1. Texas A&M University

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    1. Mentioned In 64 Articles

    2. Noise and sensitivity in optical coherence tomography based vibrometry

      Noise and sensitivity in optical coherence tomography based vibrometry
      There is growing interest in using the exquisite phase sensitivity of optical coherence tomography (OCT) to measure the vibratory response in organ systems such as the middle and inner ear. Using frequency domain analysis, it is possible to achieve picometer sensitivity to vibration over a wide frequency band. Here we explore the limits of the frequency domain vibratory sensitivity due to additive noise and consider the implication of phase noise ...
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    3. Picometer scale vibrometry in the human middle ear using a surgical microscope based optical coherence tomography and vibrometry system

      Picometer scale vibrometry in the human middle ear using a surgical microscope based optical coherence tomography and vibrometry system
      We have developed a highly phase stable optical coherence tomography and vibrometry system that attaches directly to the accessory area of a surgical microscope common to both the otology clinic and operating room. Careful attention to minimizing sources of phase noise has enabled a system capable of measuring vibrations of the middle ear with a sensitivity of 5 pm in an awake human patient. The system is shown to be ...
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    4. AI-Assisted In Situ Detection of Human Glioma Infiltration Using a Novel Computational Method for Optical Coherence Tomography

      AI-Assisted In Situ Detection of Human Glioma Infiltration Using a Novel Computational Method for Optical Coherence Tomography
      Purpose: In glioma surgery, it is critical to maximize tumor resection without compromising adjacent non-cancerous brain tissue. Optical Coherence Tomography (OCT) is a non-invasive, label-free, real-time, high-resolution imaging modality that has been explored for glioma infiltration detection. Here we report a novel artificial intelligence (AI) assisted method for automated, real-time, in situ detection of glioma infiltration at high spatial resolution. Experimental Design: Volumetric OCT datasets were intraoperatively obtained from resected ...
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    5. Application of Multi-Tonal Complex with Optical Coherence Tomography Imaging System for Vibrometric Analysis of Inner-Ear Structures (Thesis)

      Application of Multi-Tonal Complex with Optical Coherence Tomography Imaging System for Vibrometric Analysis of Inner-Ear Structures (Thesis)
      Currently, research is being conducted on single tone sound transduction within the auditory portion of the inner ear, the cochlea [1]. The study of cochlear mechanics in large rodents has provided important insight into cochlear function [1]. Additionally, multi-tone stimuli can provide a new perspective in vibrometric analyses that could be used in audiometry as a measure of hearing loss for patients in terms of both magnitude and their unique ...
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    6. Data on SD-OCT image acquisition, ultrastructural features, and horizontal tissue shrinkage in the porcine retina

      Data on SD-OCT image acquisition, ultrastructural features, and horizontal tissue shrinkage in the porcine retina
      The data presented in this article are related to the research paper entitled Correlation of Spectral Domain Optical Coherence Tomography with Histology and Electron Microscopy in the Porcine Retina (Xie et al., 2018) [2]. This research data highlights our technique for retinal fundus image acquisition during spectral domain optical coherence tomography (SD-OCT) in a large animal model. Low and high magnification electron micrographs are included to demonstrate the ultrastructural features ...
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    7. Organ of Corti vibration within the intact gerbil cochlea measured by volumetric optical coherence tomography and vibrometry

      Organ of Corti vibration within the intact gerbil cochlea measured by volumetric optical coherence tomography and vibrometry
      There is indirect evidence that the mammalian cochlea in the low-frequency apical and the more commonly-studied high-frequency basal regions function in fundamentally different ways. Here, we directly tested this hypothesis by measuring sound-induced vibrations of the organ of Corti (OoC) at three turns of the gerbil cochlea using volumetric optical coherence tomography vibrometry (VOCTV), an approach that permits non-invasive imaging through the bone. In the apical turn, there was little ...
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    8. Correlation of spectral domain optical coherence tomography with histology and electron microscopy in the porcine retina

      Correlation of spectral domain optical coherence tomography with histology and electron microscopy in the porcine retina
      Spectral domain optical coherence tomography (SD-OCT) is used as a non-invasive tool for retinal morphological assessment in vivo . Information on the correlation of SD-OCT with retinal histology in the porcine retina, a model resembling the human retina, is limited. Herein, we correlated the hypo- and hyper-reflective bands on SD-OCT with histology of the lamellar architecture and cellular constituents of the porcine retina. SD-OCT images were acquired with the Heidelberg Spectralis ...
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    9. Osmotic stabilization prevents cochlear synaptopathy after blast trauma

      Osmotic stabilization prevents cochlear synaptopathy after blast trauma
      Traumatic noise causes hearing loss by damaging sensory hair cells and their auditory synapses. There are no treatments. Here, we investigated mice exposed to a blast wave approximating a roadside bomb. In vivo cochlear imaging revealed an increase in the volume of endolymph, the fluid within scala media, termed endolymphatic hydrops. Endolymphatic hydrops, hair cell loss, and cochlear synaptopathy were initiated by trauma to the mechanosensitive hair cell stereocilia and ...
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    10. Endoscopic optical coherence tomography enables morphological and subnanometer vibratory imaging of the porcine cochlea through the round window

