1. Sun Yat-Sen University

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    1. Mentioned In 153 Articles

    2. Optical coherence tomography angiography helps distinguish multiple sclerosis from AQP4-IgG-seropositive neuromyelitis optica spectrum disorder

      Optical coherence tomography angiography helps distinguish multiple sclerosis from AQP4-IgG-seropositive neuromyelitis optica spectrum disorder
      Introduction: The aim was to characterize the optical coherence tomography (OCT) angiography measures in patients with multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) and to evaluate their disease discrimination capacity. Methods: Patients with MS (n = 83) and AQP4-IgG-seropositive NMOSD (n = 91) with or without a history of optic neuritis, together with healthy controls (n = 34), were imaged. The main outcome measures were peripapillary retinal nerve fiber layer (pRNFL ...
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    3. The anterior and posterior biometric characteristics in primary angle-closure disease: Data based on anterior segment optical coherence tomography and swept-source optical coherence tomography

      The anterior and posterior biometric characteristics in primary angle-closure disease: Data based on anterior segment optical coherence tomography and swept-source optical coherence tomography
      ... University, Guangzhou; Hainan Eye Hospital and Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Haikou, People's Republic of China 2 Zhongshan Ophthalmic Center, State Key Laboratory...
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    4. Radiation-Induced Optical Coherence Tomography Angiography Retinal Alterations in Patients With Nasopharyngeal Carcinoma

      Radiation-Induced Optical Coherence Tomography Angiography Retinal Alterations in Patients With Nasopharyngeal Carcinoma
      Aim: The aim of the study was to investigate the early neurovascular alterations of the retina in radiation encephalopathy (RE) patients with normal-ranged visual acuity after radiotherapy for nasopharyngeal carcinoma. Methods: Fifty-five RE patients and 54 healthy age-matched subjects were enrolled in this retrospective cross-sectional case-control study. The best corrected visual acuity (LogMAR) of the included eye should not be more than 0. The vessel density and thickness of different ...
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    5. Angle-closure assessment in anterior segment OCT images via deep learning

      Angle-closure assessment in anterior segment OCT images via deep learning
      Precise characterization and analysis of anterior chamber angle (ACA) are of great importance in facilitating clinical examination and diagnosis of angle-closure disease. Currently, the gold standard for diagnostic angle assessment is observation of ACA by gonioscopy. However, gonioscopy requires direct contact between the gonioscope and patients' eye, which is uncomfortable for patients and may deform the ACA, leading to false results. To this end, in this paper, we explore a ...
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    6. Longitudinal Changes in Macular Optical Coherence Tomography Angiography Metrics in Primary Open-Angle Glaucoma With High Myopia: A Prospective Study

      Longitudinal Changes in Macular Optical Coherence Tomography Angiography Metrics in Primary Open-Angle Glaucoma With High Myopia: A Prospective Study
      Purpose : To characterize longitudinal changes in macular microvasculature as quantified from optical coherence tomography angiography (OCTA) metrics in primary open-angle glaucoma (POAG) eyes with and without high myopia. Methods : In total, 63 and 61 POAG eyes with and without high myopia, respectively, underwent swept-source OCTA imaging in at least four follow-up visits at an ophthalmic center, with a scanning protocol of 3- 3-mm centered at the fovea. The foveal avascular ...
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    7. Retinal neurodegeneration in diabetic peripheral neuropathy by optical coherence tomography: a systematic review and meta-analysis

      Retinal neurodegeneration in diabetic peripheral neuropathy by optical coherence tomography: a systematic review and meta-analysis
      Purpose: The optical coherence tomography (OCT) has been used to evaluate the changes of retinal degeneration in patients with diabetic peripheral neuropathy (DPN) in recent years, but the results of previous studies were controversial. Therefore, a systematic review and meta-analysis was performed to evaluate the degree of retinal neurodegeneration in DPN measured by OCT. Methods: A comprehensive search of PubMed, Embase, Web of Science, Scopus, China Biomedical Literature (CBM), China ...
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    8. Objective quantification of lens nuclear opacities using swept-source anterior segment optical coherence tomography

      Objective quantification of lens nuclear opacities using swept-source anterior segment optical coherence tomography
      Background/aims: The primary objective is to quantify the lens nuclear opacity using swept-source anterior segment optical coherence tomography (SS-ASOCT) and to evaluate its correlations with Lens Opacities Classification System III (LOCS-III) system and surgical parameters. The secondary objective is to assess the diagnostic performance for hard nuclear cataract. Methods: This cross-sectional study included 1222 patients eligible for cataract surgery (1222 eyes). The latest SS-ASOCT (CASIA-2) was used to obtain ...
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    9. Development and validation of a deep learning system to screen vision-threatening conditions in high myopia using optical coherence tomography image

