1. Steven L. Jacques

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    1. Mentioned In 35 Articles

    2. Minimal basilar membrane motion in low-frequency hearing

      Minimal basilar membrane motion in low-frequency hearing
      To perceive speech, the brain relies on inputs from sensory cells located near the top of the spiral-shaped cochlea. This low-frequency region of the inner ear is anatomically difficult to access, and it has not previously been possible to study its mechanical response to sound in intact preparations. Here, we used optical coherence tomography to image sound-evoked vibration inside the intact cochlea. We show that low-frequency sound moves a small ...
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    3. Oregon Health and Science University Receives NIH Grant for Ossicle Vibration Measurement sin Conductive Hearing Loss

      Oregon Health and Science University Receives NIH Grant for Ossicle Vibration Measurement sin Conductive Hearing Loss
      Oregon Health and Science University Receives a 2016 NIH Grant for $418,717 for Ossicle Vibration Measurement sin Conductive Hearing Loss. The principal investigator is Steven Jaques. The program began in 2013 and ends in 2017. Below is a summary of the proposed work. The proposal develops a hand-held otoscope that uses optical coherence tomography (OCT) to image the tympanic membrane and ossicles behind an intact tympanic membrane. The system ...
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    4. BIOPHOTONICS AND IMAGING SUMMER SCHOOL (BIGSS 2016)

      BIOPHOTONICS AND IMAGING SUMMER SCHOOL (BIGSS 2016)
      The Bi-annual Biophotonics and Imaging Summer School (BIGSS16) will be held 5-9 September 2016 in Galway, Ireland. It is a five ECTS accredited course with leading professors teaching. Sessions are approx. four hours each to give a substantial grounding in the main topics of Biophotonics. The location is in the picturesque village of Ballyvaughanin the Burren . This will be augmented with hands on training at NUI Galway. Fee: 800 including ...
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    5. Minimally invasive surgical method to detect sound processing in the cochlear apex by optical coherence tomography

      Minimally invasive surgical method to detect sound processing in the cochlear apex by optical coherence tomography
      Sound processing in the inner ear involves separation of the constituent frequencies along the length of the cochlea. Frequencies relevant to human speech (100 to 500 Hz) are processed in the apex region. Among mammals, the guinea pig cochlear apex processes similar frequencies and is thus relevant for the study of speech processing in the cochlea. However, the requirement for extensive surgery has challenged the optical accessibility of this area ...
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    6. Development of a phase-sensitive Fourier domain optical coherence tomography system to measure mouse organ of Corti vibrations in two cochlear turns

      Development of a phase-sensitive Fourier domain optical coherence tomography system to measure mouse organ of Corti vibrations in two cochlear turns
      In this study, we have developed a phase-sensitive Fourier-domain optical coherence tomography system to simultaneously measure the in vivo inner ear vibrations in the hook area and second turn of the mouse cochlea. This technical development will enable measurement of intra-cochlear distortion products at ideal locations such as the distortion product generation site and reflection site. This information is necessary to un-mix the complex mixture of intra-cochlear waves comprising the ...
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    7. Methods of Melanoma Detection

      Methods of Melanoma Detection
      Detection and removal of melanoma, before it has metastasized, dramatically improves prognosis and survival. The purpose of this chapter is to (1) summarize current methods of melanoma detection and (2) review state-of-the-art detection methods and technologies that have the potential to reduce melanoma mortality. Current strategies for the detection of melanoma range from population-based educational campaigns and screening to the use of algorithm-driven imaging technologies and performance of assays that ...
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    8. Two dimensional vibrations of the guinea pig apex organ of Corti measured in vivo using phase sensitive Fourier domain optical coherence tomography

      Two dimensional vibrations of the guinea pig apex organ of Corti measured in vivo using phase sensitive Fourier domain optical coherence tomography
      ...079673; Sripriya Ramamoorthy ; Yuan Zhang ; Tracy Petrie ; Anders Fridberger ; Tianying Ren ; Ruikang Wang ; Steven L. Jacques ; Alfred L. Nuttall; Two dimensional vibrations of the guinea pig apex organ of Corti measur...
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    9. Oregon Health & Science University Receives NIH Grant for Ossicle Vibration Measurements in Conductive Hearing Loss.

      Oregon Health & Science University Receives NIH Grant for Ossicle Vibration Measurements in Conductive Hearing Loss.
      ...ant for $427,225 for Ossicle Vibration Measurements in Conductive Hearing Loss. The principle investigator is Steven Jacques. The program began in 2013 and ends in 2017. Below is a summary of hte propose work.

