1. Taner Akkin

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    1. Mentioned In 27 Articles

    2. Human Brain Imaging by Optical Coherence Tomography (Book Chapter)

      Human Brain Imaging by Optical Coherence Tomography (Book Chapter)
      The Handbook of Neurophotonics provides a dedicated overview of neurophotonics, covering the use of advanced optical technologies to record, stimulate, and control the activity of the brain, yielding new insight and advantages over conventional tools due to the adaptability and non-invasive nature of light. Including 30 colour figures, this book addresses functional studies of neurovascular signaling, metabolism, electrical excitation, and hemodynamics, as well as clinical applications for imaging and manipulating ...
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    3. Glioma cell migration dynamics in brain tissue assessed by multimodal optical imaging

      Glioma cell migration dynamics in brain tissue assessed by multimodal optical imaging
      Glioblastoma is a primary malignant brain tumor characterized by highly infiltrative glioma cells. Vasculature and white matter tracts are considered to be the preferred and fastest routes for glioma invasion through brain tissue. In this study, we systematically quantified the routes and motility of the U251 human glioblastoma cell line in mouse brain slices by multimodal imaging. Specifically, we used polarization-sensitive optical coherence tomography to delineate nerve fiber tracts while ...
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    4. Contrast-enhanced serial optical coherence scanner with deep learning network reveals vasculature and white matter organization of mouse brain

      Contrast-enhanced serial optical coherence scanner with deep learning network reveals vasculature and white matter organization of mouse brain
      Optical coherence tomography provides volumetric reconstruction of brain structure with micrometer resolution. Gray matter and white matter can be highlighted using conventional and polarization-based contrasts; however, vasculature in ex-vivo fixed brain has not been investigated at large scale due to lack of intrinsic contrast. We present contrast enhancement to visualize the vasculature by perfusing titanium dioxide particles transcardially into the mouse vascular system. The brain, after dissection and fixation, is ...
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    5. Polarization-sensitive optical coherence tomography reveals gray matter and white matter atrophy in SCA1 mouse models

      Polarization-sensitive optical coherence tomography reveals gray matter and white matter atrophy in SCA1 mouse models
      Spinocerebellar ataxia type 1 (SCA1) is a fatal inherited neurodegenerative disease. In this study, we demonstrate the label-free optical imaging methodology that can detect, with a high degree of sensitivity, discrete areas of degeneration in the cerebellum of the SCA1 mouse models. We used ATXN1[82Q] and ATXN1[30Q]-D776 mice in which the transgene is directed only to Purkinje cells. Molecular layer, granular layer, and white matter regions are ...
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    6. White matter atrophy in spinocerebellar ataxia type 1 mouse models revealed by serial optical coherence scanner

      White matter atrophy in spinocerebellar ataxia type 1 mouse models revealed by serial optical coherence scanner
      Spinocerebellar ataxia type 1 (SCA1) is a fatal inherited neurodegenerative disease. Post-mortem studies showed neurodegeneration involving white matter components in the cerebral lobes, the cerebellar peduncles and the more distal cranial nerves in human patients. However, the progression of SCA1 in the brain remains unclear. We present the study of white matter atrophy of SCA1 mouse models using serial optical coherence scanner (SOCS). SOCS consists of a polarization sensitive optical ...
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    7. Visualizing and mapping the cerebellum with serial optical coherence scanner

      Visualizing and mapping the cerebellum with serial optical coherence scanner
      We present the visualization of the mouse cerebellum and adjacent brainstem using a serial optical coherence scanner, which integrates a vibratome slicer and polarization-sensitive optical coherence tomography for ex vivo imaging. The scanner provides intrinsic optical contrasts to distinguish the cerebellar cortical layers and white matter. Images from serial scans reveal the large-scale anatomy in detail and map the nerve fiber pathways in the cerebellum and brainstem. By incorporating a ...
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    8. Quantifying three-dimensional optic axis using polarization-sensitive optical coherence tomography

