1. Sun Yat-Sen University

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    1. Mentioned In 119 Articles

    2. MDAN-UNet: Multi-Scale and Dual Attention Enhanced Nested U-Net Architecture for Segmentation of Optical Coherence Tomography Images

      MDAN-UNet: Multi-Scale and Dual Attention Enhanced Nested U-Net Architecture for Segmentation of Optical Coherence Tomography Images
      Optical coherence tomography (OCT) is an optical high-resolution imaging technique for ophthalmic diagnosis. In this paper, we take advantages of multi-scale input, multi-scale side output and dual attention mechanism and present an enhanced nested U-Net architecture (MDAN-UNet), a new powerful fully convolutional network for automatic end-to-end segmentation of OCT images. We have evaluated two versions of MDAN-UNet (MDAN-UNet-16 and MDAN-UNet-32) on two publicly available benchmark datasets which are the Duke ...
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    3. Association of renal function with retinal vessel density in patients with type 2 diabetes by using swept-source optical coherence tomographic angiography

      Association of renal function with retinal vessel density in patients with type 2 diabetes by using swept-source optical coherence tomographic angiography
      Aims To investigate the relationship between retinal vessel density and renal function in patients with diabetes mellitus (DM) using non-invasive optical coherence tomographic angiography (OCTA). Methods This prospective cross-sectional study recruited ocular-treatment-nave patients with DM registered in the community of Guangzhou, China. The retinal vessel density of the superficial capillary plexus in the macula was obtained by using swept-source OCTA imaging. The Xiangya equation was used to calculate the estimated ...
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    4. Macular vessel density in diabetes and diabetic retinopathy with swept-source optical coherence tomography angiography

      Macular vessel density in diabetes and diabetic retinopathy with swept-source optical coherence tomography angiography
      Purpose: Previous studies on the association between macular vessel density (VD) and diabetic retinopathy had conflicting conclusions. This study assessed the alterations of macular VD, as well as other factors, in diabetic patients using swept-source optical coherence tomography angiography (SS-OCTA) in a large-scale sample from Chinese communities. Methods: Patients with type 2 diabetes without history of ocular treatment were recruited from 2017 to 2018. The average and quadrant parafoveal vessel ...
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    5. Automatic Segmentation and Visualization of Choroid in OCT with Knowledge Infused Deep Learning

      Automatic Segmentation and Visualization of Choroid in OCT with Knowledge Infused Deep Learning
      The choroid provides oxygen and nourishment to the outer retina thus is related to the pathology of various ocular diseases. Optical coherence tomography (OCT) is advantageous in visualizing and quantifying the choroid in vivo, because it does not suffer from the information contamination of the outer retina in fundus photography and scanning laser ophthalmoscopy and the resolution deficiency in ocular ultrasound. We propose a biomarker infused global-to-local network, for the ...
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    6. The influence of insulin therapy on measurements of optical coherence tomography parameters in diabetic patients without retinopathy

      The influence of insulin therapy on measurements of optical coherence tomography parameters in diabetic patients without retinopathy
      Purpose To determine whether there was a change in the fundus of the eye in diabetic patients without retinopathy after insulin therapy. Methods The diabetic patients without retinopathy were included in this study. A swept-source optical coherence tomography/angiography (SS-OCT/A) was used to obtain the measurements of macular retinal nerve fibre layer (mRNFL) thickness, ganglion cell-inner plexiform layer (GC-IPL) thickness, retinal thickness (RT), macular choroidal thickness (MCT), peripapillary retinal ...
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    7. Real-time, non-contact, cellular imaging and angiography of human cornea and limbus with common-path Full-field/SD OCT

      Real-time, non-contact, cellular imaging and angiography of human cornea and limbus with common-path Full-field/SD OCT
      In todays clinics, a cellular-resolution view of the cornea can be achieved only with an in vivo confocal microscope (IVCM) in contact with the eye. Here, we present a common-path Full-field/Spectral-domain OCT microscope (FF/SD OCT), which, for the first time, enables cell-detail imaging of the entire ocular surface (central and peripheral cornea, limbus, sclera, tear film) without contact and in real time. The device, that has been successfully ...
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    8. Associations Between Retina and Brain Function

      Associations Between Retina and Brain Function
      Case-control studies and meta-analysis have reported that several fundus features, especially the thickness of the peripapillary retinal nerve fiber layer, are related to the brain degeneration and cognitive impairment. In our study, we aim to quantitatively assess retina features using OCT and define its associations with brain development and intelligence in children.
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    9. Study on Intraocular Structural Parameters and Surgical Effect Before and After the Onset of Malignant Glaucoma

      Study on Intraocular Structural Parameters and Surgical Effect Before and After the Onset of Malignant Glaucoma
      In this retrospective observational study, we collected intraocular structure parameters of malignant glaucoma and primary angle closure glaucoma. Anterior chamber depth (ACD) and width (ACW), lens vault (LV), ciliary process-ciliary process distance(CCD), trabecular-ciliary processes distance (TCPD), ciliary body max thickness (CBMT), peripheral iris thickness (PIT), trabecular ciliary process angle (TCPA), and anterior vault (AV), were measured by ultrasound biomicroscopy. Other parameters measured by A-scan ultrasonography and optical coherence tomography ...
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    10. The vascular densities of the macula and optic disc in normal eyes from children by optical coherence tomography angiography

