1. Takashi Kubo

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    1. Mentioned In 87 Articles

    2. Imaging assessment and accuracy in coronary artery autopsy: comparison of frequency-domain optical coherence tomography with intravascular ultrasound and histology

      Imaging assessment and accuracy in coronary artery autopsy: comparison of frequency-domain optical coherence tomography with intravascular ultrasound and histology
      ptical coherence tomography (OCT) is a coronary artery imaging technique with high resolution. Second-generation frequency-domain OCT (FD-OCT) technology allows safer and faster clinical application compared with first-generation time-domain OCT (TD-OCT). Only limited validation studies compare FD-OCT with other modes of analysis: histology, which is the current gold standard, and intravascular ultrasound (IVUS). This study therefore aims to demonstrate the accuracy of FD-OCT images compared with IVUS and histology. FD-OCT and ...
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    3. Stabilization of High Risk Coronary Plaque on Optical Coherence Tomography and Near-Infrared Spectroscopy by Intensive Lipid-Lowering Therapy With Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitor

      Stabilization of High Risk Coronary Plaque on Optical Coherence Tomography and Near-Infrared Spectroscopy by Intensive Lipid-Lowering Therapy With Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitor
      A 70-year-old woman with hypertension and dyslipidemia underwent drug-eluting stent implantation in the mid-left anterior descending artery (LAD) due to acute coronary syndrome (ACS). Optical coherence tomography (OCT) during the index procedure showed lipid-rich plaque in non-culprit lesions of the proximal LAD and mid-right coronary artery (Figure B,E). Near-infrared spectroscopy-intravascular ultrasound (NIRS-IVUS) showed plaque with high lipid burden in both sites (Figure C,F). Intensive lipid-lowering therapy with combined ...
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    4. Role of Optical Coherence Tomography in the Diagnosis of Spontaneous Coronary Artery Dissection

      Role of Optical Coherence Tomography in the Diagnosis of Spontaneous Coronary Artery Dissection
      Spontaneous coronary artery dissection (SCAD) is an infrequent and often missed diagnosis among patients with acute coronary syndrome (ACS), especially young healthy females. Unfortunately, SCAD can result in significant morbidity, such as ischemia and infarction. Currently, there has been a surge in the diagnosis of SCAD due to the widespread use of new intracoronary imaging modalities, especially optical coherence tomography (OCT).However, no specific guidelines exist concerning appropriate treatment for ...
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    5. Late clinical outcome of suboptimal stent implantation defined by intracoronary optical coherence tomography

      Late clinical outcome of suboptimal stent implantation defined by intracoronary optical coherence tomography
      Optical coherence tomography (OCT) is an intravascular imaging technique that provides high-resolution (10-20 m) images. During percutaneous coronary intervention (PCI), OCT offers useful information to guide treatment strategies and assess optimal stent implantation (Figure 1) . However, OCT remains markedly underused in the real world. For further integration of OCT into clinical practice, it is necessary to accumulate evidence showing that OCT has a beneficial impact on the outcomes of PCI ...
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    6. In vivo optical coherence tomography imaging and histopathology of healed coronary plaques

      In vivo optical coherence tomography imaging and histopathology of healed coronary plaques
      Background and aims The aims of this study were to assess agreement between optical coherence tomography (OCT) and histopathology for healed coronary plaques (HCPs) in human coronary arteries ex vivo , and to evaluate the prevalence and characteristics of HCPs in vivo . Methods Ex vivo OCT images were co-registered with histopathology in 144 cross-sections with 50% stenosis. Of these, 30 randomly selected pairs were employed to define morphological features of OCT ...
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    7. Comparison between Optical COherence tomography guidance and Angiography guidance in percutaneous coronary intervention (COCOA): Study protocol for a randomized controlled trial

      Comparison between Optical COherence tomography guidance and Angiography guidance in percutaneous coronary intervention (COCOA): Study protocol for a randomized controlled trial
      Background Optical coherence tomography (OCT) is increasingly used as an adjunct to coronary angiography for guiding percutaneous coronary intervention (PCI). The current consensus on PCI is that the large final stent area offers the best chance of a good late clinical outcome. Since OCT provides more accurate information about the coronary artery and implanted stents, OCT-guided stent implantation is expected to achieve greater stent expansion than angiography guidance alone. Therefore ...
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    8. Optical Frequency Domain Imaging Versus Intravascular Ultrasound in Percutaneous Coronary Intervention (OPINION Trial) : Results From the OPINION Imaging Study

      Optical Frequency Domain Imaging Versus Intravascular Ultrasound in Percutaneous Coronary Intervention (OPINION Trial) : Results From the OPINION Imaging Study
      Objectives We sought to clarify how intravascular ultrasound (IVUS) and optical coherence tomography affect percutaneous coronary intervention (PCI) with current-generation drug-eluting stents in a pre-specified substudy of the OPINION (OPtical frequency domain imaging versus INtravascular ultrasound in percutaneous coronary interventiON) trial, a multicenter, prospective, randomized, noninferiority trial comparing optical frequency domain imaging (OFDI)-guided PCI with IVUS-guided PCI. Background The impact of these 2 imaging modalities in guiding PCI remains ...
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    9. Effect of Early Pitavastatin Therapy on Coronary Fibrous-Cap Thickness Assessed by Optical Coherence Tomography in Patients With Acute Coronary Syndrome : The ESCORT Study