      Quantifying three-dimensional optic axis using polarization-sensitive optical coherence tomography
      The optic axis of birefringent samples indicates the direction of optical anisotropy, which should be described in three-dimensional (3-D) space. We present a method to quantify the complete 3-D optic axis orientation calculated from in-plane optic axis measurements from a polarization-sensitive optical coherence tomography system. The in-plane axis orientations with different illumination angles allow the calculation of the necessary polar angle. The method then provides the information to produce the ...
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    9. Polarization sensitive optical coherence microscopy for brain imaging

      Polarization sensitive optical coherence microscopy for brain imaging
      Optical coherence tomography (OCT) and optical coherence microscopy (OCM) have demonstrated the ability to investigate cyto- and myelo-architecture in the brain. Polarization-sensitive OCT provides sensitivity to additional contrast mechanisms, specifically the birefringence of myelination and, therefore, is advantageous for investigating white matter fiber tracts. In this Letter, we developed a polarization-sensitive optical coherence microscope (PS-OCM) with a 3.5 m axial and 1.3 m transverse resolution to investigate fiber ...
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    10. Optical coherence tomography for cross-sectional imaging of neural activity

      Optical coherence tomography for cross-sectional imaging of neural activity
      Abstract. We report a functional optical coherence tomography cross-sectional scanner to detect neural activity using unmyelinated nerves dissected from squid. The nerves, unstained or stained with a voltage-sensitive dye, were imaged in a nerve chamber. Transient phase changes from backscattered light were detected during action potential propagation. The results show that the scanner can provide high spatiotemporal resolution cross-sectional images of neural activity ( 15 s / A - line ; 0.25 ms ...
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    11. Marker-Free Tracking of Facet Capsule Motion Using Polarization-Sensitive Optical Coherence Tomography

      Marker-Free Tracking of Facet Capsule Motion Using Polarization-Sensitive Optical Coherence Tomography
      We proposed and tested a method by which surface strains of biological tissues can be captured without the use of fiducial markers by instead, utilizing the inherent structure of the tissue. We used polarization-sensitive optical coherence tomography (PS OCT) to obtain volumetric data through the thickness and across a partial surface of the lumbar facet capsular ligament during three cases of static bending. Reflectivity and phase retardance were calculated from ...
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    12. Multi-contrast optical coherence tomography for brain imaging and mapping (Thesis)

      Multi-contrast optical coherence tomography for brain imaging and mapping (Thesis)
      Although our knowledge of neuronal function and regional activity has been tremendously enriched in the past decades, coordination of these neurons to form the complex behaviors has yet to be understood. The neuronal pathways (also named connectome) form the structural foundation of the dynamic circuits in the brain. The recent interests in connectome and brainwide database have imposed a pressing need for high-resolution imaging techniques that allows large coverage. This ...
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    13. Cross-validation of serial optical coherence scanning and diffusion tensor imaging: A study on neural fiber maps in human medulla oblongata

      Cross-validation of serial optical coherence scanning and diffusion tensor imaging: A study on neural fiber maps in human medulla oblongata
      We established a strategy to perform cross-validation of serial optical coherence scanner imaging (SOCS) and diffusion tensor imaging (DTI) on a postmortem human medulla. Following DTI, the sample was serially scanned by SOCS, which integrates a vibratome slicer and a multi-contrast optical coherence tomography rig for large-scale three-dimensional imaging at microscopic resolution. The DTI dataset was registered to the SOCS space. An average correlation coefficient of 0.9 was found ...
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    14. 1-15 of 27 1 2 »
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  2. About Taner Akkin

    Taner Akkin

    Taner Akkin is the McKnight Land-Grant Assistant Professor in the Department of Biomedical Engineering at the University of Minnesota. Dr. Akkin's research interests lie in the development of interferometric techniques to image depth-resolved tissue microstructures and function. Non-invasive or minimally invasive applications in medicine are possible, since the techniques use back-scattered light.