      The vascular densities of the macula and optic disc in normal eyes from children by optical coherence tomography angiography
      Purpose This study aims to describe the variation and characteristics of vessel density (VD) of the macula and optic disc in the normal eyes of children. Methods This was a retrospective study where subjects aged 518 years with normal eyes were enrolled. The macula and optic disc were scanned by optical coherence tomography angiography (OCTA). The influences of age, gender, and axial length (AL) on VD were analyzed. Results A ...
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    11. ASSESSING THE ACTIVITY OF MYOPIC CHOROIDAL NEOVASCULARIZATION Comparison Between Optical Coherence Tomography Angiography and Dye Angiography

      ASSESSING THE ACTIVITY OF MYOPIC CHOROIDAL NEOVASCULARIZATION Comparison Between Optical Coherence Tomography Angiography and Dye Angiography
      Purpose: This study aims to suggest a novel strategy for assessing the activity of myopic choroidal neovascularization ( mCNV ) based on optical coherence tomography angiography ( OCTA ) and to compare it with traditional fundus fluorescein angiography as the gold standard. Methods: Macular OCTA images were obtained using RTVue XR Avanti with AngioVue. Morphologic features of mCNV lesions were analyzed. Characteristics of OCTA in 41 eyes with active mCNV and 41 eyes with ...
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    12. Effect of Choroidal Vessel Density on the Ellipsoid Zone and Visual Function in Retinitis Pigmentosa Using Optical Coherence Tomography Angiography

      Effect of Choroidal Vessel Density on the Ellipsoid Zone and Visual Function in Retinitis Pigmentosa Using Optical Coherence Tomography Angiography
      Purpose : We evaluate the effect of choroidal vessel density on the residual length of the ellipsoid zone (EZ) and visual function in patients with retinitis pigmentosa (RP) using optical coherence tomography angiography (OCTA). Methods : Fifty-three patients with RP ( n = 101 eyes) and 53 normal participants ( n = 76 eyes) were enrolled in this study. Patients with RP were assigned to three groups according to their best-corrected visual acuity (BCVA). All patients ...
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    13. Comparison of vascular parameters between normal cynomolgus macaques and healthy humans by optical coherence tomography angiography

      Comparison of vascular parameters between normal cynomolgus macaques and healthy humans by optical coherence tomography angiography
      Background The metabolic activity of retina is higher than other human tissues and is crucial to the vision. Cynomolgus macaques is widely used in ophthalmic disease research. The evaluation and comparison of macular and optic disc vascular circulation parameters between normal adult cynomolgus macaques and healthy adult humans using OCT-A can promote better use of nonhuman primate models in studies of ophthalmic vascular disease. Methods Twelve normal adult cynomolgus macaques ...
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    14. Comparison of clinical outcomes of different components of diabetic macular edema on optical coherence tomography

      Comparison of clinical outcomes of different components of diabetic macular edema on optical coherence tomography
      To evaluate the edema reduction after intravitreal injection of ranibizumab (IVR) in two diabetic macular edema (DME) components in the same eye using optical coherence tomography (OCT). Methods Totally 113 eyes with mixed OCT pattern of DME were included. All the eyes underwent best-corrected visual acuity (BCVA) examination and OCT scanning at baseline and follow-up visits (1, 3, and 6 months after 3 monthly consecutive IVR). The mixed OCT pattern ...
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    15. Upside-down position leads to choroidal expansion and anterior chamber shallowing: OCT study

      Upside-down position leads to choroidal expansion and anterior chamber shallowing: OCT study
      Background To determine whether dynamic changes in choroidal thickness (CT) cause shallowing of the anterior chamber. Methods 34 healthy volunteers were enrolled. The participants in our study adopted the upside-down position for 1.5min, which was the model we used to study the dynamic changes in CT. Intraocular pressure (IOP) elevation, optical coherence tomography images of the choroid and anterior chamber were obtained at baseline, after being in an upside-down ...
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    16. Comparison between non-visualized polyps and visualized polyps on optical coherence tomography angiography in polypoidal choroidal vasculopathy

      Comparison between non-visualized polyps and visualized polyps on optical coherence tomography angiography in polypoidal choroidal vasculopathy
      Purpose To determine the underlying reasons for the non-visualization of polyps on en face optical coherence tomography angiography (OCTA) in patients with polypoidal choroidal vasculopathy (PCV). Methods A cross-sectional study of consecutive treatment-nave 30 eyes with active PCV was included. Results of fundus photography, fundus fluorescein angiography (FFA), indocyanine green angiography (ICGA), spectral domain optical coherence tomography (SD-OCT), and en face OCTA were analyzed. Results A total of 64 active ...
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  2. About Sun Yat-Sen University

    Sun Yat-Sen University

    Sun Yat-Sen University is located in Guangdong Province, the frontal of reform and opening. At present the University has 4 campuses with a total area of 6.17 square kilometers sitting respectively on both sides of the Pearl River or facing the South China Sea.  Zhongshan Ophthalmic Center is at the Sun Yat-Sen University of Medical Sciences, Guangzhou, China