1. Sun Yat-Sen University

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    1. Mentioned In 97 Articles

    2. Probing dynamic processes in the eye at multiple spatial and temporal scales with multimodal full field OCT

      Probing dynamic processes in the eye at multiple spatial and temporal scales with multimodal full field OCT
      We describe recent technological progress in multimodal en face full-field optical coherence tomography that has allowed detection of slow and fast dynamic processes in the eye. We show that by combining static, dynamic and fluorescence contrasts we can achieve label-free high-resolution imaging of the retina and anterior eye with temporal resolution from milliseconds to several hours, allowing us to probe biological activity at subcellular scales inside 3D bulk tissue. Our ...
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    3. Evaluation of spectral domain optical coherence tomography parameters in discriminating preperimetric glaucoma from high myopia

      Evaluation of spectral domain optical coherence tomography parameters in discriminating preperimetric glaucoma from high myopia
      AIM : To evaluate the diagnostic ability of macular ganglion cell-inner plexiform layer (GCIPL) thickness obtained by spectral-domain optical coherence tomography (SD-OCT) in discriminating non-highly myopic eyes with preperimetric glaucoma (PPG) from highly myopic healthy eyes. METHODS : A total of 254 eyes, including 76 normal controls (NC), 116 eyes with high myopia (HM) and 62 non-highly myopic eyes with PPG were enrolled. The diagnostic ability of OCT parameters was accessed by ...
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    4. Do microvascular changes occur preceding neural impairment in early-stage diabetic retinopathy? Evidence based on the optic nerve head using optical coherence tomography angiography

      Do microvascular changes occur preceding neural impairment in early-stage diabetic retinopathy? Evidence based on the optic nerve head using optical coherence tomography angiography
      Aims To evaluate the microvascular and neural differences of the optic nerve head (ONH) between type 2 diabetes mellitus (T2DM) subjects and controls. Methods This was a cross-sectional observational study. One hundred and eight eyes of 108 T2DM subjects with or without diabetic retinopathy (DR) (54 preclinical DR and 54 mild-to-moderate DR) were included. Fifty-two eyes of 52 healthy subjects were included as controls. The 4.5-mm Angio Disc scan ...
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    5. Optical Coherence Tomography Angiography in Familial Exudative Vitreoretinopathy: Clinical Features and Phenotype-Genotype Correlatio

      Optical Coherence Tomography Angiography in Familial Exudative Vitreoretinopathy: Clinical Features and Phenotype-Genotype Correlatio
      Purpose : To evaluate the microstructure of the fovea in patients with familial exudative vitreoretinopathy (FEVR) compared to healthy controls using optical coherence tomography angiography (OCTA). Methods : In this consecutive, cross-sectional, observational case series, 41 eyes of 41 patients diagnosed as FEVR and 37 eyes in 37 control subjects were studied. OCTA was utilized to automatically measure the foveal avascular zone (FAZ) and the vessel density (VD). Inner retinal thicknesses (IRT ...
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    6. Macular microvasculature features before and after vitrectomy in idiopathic macular epiretinal membrane: an OCT angiography analysis

      Macular microvasculature features before and after vitrectomy in idiopathic macular epiretinal membrane: an OCT angiography analysis
      Purpose To evaluate pre-operative and post-operative morphologic characteristics in idiopathic macular epiretinal membrane (ERM) by optical coherence tomography angiography (OCTA). Methods Thirty-three subjects with unilateral idiopathic ERM were enrolled and the contralateral eyes served as controls. Vascular parameters including superficial capillary plexus (SCP), deep capillary plexus (DCP), outer capillary plexus (OCP), and choroidal capillary plexus (CCP) were evaluated by OCTA. Results The superficial foveal avascular zone (FAZ) was significantly smaller ...
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    7. Optical coherence tomography angiography findings of neurovascular changes in type 2 diabetes mellitus patients without clinical diabetic retinopathy

      Optical coherence tomography angiography findings of neurovascular changes in type 2 diabetes mellitus patients without clinical diabetic retinopathy
      Aims To evaluate the effect of early screening with OCTA in type 2 diabetes mellitus (T2DM) patients without clinical DR (NDR). Methods This was a cross-sectional casecontrol clinical study. Eighty-four eyes of 84 patients (44 T2DM and 40 control subjects) were included. Images were obtained using AngioVue software 2.0 of the OCTA device. Foveal avascular zone (FAZ) area, FAZ perimeter (PERIM), choriocapillary flow area (CCF), acircularity index (AI), foveal ...
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    8. Analysis of peripapillary retinal nerve fiber layer and inner macular layers by spectral-domain optical coherence tomography for detection of early glaucoma

      Analysis of peripapillary retinal nerve fiber layer and inner macular layers by spectral-domain optical coherence tomography for detection of early glaucoma
      AIM : To analyze the diagnostic capabilities of peripapillary retinal nerve fiber layer (pRNFL) thickness and segmented inner macular layer (IML) thickness measured by spectral-domain optical coherence tomography for detection of early glaucoma. METHODS : Fifty-three patients with primary open angle glaucoma (POAG), 60 patients with normal tension glaucoma (NTG) and 32 normal control subjects were enrolled. Thicknesses of pRNFL, total macular layers (TML), and the IML, including macular RNFL (mRNFL) and ...
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    9. Efficient Deep Learning-Based Automated Pathology Identification in Retinal Optical Coherence Tomography Images

