1. Technical University of Munich

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    1. Mentioned In 63 Articles

    2. Towards phase-stabilized Fourier domain mode-locked frequency combs

      Towards phase-stabilized Fourier domain mode-locked frequency combs
      Fourier domain mode-locked (FDML) lasers are some of the fastest wavelength-swept light sources, and used in many applications like optical coherence tomography (OCT), OCT endoscopy, Raman microscopy, light detection and ranging, and two-photon microscopy. For a deeper understanding of the underlying laser physics, it is crucial to investigate the light field evolution of the FDML laser and to clarify whether the FDML laser provides a frequency comb structure. In this ...
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    3. Normative Data and Conversion Equation for Spectral-Domain Optical Coherence Tomography in an International Healthy Control Cohort

      Normative Data and Conversion Equation for Spectral-Domain Optical Coherence Tomography in an International Healthy Control Cohort
      Background: Spectral-domain (SD-) optical coherence tomography (OCT) can reliably measure axonal (peripapillary retinal nerve fiber layer [pRNFL]) and neuronal (macular ganglion cell + inner plexiform layer [GCIPL]) thinning in the retina. Measurements from 2 commonly used SD-OCT devices are often pooled together in multiple sclerosis (MS) studies and clinical trials despite software and segmentation algorithm differences; however, individual pRNFL and GCIPL thickness measurements are not interchangeable between devices. In some circumstances ...
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    4. Surgical scene generation and adversarial networks for physics-based iOCT synthesis

      Surgical scene generation and adversarial networks for physics-based iOCT synthesis
      The development and integration of intraoperative optical coherence tomography (iOCT) into modern operating rooms has motivated novel procedures directed at improving the outcome of ophthalmic surgeries. Although computer-assisted algorithms could further advance such interventions, the limited availability and accessibility of iOCT systems constrains the generation of dedicated data sets. This paper introduces a novel framework combining a virtual setup and deep learning algorithms to generate synthetic iOCT data in a ...
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    5. Stent Optimization Using Optical Coherence Tomography and Its Prognostic Implications After Percutaneous Coronary Intervention

      Stent Optimization Using Optical Coherence Tomography and Its Prognostic Implications After Percutaneous Coronary Intervention
      Background Stent underexpansion has been known to be associated with worse outcomes. We sought to define optical coherence tomography assessed optimal stent expansion index (SEI), which associates with lower incidence of follow-up major adverse cardiac events (MACEs). Methods and Results A total of 315 patients (involving 370 lesions) who underwent optical coherence tomography-aided coronary stenting were retrospectively included. SEI was calculated separately for equal halves of each stented segment using ...
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    6. Optical coherence tomography in coronary atherosclerosis assessment and intervention

      Optical coherence tomography in coronary atherosclerosis assessment and intervention
      Since optical coherence tomography (OCT) was first performed in humans two decades ago, this imaging modality has been widely adopted in research on coronary atherosclerosis and adopted clinically for the optimization of percutaneous coronary intervention. In the past 10 years, substantial advances have been made in the understanding of in vivo vascular biology using OCT. Identification by OCT of culprit plaque pathology could potentially lead to a major shift in ...
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    7. A Tool for High-Resolution Volumetric Optical Coherence Tomography by Compounding Radial-and Linear Acquired B-Scans Using Registration

      A Tool for High-Resolution Volumetric Optical Coherence Tomography by Compounding Radial-and Linear Acquired B-Scans Using Registration
      Optical coherence tomography (OCT) is a medical imaging modality that is commonly used to diagnose retinal diseases. In recent years, linear and radial scanning patterns have been proposed to acquire three-dimensional OCT data. These patterns show differences in A-scan acquisition density across the generated volumes, and thus differ in their suitability for the diagnosis of retinal diseases. While radial OCT volumes exhibit a higher A-scan sampling rate around the scan ...
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    8. Optical coherence tomography tissue coverage and characterization at six months after implantation of bioresorbable scaffolds versus conventional everolimus eluting stents in the ISAR-Absorb MI trial

      Optical coherence tomography tissue coverage and characterization at six months after implantation of bioresorbable scaffolds versus conventional everolimus eluting stents in the ISAR-Absorb MI trial
      Purpose: Data regarding vessel healing by optical coherence tomography (OCT) after everolimus-eluting bioresorbable scaffolds (BRS) or everolimus-eluting metallic stent (EES) implantation in acute myocardial infarction (AMI) patients is scarce. We compared OCT findings after BRS or EES implantation in patients with AMI enrolled in a randomized trial. Methods: In ISAR-Absorb MI, AMI patients were randomized to BRS or EES implantation, with 6-8 month angiographic follow-up. This analysis includes patients who ...
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    9. In vivo optical molecular imaging of inflammation and immunity

