1. Steven G. Adie

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    1. Mentioned In 52 Articles

    2. Aberration-diverse optical coherence tomography for suppression of multiple scattering and speckle

      Explore OSA | OSA Publishing
      Aberration-diverse optical coherence tomography for suppression of multiple scattering and speckle
      Multiple scattering is a major barrier that limits the optical imaging depth in scattering media. In order to alleviate this effect, we demonstrate aberration-diverse optical coherence tomography (AD-OCT), which exploits the phase correlation between the deterministic signals from single-scattered photons to suppress the random background caused by multiple scattering and speckle. AD-OCT illuminates the sample volume with diverse aberrated point spread functions, and computationally removes these intentionally applied aberrations. After ...
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      Mentions: Cornell University Steven G. Adie

    3. Volumetric optical coherence microscopy with a high space-bandwidth-time product enabled by hybrid adaptive optics

      Explore OSA | OSA Publishing Microscopy
      Volumetric optical coherence microscopy with a high space-bandwidth-time product enabled by hybrid adaptive optics
      Optical coherence microscopy (OCM) is a promising modality for high resolution imaging, but has limited ability to capture large-scale volumetric information about dynamic biological processes with cellular resolution. To enhance the throughput of OCM, we implemented a hybrid adaptive optics (hyAO) approach that combines computational adaptive optics with an intentionally aberrated imaging beam generated via hardware adaptive optics. Using hyAO, we demonstrate the depth-equalized illumination and collection ability of an ...
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      Mentions: Cornell University Steven G. Adie

    4. Photonic force optical coherence elastography for three-dimensional mechanical microscopy

      Explore Nature Publishing Group
      Photonic force optical coherence elastography for three-dimensional mechanical microscopy
      Optical tweezers are an invaluable tool for non-contact trapping and micro-manipulation, but their ability to facilitate high-throughput volumetric microrheology of biological samples for mechanobiology research is limited by the precise alignment associated with the excitation and detection of individual bead oscillations. In contrast, radiation pressure from a low-numerical aperture optical beam can apply transversely localized force over an extended depth range. Here we present photonic force optical coherence elastography (PF-OCE ...
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      Mentions: Cornell University University of Western Australia Steven G. Adie

    5. Depth-resolved measurement of optical radiation-pressure forces with optical coherence tomography

      Explore OSA | OSA Publishing
      Depth-resolved measurement of optical radiation-pressure forces with optical coherence tomography
      A weakly focused laser beam can exert sufficient radiation pressure to manipulate microscopic particles over a large depth range. However, depth-resolved continuous measurement of radiation-pressure force profiles over an extended range about the focal plane has not been demonstrated despite decades of research on optical manipulation. Here, we present a method for continuous measurement of axial radiation-pressure forces from a weakly focused beam on polystyrene micro-beads suspended in viscous fluids ...
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      Mentions: Cornell University Steven G. Adie

    6. Photonic force optical coherence elastography for threedimensional mechanical microscopy

      Explore arxiv.org
      Photonic force optical coherence elastography for threedimensional mechanical microscopy
      Optical tweezers are an invaluable tool for non-contact trapping and micro-manipulation, but their ability to facilitate high-throughput volumetric microrheology of biological samples for mechanobiology research is limited by the precise alignment associated with the excitation and detection of individual bead oscillations. In contrast, radiation pressure from a low numerical aperture optical beam can apply transversely localized force over an extended depth range. We propose photonic force optical coherence elastography (PF-OCE ...
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      Mentions: Cornell University University of Western Australia Steven G. Adie

    7. Cornell University Receives NIH Grant for Development of Hybrid Adaptive Optics for Multimodal Microscopy Deep in The Mouse Brain

      Explore Optical Coherence Tomography News Neurology , Funding
      Cornell University Receives NIH Grant for Development of Hybrid Adaptive Optics for Multimodal Microscopy Deep in The Mouse Brain
      ...nt of Hybrid Adaptive Optics for Multimodal Microscopy Deep in The Mouse Brain. The principal investigator is Steven Adie. The program began in 2017 and ends in 2019. Below is a summary of the proposed work.

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      Mentions: National Institutes of Health Cornell University Steven G. Adie

    9. Measurement of dynamic cell-induced 3D displacement fields in vitro for traction force optical coherence microscopy

      Explore OSA | OSA Publishing Microscopy
      Measurement of dynamic cell-induced 3D displacement fields in vitro for traction force optical coherence microscopy
      Traction force microscopy (TFM) is a method used to study the forces exerted by cells as they sense and interact with their environment. Cell forces play a role in processes that take place over a wide range of spatiotemporal scales, and so it is desirable that TFM makes use of imaging modalities that can effectively capture the dynamics associated with these processes. To date, confocal microscopy has been the imaging ...
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      Mentions: Cornell University Steven G. Adie

    11. Computational adaptive optics for broadband interferometric tomography of tissues and cells

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      Computational adaptive optics for broadband interferometric tomography of tissues and cells
      Adaptive optics (AO) can shape aberrated optical wavefronts to physically restore the constructive interference needed for high-resolution imaging. With access to the complex optical field, however, many functions of optical hardware can be achieved computationally, including focusing and the compensation of optical aberrations to restore the constructive interference required for diffraction-limited imaging performance. Holography, which employs interferometric detection of the complex optical field, was developed based on this connection between ...
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      Mentions: Cornell University Steven G. Adie

