1. Sun Yat-Sen University

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    1. Mentioned In 223 Articles

    2. Asynchronous feature regularization and cross-modal distillation for OCT based glaucoma diagnosis

      Asynchronous feature regularization and cross-modal distillation for OCT based glaucoma diagnosis
      Glaucoma has become a major cause of vision loss. Early-stage diagnosis of glaucoma is critical for treatment planning to avoid irreversible vision damage. Meanwhile, interpreting the rapidly accumulated medical data from ophthalmic exams is cumbersome and resource-intensive. Therefore, automated methods are highly desired to assist ophthalmologists in achieving fast and accurate glaucoma diagnosis. Deep learning has achieved great successes in diagnosing glaucoma by analyzing data from different kinds of tests ...
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    3. Use of multimodal dataset in AI for detecting glaucoma based on fundus photographs assessed with OCT: focus group study on high prevalence of myopia

      Use of multimodal dataset in AI for detecting glaucoma based on fundus photographs assessed with OCT: focus group study on high prevalence of myopia
      Background: Glaucoma is one of the major causes of blindness; it is estimated that over 110 million people will be affected by glaucoma worldwide by 2040. Research on glaucoma detection using deep learning technology has been increasing, but the diagnosis of glaucoma in a large population with high incidence of myopia remains a challenge. This study aimed to provide a decision support system for the automatic detection of glaucoma using ...
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    4. Optical coherence tomography angiography for the characterisation of retinal microvasculature alterations in pregnant patients with anaemia: a nested case‒control study

      Optical coherence tomography angiography for the characterisation of retinal microvasculature alterations in pregnant patients with anaemia: a nested case‒control study
      Aims: To characterise retinal microvascular alterations in the eyes of pregnant patients with anaemia (PA) and to compare the alterations with those in healthy controls (HC) using optical coherence tomography angiography (OCTA). Methods: This nested case‒control study included singleton PA and HC from the Eye Health in Pregnancy Study. Fovea avascular zone (FAZ) metrics, perfusion density (PD) in the superficial capillary plexus, deep capillary plexus and flow deficit (FD ...
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    5. Accuracy of intraocular lens power calculation based on total keratometry in patients with flat and steep corneas

      Accuracy of intraocular lens power calculation based on total keratometry in patients with flat and steep corneas
      Purpose To analyze the accuracy of the current intraocular lens power calculation formulas using standard keratometry (K) and total keratometry (TK) data in patients with flat and steep corneas. Design Retrospective consecutive cross-sectional study. Methods An optical biometer with swept-source optical coherence tomography was used in this retrospective study. The standard deviation (SD), mean absolute error (MAE), median absolute error (MedAE), and the proportion of eyes with prediction error (PE ...
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    6. Optical coherence tomography of the retina combined with color Doppler ultrasound of the tibial nerve in the diagnosis of diabetic peripheral neuropathy

      Optical coherence tomography of the retina combined with color Doppler ultrasound of the tibial nerve in the diagnosis of diabetic peripheral neuropathy
      Objective: To investigate the value of the retinal nerve fiber layer (RNFL) thickness in the optic disc and the cross-sectional area (CSA) of lower limb nerves in the diagnosis of diabetic peripheral neuropathy (DPN) separately and in combination. Methods: A total of 140 patients with type 2 diabetes were enrolled, including 51 patients with DPN (DPN group) and 89 patients without DPN (NDPN group). Clinical data and biochemical parameters were ...
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    7. Metalens for improving optical coherence tomography

      Metalens for improving optical coherence tomography
      Optical coherence tomography is one of the most attractive new tomographic techniques, especially in the detection and imaging of biological tissues. For the detection and imaging of human corneas, the current ultra-high-resolution optical coherence tomography technology faces the challenge that the depth of focus is too short to scan the entire human cornea in a single amplitude scan. Here, we propose and design a silicon metalens to replace the objective ...
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    8. Real-time delineation of basement membrane in human oral and esophageal mucosa with micro-optical coherence tomography

      Real-time delineation of basement membrane in human oral and esophageal mucosa with micro-optical coherence tomography
      Basement membrane is a thin, extracellular matrix-like structure, separating the epithelium from the stroma and having a vital role in determining cancer progression. Identification of this diagnostically important structure with histology is invasive and labor-intensive. Micro-optical coherence tomography (OCT) which has the capability to recognize subcellular-level microstructures underneath the surface offers the possibility to resolve basement membrane noninvasively in situ and in vivo . In this study, we conducted numerical analysis ...
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    9. AV-casNet: Fully Automatic Arteriole-Venule Segmentation and Differentiation in OCT Angiography

      AV-casNet: Fully Automatic Arteriole-Venule Segmentation and Differentiation in OCT Angiography
      Automatic segmentation and differentiation of retinal arteriole and venule (AV), defined as small blood vessels directly before and after the capillary plexus, are of great importance for the diagnosis of various eye diseases and systemic diseases, such as diabetic retinopathy, hypertension, and cardiovascular diseases. Optical coherence tomography angiography (OCTA) is a recent imaging modality that provides capillary-level blood flow information. However, OCTA does not have the colorimetric and geometric differences ...
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    10. Macular and peripapillary optical coherence tomography angiography metrics in thyroid-associated ophthalmopathy with chorioretinal folds

