1. SUNY at Stony Brook

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    1. Mentioned In 34 Articles

    2. Optical Coherence Tomography in Neuroretinitis: Epipapillary Infiltrates and Retinal Folds

      Optical Coherence Tomography in Neuroretinitis: Epipapillary Infiltrates and Retinal Folds
      Neuroretinitis is a form of papillitis associated with the delayed onset of an exudative macular star among other inflammatory ocular findings. We describe 4 patients with neuroretinitis who displayed several distinctive and novel findings on spectral-domain optical coherence tomography (OCT) that include "epipapillary infiltrates" and an atypical pattern of inner retinal folds. The recognition of these findings on OCT may help in the early diagnosis of neuroretinitis.
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    3. Characterization of human oral tissues based on quantitative analysis of optical coherence tomography images

      Characterization of human oral tissues based on quantitative analysis of optical coherence tomography images
      In this paper, five types of tissues, human enamel, human cortical bone, human trabecular bone, muscular tissue, and fatty tissue were imaged ex vivo using optical coherence tomography (OCT). The specimens were prepared in blocks of 5 x 5 x 3 mm (width x length x height). The OCT imaging system was a swept source OCT system operating at wavelengths ranging between 1250 nm and 1360 nm with an average ...
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    4. State University of New York at Stony Brook Receives NIH Grant for Calcium-Related Neurotoxity of Cocaine

      State University of New York at Stony Brook Receives NIH Grant for Calcium-Related Neurotoxity of Cocaine
      State University of New York at Stony Brook Receives a 2017 NIH Grant for $344,250 for Calcium-Related Neurotoxity of Cocaine. The principal investigator is Congwu Du. The program began in 2012 and ends in 2018. Below is a summary of the proposed work. Cocaine-induced stroke and hemorrhage in the brain are among the most serious medical complications. The mechanisms underlying these effects are poorly understood but are likely to ...
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    5. Volumetric Doppler angle correction for ultrahigh-resolution optical coherence Doppler tomography

      Volumetric Doppler angle correction for ultrahigh-resolution optical coherence Doppler tomography
      Ultrahigh-resolution optical coherence Doppler tomography (ODT) demonstrates great potential for quantitative blood flow imaging owing to its large field of view and capillary resolution. However, ODT only detects the axial flow velocity and requires Doppler angle correction to retrieve the absolute velocity. Although methods for Doppler angle tracking of single or few large vessels have been reported, a method that enables angle correction of the entire 3D microvascular networks remains ...
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    6. Tissue characterization using optical coherence tomography and cone beam computed tomography: A comparative pilot study

      Tissue characterization using optical coherence tomography and cone beam computed tomography: A comparative pilot study
      Objectives To evaluate the ability of optical coherence tomography (OCT) in differentiating between human oral tissues in comparison with cone beam computed tomography (CBCT). Study design In this study, we imaged four types of tissues ex vivo , i.e., human enamel, human cortical bone, human trabecular bone, fatty tissue plus water and air using OCT (Axsun Inc. Billerica, MA). We then developed a method for qualitative and quantitative analysis of ...
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    7. RETINAL VASCULAR PERFUSION DENSITY MAPPING USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN NORMALS AND DIABETIC RETINOPATHY PATIENTS

      RETINAL VASCULAR PERFUSION DENSITY MAPPING USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN NORMALS AND DIABETIC RETINOPATHY PATIENTS
      Purpose: To describe a new method of retinal vascular perfusion density mapping using optical coherence tomography angiography and to compare current staging of diabetic retinopathy based on clinical features with a new grading scale based on perifoveal perfusion densities. Methods: A retrospective review was performed on subjects with diabetic retinopathy and age-matched controls imaged with a spectral domain optical coherence tomography system (Optovue XR Avanti, Fremont, CA). Split-spectrum amplitude-decorrelation angiography ...
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    8. Ultrasensitive quantification of 3D cerebral capillary blood flow network dynamics