      Development and validation of a deep learning system to screen vision-threatening conditions in high myopia using optical coherence tomography image
      Background/aims To apply deep learning technology to develop an artificial intelligence (AI) system that can identify vision-threatening conditions in high myopia patients based on optical coherence tomography (OCT) macular images. Methods In this cross-sectional, prospective study, a total of 5505 qualified OCT macular images obtained from 1048 high myopia patients admitted to Zhongshan Ophthalmic Centre (ZOC) from 2012 to 2017 were selected for the development of the AI system ...
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    10. Reduced Pulsatile Trabecular Meshwork Motion in Eyes With Primary Open Angle Glaucoma Using Phase-Sensitive Optical Coherence Tomography

      Reduced Pulsatile Trabecular Meshwork Motion in Eyes With Primary Open Angle Glaucoma Using Phase-Sensitive Optical Coherence Tomography
      Purpose: The purpose of this study was to investigate the difference in pulsatile trabecular meshwork (TM) motion between normal and eyes with POAG using phase-sensitive optical coherence tomography (PhS-OCT). Methods: In this cross-sectional study, eight healthy subjects (16 eyes) and nine patients with POAG (18 eyes) were enrolled. A laboratory-based prototype PhS-OCT system was used to measure pulsatile TM motion. PhS-OCT images were analyzed to obtain parameters of pulsatile TM ...
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    11. Dynamic-range compression and contrast enhancement in swept-source optical coherence tomography systems with a frequency gain compensation amplifier

      Dynamic-range compression and contrast enhancement in swept-source optical coherence tomography systems with a frequency gain compensation amplifier
      Significance: Optical coherence tomography (OCT) has been widely used in clinical studies. However, the image quality of OCT decreases with increasing imaging depth since the light is rapidly attenuated in biological tissues. Aim: We present a compensation approach to preserve weak high-frequency signals from deep structures and compress the dynamic range of the detected signal for superior analog-to-digital conversion and image display capability. Approach: A homemade frequency gain compensation amplifier ...
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    12. Integrated Multifunctional Laryngoscope for Medical Diagnosis and Treatment

      Integrated Multifunctional Laryngoscope for Medical Diagnosis and Treatment
      Laryngeal lesions can cause great inconvenience to patients. Early diagnosis and corresponding treatments are critical to the survival of patients. However, the diagnosis and precise removal of tumors remain a challenge under the use of a white light laryngoscope. In this work, an integrated, multifunctional laryngoscope was designed and tested for the imaging evaluation and precision laser surgery for laryngeal tissue. This integrated diagnostic and therapeutic endoscopic system included two ...
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    13. Open-Appositional-Synechial Anterior Chamber Angle Classification in AS-OCT Sequences

      Open-Appositional-Synechial Anterior Chamber Angle Classification in AS-OCT Sequences
      Anterior chamber angle (ACA) classification is a key step in the diagnosis of angle-closure glaucoma in Anterior Segment Optical Coherence Tomography (AS-OCT). Existing automated analysis methods focus on a binary classification system (i.e., open angle or angle-closure) in a 2D AS-OCT slice. However, clinical diagnosis requires a more discriminating ACA three-class system (i.e., open, appositional, or synechial angles) for the benefit of clinicians who seek better to understand ...
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    14. Redox responsive nanoparticle encapsulating black phosphorus quantum dots for cancer theranostics

      Redox responsive nanoparticle encapsulating black phosphorus quantum dots for cancer theranostics
      Effective cancer treatment puts high demands for cancer theranostics. For cancer diagnostics, optical coherence tomography (OCT) technology (including photothermal optical coherence tomography (PT-OCT)) has been widely investigated since it induces changes in optical phase transitions in tissue through environmental changes (such as temperature change for PT-OCT). In this report, redox responsive nanoparticle encapsulating black phosphorus quantum dots was developed as a robust PT-OCT agent. Briefly, black phosphorus quantum dots (BPQDs ...
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    15. AGE challenge: Angle Closure Glaucoma Evaluation in Anterior Segment Optical Coherence Tomography

      AGE challenge: Angle Closure Glaucoma Evaluation in Anterior Segment Optical Coherence Tomography
      Angle closure glaucoma (ACG) is a more aggressive disease than open-angle glaucoma, where the abnormal anatomical structures of the anterior chamber angle (ACA) may cause an elevated intraocular pressure and gradually lead to glaucomatous optic neuropathy and eventually to visual impairment and blindness. Anterior Segment Optical Coherence Tomography (AS-OCT) imaging provides a fast and contactless way to discriminate angle closure from open angle. Although many medical image analysis algorithms have ...
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  2. About Sun Yat-Sen University

    Sun Yat-Sen University

    Sun Yat-Sen University is located in Guangdong Province, the frontal of reform and opening. At present the University has 4 campuses with a total area of 6.17 square kilometers sitting respectively on both sides of the Pearl River or facing the South China Sea.  Zhongshan Ophthalmic Center is at the Sun Yat-Sen University of Medical Sciences, Guangzhou, China