      Macular and peripapillary optical coherence tomography angiography metrics in thyroid-associated ophthalmopathy with chorioretinal folds
      Purpose: To evaluate macular and radial peripapillary capillary (RPC) microvascular densities and the thickness of the retinal nerve fiber layer (RNFL) in thyroid-associated ophthalmopathy (TAO) with chorioretinal folds (CRFs) and the associations of these characteristics with visual function. Method: A cross-sectional study was performed at the Ophthalmology Department of the Sun Yat-sen Memorial Hospital from March 2018 to August 2021. All patients underwent ocular examination, ophthalmic function tests and optical ...
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    11. Multimodal Equipment for Teleophthalmology Assessment (META)

      Multimodal Equipment for Teleophthalmology Assessment (META)
      We have developed a Multimodal Equipment for Teleophthalmology Assessment (META) device. This novel device is compact, portable and suitable for packaging and express delivery. With this device, there is a potential to implement a new concept of "hospital-at-home" eye care model. The present study is designed to validate the META device for future clinical usage and investigation. We will compare the performance of the META device with those provided by ...
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    12. Changes in macrophage-like cells characterized by en face optical coherence tomography after retinal stroke

      Changes in macrophage-like cells characterized by en face optical coherence tomography after retinal stroke
      Purpose: The retina could serve as a window of neuroinflammation, but the in vivo changes in macrophage-like cell (MLC), such as microglia, in acute ischemic retinal stroke remain unclear. Thus, the current study aimed to investigate the in vivo changes in MLC characterized by en face optical coherence tomography (OCT) after acute ischemic retinal stroke. Methods: Twenty patients with unilateral acute nonarteritic reperfused central retinal artery occlusion (CRAO) were participated ...
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    13. Detection of pachychoroid neovasculopathy with optical coherence tomography angiography versus dye angiography imaging

      Detection of pachychoroid neovasculopathy with optical coherence tomography angiography versus dye angiography imaging
      Background: To investigate the sensitivity and specificity of optical coherence tomography angiography (OCTA) versus dye angiography for detecting pachychoroid neovasculopathy (PNV) and to determine the morphological factors that affect PNV detection. Methods: Patients with pachychoroid phenotype wereprospectively enrolled and underwent multimodal imaging examinations during the same visit. The diagnostic accuracy of fundus fluorescein angiography (FFA), FFA combined with indocyanine green angiography (ICGA) and OCTA for PNV was evaluated using multimodal ...
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    14. Impact of lens opacity and axial length on concomitant screening of maculopathy by swept-source optical coherence tomography-based optical biometer

      Impact of lens opacity and axial length on concomitant screening of maculopathy by swept-source optical coherence tomography-based optical biometer
      Background: Preoperative evaluation of macular disorders is crucial to predict postoperative visual outcomes among patients with cataract. The swept-source optical coherence tomography (SS-OCT) based optical biometer was proved to be useful in screening macular pathology, while the impact of lens opacities and axial lengths on macular disease screening using SS-OCT based optical biometer remained unknown. This study aimed to evaluate the influence of lens opacities and axial lengths on foveal ...
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    15. Retinal Microvasculature and Choriocapillaris Flow Deficit in Relation to Serum Uric Acid Using Swept-Source Optical Coherence Tomography Angiography

      Retinal Microvasculature and Choriocapillaris Flow Deficit in Relation to Serum Uric Acid Using Swept-Source Optical Coherence Tomography Angiography
      Purpose: To explore the relationship between serum uric acid (SUA) and retinochoroidal microcirculation in the Chinese population. Methods: This prospective cross-sectional study was conducted among the residents of Guangzhou, southern China. A commercially available optical coherence tomography angiography (OCTA) device was used to obtain the superficial vessel density (SVD) and deep vessel density in the retina and the choriocapillaris flow deficit (CFD) in the macular region. Univariable and multivariable linear ...
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    16. Evaluation of macular microvascular density using optical coherence tomography angiography in patients with Posner-Schlossman syndrome

      Evaluation of macular microvascular density using optical coherence tomography angiography in patients with Posner-Schlossman syndrome
      Background Optical coherence tomography angiography (OCTA) is a novel technology that provides a noninvasive, dye-less method to visualize the blood vessels of the retina. In the present study, we investigate macular microvascular density and the correlation of ocular and demographic factors using OCTA in Posner-Schlossman syndrome (PSS) patients. Methods This is a prospective observational study. All PSS patients and age- and sex-matched healthy subjects underwent complete ophthalmologic examination, and RE ...
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  2. About Sun Yat-Sen University

    Sun Yat-Sen University

    Sun Yat-Sen University is located in Guangdong Province, the frontal of reform and opening. At present the University has 4 campuses with a total area of 6.17 square kilometers sitting respectively on both sides of the Pearl River or facing the South China Sea.  Zhongshan Ophthalmic Center is at the Sun Yat-Sen University of Medical Sciences, Guangzhou, China