      Ultrasensitive quantification of 3D cerebral capillary blood flow network dynamics
      Ultra-high resolution optical Doppler coherence tomography (ODT) is a promising tool for brain functional imaging. However, its sensitivity for detecting slow flows in capillary beds may limit its utility in visualizing and quantifying subtle changes in brain microcirculation. To address this limitation, we developed a novel method called contrast-enhanced ODT (c-ODT) in which intralipid is injected into mouse tail vein to enhance ODT detection sensitivity. We demonstrate that after intralipid ...
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    9. Ultrasensitive detection of 3D cerebral microvascular network dynamics in vivo

      Ultrasensitive detection of 3D cerebral microvascular network dynamics in vivo
      Despite widespread applications of multiphoton microscopy in microcirculation, its small field of view and inability to instantaneously quantify cerebral blood flow velocity (CBFv) in vascular networks limit its utility in investigating the heterogeneous responses to brain stimulations. Optical Doppler tomography (ODT) provides 3D images of CBFv networks, but it suffers poor sensitivity for measuring capillary flows. Here we report on a new method, contrast-enhanced ODT with Intralipid that significantly improves ...
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    10. Optical coherence Doppler tomography for quantitative cerebral blood flow imaging

      Optical coherence Doppler tomography for quantitative cerebral blood flow imaging
      Optical coherence Doppler tomography (ODT) is a promising neurotechnique that permits 3D imaging of the cerebral blood flow (CBF) network; however, quantitative CBF velocity (CBFv) imaging remains challenging. Here we present a simple phase summation method to enhance slow capillary flow detection sensitivity without sacrificing dynamic range for fast flow and vessel tracking to improve angle correction for absolute CBFv quantification. Flow phantom validation indicated that the CBFv quantification accuracy ...
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    11. Optical coherence tomography imaging of erythematotelangiectatic rosacea during treatment with brimonidine topical gel 0.33%: a potential method for treatment outcome assessment

      Optical coherence tomography imaging of erythematotelangiectatic rosacea during treatment with brimonidine topical gel 0.33%: a potential method for treatment outcome assessment
      BACKGROUND: Patients with moderate to severe rosacea often seek treatment to reduce erythema and vascular markings. Few studies have looked at the effectiveness of the novel treatment, brimonidine topical gel 0.33%, trademark name Mirvaso, in the treatment of rosacea. We report the use of optical coherence tomography (OCT) scanning to monitor the effectiveness of Mirvaso on in vivo skin. OCT is a non-invasive optical imaging technique that can provide ...
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    12. Cerebral blood flow imaged with ultrahigh-resolution optical coherence angiography and Doppler tomography

      Cerebral blood flow imaged with ultrahigh-resolution optical coherence angiography and Doppler tomography
      Speckle contrast based optical coherence angiography (OCA) and optical coherence Doppler tomography (ODT) have been applied to image cerebral blood flow previously. However, the contrast mechanisms of these two methods are not fully studied. Here, we present both flow phantom and in vivo animal experiments using ultrahigh-resolution OCA (μOCA) and ODT (μODT) to investigate the flow sensitivity differences between these two methods. Our results show that the high sensitivity of ...
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    13. Characterization of dynamic physiology of the bladder by optical coherence tomography

      Characterization of dynamic physiology of the bladder by optical coherence tomography
      Because of its high spatial resolution and noninvasive imaging capabilities, optical coherence tomography has been used to characterize the morphological details of various biological tissues including urinary bladder and to diagnose their alternations (e.g., cancers). In addition to static morphology, the dynamic features of tissue morphology can provide important information that can be used to diagnose the physiological and functional characteristics of biological tissues. Here, we present the imaging ...
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  2. About SUNY at Stony Brook

    SUNY at Stony Brook

    State University of New York at Stony Brook has been characterized by innovation, energy, and progress, transforming the lives of people who earn degrees, work, and make groundbreaking discoveries here. A dramatic trajectory of growth has turned what was once a small teacher preparation college into an internationally recognized research institution that is changing the world.