1. Steven J. Matcher

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    1. Mentioned In 72 Articles

    2. Depth-Resolved Dynamics of Aceto-Whitening in Rabbit Cornea Studied by 1300 nm Optical Coherence Tomography

      Depth-Resolved Dynamics of Aceto-Whitening in Rabbit Cornea Studied by 1300 nm Optical Coherence Tomography
      In many developing parts of the world, colposcopy supplemented by aceto-whitening remains the most widespread means of reliably diagnosing cervical dysplasia, potentially leading to cervical cancer. The use of aceto-whitening to enhance detection rates for Barretts esophagus is also emerging in recent years. Here we quantitatively study the aceto-whitening phenomenon using 1300 nm optical coherence tomography. By exposing a simple epithelial tissue model (excised rabbit cornea) to 0.5 M ...
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    3. Optical coherence tomography measurements of biological fluid flows with picolitre spatial localization

      Optical coherence tomography measurements of biological fluid flows with picolitre spatial localization
      Interest in studying the human and animal microcirculation has burgeoned in recent years. In part this has been driven by recent advances in volumetric microscopy modalities, which allow the study of the 3-D morphology of the microcirculation without the limitations of 2-D intra-vital microscopy. In this paper we highlight the power of optical coherence tomography (OCT) to image the normal and pathological microcirculation with picolitre voxel sizes. Both Doppler and ...
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    4. Feature Of The Week 8/25/13: Anti-biofouling Conducting Polymer Nanoparticles as a Label-Free Optical Contrast Agent for High Resolution Subsurface Biomedical Imaging

      Feature Of The Week 8/25/13: Anti-biofouling Conducting Polymer Nanoparticles as a Label-Free Optical Contrast Agent for High Resolution Subsurface Biomedical Imaging
      Optical coherence tomography (OCT) is a modern optical imaging technique that has been widely use in ophthalmic imaging for more than a decade. There has been increasing interest in extending its imaging applications to include other sub-surface biomedical imaging applications (e.g. cancer diagnosis). However, poor image contrast caused by multiple light scattering is a major challenge for OCT imaging in heterogeneous poorly transparent tissues (e.g. skin). We report ...
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    5. Anti-biofouling conducting polymer nanoparticles as a label-free optical contrast agent for high resolution subsurface biomedical imaging

      Anti-biofouling conducting polymer nanoparticles as a label-free optical contrast agent for high resolution subsurface biomedical imaging
      Optical coherence tomography (OCT) is a modern high resolution subsurface medical imaging technique. Herein we describe: (i) the synthesis of a thiophene-functionalized oligo(ethylene glycol) methacrylate (OEGMA)-based statistical copolymer, denoted poly(2TMOIOEGMA); (ii) the preparation of sterically-stabilized polypyrrole (PPy) nanoparticles of approximately 60 nm diameter; (iii) the evaluation of these nanoparticles as a NIR-absorbing optical contrast agent for high-resolution OCT imaging. We show that poly(2TMOIOEGMA)-stabilized PPy nanoparticles ...
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    6. PhD Studentship in High Speed 3D Studies of the Biomechanics of Skin Friction at University of Sheffield

      PhD Studentship in High Speed 3D Studies of the Biomechanics of Skin Friction at University of Sheffield
      ...rch facilities. The team of supervisors on the project will be: Dr Roger Lewis (Mechanical Engineering) Dr Steve Matcher (Materials Science and Engineering) Dr Matt Carré (Mechanical Engineering) Further Information ...
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    7. Optical coherence tomography demonstrates differential epidermal thinning of human forearm volar skin after 2 weeks application of a topical corticosteroid vs a non-steroidal anti-inflammatory alternative

      Optical coherence tomography demonstrates differential epidermal thinning of human forearm volar skin after 2 weeks application of a topical corticosteroid vs a non-steroidal anti-inflammatory alternative
      ...oid vs a non-steroidal anti-inflammatory alternative Zenghai Lu ; Joseph Boadi ; Simon Danby ; Michael Cork ; Stephen J. Matcher; Optical coherence tomography demonstrates differential epidermal thinning of human forearm...
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    8. Quantum dot selective area intermixing for broadband light sources

      Quantum dot selective area intermixing for broadband light sources
      We report a comparison of different capping materials on the intermixing of modulation p-doped InAs/In(Ga)As quantum dots (QD). QD materials with different caps are shown to exhibit significant difference in their optical properties during the annealing process. The selective area intermixing technique is demonstrated to laterally integrate two and three different QD light emitting devices with a single electrical contact. A spectral bandwidth of 240nm centered at ...
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    9. Contrast Agents For Biophotonic Imaging

      Contrast Agents For Biophotonic Imaging
      The present invention relates to the use of sterically-stabilised organic conducting polymeric nanoparticles as a contrast agent for biophotonic imaging, especially in optical coherence tomography (OCT) imaging. Exposing biological tissue to said contrast agent (whether in vivo or in vitro) prior to OCT imaging significantly enhances the contrast of the resulting OCT images and allows for enhanced detection and diagnosis of clinical conditions, such as cancerous tumours.
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    10. Feasibility of using Optical Coherence Tomography to Study the Influence of Skin Structure on Finger Friction

      Feasibility of using Optical Coherence Tomography to Study the Influence of Skin Structure on Finger Friction
      This paper presents work using an in-vivo technique, Optical Coherence Tomography (OCT), to investigate the structure of human finger pad skin and the influences of some related parameters on skin friction, such as contact area, deformation and hydration. The experimental results show that there was no significant relationship between the thickness of the stratum corneum (SC) and the friction coefficient, as well as the number of sweat ducts (SD). The ...
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    11. 16-30 of 72 « 1 2 3 4 5 »
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  2. About Steven J. Matcher

    Steven J. Matcher

    Stephen Matcher graduated from Imperial College London with a BSc in Physics and subsequently a PhD in optical astronomy, where he used high-speed, low-light-level imaging to overcome atmospheric turbulence and achieve diffraction-limited ground-based imaging. He translated his expertise in low-light-level imaging into medicine at University College London, where he developed near-infrared spectroscopy techniques to study tissue oxygen delivery, especially in newborn infants at risk from birth asphyxia. He then joined the staff of the Physics department at the University of Exeter, where he established research programmes in visible light spectroscopy of skin and optical coherence tomography (OCT). In 2006 he joined the University of Sheffield where he is currently Reader in Biomedical Engineering. His chief research interest lies in the development and application of novel biophotonic imaging tools to aid the characterisation of native and engineered biological tissues. Primarily he works with OCT, including novel variants such as polarization-sensitive OCT for the non-invasive assessment of collagen organization and Doppler OCT for the measurement of fluid flow. He is currently collaborating with clinical colleagues to improve the detection of corneal stem cells post-implantation, to provide tools for the early detection and staging of epithelial cancer and to develop non-invasive tools to characterise skin barrier function. He also actively collaborates with the National Centre for III-V Technologies to develop improved light sources for biophotonic imaging.

  3. Quotes

    1. I am very pleased that the RAE is supporting my secondment to Michelson Diagnostics, a world leader in OCT imaging and I hope that my skills and expertise will be of practical benefit to the company
      In Dr Stephen Matcher Biomedical Imaging Expert Seconded to Michelson Diagnostics