1. Sunnybrook Health Sciences Centre

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    1. Mentioned In 67 Articles

    2. Scanning mechanisms for imaging probe

      Scanning mechanisms for imaging probe
      The present invention provides scanning mechanisms for imaging probes for imaging mammalian tissues and structures using high resolution imaging, including high frequency ultrasound and/or optical coherence tomography. The imaging probes include adjustable rotational drive mechanism for imparting rotational motion to an imaging assembly containing either optical or ultrasound transducers which emit energy into the surrounding area. The imaging assembly includes a scanning mechanism including a movable member configured to ...
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    3. Intraoperative handheld optical coherence tomography forward-viewing probe: physical performance and preliminary animal imaging

      Intraoperative handheld optical coherence tomography forward-viewing probe: physical performance and preliminary animal imaging
      A prototype intraoperative hand-held optical coherence tomography (OCT) imaging probe was developed to provide micron resolution cross-sectional images of subsurface tissue during open surgery. This new ergonomic probe was designed based on electrostatically driven optical fibers, and packaged into a catheter probe in the form factor of clinically accepted Bayonet shaped neurosurgical probes. Optical properties of the probe were measured to have a ~20 μm spot size, 5 mm working ...
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    4. Hybrid intravascular ultrasound and optical coherence tomography catheter for imaging of coronary atherosclerosis

      Hybrid intravascular ultrasound and optical coherence tomography catheter for imaging of coronary atherosclerosis
      Objective To demonstrate the feasibility of imaging human coronary atherosclerosis using a novel hybrid intravascular ultrasound (IVUS) and optical coherence tomography (OCT) imaging catheter. Background IVUS and OCT have synergistic advantages and recent studies involving both modalities suggest the use of a hybrid imaging catheter may offer improved guidance of coronary interventions and plaque characterization. Methods A 1.3 m custom hybrid IVUS-OCT imaging probe was built within a 4F ...
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    5. Methods and devices for image-guided manipulation or sensing or anatomic structures

      Methods and devices for image-guided manipulation or sensing or anatomic structures
      Forward-looking ultrasound transducers are positioned at the tip of a transseptal catheter to facilitate transseptal puncture and interventions within the left atrium, pulmonary veins and mitral valve. Catheter devices and systems are guided by forward-looking ultrasound or optical coherence tomography imaging for penetrating from one location within a mammalian patient's body to another location, and/or performing diagnostic or therapeutic interventions. A penetrator, diagnostic, or interventional device (eg. probe ...
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    6. Comprehensive data visualization for high resolution endovascular carotid arterial wall imaging

      Comprehensive data visualization for high resolution endovascular carotid arterial wall imaging
      Carotid angioplasty and stenting is a minimally invasive endovascular procedure that may benefit from in vivo high resolution imaging for monitoring the physical placement of the stent and potential complications. The purpose of this pilot study was to evaluate the ability of optical coherence tomography to construct high resolution 2D and 3D images of stenting in porcine carotid artery. Four Yorkshire pigs were anaesthetized and catheterized. A state-of-the-art optical coherence ...
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    7. Feasibility and methodology of optical coherence tomography imaging of human intracranial aneurysms: ex vivo pilot study

      Feasibility and methodology of optical coherence tomography imaging of human intracranial aneurysms: ex vivo pilot study
      Rupture of intracranial aneurysm is a common cause of subarachnoid hemorrhage. An aneurysm may undergo microscopic morphological changes or remodeling of the vessel wall prior to rupture, which could potentially be imaged. In this study we present methods of tissue sample preparation of intracranial aneurysms and correlation between optical coherence tomography imaging and routine histology. OCT has a potential future in the assessment of microscopic features of aneurysms, which may ...
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    8. Detecting apoptosis using dynamic light scattering with optical coherence tomography

      Detecting apoptosis using dynamic light scattering with optical coherence tomography
      A dynamic light scattering technique is implemented using optical coherence tomography (OCT) to measure the change in intracellular motion as cells undergo apoptosis. Acute myeloid leukemia cells were treated with cisplatin and imaged at a frame rate of 166 Hz using a 1300 nm swept-source OCT system at various times over a period of 48 h. Time correlation analysis of the speckle intensities indicated a significant increase in intracellular motion ...
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    9. An engineer and doctor, researcher Victor Yang develops medical technology to detect and treat disease

