1. Steven G. Adie

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    1. Mentioned In 57 Articles

    2. Quantitative reconstruction of time-varying 3D cell forces with traction force optical coherence microscopy

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      Quantitative reconstruction of time-varying 3D cell forces with traction force optical coherence microscopy
      Cellular traction forces (CTFs) play an integral role in both physiological processes and disease, and are a topic of interest in mechanobiology. Traction force microscopy (TFM) is a family of methods used to quantify CTFs in a variety of settings. State-of-the-art 3D TFM methods typically rely on confocal fluorescence microscopy, which can impose limitations on acquisition speed, volumetric coverage, and temporal sampling or coverage. In this report, we present the ...
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      Mentions: Cornell University Steven G. Adie

    4. Optical sensing based on measurements of displacements induced by optical forces in viscoelastic media using phase-sensitive optical coherence tomography

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      Optical sensing based on measurements of displacements induced by optical forces in viscoelastic media using phase-sensitive optical coherence tomography
      A system for providing optical actuation and optical sensing can include an optical coherence tomography (OCT) device that performs optical imaging of a sample based on optical interferometry from an optical sampling beam interacting with an optical sample and an optical reference beam; an OCT light source to provide an OCT imaging beam into the OCT device which splits the OCT imaging beam into the optical sampling beam and the ...
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      Mentions: Cornell University Steven G. Adie

    5. Feature Of The Week 09/29/2018: Cornell University Researchers Develop New Method for Ultra-Deep, Speckle-Suppressed, Volumetric Optical Coherence Microscopy

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      Feature Of The Week 09/29/2018: Cornell University Researchers Develop New Method for Ultra-Deep, Speckle-Suppressed, Volumetric Optical Coherence Microscopy
      ...ch for ultra-deep volumetric optical coherence microscopy. For more information see recent Article . Courtesy Steven G. Adie from Cornell University . Multiple scattering is a major barrier that limits the optical imagin...
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      Mentions: Cornell University Steven G. Adie

    6. Aberration-diverse optical coherence tomography for suppression of multiple scattering and speckle

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      Aberration-diverse optical coherence tomography for suppression of multiple scattering and speckle
      Multiple scattering is a major barrier that limits the optical imaging depth in scattering media. In order to alleviate this effect, we demonstrate aberration-diverse optical coherence tomography (AD-OCT), which exploits the phase correlation between the deterministic signals from single-scattered photons to suppress the random background caused by multiple scattering and speckle. AD-OCT illuminates the sample volume with diverse aberrated point spread functions, and computationally removes these intentionally applied aberrations. After ...
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      Mentions: Cornell University Steven G. Adie

    7. Optical sensing based on measurements of displacements induced by optical scattering forces in viscoelastic media using phase-sensitive optical coherence tomography

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      Optical sensing based on measurements of displacements induced by optical scattering forces in viscoelastic media using phase-sensitive optical coherence tomography
      Disclosed are devices and techniques based on optical coherence tomography (OCT) technology in combination with optical actuation. A system for providing optical actuation and optical sensing can include an optical coherence tomography (OCT) device that performs optical imaging of a sample based on optical interferometry from an optical sampling beam interacting with an optical sample and an optical reference beam; an OCT light source to provide an OCT imaging beam ...
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      Mentions: Cornell University Steven G. Adie

    8. Volumetric optical coherence microscopy with a high space-bandwidth-time product enabled by hybrid adaptive optics

      Explore OSA | OSA Publishing Microscopy
      Volumetric optical coherence microscopy with a high space-bandwidth-time product enabled by hybrid adaptive optics
      Optical coherence microscopy (OCM) is a promising modality for high resolution imaging, but has limited ability to capture large-scale volumetric information about dynamic biological processes with cellular resolution. To enhance the throughput of OCM, we implemented a hybrid adaptive optics (hyAO) approach that combines computational adaptive optics with an intentionally aberrated imaging beam generated via hardware adaptive optics. Using hyAO, we demonstrate the depth-equalized illumination and collection ability of an ...
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      Mentions: Cornell University Steven G. Adie

    9. Photonic force optical coherence elastography for three-dimensional mechanical microscopy

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      Photonic force optical coherence elastography for three-dimensional mechanical microscopy
      Optical tweezers are an invaluable tool for non-contact trapping and micro-manipulation, but their ability to facilitate high-throughput volumetric microrheology of biological samples for mechanobiology research is limited by the precise alignment associated with the excitation and detection of individual bead oscillations. In contrast, radiation pressure from a low-numerical aperture optical beam can apply transversely localized force over an extended depth range. Here we present photonic force optical coherence elastography (PF-OCE ...
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      Mentions: Cornell University University of Western Australia Steven G. Adie

