1. Stephen Lam

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    1. Mentioned In 22 Articles

    2. High speed, wide velocity dynamic range Doppler optical coherence tomography (Part IV): split spectrum processing in rotary catheter probes

      High speed, wide velocity dynamic range Doppler optical coherence tomography (Part IV): split spectrum processing in rotary catheter probes
      ...ctor X.D. Yang »View Author Affiliations Barry Vuong,^1 Anthony M.D. Lee,^2 Timothy W.H. Luk,^1 Cuiru Sun,^1 Stephen Lam,^2 Pierre Lane,^2 and Victor X.D. Yang^1,^3,^4,^* ^1Biophotonics and Bioengineering Laboratory, ...
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    3. Automated segmentation of porcine airway wall layers using optical coherence tomography: comparison with manual segmentation and histology

      Automated segmentation of porcine airway wall layers using optical coherence tomography: comparison with manual segmentation and histology
      ...segmentation and histology Miranda Kirby ; Anthony M. D. Lee ; Tara Candido ; Calum MacAulay ; Pierre Lane ; Stephen Lam ; Harvey O. Coxson; Automated segmentation of porcine airway wall layers using optical coherence t...
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    4. Multimodal tissue imaging: using coregistered optical tomography data to estimate tissue autofluorescence intensity change due to scattering and absorption by neoplastic epithelial cells

      Multimodal tissue imaging: using coregistered optical tomography data to estimate tissue autofluorescence intensity change due to scattering and absorption by neoplastic epithelial cells

      Autofluorescence (AF) imaging provides valuable information about the structural and chemical states of tissue that can be used for early cancer detection. Optical scattering and absorption of excitation and emission light by the epithelium can significantly affect observed tissue AF intensity. Determining the effect of epithelial attenuation on the AF intensity could lead to a more accurate interpretation of AF intensity. We propose to use optical coherence tomography coregistered with AF imaging to characterize the AF attenuation due to the epithelium. We present imaging results from three vital tissue models, each consisting of a three-dimensional tissue culture grown from one ...

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    5. In vivo lung microvasculature visualized in three dimensions using fiber-optic color Doppler optical coherence tomography

      In vivo lung microvasculature visualized in three dimensions using fiber-optic color Doppler optical coherence tomography

      For the first time, the use of fiber-optic color Doppler optical coherence tomography (CDOCT) to map in vivo the three-dimensional (3-D) vascular network of airway segments in human lungs is demonstrated. Visualizing the 3-D vascular network in the lungs may provide new opportunities for detecting and monitoring lung diseases such as asthma, chronic obstructive pulmonary disease, and lung cancer. Our CDOCT instrument employs a rotary fiber-optic probe that provides simultaneous two-dimensional (2-D) real-time structural optical coherence tomography (OCT) and CDOCT imaging at frame rates up to 12.5 frames per second. Controlled pullback of the probe allows 3-D vascular mapping ...

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    6. Interventions in Pulmonary Medicine (Book)

      Interventions in Pulmonary Medicine (Book)

      Optical coherence tomography (OCT) is a promising technique for clinical diagnosis of various types of tissue, because high-resolution tomography is easily obtained by its compact imaging optics. The fundamental principles of OCT evolved from optical one-dimensional low-coherence reflectometry, which uses a Michelson interferometer and a broadband light source. Due to the additional transverse scanning (B-scan), two-dimensional imaging was obtained, and this technique was named OCT by Fujimoto and rapidly expanded to numerous biomedical and clinical applications

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    7. Lung vasculature imaging using speckle variance optical coherence tomography

      Lung vasculature imaging using speckle variance optical coherence tomography

      Architectural changes in and remodeling of the bronchial and pulmonary vasculature are important pathways in diseases such as asthma, chronic obstructive pulmonary disease (COPD), and lung cancer. However, there is a lack of methods that can find and examine small bronchial vasculature in vivo. Structural lung airway imaging using optical coherence tomography (OCT) has previously been shown to be of great utility in examining bronchial lesions during lung cancer screening under the guidance of autofluorescence bronchoscopy. Using a fiber optic endoscopic OCT probe, we acquire OCT images from in vivo human subjects. The side-looking, circumferentially-scanning probe is inserted down the ...

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  2. About Stephen Lam

    Stephen Lam

    Stephen Lam is with the Cancer Imaging Department at the  British Columbia Cancer Agency in Canada.