1. Stephen Lam

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    1. Mentioned In 31 Articles

    2. Sex Differences in Airway Remodeling in a Mouse Model of Chronic Obstructive Pulmonary Disease

      Sex Differences in Airway Remodeling in a Mouse Model of Chronic Obstructive Pulmonary Disease
      Rationale: Adjusting for the amount of smoking, women have a 50% increased risk of COPD compared with men. It is not known what the anatomic basis/mechanism(s) of these sex-related differences in COPD might be. Objective: To characterize the impact of female sex hormones on chronic cigarette smoke-induced airway remodeling and emphysema in a mouse model of COPD. Methods: Airway remodeling and emphysema were determined morphometrically in male, female ...
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    3. Reproducibility of optical coherence tomography airway imaging

      Reproducibility of optical coherence tomography airway imaging
      Optical coherence tomography (OCT) is a promising imaging technique to evaluate small airway remodeling. However, the short-term insertion-reinsertion reproducibility of OCT for evaluating the same bronchial pathway has yet to be established. We evaluated 74 OCT data sets from 38 current or former smokers twice within a single imaging session. Although the overall insertion-reinsertion airway wall thickness (WT) measurement coefficient of variation (CV) was moderate at 12%, much of the ...
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    4. Endoscopic Doppler optical coherence tomography and autofluorescence imaging of peripheral pulmonary nodules and vasculature

      Endoscopic Doppler optical coherence tomography and autofluorescence imaging of peripheral pulmonary nodules and vasculature
      We present the first endoscopic Doppler optical coherence tomography and co-registered autofluorescence imaging (DOCT-AFI) of peripheral pulmonary nodules and vascular networks in vivo using a small 0.9 mm diameter catheter. Using exemplary images from volumetric data sets collected from 31 patients during flexible bronchoscopy, we demonstrate how DOCT and AFI offer complementary information that may increase the ability to locate and characterize pulmonary nodules. AFI offers a sensitive visual ...
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    5. Systems For Optical Imaging Of Biological Tissues

      Systems For Optical Imaging Of Biological Tissues
      A fiber-based polarization sensitive optical coherence tomography (PS-OCT) system uses a new polarization diversity detection (PDD) scheme and requires no active polarization modulating components. Retardation of the sample can be determined from amplitudes of arbitrarily-oriented x- and y-components of the reflected light. A hybrid custom 50/50 coupler with single-mode fiber inputs and polarization maintaining (PM) fiber outputs combines light from sample and reference arms of an interferometer. Another embodiment ...
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    6. Bronchial thermoplasty in asthma: 2-year follow-up using optical coherence tomography

      Bronchial thermoplasty in asthma: 2-year follow-up using optical coherence tomography
      Bronchial thermoplasty (BT) is a novel, nonpharmacological procedure for treatment of severe asthma. Recently, the Asthma Intervention Research 2 clinical trial demonstrated asthmatics had fewer hospitalisations following BT, which persisted 5 years after therapy [1]. However, it is well recognised that asthma is a heterogeneous disease with distinct asthma phenotypes and, not surprisingly, not all asthmatics in that trial benefited from BT [2].
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    7. Passive endoscopic polarization sensitive optical coherence tomography with completely fiber based optical components

      Passive endoscopic polarization sensitive optical coherence tomography with completely fiber based optical components
      ... Lane Samson Ng Endoscopic Microscopy X; and Optical Techniques in Pulmonary Medicine II Melissa J. Suter; Stephen Lam; Matthew Brenner; Guillermo J. Tearney; Thomas D. Wang San Francisco, California, United States |...
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    8. A high-efficiency fiber-based imaging system for co-registered autofluorescence and optical coherence tomography

      A high-efficiency fiber-based imaging system for co-registered autofluorescence and optical coherence tomography
      We present a power-efficient fiber-based imaging system capable of co-registered autofluorescence imaging and optical coherence tomography (AF/OCT). The system employs a custom fiber optic rotary joint (FORJ) with an embedded dichroic mirror to efficiently combine the OCT and AF pathways. This three-port wavelength multiplexing FORJ setup has a throughput of more than 83% for collected AF emission, significantly more efficient compared to previously reported fiber-based methods. A custom 900 ...
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    9. High speed, wide velocity dynamic range Doppler optical coherence tomography (Part IV): split spectrum processing in rotary catheter probes

      High speed, wide velocity dynamic range Doppler optical coherence tomography (Part IV): split spectrum processing in rotary catheter probes
      ...ctor X.D. Yang »View Author Affiliations Barry Vuong,^1 Anthony M.D. Lee,^2 Timothy W.H. Luk,^1 Cuiru Sun,^1 Stephen Lam,^2 Pierre Lane,^2 and Victor X.D. Yang^1,^3,^4,^* ^1Biophotonics and Bioengineering Laboratory, ...
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    10. Automated segmentation of porcine airway wall layers using optical coherence tomography: comparison with manual segmentation and histology

      Automated segmentation of porcine airway wall layers using optical coherence tomography: comparison with manual segmentation and histology
      ...segmentation and histology Miranda Kirby ; Anthony M. D. Lee ; Tara Candido ; Calum MacAulay ; Pierre Lane ; Stephen Lam ; Harvey O. Coxson; Automated segmentation of porcine airway wall layers using optical coherence t...
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    11. 1-15 of 31 1 2 »
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  2. About Stephen Lam

    Stephen Lam

    Stephen Lam is with the Cancer Imaging Department at the  British Columbia Cancer Agency in Canada.