1. Sylvia Otto

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    1. Mentioned In 6 Articles

    2. Endothelial progenitor cells and plaque burden in stented coronary artery segments: an optical coherence tomography study six months after elective PCI

      Endothelial progenitor cells and plaque burden in stented coronary artery segments: an optical coherence tomography study six months after elective PCI
      Background Endothelial progenitor cells (EPC) are involved in neovascularization and endothelial integrity. They might be protective in atherosclerosis. Optical coherence tomography (OCT) is a precise intracoronary imaging modality that allows assessment of subintimal plaque development. We evaluated the influence of EPC on coronary plaque burden in stable disease and implemented a novel computational plaque analysis algorithm using OCT. Methods Forty-three patients (69.8% males, 69.6 7.7 years) were ...
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    3. Fractional flow reserve-guided coronary angioplasty using paclitaxel-coated balloons without stent implantation: feasibility, safety and 6-month results by angiography and optical coherence tomography

      Fractional flow reserve-guided coronary angioplasty using paclitaxel-coated balloons without stent implantation: feasibility, safety and 6-month results by angiography and optical coherence tomography
      Background Percutaneous coronary interventions (PCI) with drug-coated balloons (DCB) might be a promising trade-off between balloon angioplasty and drug-eluting stents, since DCB inhibit neointimal proliferation and limit duration of dual antiplatelet therapy. We investigated the safety, feasibility, and 6-month results of fractional flow reserve (FFR)-guided use of the paclitaxel-coated SeQuent Please balloon without stenting for elective PCI of de novo lesions. Methods and results In 46 patients (54 lesions ...
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      Mentions: Sylvia Otto
    4. Time course of vascular response after an a priori strategy of bare metal stent implantation post-dilated with a paclitaxel-coated balloon: Implementation of a three dimensional analysis algorithm with optical coherence tomography

      Time course of vascular response after an a priori strategy of bare metal stent implantation post-dilated with a paclitaxel-coated balloon: Implementation of a three dimensional analysis algorithm with optical coherence tomography
      Background: An a priori combined therapy of a bare metal stent (BMS) post-dilated with a paclitaxel-coated balloon (PCB) was investigated with optical coherence tomography (OCT) at 2- and 6 months regarding vessel response. Previous studies have shown inconsistent results and the time course of vessel healing after such an interventional strategy is unknown. Methods: Thirty-three de novo lesions in 32 patients were electively treated. Six-month OCT analysis was available in ...
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    5. Determinants of Neointimal Proliferation and Stent Coverage After Intracoronary Therapy With Drug-Eluting Devices in Stable Coronary Artery Disease: Role of Endothelial Progenitor Cells and Interleukin-1 Family Cytokines

      Determinants of Neointimal Proliferation and Stent Coverage After Intracoronary Therapy With Drug-Eluting Devices in Stable Coronary Artery Disease: Role of Endothelial Progenitor Cells and Interleukin-1 Family Cytokines
      Background. Endothelial progenitor cells (EPCs) and cytokines seem to play a pivotal role in arterial healing after stent implantation. Using optical coherence tomography (OCT) as a high-resolution imaging technique, we aimed to assess the influence of circulating EPCs and levels of Il-1 cytokines on stent coverage and in-stent proliferation. Methods. Eighty-nine patients were randomly treated with either Xience V drug-eluting stent (DES; n = 48) or bare-metal stent (BMS) postdilated with ...
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    6. Stent Coverage and Neointimal Proliferation in Bare Metal Stents Postdilated With a Paclitaxel-Eluting Balloon Versus Everolimus-Eluting Stents: Prospective Randomized Study Using Optical Coherence Tomography at 6-Month Follow-Up

      Stent Coverage and Neointimal Proliferation in Bare Metal Stents Postdilated With a Paclitaxel-Eluting Balloon Versus Everolimus-Eluting Stents: Prospective Randomized Study Using Optical Coherence Tomography at 6-Month Follow-Up
      ...ctive Randomized Study Using Optical Coherence Tomography at 6-Month Follow-Up 1. Tudor C. Poerner, MD*, 2. Sylvia Otto, MD*, 3. Johannes Gassdorf, 4. Kristina Nitsche, 5. Florian Janiak, 6. Bruno Scheller, MD, 7. Björ...
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    7. A prospective randomised study using optical coherence tomography to assess endothelial coverage and neointimal proliferation at 6-months after implantation of a coronary everolimus-eluting stent compared with a bare metal stent postdilated with a paclita

      A prospective randomised study using optical coherence tomography to assess endothelial coverage and neointimal proliferation at 6-months after implantation of a coronary everolimus-eluting stent compared with a bare metal stent postdilated with a paclita
      Saftey concerns regardign the use of drug-eluting stents systems (DES) are related mostlly to late stent thrombosis, which is facilitated by incomplete stent endothelial coverge. Specific information aboaut time course and amount of endothelial strut coverage of different DES is required, in order to further refine the concept of antiplatelet therapy after DES implantation, Optical coherence tomography (OCT) is emerging as a new gold standard for endovascular imaging of stents ...
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  2. About Sylvia Otto

    Sylvia Otto is with the 1st Department of Medicine, Division of Cardiology, University Hospital of Jena, Jena, German