tissue morphology in three dimensions as well as measure picometer scale motion at each spatial position. Most PhOCT systems to date have relied upon the phase stability offered by spectrometer detection. On the other hand swept laser source based ...
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    12. Fingerprint Matching with Optical Coherence Tomography

      Fingerprint Matching with Optical Coherence Tomography
      Fingerprint recognition is an important security technique with a steadily growing usage for the identification and verification of individuals. However, current fingerprint acquisition systems have certain disadvantages, which include the requirements of physical contact with the acquisition device, and the presence of undesirable artefacts, such as scars, on the surface of the fingerprint. This paper evaluates the accuracy of a complete framework for the capturing of undamaged, undistorted fingerprints from ...
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    13. 4D subject-specific inverse modeling of the chick embryonic heart outflow tract hemodynamics

      4D subject-specific inverse modeling of the chick embryonic heart outflow tract hemodynamics
      Blood flow plays a critical role in regulating embryonic cardiac growth and development, with altered flow leading to congenital heart disease. Progress in the field, however, is hindered by a lack of quantification of hemodynamic conditions in the developing heart. In this study, we present a methodology to quantify blood flow dynamics in the embryonic heart using subject-specific computational fluid dynamics (CFD) models. While the methodology is general, we focused ...
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    14. Miniature, minimally invasive, tunable endoscope for investigation of the middle ear

      Miniature, minimally invasive, tunable endoscope for investigation of the middle ear
      We demonstrate a miniature, tunable, minimally invasive endoscope for diagnosis of the auditory system. The probe is designed to sharply image anatomical details of the middle ear without the need for physically adjusting the position of the distal end of the endoscope. This is achieved through the addition of an electrowetted, tunable, electronically-controlled lens to the optical train. Morphological imaging is enabled by scanning light emanating from an optical coherence ...
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    15. Texas Engineering Experiment Station Receives NIH Grant for Morphological and Molecular Imaging System for In Vivo Atherosclerosis Research

      Texas Engineering Experiment Station Receives NIH Grant for Morphological and Molecular Imaging System for In Vivo Atherosclerosis Research
      Texas Engineering Experiment Station Receives a 2015 NIH Grant for Morphological and Molecular Imaging System for In Vivo Atherosclerosis Research. The Principal invesigator is Brian Applegate. The program began in 2012 and ends in 2017. Below is a summary of the proposed work. Atherosclerosis is the leading cause of morbidity and mortality in the United States and is characterized as a systemic, progressive disease process in which the arterial wall ...
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    16. Feature Of The Week 04/05/15: Noninvasive in vivo Imaging Reveals Differences Between Tectorial Membrane and Basilar Membrane Traveling Waves in the Mouse Cochlea

      Feature Of The Week 04/05/15: Noninvasive in vivo Imaging Reveals Differences Between Tectorial Membrane and Basilar Membrane Traveling Waves in the Mouse Cochlea
      Sound is encoded within the auditory portion of the inner ear, the cochlea, after propagating down its length as a traveling wave. For over half a century, vibratory measurements to study cochlear traveling waves have been made using invasive approaches such as laser Doppler vibrometry. While these studies have provided critical information regarding the non-linear processes within the living cochlea that increase the amplitude of vibration and sharpen frequency tuning ...
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  2. About Texas A&M University

    Texas A&M University

    Texas A&M University.  From humble beginnings in 1876 as Texas' first public institution of higher learning, to a bustling 5,000-acre campus with a nationally recognized faculty, Texas A&M University is one of a select few universities with land-grant, sea-grant and space-grant designations. With an enrollment of about half men and half women, 25 percent of the freshman class are the first in their family to attend college. Here, 38,000-plus undergraduates and more than 9,000 graduate students have access to world-class research programs and award-winning faculty. Texas A&M has two branch campuses, one in Galveston, Texas, and one in the Middle Eastern country of Qatar.