1. Sun Yat-Sen University

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    1. Mentioned In 111 Articles

    2. The vascular densities of the macula and optic disc in normal eyes from children by optical coherence tomography angiography

      The vascular densities of the macula and optic disc in normal eyes from children by optical coherence tomography angiography
      Purpose This study aims to describe the variation and characteristics of vessel density (VD) of the macula and optic disc in the normal eyes of children. Methods This was a retrospective study where subjects aged 518 years with normal eyes were enrolled. The macula and optic disc were scanned by optical coherence tomography angiography (OCTA). The influences of age, gender, and axial length (AL) on VD were analyzed. Results A ...
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    3. ASSESSING THE ACTIVITY OF MYOPIC CHOROIDAL NEOVASCULARIZATION Comparison Between Optical Coherence Tomography Angiography and Dye Angiography

      ASSESSING THE ACTIVITY OF MYOPIC CHOROIDAL NEOVASCULARIZATION Comparison Between Optical Coherence Tomography Angiography and Dye Angiography
      Purpose: This study aims to suggest a novel strategy for assessing the activity of myopic choroidal neovascularization ( mCNV ) based on optical coherence tomography angiography ( OCTA ) and to compare it with traditional fundus fluorescein angiography as the gold standard. Methods: Macular OCTA images were obtained using RTVue XR Avanti with AngioVue. Morphologic features of mCNV lesions were analyzed. Characteristics of OCTA in 41 eyes with active mCNV and 41 eyes with ...
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    4. Effect of Choroidal Vessel Density on the Ellipsoid Zone and Visual Function in Retinitis Pigmentosa Using Optical Coherence Tomography Angiography

      Effect of Choroidal Vessel Density on the Ellipsoid Zone and Visual Function in Retinitis Pigmentosa Using Optical Coherence Tomography Angiography
      Purpose : We evaluate the effect of choroidal vessel density on the residual length of the ellipsoid zone (EZ) and visual function in patients with retinitis pigmentosa (RP) using optical coherence tomography angiography (OCTA). Methods : Fifty-three patients with RP ( n = 101 eyes) and 53 normal participants ( n = 76 eyes) were enrolled in this study. Patients with RP were assigned to three groups according to their best-corrected visual acuity (BCVA). All patients ...
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    5. Comparison of vascular parameters between normal cynomolgus macaques and healthy humans by optical coherence tomography angiography

      Comparison of vascular parameters between normal cynomolgus macaques and healthy humans by optical coherence tomography angiography
      Background The metabolic activity of retina is higher than other human tissues and is crucial to the vision. Cynomolgus macaques is widely used in ophthalmic disease research. The evaluation and comparison of macular and optic disc vascular circulation parameters between normal adult cynomolgus macaques and healthy adult humans using OCT-A can promote better use of nonhuman primate models in studies of ophthalmic vascular disease. Methods Twelve normal adult cynomolgus macaques ...
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    6. Comparison of clinical outcomes of different components of diabetic macular edema on optical coherence tomography

      Comparison of clinical outcomes of different components of diabetic macular edema on optical coherence tomography
      To evaluate the edema reduction after intravitreal injection of ranibizumab (IVR) in two diabetic macular edema (DME) components in the same eye using optical coherence tomography (OCT). Methods Totally 113 eyes with mixed OCT pattern of DME were included. All the eyes underwent best-corrected visual acuity (BCVA) examination and OCT scanning at baseline and follow-up visits (1, 3, and 6 months after 3 monthly consecutive IVR). The mixed OCT pattern ...
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    7. Upside-down position leads to choroidal expansion and anterior chamber shallowing: OCT study

      Upside-down position leads to choroidal expansion and anterior chamber shallowing: OCT study
      Background To determine whether dynamic changes in choroidal thickness (CT) cause shallowing of the anterior chamber. Methods 34 healthy volunteers were enrolled. The participants in our study adopted the upside-down position for 1.5min, which was the model we used to study the dynamic changes in CT. Intraocular pressure (IOP) elevation, optical coherence tomography images of the choroid and anterior chamber were obtained at baseline, after being in an upside-down ...
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    8. Comparison between non-visualized polyps and visualized polyps on optical coherence tomography angiography in polypoidal choroidal vasculopathy

      Comparison between non-visualized polyps and visualized polyps on optical coherence tomography angiography in polypoidal choroidal vasculopathy
      Purpose To determine the underlying reasons for the non-visualization of polyps on en face optical coherence tomography angiography (OCTA) in patients with polypoidal choroidal vasculopathy (PCV). Methods A cross-sectional study of consecutive treatment-nave 30 eyes with active PCV was included. Results of fundus photography, fundus fluorescein angiography (FFA), indocyanine green angiography (ICGA), spectral domain optical coherence tomography (SD-OCT), and en face OCTA were analyzed. Results A total of 64 active ...
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    9. Microvascular changes after conbercept therapy in central retinal vein occlusion analyzed by optical coherence tomography angiography

      Microvascular changes after conbercept therapy in central retinal vein occlusion analyzed by optical coherence tomography angiography
      AIM : To investigate microvascular changes in eyes with central retinal vein occlusion (CRVO) complicated by macular edema before and after intravitreal conbercept injection and evaluate correlations between these changes and best-corrected visual acuity (BCVA) and retinal thickness. METHODS : Twenty-eight eyes of 28 patients with macular edema caused by CRVO were included in this retrospective study. All patients received a single intravitreal conbercept injection to treat macular edema. BCVA and the ...
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    10. Quantitative Analysis of Retinal Microvascular Changes after Conbercept Therapy in Branch Retinal Vein Occlusion Using Optical Coherence Tomography Angiography