    12. GPU-based computational adaptive optics for volumetric optical coherence microscopy

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      GPU-based computational adaptive optics for volumetric optical coherence microscopy
      Optical coherence tomography (OCT) is a non-invasive imaging technique that measures reflectance from within biological tissues. Current higher-NA optical coherence microscopy (OCM) technologies with near cellular resolution have limitations on volumetric imaging capabilities due to the trade-offs between resolution vs. depth-of-field and sensitivity to aberrations. Such trade-offs can be addressed using computational adaptive optics (CAO), which corrects aberration computationally for all depths based on the complex optical field measured by ...
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      Mentions: Cornell University Steven G. Adie

    13. Intraoperative optical coherence tomography for assessing human lymph nodes for metastatic cancer

      Explore Home - Springer
      Intraoperative optical coherence tomography for assessing human lymph nodes for metastatic cancer
      Background Evaluation of lymph node (LN) status is an important factor for detecting metastasis and thereby staging breast cancer. Currently utilized clinical techniques involve the surgical disruption and resection of lymphatic structure, whether nodes or axillary contents, for histological examination. While reasonably effective at detection of macrometastasis , the majority of the resected lymph nodes are histologically negative. Improvements need to be made to better detect micrometastasis , minimize or eliminate lymphatic ...
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      Mentions: Stephen A. Boppart University of Illinois at Urbana-Champaign Eric J. Chaney

    14. Real-time Imaging of the Resection Bed Using a Handheld Probe to Reduce Incidence of Microscopic Positive Margins in Cancer Surgery

      Explore Cancer Research Oncology , Probes
      Real-time Imaging of the Resection Bed Using a Handheld Probe to Reduce Incidence of Microscopic Positive Margins in Cancer Surgery
      Wide local excision (WLE) is a common surgical intervention for solid tumors such as those in melanoma, breast, pancreatic, and gastrointestinal cancer. However, adequate margin assessment during WLE remains a significant challenge, resulting in surgical reinterventions to achieve adequate local control. Currently, no label-free imaging method is available for surgeons to examine the resection bed in vivo for microscopic residual cancer. Optical coherence tomography (OCT) enables real-time high-resolution imaging of ...
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      Mentions: Stephen A. Boppart University of Illinois at Urbana-Champaign Eric J. Chaney

    15. Computational high-resolution optical imaging of the living human retina

      Explore Nature Publishing Group Ophthalmology
      Computational high-resolution optical imaging of the living human retina
      High-resolution in vivo imaging is of great importance for the fields of biology and medicine. The introduction of hardware-based adaptive optics (HAO) has pushed the limits of optical imaging, enabling high-resolution near diffraction-limited imaging of previously unresolvable structures 1 , 2 . In ophthalmology, when combined with optical coherence tomography, HAO has enabled a detailed three-dimensional visualization of photoreceptor distributions 3 , 4 and individual nerve fibre bundles 5 in the living human ...
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      Mentions: Stephen A. Boppart University of Illinois at Urbana-Champaign Steven G. Adie

    16. Feature Of The Week 10/12/14: University of Illinois at Urbana-Champaign Investigates PS-OCT with Ultimate Aim of Intraoperative Breast Cancer Tumor Margin Assessment

      Explore Optical Coherence Tomography News Oncology
      Feature Of The Week 10/12/14: University of Illinois at Urbana-Champaign Investigates PS-OCT with Ultimate Aim of Intraoperative Breast Cancer Tumor Margin Assessment
      Successful treatment of breast cancer typically requires surgical removal of the tumor. Optical coherence tomography (OCT) has been previously developed for real-time imaging of the surgical margin. However, it can be difficult to distinguish between normal stromal tissue and cancer tissue based on scattering intensity and structure alone. Polarization-sensitive optical coherence tomography (PS-OCT) is sensitive to form birefringence of biological tissue. We report on the development of a high-speed PS-OCT ...
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      Mentions: Stephen A. Boppart University of Illinois at Urbana-Champaign Eric J. Chaney
    17. 1-15 of 52 1 2 3 4 »
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  4. About Steven G. Adie

    Steven G. Adie

    Steven Adie is an Assistant Professor in the Nancy E. and Peter C. Meinig School of Biomedical Engineering at Cornell University. He earned his PhD in Electrical Engineering (Biomedical Optics emphasis) in Prof. David Sampson’s group at The University of Western Australia. After this he did a postdoc in Prof. Stephen Boppart’s group at the Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, before joining Cornell in 2013. His group develops novel OCT, optical coherence elastography (OCE), computational, and multimodal imaging techniques for application to cancer and stem cell mechanobiology, and imaging in the mouse brain. Located on the picturesque Ithaca campus of Cornell University, his group is part of a creative interdisciplinary research environment that has a strong emphasis on Biomedical Optical Imaging, Mechanobiology, and Neurotechology/Neuroscience.

  5. Related Topics

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      39 articles also mentioned University of Illinois at Urbana-Champaign
    2. Three-dimensional optical coherence tomography of whole muscle autografts as a precursor to morphological assessment of muscular dystrophy in mice
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  6. Quotes

    1. Being able to correct aberrations of the entire volume helps us to get a high-resolution image anywhere in that volume...Now you can see tissue structures that previously were not very clear at all.
      In Computing the best high-resolution 3-D tissue images - News from Beckman Institute at UIUC