1. Stephen Lam

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    1. Mentioned In 37 Articles

    2. Fiber optic endoscopic optical coherence tomography (OCT) to assess human airways: The relationship between anatomy and physiological function during dynamic exercise

      Explore The Physiological Society Pulmonology
      Fiber optic endoscopic optical coherence tomography (OCT) to assess human airways: The relationship between anatomy and physiological function during dynamic exercise
      Airway luminal area (A i ) influences respiratory mechanics during dynamic exercise; however, previous studies have investigated the relationship between airway anatomy and physiological function in different groups of individuals. The purpose of this study was to determine the effect of A i on respiratory mechanics by making in vivo measures of airway dimensions and work of breathing (Wb) in the same individuals. Healthy participants (3F/2M; 23-45 years) completed a ...
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      Mentions: University of British Columbia Stephen Lam Pierre M. Lane

    3. Feasibility of combined optical coherence tomography and autofluorescence imaging for visualization of needle biopsy placement

      Explore SPIE Digital Library Probes
      Feasibility of combined optical coherence tomography and autofluorescence imaging for visualization of needle biopsy placement
      Significance: Diagnosis of suspicious lung nodules requires precise collection of relevant biopsies for histopathological analysis. Using optical coherence tomography and autofluorescence imaging (OCT-AFI) to improve diagnostic yield in parts of the lung inaccessible to larger imaging methods may allow for reducing complications related to the alternative of computed tomography-guided biopsy. Aim: Feasibility of OCT-AFI combined with a commercially available lung biopsy needle was demonstrated for visualization of needle puncture sites ...
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      Mentions: British Columbia Cancer Agency Stephen Lam Simon Fraser University

    4. Systems for optical imaging of biological tissues

      Explore uspto.gov Patents
      Systems for optical imaging of biological tissues
      A fiber-based polarization sensitive optical coherence tomography (PS-OCT) system uses a new polarization diversity detection (PDD) scheme and requires no active polarization modulating components. Retardation of the sample can be determined from amplitudes of arbitrarily-oriented x- and y-components of the reflected light. A hybrid custom 50/50 coupler with single-mode fiber inputs and polarization maintaining (PM) fiber outputs combines light from sample and reference arms of an interferometer. Another embodiment ...
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      Mentions: British Columbia Cancer Agency Stephen Lam Pierre M. Lane

    5. Correction of motion artifacts in endoscopic optical coherence tomography and autofluorescence images based on azimuthal en face image registration

      Explore SPIE Digital Library Cardiology
      Correction of motion artifacts in endoscopic optical coherence tomography and autofluorescence images based on azimuthal en face image registration
      We present a method for the correction of motion artifacts present in two- and three-dimensionalin vivoendoscopic images produced by rotary-pullback catheters. This method can correct for cardiac/breathing-based motion artifacts and catheter-based motion artifacts such as nonuniform rotational distortion (NURD). This method assumes thaten facetissue imaging contains slowly varying structures that are roughly parallel to the pullback axis. The method reduces motion artifacts using a dynamic time warping solution through ...
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      Mentions: British Columbia Cancer Agency Stephen Lam Pierre M. Lane

    6. Early Cancer Detection (Book Chapter)

      Explore European Respiratory Society Pulmonology , Textbooks
      Early Cancer Detection (Book Chapter)
      Lung cancer is the leading cause of cancer deaths worldwide as the majority of patient shave advanced disease at diagnosis. Detection and early treatment of pre-invasive and minimally invasive lung cancer can significantly improve the current 5-year survival of 18%, Endoscopic optical imaging (such as autoflourescence imaging), NBI, and OCT provide sensitive means to rapidly scan the central airways , in order to detect early lung cancer for biopsy confirmation and ...
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      Mentions: British Columbia Cancer Agency Stephen Lam

    7. Optical Coherence Tomography: A Review (Book Chapter)

      Explore Home - Springer Pulmonology , Textbooks
      Optical Coherence Tomography: A Review (Book Chapter)
      Optical coherence tomography (OCT), with polarization-sensitive (PS), Doppler, and autofluorescence (AF) capabilities, is emerging as a promising bronchoscopic diagnostic tool. In the upper and central airways, it allows accurate real-time airway measurements to assist bronchoscopic assessment of obstructive sleep apnea, severity of tracheomalacia, airway stenosis, or extent of tumor involvement into the bronchial wall or distally beyond the bronchoscopic view. OCT can visualize cellular and extracellular structures at and below ...
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      Mentions: British Columbia Cancer Agency Stephen Lam

    8. Sex Differences in Airway Remodeling in a Mouse Model of Chronic Obstructive Pulmonary Disease

      Explore Home (thoracic) Pulmonology
      Sex Differences in Airway Remodeling in a Mouse Model of Chronic Obstructive Pulmonary Disease
      Rationale: Adjusting for the amount of smoking, women have a 50% increased risk of COPD compared with men. It is not known what the anatomic basis/mechanism(s) of these sex-related differences in COPD might be. Objective: To characterize the impact of female sex hormones on chronic cigarette smoke-induced airway remodeling and emphysema in a mouse model of COPD. Methods: Airway remodeling and emphysema were determined morphometrically in male, female ...
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      Mentions: British Columbia Cancer Agency Stephen Lam Harvey O. Coxson