      Endoscopic optical coherence tomography enables morphological and subnanometer vibratory imaging of the porcine cochlea through the round window
      A highly phase stable hand-held (HH) endoscopic system has been developed for optical coherence tomography and vibrometry. Designed to transit the ear canal to the middle ear space and peer through the round window (RW), it is capable of imaging the vibratory function of the cochlear soft tissues with subnanometer scale sensitivity. A side-looking, 9 cm long rigid endoscope with a distal diameter of 1.2 mm, was able to ...
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    11. Multiple Research Scientist and Postdoctoral Positions in Computer Aided Diagnosis Department of Biomedical Engineering, Texas A&M University, College Station-Texas

      Multiple Research Scientist and Postdoctoral Positions in Computer Aided Diagnosis Department of Biomedical Engineering, Texas A&M University, College Station-Texas
      The Laboratory for Optical Diagnosis and Imaging ( http://biomed.tamu.edu/LODI ) in the Department of Biomedical Engineering at Texas AM University invites applications for multiple research scientist and postdoctoral positions in the area of computer aided diagnosis (CAD) system development. Ideal candidates should have substantial experience in 2D and 3D pattern recognition, computer vision, image analysis, and machine learning. Experience in both deep learning and medical imaging analysis is ...
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    12. Multiple Research Scientist and Postdoctoral Positions in Endoscopic Instrumentation Department of Biomedical Engineering, Texas A&M University, College Station-Texas

      Multiple Research Scientist and Postdoctoral Positions in Endoscopic Instrumentation Department of Biomedical Engineering, Texas A&M University, College Station-Texas
      The Laboratory for Optical Diagnosis and Imaging ( http://biomed.tamu.edu/LODI ) in the Department of Biomedical Engineering at Texas AM University invites applications for multiple research scientist and postdoctoral positions in the area of endoscopic instrumentation development. Ideal candidates should have expertise in optical design, data acquisition instrumentation and software development, and substantial demonstrated experience in optical imaging and/or spectroscopic instrumentation design and implementation. Experience in fluorescence lifetime ...
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    13. Contrast enhancement of pump-probe optical coherence tomography (PP-OCT) based molecular imaging using methylene blue loaded PLGA particles

      Contrast enhancement of pump-probe optical coherence tomography (PP-OCT) based molecular imaging using methylene blue loaded PLGA particles
      Atherosclerosis, a condition in which plaque accumulates on the inner wall of arteries, is often recognized as a precursor to cardiovascular diseases (CVDs), the most common causes of death in the US. Optical Coherence Tomography (OCT) is an intravascular optical diagnosis tool, which can be used to obtain high resolution morphological images of atherosclerotic plaque. However, atherosclerotic plaque components, such as macrophages, can be misclassified due to their signal similarities ...
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    14. ELHnet: a convolutional neural network for classifying cochlear endolymphatic hydrops imaged with optical coherence tomography

      ELHnet: a convolutional neural network for classifying cochlear endolymphatic hydrops imaged with optical coherence tomography
      Detection of endolymphatic hydrops is important for diagnosing Menieres disease, and can be performed non-invasively using optical coherence tomography (OCT) in animal models as well as potentially in the clinic. Here, we developed ELHnet, a convolutional neural network to classify endolymphatic hydrops in a mouse model using learned features from OCT images of mice cochleae. We trained ELHnet on 2159 training and validation images from 17 mice, using only the ...
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    15. Computer-aided detection and quantification of endolymphatic hydrops within the mouse cochlea in vivo using optical coherence tomography

      Computer-aided detection and quantification of endolymphatic hydrops within the mouse cochlea in vivo using optical coherence tomography
      Diseases that cause hearing loss and/or vertigo in humans such as Menieres disease are often studied using animal models. The volume of endolymph within the inner ear varies with these diseases. Here, we used a mouse model of increased endolymph volume, endolymphatic hydrops, to develop a computer-aided objective approach to measure endolymph volume from images collected in vivo using optical coherence tomography. The displacement of Reissners membrane from its ...
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    16. AN EFFICIENT ESTIMATION ALGORITHM FOR THE CALIBRATION OF LOW-COST SS-OCT SYSTEMS

      AN EFFICIENT ESTIMATION ALGORITHM FOR THE CALIBRATION OF LOW-COST SS-OCT SYSTEMS
      In this paper, we present a real-time instantaneous phase estimation technique for the calibration of swept source optical coherence tomography (SS-OCT) systems. The proposed algorithm is able to accurately estimate both the amplitude and phase content of a swept source signal. The results are robust in the presence of substantial noise. Furthermore, the resulting phase profile is readily unwrapped, allowing for the generation of a k-linear sampling clock by means ...
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  2. About Texas A&M University

    Texas A&M University

    Texas A&M University.  From humble beginnings in 1876 as Texas' first public institution of higher learning, to a bustling 5,000-acre campus with a nationally recognized faculty, Texas A&M University is one of a select few universities with land-grant, sea-grant and space-grant designations. With an enrollment of about half men and half women, 25 percent of the freshman class are the first in their family to attend college. Here, 38,000-plus undergraduates and more than 9,000 graduate students have access to world-class research programs and award-winning faculty. Texas A&M has two branch campuses, one in Galveston, Texas, and one in the Middle Eastern country of Qatar.