      Quantitative Analysis of Retinal Microvascular Changes after Conbercept Therapy in Branch Retinal Vein Occlusion Using Optical Coherence Tomography Angiography
      Purpose: To quantitatively evaluate microvascular changes in eyes with macular oedema due to branch retinal vein occlusion (BRVO) using optical coherence tomography angiography (OCTA) before and after intravitreal conbercept injection and the correlation of such changes with best-corrected visual acuity (BCVA) and retinal thickness. Methods: Twenty-eight eyes of 28 patients treated with a single intravitreal injection of conbercept for macular oedema due to BRVO were included in this study. The ...
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    11. Automatic detection of retinal regions using fully convolutional networks for diagnosis of abnormal maculae in optical coherence tomography images

      Automatic detection of retinal regions using fully convolutional networks for diagnosis of abnormal maculae in optical coherence tomography images
      In conventional retinal region detection methods for optical coherence tomography (OCT) images, many parameters need to be set manually, which is often detrimental to their generalizability. We present a scheme to detect retinal regions based on fully convolutional networks (FCN) for automatic diagnosis of abnormal maculae in OCT images. The FCN model is trained on 900 labeled age-related macular degeneration (AMD), diabetic macular edema (DME) and normal (NOR) OCT images ...
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    12. Peripapillary and Macular Vessel Density in Dysthyroid Optic Neuropathy: An Optical Coherence Tomography Angiography Study

      Peripapillary and Macular Vessel Density in Dysthyroid Optic Neuropathy: An Optical Coherence Tomography Angiography Study
      Purpose : To evaluate peripapillary and macular vessel density in eyes with dysthyroid optic neuropathy (DON) and its correlation with visual function. Methods : Patients diagnosed as thyroid-associated ophthalmopathy (TAO) with or without DON and healthy participants were recruited. All subjects underwent a complete ophthalmic examination and optical coherence tomography angiography centered on the fovea and the optic nerve head. Microvascular measurements were summarized as vessel density in the whole image and ...
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    13. Effects of chronic elevated intraocular pressure on parameters of optical coherence tomography in rhesus monkeys

      Effects of chronic elevated intraocular pressure on parameters of optical coherence tomography in rhesus monkeys
      AIM : To determine the progression of parameters from optical coherence tomography (OCT) in chronic elevated intraocular pressure (IOP) monkeys. METHODS : A chronic elevated IOP model of rhesus monkeys was induced by laser photocoagulation. Representative OCT parameters, including the average and four-quadrant retinal nerve fiber layer (RNFL) thickness, and parameters from optic nerve head (ONH) analysis were collected before and after laser treatments biweekly for up to 28wk. The performance of ...
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    14. In vivo detecting mouse persistent hyperplastic primary vitreous by Spectralis Optical Coherence Tomography

      In vivo detecting mouse persistent hyperplastic primary vitreous by Spectralis Optical Coherence Tomography
      To identify imaging characteristics of mouse persistent hyperplastic primary vitreous (PHPV) by Spectralis Optical Coherence Tomography (OCT), as well as to assess and compare the sensitivity and precision of OCT with color photography and Fundus Fluorescein Angiography (FFA) imaging in detecting mouse PHPV. NOTCH4 / C57BL/6J mice (224 eyes) aged from 3 months to 7 months were examined in this study. Color photography (CP), FFA and OCT imaging were utilized ...
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    15. Optimized Deep Convolutional Neural Networks for Identification of Macular Diseases from Optical Coherence Tomography Images

      Optimized Deep Convolutional Neural Networks for Identification of Macular Diseases from Optical Coherence Tomography Images
      Finetuning pre-trained deep neural networks (DNN) delicately designed for large-scale natural images may not be suitable for medical images due to the intrinsic difference between the datasets. We propose a strategy to modify DNNs, which improves their performance on retinal optical coherence tomography (OCT) images. Deep features of pre-trained DNN are high-level features of natural images. These features harm the training of transfer learning. Our strategy is to remove some ...
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    16. Probing dynamic processes in the eye at multiple spatial and temporal scales with multimodal full field OCT

      Probing dynamic processes in the eye at multiple spatial and temporal scales with multimodal full field OCT
      We describe recent technological progress in multimodal en face full-field optical coherence tomography that has allowed detection of slow and fast dynamic processes in the eye. We show that by combining static, dynamic and fluorescence contrasts we can achieve label-free high-resolution imaging of the retina and anterior eye with temporal resolution from milliseconds to several hours, allowing us to probe biological activity at subcellular scales inside 3D bulk tissue. Our ...
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  2. About Sun Yat-Sen University

    Sun Yat-Sen University

    Sun Yat-Sen University is located in Guangdong Province, the frontal of reform and opening. At present the University has 4 campuses with a total area of 6.17 square kilometers sitting respectively on both sides of the Pearl River or facing the South China Sea.  Zhongshan Ophthalmic Center is at the Sun Yat-Sen University of Medical Sciences, Guangzhou, China