1. Steven L. Jacques

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    1. Mentioned In 28 Articles

    2. Two dimensional vibrations of the guinea pig apex organ of Corti measured in vivo using phase sensitive Fourier domain optical coherence tomography

      Two dimensional vibrations of the guinea pig apex organ of Corti measured in vivo using phase sensitive Fourier domain optical coherence tomography
      ...079673; Sripriya Ramamoorthy ; Yuan Zhang ; Tracy Petrie ; Anders Fridberger ; Tianying Ren ; Ruikang Wang ; Steven L. Jacques ; Alfred L. Nuttall; Two dimensional vibrations of the guinea pig apex organ of Corti measur...
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    3. Oregon Health & Science University Receives NIH Grant for Ossicle Vibration Measurements in Conductive Hearing Loss.

      Oregon Health & Science University Receives NIH Grant for Ossicle Vibration Measurements in Conductive Hearing Loss.
      ...ant for $427,225 for Ossicle Vibration Measurements in Conductive Hearing Loss. The principle investigator is Steven Jacques. The program began in 2013 and ends in 2017. Below is a summary of hte propose work.

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    4. Feature Of The Week 3/17/13: Using Optical Coherence Tomography to Study Mechanisms of Hearing

      Feature Of The Week 3/17/13: Using Optical Coherence Tomography to Study Mechanisms of Hearing
      ...eliminary study”, J. Biomed. Opt. 15, 056005 (2010).5. Hrebesh M. Subhash, Anh Nguyen-Huynh, Ruikang K. Wang, Steven L. Jacques and Alfred L. Nuttall, "Feasibility of spectral-domain phase-sensitive optical coherence tom...
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    5. Measurement of in vivo basal-turn vibrations of the organ of Corti using phase-sensitive Fourier domain optical coherence tomography

      Measurement of in vivo basal-turn vibrations of the organ of Corti using phase-sensitive Fourier domain optical coherence tomography
      ...Ramamoorthy ; Yuan Zhang ; Tracy Petrie ; Fangyi Chen ; Hrebesh M. Subhash ; Niloy Choudhury ; Ruikang Wang ; Steven L. Jacques ; Alfred L. Nuttall; Measurement of in vivo basal-turn vibrations of the organ of Corti usin...
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    6. Depth-resolved dual-beamlet vibrometry based on Fourier domain low coherence interferometry

      Depth-resolved dual-beamlet vibrometry based on Fourier domain low coherence interferometry
      We present an optical vibrometer based on delay-encoded, dual-beamlet phase-sensitive Fourier domain interferometric system to provide depth-resolved subnanometer scale vibration information from scattering biological specimens. System characterization, calibration, and preliminary vibrometry with biological specimens were performed. The proposed system has the potential to provide both amplitude and direction of vibration of tissue microstructures on a single two-dimensional plane.
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    7. Feature Of The Week 07/01/12: Enhanced Optical Clearing of Skin In Vivo and OCT In-Depth Imaging

      Feature Of The Week 07/01/12: Enhanced Optical Clearing of Skin In Vivo and OCT In-Depth Imaging
      Imaging methods such as optical coherence tomography (OCT), confocal reflectance/ fluorescence microscopy, second-harmonic generation microscopy, and 2-photon microscopy are limited by the optical scattering properties of the skin to superficial depths. Optical clearing technique using high refractive index and hyperosmolarity agents can reduce the scattering of biological tissues. With this approach, better optical imaging depth and contrast have been presented and deeper optical treatment has been achieved. However, noninvasive optical ...
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    8. Feature Of The Week 6/17/12: Middle Ear Vibrometry of Human Cadaver Temporal Bone with Spectral Domain Phase-Sensitive Optical Coherence Tomography

      Feature Of The Week 6/17/12: Middle Ear Vibrometry of Human Cadaver Temporal Bone with Spectral Domain Phase-Sensitive Optical Coherence Tomography
      Hearing loss is the most frequent sensory deficit in the human population, affecting more than 250 million people in the world. The National Center for Health Statistics estimates that 37 million adults (17%) in the United States have hearing difficulty. Analysis of a large database of audiometric records from the University of Minnesota reveals that 39% of patients diagnosed with hearing loss have conductive hearing loss (CHL) either alone (15 ...
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    9. Enhanced optical clearing of skin in vivo and optical coherence tomography in-depth imaging