      Effect of Early Pitavastatin Therapy on Coronary Fibrous-Cap Thickness Assessed by Optical Coherence Tomography in Patients With Acute Coronary Syndrome : The ESCORT Study
      ...CORT): UMIN000002678 ). JACC: Cardiovascular Imaging, Volume null, Issue null, Page null Tsuyoshi Nishiguchi, Takashi Kubo, Takashi Tanimoto, Yasushi Ino, Yoshiki Matsuo, Takashi Yamano, Kosei Terada, Hiroki Emori, Yosuk...
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    10. Optical frequency domain imaging vs. intravascular ultrasound in percutaneous coronary intervention (OPINION trial): one-year angiographic and clinical results

      Optical frequency domain imaging vs. intravascular ultrasound in percutaneous coronary intervention (OPINION trial): one-year angiographic and clinical results
      Aims Optical frequency domain imaging (OFDI) is a recently developed, light-based, high-resolution intravascular imaging technique. Intravascular ultrasound (IVUS) is a widely used, conventional imaging technique for guiding percutaneous coronary intervention (PCI). We aimed to demonstrate the non-inferiority of OFDI-guided PCI compared with IVUS-guided PCI in terms of clinical outcomes. Methods and results We did a prospective, multicentre, randomized (ratio 1:1), active-controlled, non-inferiority study to compare head-to-head OFDI vs. IVUS ...
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    11. Suboptimal agreement between optical coherence tomography and near-infrared spectroscopy for identification of lipid-laden plaque

      Suboptimal agreement between optical coherence tomography and near-infrared spectroscopy for identification of lipid-laden plaque
      Recently developed intracoronary imaging techniques allow real-time, in vivo identification of lipid in atherosclerotic plaques. Optical coherence tomography (OCT), a light-based imaging technique with high axial resolution (10-20 m), identifies lipid-laden plaques as signal-poor regions with diffuse borders. A validation study performed versus histopathology confirmed the high sensitivity (90% to 94%) and specificity (90% to 92%) of OCT to identify lipid-laden plaques 1 . Near-infrared spectroscopy (NIRS) detects lipid-laden plaque by ...
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    12. Two-year vascular responses to drug-eluting stents with biodegradable polymer versus durable polymer: An optical coherence tomography sub-study of the NEXT

      Two-year vascular responses to drug-eluting stents with biodegradable polymer versus durable polymer: An optical coherence tomography sub-study of the NEXT
      Background This study aimed to compare very late vascular response after stent implantation between everolimus-eluting stent (EES) with a thin, non-adhesive, durable, biocompatible fluorinated polymer and biolimus-eluting stent (BES) with a biodegradable polymer by optical coherence tomography (OCT). Methods and results In the NOBORI-BES Versus XIENCE V/PROMUS-EES Trial (NEXT), a formal OCT substudy investigated 48 patients (27 EES-treated lesions in 23 patients and 28 BES-treated lesions in 25 patients ...
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    13. Impact of Plaque Rupture Detected by Optical Coherence Tomography on Transmural Extent of Infarction After Successful Stenting in ST-Segment Elevation Acute Myocardial Infarction

      Impact of Plaque Rupture Detected by Optical Coherence Tomography on Transmural Extent of Infarction After Successful Stenting in ST-Segment Elevation Acute Myocardial Infarction
      bjectives The aim of the present study was to investigate the association between plaque rupture (PR) assessed by optical coherence tomography (OCT), and the transmural extent of infarction (TEI) assessed by contrast-enhanced cardiac magnetic resonance imaging (CE-CMR) in ST-segment elevation myocardial infarction (STEMI) patients after primary percutaneous coronary intervention (PCI). Background PR is associated with larger infarct size as assessed by cardiac enzymes in STEMI patients. CE-CMR is a favorable ...
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    14. Optical Coherence Tomography Predictors for Edge Restenosis After Everolimus-Eluting Stent Implantation

      Optical Coherence Tomography Predictors for Edge Restenosis After Everolimus-Eluting Stent Implantation
      Background Stent edge restenosis (SER) remains a potential limitation of drug-eluting stents. The aim of this study was to determine optical coherence tomography (OCT) predictors for angiographic late SER after everolimus-eluting stent implantation. Methods and Results We retrospectively analyzed 319 patients who underwent OCT immediately after everolimus-eluting stent implantation and scheduled 9- to 12-month follow-up angiography. The binary angiographic SER rate was 10% (32/319) in the patients, 8.4 ...
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  2. About Takashi Kubo

    Takashi Kubo is at the department of Cardiovascular Medicine, Wakayama Medical University.