    10. Depth-resolved measurement of optical radiation-pressure forces with optical coherence tomography

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      Depth-resolved measurement of optical radiation-pressure forces with optical coherence tomography
      A weakly focused laser beam can exert sufficient radiation pressure to manipulate microscopic particles over a large depth range. However, depth-resolved continuous measurement of radiation-pressure force profiles over an extended range about the focal plane has not been demonstrated despite decades of research on optical manipulation. Here, we present a method for continuous measurement of axial radiation-pressure forces from a weakly focused beam on polystyrene micro-beads suspended in viscous fluids ...
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      Mentions: Cornell University Steven G. Adie

    11. Photonic force optical coherence elastography for threedimensional mechanical microscopy

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      Photonic force optical coherence elastography for threedimensional mechanical microscopy
      Optical tweezers are an invaluable tool for non-contact trapping and micro-manipulation, but their ability to facilitate high-throughput volumetric microrheology of biological samples for mechanobiology research is limited by the precise alignment associated with the excitation and detection of individual bead oscillations. In contrast, radiation pressure from a low numerical aperture optical beam can apply transversely localized force over an extended depth range. We propose photonic force optical coherence elastography (PF-OCE ...
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      Mentions: Cornell University University of Western Australia Steven G. Adie

    12. Cornell University Receives NIH Grant for Development of Hybrid Adaptive Optics for Multimodal Microscopy Deep in The Mouse Brain

      Explore Optical Coherence Tomography News Neurology , Funding
      Cornell University Receives NIH Grant for Development of Hybrid Adaptive Optics for Multimodal Microscopy Deep in The Mouse Brain
      ...nt of Hybrid Adaptive Optics for Multimodal Microscopy Deep in The Mouse Brain. The principal investigator is Steven Adie. The program began in 2017 and ends in 2019. Below is a summary of the proposed work.

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      Mentions: National Institutes of Health Cornell University Steven G. Adie

    14. Measurement of dynamic cell-induced 3D displacement fields in vitro for traction force optical coherence microscopy

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      Measurement of dynamic cell-induced 3D displacement fields in vitro for traction force optical coherence microscopy
      Traction force microscopy (TFM) is a method used to study the forces exerted by cells as they sense and interact with their environment. Cell forces play a role in processes that take place over a wide range of spatiotemporal scales, and so it is desirable that TFM makes use of imaging modalities that can effectively capture the dynamics associated with these processes. To date, confocal microscopy has been the imaging ...
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      Mentions: Cornell University Steven G. Adie

    16. Computational adaptive optics for broadband interferometric tomography of tissues and cells

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      Computational adaptive optics for broadband interferometric tomography of tissues and cells
      Adaptive optics (AO) can shape aberrated optical wavefronts to physically restore the constructive interference needed for high-resolution imaging. With access to the complex optical field, however, many functions of optical hardware can be achieved computationally, including focusing and the compensation of optical aberrations to restore the constructive interference required for diffraction-limited imaging performance. Holography, which employs interferometric detection of the complex optical field, was developed based on this connection between ...
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      Mentions: Cornell University Steven G. Adie
    17. 1-15 of 57 1 2 3 4 »
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  4. About Steven G. Adie

    Steven G. Adie

    Steven Adie is an Assistant Professor in the Nancy E. and Peter C. Meinig School of Biomedical Engineering at Cornell University. He earned his PhD in Electrical Engineering (Biomedical Optics emphasis) in Prof. David Sampson’s group at The University of Western Australia. After this he did a postdoc in Prof. Stephen Boppart’s group at the Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, before joining Cornell in 2013. His group develops novel OCT, optical coherence elastography (OCE), computational, and multimodal imaging techniques for application to cancer and stem cell mechanobiology, and imaging in the mouse brain. Located on the picturesque Ithaca campus of Cornell University, his group is part of a creative interdisciplinary research environment that has a strong emphasis on Biomedical Optical Imaging, Mechanobiology, and Neurotechology/Neuroscience.

  5. Related Topics

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    2. Three-dimensional optical coherence tomography of whole muscle autografts as a precursor to morphological assessment of muscular dystrophy in mice
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  6. Quotes

    1. Being able to correct aberrations of the entire volume helps us to get a high-resolution image anywhere in that volume...Now you can see tissue structures that previously were not very clear at all.
      In Computing the best high-resolution 3-D tissue images - News from Beckman Institute at UIUC