Cornell University Receives NIH Grant for Development of Hybrid Adaptive Optics for Multimodal Microscopy Deep in The Mouse Brain
...nt of Hybrid Adaptive Optics for Multimodal Microscopy Deep in The Mouse Brain. The principal investigator is Steven Adie. The program began in 2017 and ends in 2019. Below is a summary of the proposed work.
Cornell University Receives a NIH Grant for Volumetric Traction Force Tomography of Collective Sell Migration Dynamics
...for Volumetric Traction Force Tomography of Collective Sell Migration Dynamics. The principal investigator is Steven Adie. The program began in 2016 and ends in 2018. Below is a summary of the proposed work.
Measurement of dynamic cell-induced 3D displacement fields in vitro for traction force optical coherence microscopy
Traction force microscopy (TFM) is a method used to study the forces exerted by cells as they sense and interact with their environment. Cell forces play a role in processes that take place over a wide range of spatiotemporal scales, and so it is desirable that TFM makes use of imaging modalities that can effectively capture the dynamics associated with these processes. To date, confocal microscopy has been the imaging ...
Read Full Article
Postdoctoral Research Associate – Biophotonics / Biomedical Optical Imaging – Cornell University, Ithaca New York
...a cover letter describing your previous research training and its relevance to the areas stated above, to Dr. Steven Adie (sga42@cornell.edu).
About the Adie Lab
Our group develops novel OCT, OCE, computational, and ...
Read Full Article
Computational adaptive optics for broadband interferometric tomography of tissues and cells
Adaptive optics (AO) can shape aberrated optical wavefronts to physically restore the constructive interference needed for high-resolution imaging. With access to the complex optical field, however, many functions of optical hardware can be achieved computationally, including focusing and the compensation of optical aberrations to restore the constructive interference required for diffraction-limited imaging performance. Holography, which employs interferometric detection of the complex optical field, was developed based on this connection between ...
Read Full Article
GPU-based computational adaptive optics for volumetric optical coherence microscopy
Optical coherence tomography (OCT) is a non-invasive imaging technique that measures reflectance from within biological tissues. Current higher-NA optical coherence microscopy (OCM) technologies with near cellular resolution have limitations on volumetric imaging capabilities due to the trade-offs between resolution vs. depth-of-field and sensitivity to aberrations. Such trade-offs can be addressed using computational adaptive optics (CAO), which corrects aberration computationally for all depths based on the complex optical field measured by ...
Read Full Article
Intraoperative optical coherence tomography for assessing human lymph nodes for metastatic cancer
Background Evaluation of lymph node (LN) status is an important factor for detecting metastasis and thereby staging breast cancer. Currently utilized clinical techniques involve the surgical disruption and resection of lymphatic structure, whether nodes or axillary contents, for histological examination. While reasonably effective at detection of macrometastasis , the majority of the resected lymph nodes are histologically negative. Improvements need to be made to better detect micrometastasis , minimize or eliminate lymphatic ...
Read Full Article
Real-time Imaging of the Resection Bed Using a Handheld Probe to Reduce Incidence of Microscopic Positive Margins in Cancer Surgery
Wide local excision (WLE) is a common surgical intervention for solid tumors such as those in melanoma, breast, pancreatic, and gastrointestinal cancer. However, adequate margin assessment during WLE remains a significant challenge, resulting in surgical reinterventions to achieve adequate local control. Currently, no label-free imaging method is available for surgeons to examine the resection bed in vivo for microscopic residual cancer. Optical coherence tomography (OCT) enables real-time high-resolution imaging of ...
Read Full Article
Computational high-resolution optical imaging of the living human retina
High-resolution in vivo imaging is of great importance for the fields of biology and medicine. The introduction of hardware-based adaptive optics (HAO) has pushed the limits of optical imaging, enabling high-resolution near diffraction-limited imaging of previously unresolvable structures 1 , 2 . In ophthalmology, when combined with optical coherence tomography, HAO has enabled a detailed three-dimensional visualization of photoreceptor distributions 3 , 4 and individual nerve fibre bundles 5 in the living human ...