      Efficient Deep Learning-Based Automated Pathology Identification in Retinal Optical Coherence Tomography Images
      We present an automatic method based on transfer learning for the identification of dry age-related macular degeneration (AMD) and diabetic macular edema (DME) from retinal optical coherence tomography (OCT) images. The algorithm aims to improve the classification performance of retinal OCT images and shorten the training time. Firstly, we remove the last several layers from the pre-trained Inception V3 model and regard the remaining part as a fixed feature extractor ...
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    10. Correction of saturation effects in endoscopic swept-source optical coherence tomography based on dual-channel detection

      Correction of saturation effects in endoscopic swept-source optical coherence tomography based on dual-channel detection
      Saturation artifacts that are commonly observed in endoscopic swept-source optical coherence tomography (SSOCT) images cause image degradation and loss of image information. We present work on the correction of saturation effects in endoscopic SSOCT imaging. This method utilizes a broadband power divider with excellent pick-off flatness to divide the detected interference signal into the two channels of an analog-to-digital converter. Based on the precise calibration of the splitting ratio between ...
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    11. Association of skin autofluorescence with plaque vulnerability evaluated by optical coherence tomography in patients with cardiovascular disease

      Association of skin autofluorescence with plaque vulnerability evaluated by optical coherence tomography in patients with cardiovascular disease
      Background and aims Accumulation of advanced glycation end products (AGEs) can be measured non-invasively by skin autofluorescence (SAF) whose values are elevated in patients with cardiovascular disease (CVD). Optical coherence tomography (OCT) is an intravascular imaging modality that could allow visualization of plaque composition. We aim to examine the relationship between SAF and plaque composition evaluated by frequency-domain OCT in patients with CVD. Methods We prospectively enrolled 108 patients with ...
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    12. Qualitative and quantitative assessment of posterior segment optical coherence tomography images using standard photos: the Liwan Eye Study

      Qualitative and quantitative assessment of posterior segment optical coherence tomography images using standard photos: the Liwan Eye Study
      Background/aims To develop a standardised grading scheme, using standard photos, for spectral-domain ocular coherence tomography (SD-OCT) images of the posterior eye and evaluate the interobserver agreement among trained ophthalmologists in identifying pathological changes. Methods Subjects were recruited from Liwan District, Guangzhou, with SD-OCT data collection from June 2013 to November 2013 as part of 10-year follow-up visits from the Liwan Eye Study. All subjects underwent SD-OCT imaging of the ...
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    13. Cross-correlation photothermal optical coherence tomography with high effective resolution

      Cross-correlation photothermal optical coherence tomography with high effective resolution
      We developed a cross-correlation photothermal optical coherence tomography (CC-PTOCT) system for photothermal imaging with high lateral and axial resolution. The CC-PTOCT system consists of a phase-sensitive OCT system, a modulated pumping laser, and a digital cross-correlator. The pumping laser was used to induce the photothermal effect in the sample, causing a slight phase modulation of the OCT signals. A spatial phase differentiation method was employed to reduce phase accumulation. The ...
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    14. Re: Kwon et al.: Subclassification of primary angle closure using anterior segment optical coherence tomography and ultrasound biomicroscopic parameters (Ophthalmology. 2017;124:1039-1047)

      Re: Kwon et al.: Subclassification of primary angle closure using anterior segment optical coherence tomography and ultrasound biomicroscopic parameters (Ophthalmology. 2017;124:1039-1047)
      To the Editor: We read with interest the article by Sung et al. 1 In this observational study, the authors concluded that the most distinct difference between the 2 subgroups in the cluster analysis was trabecularciliary process angle (TCA) and that the position of the ciliary body is important in subclassifying primary angle closure. However, there are several limitations that may affect the results. First, in the study, the authors ...
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    15. The linear artifact in enhanced depth imaging spectral domain optical coherence tomography

      The linear artifact in enhanced depth imaging spectral domain optical coherence tomography
      Optical coherence tomography (OCT) is a valuable ancillary test in the diagnosis and management of chorioretinal disease. The evaluation of choroid thickness using OCT has become the focus of clinical applications. We report a linear artifact that acts as a confounding factor in choroidal thickness measurements by enhanced depth imaging OCT. We found that the linear artifact is located stably at a depth of 485 m beneath the retinal pigment ...
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    16. Diagnostic capability of peripapillary retinal nerve fiber layer parameters in time-domain versus spectral-domain optical coherence tomography for assessing glaucoma in high myopia

      Diagnostic capability of peripapillary retinal nerve fiber layer parameters in time-domain versus spectral-domain optical coherence tomography for assessing glaucoma in high myopia
      AIM : To evaluate and compare the diagnostic capabilities of peripapillary retinal nerve fiber layer (p-RNFL) parameters of Spectralis optical coherence tomography (OCT) versus Stratus OCT to detect glaucoma in patients with high myopia. METHODS : This is a retrospective, cross-sectional study. Sixty highly myopic eyes of 60 patients were enrolled, with 30 eyes in the glaucoma group and 30 eyes in the control group. All eyes received peripapillary imaging of the ...
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  2. About Sun Yat-Sen University

    Sun Yat-Sen University

    Sun Yat-Sen University is located in Guangdong Province, the frontal of reform and opening. At present the University has 4 campuses with a total area of 6.17 square kilometers sitting respectively on both sides of the Pearl River or facing the South China Sea.  Zhongshan Ophthalmic Center is at the Sun Yat-Sen University of Medical Sciences, Guangzhou, China