      An engineer and doctor, researcher Victor Yang develops medical technology to detect and treat disease
      ..., among other sources.  Working with researchers at the University Health Network, St. Michael's Hospital and Sunnybrook Health Science Centre, Yang envisions technological leaps in multiple medical specialties:  "These ...
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    10. Detecting cell death with optical coherence tomography and envelope statistics

      Detecting cell death with optical coherence tomography and envelope statistics
      Currently no standard clinical or preclinical noninvasive method exists to monitor cell death based on morphological changes at the cellular level. In our past work we have demonstrated that quantitative high frequency ultrasound imaging can detect cell death in vitro and in vivo. In this study we apply quantitative methods previously used with high frequency ultrasound to optical coherence tomography (OCT) to detect cell death. The ultimate goal of this ...
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    11. In situ 24 kHz coherent imaging of morphology change in laser percussion drilling

      In situ 24 kHz coherent imaging of morphology change in laser percussion drilling
      We observe sample morphology changes in real time 24 kHz during and between percussion drilling pulses by integrating a low-coherence microscope into a laser micromachining platform. Nonuniform cut speed and sidewall evolution in stainless steel are observed to strongly depend on assist gas. Interpulse morphology relaxation such as hole refill is directly imaged, showing dramatic differences in the material removal process dependent on pulse duration/peak power (s/0.1 ...
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    12. Developing dual core ytterbium doped fiber ring laser in Fourier domain mode locked operation for swept-source optical coherence tomography

      Developing dual core ytterbium doped fiber ring laser in Fourier domain mode locked operation for swept-source optical coherence tomography
      We demonstrate high efficiency and wide bandwidth gain in a Ytterbium doped fiber amplifier. The highpowered amplifier has potential applications for use with a swept-source fiber ring laser in multi-channel optical coherence tomography (OCT) system. The ring cavity design includes a 976nm pumped dual core Yb doped fiber as the gain medium, where a rotating polygon mirror is used as a wavelength-sweeping filter for this source. The amplified spontaneous emission ...
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    13. Cascaded Raman fiber laser in Fourier domain mode lock operation

      Cascaded Raman fiber laser in Fourier domain mode lock operation
      In this study, a cascaded Raman fiber laser in Fourier domain mode lock operation (FDML) is presented. This laser utilizes a Ytterbium doped twin core pump laser source at 1109 nm. The pump light is directed to a cascaded Raman cavity, which consists of multiple cascaded fiber Bragg grating pairs and 3.86 km of dispersion compensation fiber, which provides Raman gain. The output wavelength of a cascaded Raman laser ...
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    14. Doppler optical coherence tomography for interventional cardiovascular guidance: in vivo feasibility and forward-viewing probe flow phantom demonstration

      Doppler optical coherence tomography for interventional cardiovascular guidance: in vivo feasibility and forward-viewing probe flow phantom demonstration
      ...nstitute, Princess Margaret Hospital, 610 University Avenue, Room 7-411, Toronto, Ontario M5G 2M9, Canada and Sunnybrook Health Sciences Centre, Imaging Research, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada Adr...
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    15. Conducting polymer actuator driven catheter: overview and applications

      In this paper conducting polymer based active catheters are presented. Design considerations along with the promise and challenges associated with conducting polymer driven devices are discussed. A conducting polymer driven intravascular catheter is described briefly and its design challenges such as structural rigidity and angle of bending are studied. Then a detailed description of a polypyrrole based active catheter that is ultimately intended for in-vivo imaging applications will be presented ...
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    16. 46-60 of 67 « 1 2 3 4 5 »
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  2. About Sunnybrook Health Sciences Centre

    Sunnybrook Health Sciences Centre

    Sunnybrook Health Sciences Centre is assocaited with the University of Toronto. We are committed to transforming healthcare for people across the Greater Toronto Area, throughout Ontario, Canada and the rest of the world through new treatments, education & training, and patient safety.

    We offer an incredible place to work, study, conduct research and receive care. Our 11 000+ staff, physicians, volunteers and students improve the lives of more than one million people annually.

    Our commitment to excellence has resulted in an international reputation & a vital role in the Ontario healthcare system. We offer highly specialized services unavailable in other communities.