Read Full Article
Feature Of The Week 10/12/14: University of Illinois at Urbana-Champaign Investigates PS-OCT with Ultimate Aim of Intraoperative Breast Cancer Tumor Margin Assessment
Successful treatment of breast cancer typically requires surgical removal of the tumor. Optical coherence tomography (OCT) has been previously developed for real-time imaging of the surgical margin. However, it can be difficult to distinguish between normal stromal tissue and cancer tissue based on scattering intensity and structure alone. Polarization-sensitive optical coherence tomography (PS-OCT) is sensitive to form birefringence of biological tissue. We report on the development of a high-speed PS-OCT ...
Read Full Article
Differentiation of ex vivo human breast tissue using polarization-sensitive optical coherence tomography
... Stephen A. Boppart »View Author Affiliations Fredrick A. South,^1,^2 Eric J. Chaney,^1 Marina Marjanovic,^1 Steven G. Adie,^1 and Stephen A. Boppart^1,^2,^3,^4,^*
^1Beckman Institute for Advanced Science and Technolo...
Read Full Article
Computed optical interferometric tomography for high-speed volumetric cellular imaging
... Scott Carney, and Stephen A. Boppart »View Author Affiliations Yuan-Zhi Liu,^1,^2 Nathan D. Shemonski,^1,^2 Steven G. Adie,^3 Adeel Ahmad,^1,^2 Andrew J. Bower,^1,^2 P. Scott Carney,^1,^2 and Stephen A. Boppart^1,^2,^4...
Read Full Article
Stability in computed optical interferometric tomography (Part II): in vivo stability assessment
.... Scott Carney, and Stephen A. Boppart »View Author Affiliations Nathan D. Shemonski,^1,^2 Adeel Ahmad,^1,^2 Steven G. Adie,^3 Yuan-Zhi Liu,^1,^2 Fredrick A. South,^1,^2 P. Scott Carney,^1,^2 and Stephen A. Boppart^1,^2...
Read Full Article
Stability in computed optical interferometric tomography (Part I): Stability requirements
...edrick A. South, P. Scott Carney, and Stephen A. Boppart »View Author Affiliations Nathan D. Shemonski,^1,^2 Steven G. Adie,^3 Yuan-Zhi Liu,^1,^2 Fredrick A. South,^1,^2 P. Scott Carney,^1,^2 and Stephen A. Boppart^1,^2...
Read Full Article
Multifocal interferometric synthetic aperture microscopy
...tephen A. Boppart, and P. Scott Carney »View Author Affiliations Yang Xu,^1,^2 Xiong Kai Benjamin Chng,^1,^2 Steven G. Adie,^3 Stephen A. Boppart,^1,^2,^4,^5 and P. Scott Carney^1,^2,^*
^1Beckman Institute for Advance...
Read Full Article
-
-
About Steven G. Adie
Steven Adie is an Assistant Professor in the Nancy E. and Peter C. Meinig School of Biomedical Engineering at Cornell University. He earned his PhD in Electrical Engineering (Biomedical Optics emphasis) in Prof. David Sampson’s group at The University of Western Australia. After this he did a postdoc in Prof. Stephen Boppart’s group at the Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, before joining Cornell in 2013. His group develops novel OCT, optical coherence elastography (OCE), computational, and multimodal imaging techniques for application to cancer and stem cell mechanobiology, and imaging in the mouse brain. Located on the picturesque Ithaca campus of Cornell University, his group is part of a creative interdisciplinary research environment that has a strong emphasis on Biomedical Optical Imaging, Mechanobiology, and Neurotechology/Neuroscience.
-
Quotes
-
Being able to correct aberrations of the entire volume helps us to get a high-resolution image anywhere in that volume...Now you can see tissue structures that previously were not very clear at all.
In Computing the best high-resolution 3-D tissue images - News from Beckman Institute at UIUC
-