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    10. Feature Of The Week 3/17/13: Using Optical Coherence Tomography to Study Mechanisms of Hearing

      Feature Of The Week 3/17/13: Using Optical Coherence Tomography to Study Mechanisms of Hearing
      ...eliminary study”, J. Biomed. Opt. 15, 056005 (2010).5. Hrebesh M. Subhash, Anh Nguyen-Huynh, Ruikang K. Wang, Steven L. Jacques and Alfred L. Nuttall, "Feasibility of spectral-domain phase-sensitive optical coherence tom...
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    11. Measurement of in vivo basal-turn vibrations of the organ of Corti using phase-sensitive Fourier domain optical coherence tomography

      Measurement of in vivo basal-turn vibrations of the organ of Corti using phase-sensitive Fourier domain optical coherence tomography
      ...Ramamoorthy ; Yuan Zhang ; Tracy Petrie ; Fangyi Chen ; Hrebesh M. Subhash ; Niloy Choudhury ; Ruikang Wang ; Steven L. Jacques ; Alfred L. Nuttall; Measurement of in vivo basal-turn vibrations of the organ of Corti usin...
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    12. Depth-resolved dual-beamlet vibrometry based on Fourier domain low coherence interferometry

      Depth-resolved dual-beamlet vibrometry based on Fourier domain low coherence interferometry
      We present an optical vibrometer based on delay-encoded, dual-beamlet phase-sensitive Fourier domain interferometric system to provide depth-resolved subnanometer scale vibration information from scattering biological specimens. System characterization, calibration, and preliminary vibrometry with biological specimens were performed. The proposed system has the potential to provide both amplitude and direction of vibration of tissue microstructures on a single two-dimensional plane.
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    13. Feature Of The Week 07/01/12: Enhanced Optical Clearing of Skin In Vivo and OCT In-Depth Imaging

      Feature Of The Week 07/01/12: Enhanced Optical Clearing of Skin In Vivo and OCT In-Depth Imaging
      Imaging methods such as optical coherence tomography (OCT), confocal reflectance/ fluorescence microscopy, second-harmonic generation microscopy, and 2-photon microscopy are limited by the optical scattering properties of the skin to superficial depths. Optical clearing technique using high refractive index and hyperosmolarity agents can reduce the scattering of biological tissues. With this approach, better optical imaging depth and contrast have been presented and deeper optical treatment has been achieved. However, noninvasive optical ...
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    14. Feature Of The Week 6/17/12: Middle Ear Vibrometry of Human Cadaver Temporal Bone with Spectral Domain Phase-Sensitive Optical Coherence Tomography

      Feature Of The Week 6/17/12: Middle Ear Vibrometry of Human Cadaver Temporal Bone with Spectral Domain Phase-Sensitive Optical Coherence Tomography
      Hearing loss is the most frequent sensory deficit in the human population, affecting more than 250 million people in the world. The National Center for Health Statistics estimates that 37 million adults (17%) in the United States have hearing difficulty. Analysis of a large database of audiometric records from the University of Minnesota reveals that 39% of patients diagnosed with hearing loss have conductive hearing loss (CHL) either alone (15 ...
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    15. Enhanced optical clearing of skin in vivo and optical coherence tomography in-depth imaging

      Enhanced optical clearing of skin in vivo and optical coherence tomography in-depth imaging
      The strong optical scattering of skin tissue makes it very difficult for optical coherence tomography (OCT) to achieve deep imaging in skin. Significant optical clearing of in vivo rat skin sites was achieved within 15 min by topical application of an optical clearing agent PEG-400, a chemical enhancer (thiazone or propanediol), and physical massage. Only when all three components were applied together could a 15 min treatment achieve a three ...
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    16. 1-15 of 35 1 2 3 »
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  2. About Steven L. Jacques

    Steven L. Jacques

    Steven L. Jacques, PhD, now serves as Professor of Dermatology and Biomedical Engineering at the Oregon Health and Science University. Professor Steven L. Jacques, PhD, received a BS degree in Biology at M.I.T., and both an MS degree in Electrical Engineering and Computer Science and a PhD degree in Biophysics and Medical Physics from the University of California-Berkeley (1984). Dr. Jacques has authored over 100 papers in peer-reviewed journals. His research interests include biomedical optics, laser-tissue interactions and development of diagnostic and therapeutic devices for medicine and biology using optical technologies.