      Enhanced optical clearing of skin in vivo and optical coherence tomography in-depth imaging
      The strong optical scattering of skin tissue makes it very difficult for optical coherence tomography (OCT) to achieve deep imaging in skin. Significant optical clearing of in vivo rat skin sites was achieved within 15 min by topical application of an optical clearing agent PEG-400, a chemical enhancer (thiazone or propanediol), and physical massage. Only when all three components were applied together could a 15 min treatment achieve a three ...
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    10. Feature Of The Week 5/27/11: Researchers Utilize Optical Coherence Tomography to Perform in vivo Investigation into the Process of Hearing

      Feature Of The Week 5/27/11: Researchers Utilize Optical Coherence Tomography to Perform in vivo Investigation into the Process of Hearing
      A multidisciplinary research groups spanning several countries (USA, China, Sweden) are using optical coherence tomography (OCT) to investigate minute changes in hair cells within the cochlea - the auditory portion of the inner ear. Below is a summary of their work. Mammalian hearing is refined by amplification of the sound-evoked vibration of the cochlear partition. This amplification is at least partly due to forces produced by protein motors residing in the ...
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    11. Simultaneous depth-resolved imaging of sub-nanometer scale ossicular vibrations and morphological features of the human-cadaver middle ear with spectral-domain phase-sensitive optical coherence tomography

      Simultaneous depth-resolved imaging of sub-nanometer scale ossicular vibrations and morphological features of the human-cadaver middle ear with spectral-domain phase-sensitive optical coherence tomography
      We describe a novel method for the detection of the tiny motions of the middle ear (ME) ossicles and their morphological features with a spectral-domain phase sensitive optical coherence tomography (PS-OCT). Laser Doppler Vibrometry (LDV) and its variations are the most extensively used methods for studding the vibrational modes of the ME. However, most techniques are limited to single point analysis methods, and do not have the ability to provide ...
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    12. Absolute measurement of subnanometer scale vibration of cochlear partition of an excised guinea pig cochlea using spectral-domain phase-sensitive optical coherence tomography

      Absolute measurement of subnanometer scale vibration of cochlear partition of an excised guinea pig cochlea using spectral-domain phase-sensitive optical coherence tomography
      Direct measurement of absolute vibration parameters from different locations within the mammalian organ of Corti is crucial for understanding the hearing mechanics such as how sound propagates through the cochlea and how sound stimulates the vibration of various structures of the cochlea, namely, basilar membrane (BM), recticular lamina, outer hair cells and tectorial membrane (TM). In this study we demonstrate the feasibility a modified phase-sensitive spectral domain optical coherence tomography ...
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    13. Imaging Organ of Corti Vibration Using Fourier-Domain OCT

      Imaging Organ of Corti Vibration Using Fourier-Domain OCT
      Measuring the sound stimulated vibration from various structures in the organ of Corti is important in understanding how the small vibrations are amplified and detected. In this study we examine the feasibility of using phase-sensitive Fourier domain optical coherence tomography (PSFD-OCT) to measure vibration of the cellular structures of the organ of Corti. PSFD-OCT is a low coherence interferrometry system where the interferrogram is detected as a function of wavelength ...
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    14. A differentially amplified motion in the ear for near-threshold sound detection

      A differentially amplified motion in the ear for near-threshold sound detection
      The ear is a remarkably sensitive pressure fluctuation detector. In guinea pigs, behavioral measurements indicate a minimum detectable sound pressure of ~20 μPa at 16 kHz. Such faint sounds produce 0.1-nm basilar membrane displacements, a distance smaller than conformational transitions in ion channels. It seems that noise within the auditory system would swamp such tiny motions, making weak sounds imperceptible. Here we propose a new mechanism contributing to a ...
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    15. Dermal reflectivity determined by optical coherence tomography is an indicator of epidermal hyperplasia and dermal edema within inflamed skin

      Dermal reflectivity determined by optical coherence tomography is an indicator of epidermal hyperplasia and dermal edema within inflamed skin
      ... G. Phillips, Yun Wang, David Levitz, Niloy Choudhury, Emily Swanzey, James Lagowski, Molly Kulesz-Martin and Steven L. Jacques, "Dermal reflectivity determined by optical coherence tomography is an indicator of epiderma...
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    16. 1-15 of 28 1 2 »
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  2. About Steven L. Jacques

    Steven L. Jacques

    Steven L. Jacques, PhD, now serves as Professor of Dermatology and Biomedical Engineering at the Oregon Health and Science University. Professor Steven L. Jacques, PhD, received a BS degree in Biology at M.I.T., and both an MS degree in Electrical Engineering and Computer Science and a PhD degree in Biophysics and Medical Physics from the University of California-Berkeley (1984). Dr. Jacques has authored over 100 papers in peer-reviewed journals. His research interests include biomedical optics, laser-tissue interactions and development of diagnostic and therapeutic devices for medicine and biology using optical technologies.