    9. Reproducibility of optical coherence tomography airway imaging

      Explore OSA | OSA Publishing Pulmonology
      Reproducibility of optical coherence tomography airway imaging
      Optical coherence tomography (OCT) is a promising imaging technique to evaluate small airway remodeling. However, the short-term insertion-reinsertion reproducibility of OCT for evaluating the same bronchial pathway has yet to be established. We evaluated 74 OCT data sets from 38 current or former smokers twice within a single imaging session. Although the overall insertion-reinsertion airway wall thickness (WT) measurement coefficient of variation (CV) was moderate at 12%, much of the ...
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      Mentions: University of British Columbia Stephen Lam Harvey O. Coxson

    10. Endoscopic Doppler optical coherence tomography and autofluorescence imaging of peripheral pulmonary nodules and vasculature

      Explore OSA | OSA Publishing Oncology , Pulmonology
      Endoscopic Doppler optical coherence tomography and autofluorescence imaging of peripheral pulmonary nodules and vasculature
      We present the first endoscopic Doppler optical coherence tomography and co-registered autofluorescence imaging (DOCT-AFI) of peripheral pulmonary nodules and vascular networks in vivo using a small 0.9 mm diameter catheter. Using exemplary images from volumetric data sets collected from 31 patients during flexible bronchoscopy, we demonstrate how DOCT and AFI offer complementary information that may increase the ability to locate and characterize pulmonary nodules. AFI offers a sensitive visual ...
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      Mentions: British Columbia Cancer Agency Stephen Lam Pierre M. Lane

    11. Systems For Optical Imaging Of Biological Tissues

      Explore patentscope.wipo.int Patents
      Systems For Optical Imaging Of Biological Tissues
      A fiber-based polarization sensitive optical coherence tomography (PS-OCT) system uses a new polarization diversity detection (PDD) scheme and requires no active polarization modulating components. Retardation of the sample can be determined from amplitudes of arbitrarily-oriented x- and y-components of the reflected light. A hybrid custom 50/50 coupler with single-mode fiber inputs and polarization maintaining (PM) fiber outputs combines light from sample and reference arms of an interferometer. Another embodiment ...
      Read Full Article
      Mentions: British Columbia Cancer Agency Stephen Lam Pierre M. Lane

    12. Bronchial thermoplasty in asthma: 2-year follow-up using optical coherence tomography

      Explore European Respiratory Journal Pulmonology
      Bronchial thermoplasty in asthma: 2-year follow-up using optical coherence tomography
      Bronchial thermoplasty (BT) is a novel, nonpharmacological procedure for treatment of severe asthma. Recently, the Asthma Intervention Research 2 clinical trial demonstrated asthmatics had fewer hospitalisations following BT, which persisted 5 years after therapy [1]. However, it is well recognised that asthma is a heterogeneous disease with distinct asthma phenotypes and, not surprisingly, not all asthmatics in that trial benefited from BT [2].
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      Mentions: University of British Columbia Stephen Lam Peking University

    13. Passive endoscopic polarization sensitive optical coherence tomography with completely fiber based optical components

      Explore Conference Proceedings Gastroenterology
      Passive endoscopic polarization sensitive optical coherence tomography with completely fiber based optical components
      ... Lane Samson Ng Endoscopic Microscopy X; and Optical Techniques in Pulmonary Medicine II Melissa J. Suter; Stephen Lam; Matthew Brenner; Guillermo J. Tearney; Thomas D. Wang San Francisco, California, United States |...
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      Mentions: University of British Columbia British Columbia Cancer Agency Stephen Lam

    16. A high-efficiency fiber-based imaging system for co-registered autofluorescence and optical coherence tomography

      Explore opticsinfobase.org Pulmonology
      A high-efficiency fiber-based imaging system for co-registered autofluorescence and optical coherence tomography
      We present a power-efficient fiber-based imaging system capable of co-registered autofluorescence imaging and optical coherence tomography (AF/OCT). The system employs a custom fiber optic rotary joint (FORJ) with an embedded dichroic mirror to efficiently combine the OCT and AF pathways. This three-port wavelength multiplexing FORJ setup has a throughput of more than 83% for collected AF emission, significantly more efficient compared to previously reported fiber-based methods. A custom 900 ...
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      Mentions: Victor X. D. Yang British Columbia Cancer Agency Stephen Lam
    17. 1-15 of 37 1 2 3 »
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  4. About Stephen Lam

    Stephen Lam

    Stephen Lam is with the Cancer Imaging Department at the British Columbia Cancer Agency in Canada.

  5. Related Topics

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    4. Multimodal tissue imaging: using coregistered optical tomography data to estimate tissue autofluorescence intensity change due to scattering and absorption by neoplastic epithelial cells
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