      In vivo optical molecular imaging of inflammation and immunity
      Inflammation is the phenotypic form of various diseases. Recent development in molecular imaging provides new insights into the diagnostic and therapeutic evaluation of different inflammatory diseases as well as diseases involving inflammation such as cancer. While conventional imaging techniques used in the clinical setting provide only indirect measures of inflammation such as increased perfusion and altered endothelial permeability, optical imaging is able to report molecular information on diseased tissue and ...
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    10. Optical coherence tomography angiography indicates subclinical retinal disease in neuromyelitis optica spectrum disorders

      Optical coherence tomography angiography indicates subclinical retinal disease in neuromyelitis optica spectrum disorders
      Background: Neuromyelitis optica spectrum disorders (NMOSD) are neuroinflammatory diseases of the central nervous system. Patients suffer from recurring relapses and it is unclear whether relapse-independent disease activity occurs and whether this is of clinical relevance. Objective: To detect disease-specific alterations of the retinal vasculature that reflect disease activity during NMOSD. Methods: Cross-sectional analysis of 16 patients with NMOSD, 21 patients with relapsing-remitting multiple sclerosis, and 21 healthy controls using retinal ...
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    11. Repeatability and Reproducibility of Macular Hole Size Measurements Using Optical Coherence Tomography

      Repeatability and Reproducibility of Macular Hole Size Measurements Using Optical Coherence Tomography
      The purpose of this study was to assess the repeatability and reproducibility of measuring the minimum linear diameter (MLD) of macular holes (MHs) using horizontal linear and radial scan modes in optical coherence tomography (OCT). Patients with concurrent sets of radial and horizontal linear OCT volume scans were included. The MLD was measured twice in both scan modes by six raters of three different experience levels (groups). Outcome measures were ...
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    12. Processing-Aware Real-Time Rendering for Optimized Tissue Visualization in Intraoperative 4D OCT

      Processing-Aware Real-Time Rendering for Optimized Tissue Visualization in Intraoperative 4D OCT
      Intraoperative Optical Coherence Tomography (iOCT) has advanced in recent years to provide real-time high resolution volumetric imaging for ophthalmic surgery. It enables real-time 3D feedback during precise surgical maneuvers. Intraoperative 4D OCT generally exhibits lower signal-to-noise ratio compared to diagnostic OCT and visualization is complicated by instrument shadows occluding retinal tissue. Additional constraints of processing data rates upwards of 6GB/s create unique challenges for advanced visualization of 4D OCT ...
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    13. The APOSTEL 2.0 Recommendations for Reporting Quantitative Optical Coherence Tomography Studies

      The APOSTEL 2.0 Recommendations for Reporting Quantitative Optical Coherence Tomography Studies
      Objective: To update the consensus recommendations for reporting of quantitative optical coherence tomography (OCT) study results, thus revising the previously published Advised Protocol for OCT Study Terminology and Elements (APOSTEL) recommendations. Methods: To identify studies reporting quantitative OCT results, we performed a PubMed search for the terms "quantitative" and "optical coherence tomography" from 2015 to 2017. Corresponding authors of the identified publications were invited to provide feedback on the initial ...
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    14. Real-time tool to layer distance estimation for robotic subretinal injection using intraoperative 4D OCT

      Real-time tool to layer distance estimation for robotic subretinal injection using intraoperative 4D OCT
      The emergence of robotics could enable ophthalmic microsurgical procedures that were previously not feasible due to the precision limits of manual delivery, for example, targeted subretinal injection. Determining the distance between the needle tip, the internal limiting membrane (ILM), and the retinal pigment epithelium (RPE) both precisely and reproducibly is required for safe and successful robotic retinal interventions. Recent advances in intraoperative optical coherence tomography (iOCT) have opened the path ...
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    15. Functional recovery after macula involving retinal detachment and its correlation with preoperative biomarkers in optical coherence tomography

      Functional recovery after macula involving retinal detachment and its correlation with preoperative biomarkers in optical coherence tomography
      To introduce an ETDRS grid-based classification for macula involving retinal detachment (MIRD) with or without center (foveal) involvement and to identify biomarkers in preoperative optical coherence tomography (OCT) associated with a favorable postoperative functional outcome in eyes with center involving retinal detachment (CIRD). One hundred and two eyes of 102 consecutive patients (f/m: 35/67) with primary rhegmatogenous retinal detachment, preoperative evidence of MIRD (perifoveal involvement of 6.0 ...
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  2. About Technical University of Munich

    Technical University of Munich

    Technische Universität München ( TUM ; University of Technology, Munich ; Technical University of Munich ) is a research university with campuses in Munich , Garching and Freising - Weihenstephan . It is a member of TU9 , an incorporated society of the largest and most notable German institutes of technology.