1. Stephen A. Boppart

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    1. Mentioned In 169 Articles

    2. Aberration characterization for the optimal design of high-resolution endoscopic optical coherence tomography catheters

      Aberration characterization for the optimal design of high-resolution endoscopic optical coherence tomography catheters
      ...icroscopy : Coherence tomography ToC Category: Microscopy Citation Wladimir A. Benalcazar, Woonggyu Jung, and Stephen A. Boppart, "Aberration characterization for the optimal design of high-resolution endoscopic optical ...
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    3. Integrated multimodal optical microscopy for structural and functional imaging of engineered and natural skin

      Integrated multimodal optical microscopy for structural and functional imaging of engineered and natural skin

      An integrated multimodal optical microscope is demonstrated for high-resolution, structural and functional imaging of engineered and natural skin. This microscope incorporates multiple imaging modalities including optical coherence (OCM), multi-photon (MPM), and fluorescence lifetime imaging microscopy (FLIM), enabling simultaneous visualization of multiple contrast sources and mechanisms from cells and tissues. Spatially co-registered OCM/MPM/FLIM images of multi-layered skin tissues are obtained, which are formed based on complementary information provided by different modalities, i.e., scattering information from OCM, molecular information from MPM, and functional cellular metabolism states from FLIM. Cellular structures in both the dermis and epidermis, especially different morphological ...

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    4. Device and method for imaging the ear using optical coherence tomography

      Device and method for imaging the ear using optical coherence tomography

      A method of forming an image of tissue. The method includes non-invasively inserting a fiber-based device into a patient's ear canal and acquiring OCT data from ear tissue while the fiber-based device is in the ear canal. The method also includes converting the OCT data into at least one image.

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    5. 4th Biophotonics Summer School at University of Illinois at Urbana-Champaign May 21st - June 1st, 2012

      4th Biophotonics Summer School at University of Illinois at Urbana-Champaign May 21st - June 1st, 2012

      The 4th Biophotonics Summer School, funded in part by the Network for Computational Nanotechnology (a resource supported by the National Science Foundation), and the University of Illinois Imaging Initiative, will take place at the University of Illinois at Urbana-Champaign, May 21- June 1, 2012. This is a two-week event aimed at training graduate students and post-doctoral associates with research interests at the interface between optics, biomedicine, and nanotechnology. The School combines lectures and presentations with hands-on labs, delivered by experts in the field.

      The tuition and lodging are free for qualified students who register by March 15. There is a ...

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    6. Real Time Optical Coherence Tomography (OCT) of Human Tissue

      Real Time Optical Coherence Tomography (OCT) of Human Tissue
      This is a single-arm, prospective, study of an optical imaging device on approximately twenty (20) subjects undergoing lumpectomies at one study site. In vivo and ex vivo imaging will be performed on study subjects with results being compared to final pathology. This study is a single-center, prospective, two-part open label study of an optical imaging device on approximately twenty (20) subjects at one (1) study site. Patients scheduled to undergo a lumpectomy will be recruited by the clinical investigators at the investigational site in accordance with the inclusion and exclusion criteria. The study period per subject is the time it ...
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    7. Multimodal in vivo skin imaging with integrated optical coherence and multiphoton microscopy

      Multimodal in vivo skin imaging with integrated optical coherence and multiphoton microscopy
      In this paper we demonstrate high resolution, multimodal in vivo imaging of human skin using optical coherence (OCM) and multiphoton microscopy (MPM). These two modalities are integrated into a single instrument to enable simultaneous acquisition and co-registration. The system design and the OCM image processing architecture enable sufficient performance of both modalities for in vivo imaging of human skin. Examples of multimodal in vivo imaging are presented as well as time lapse imaging of blood flow in single capillaries. By making use of multiple intrinsic contrast mechanisms this integrated technique improves the ability to non-invasively visualize living tissue. Integrated OCM ...
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    8. Optical coherence tomography for rapid tissue screening and directed histological sectioning

      Optical coherence tomography for rapid tissue screening and directed histological sectioning
      In pathology, histological examination of the tissue is the “gold standard” to diagnose various diseases. It has contributed significantly toward identifying the abnormalities in tissues and cells, but has inherent drawbacks when used for fast and accurate diagnosis. These limitations include the lack of in vivo observation in real time and sampling errors due to limited number and area coverage of tissue sections. Its diagnostic yield also varies depending on the ability of the physician and the effectiveness of any image guidance technique that may be used for tissue screening during excisional biopsy. In order to overcome these current limitations ...
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    9. Evaluation of caries-affected dentin with optical coherence tomography

      Evaluation of caries-affected dentin with optical coherence tomography
      The purpose of this study was to evaluate the degree of demineralization of artificially induced caries-affected human dentin by an in vitro microbiological method. The occlusal surfaces of 6 human molar teeth were abraded until a flat surface was obtained, and the enamel was removed to expose the occlusal dentin surface. These teeth were sectioned in 12 halves in the vestibular-lingual direction and divided into 3 groups according to the period length of the microbiological essay (n = 4): G1, 7 days; G2, 14 days; and G3, 21 days. The surfaces of all specimens were protected by an acid-resistant nail varnish ...
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    10. Interferometric Synthetic Aperture Microscopy (ISAM) Reconstruction and Characterization In A High Numerical Aperture System (Thesis)

      Interferometric Synthetic Aperture Microscopy (ISAM) Reconstruction and Characterization In A High Numerical Aperture System (Thesis)
      Optical coherence microscopy (OCM) is an imaging modality that is capable of visualizing structural features of biological samples at high resolution based on their scattering properties. Interferometric synthetic aperture microscopy (ISAM) is a newer technique that can overcome the typical dependence between lateral resolution and depth-of-focus of an optical coherence tomography (OCT) imaging system by offering spatially invariant resolution within the whole 3D data set, including regions that are outside of the focal region. Both OCM and ISAM have many potential research and clinical applications. By combining OCM and ISAM, it is possible to visualize an entire 3D volumetric data ...
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    11. 61-75 of 169 « 1 2 3 4 5 6 7 8 ... 10 11 12 »
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  2. About Stephen A. Boppart

    Stephen A. Boppart

    Stephen A. Boppart is a professor in the Biophotonics Imaging Laboratory at the University of Illinois Urbana Champaign.  Dr. Boppart received his Ph.D. from the Massachusetts Institute of Technology in 1998, followed by a M.D. from Harvard Medical School in 2000. Currently Prof. Boppart is a full-time faculty member in the Beckman Institute Nanoelectronics and Biophotonics Group as well as an associate professor in the UIUC Department of Electrical and Computer Engineering and the Bioengineering Department. In January 2007, he was named the Founding Director of the Mills Breast Cancer Institute at Carle Foundation Hospital. Dr. Boppart is also a Clinical Research Physician in the UI College of Medicine-Urbana. His fields of professional interest include optical imaging (specifically in Optical Coherence Tomography) and biophotonics in medicine and biology.

  3. Quotes

    1. Jim's innovation, scholarly activities, professional service, entrepreneurial efforts, and impact on the field of biomedical optics typifies the spirit of this award, and reflects the seminal changes that Britton Chance made during his lifetime...Few researchers in the world today have had such a profound impact as a result of their technological work that has literally changed our field, changed the way we practice medicine, and directly improved the lives of perhaps hundreds of thousands of patients (considering ophthalmology and cardiology).
      In Fujimoto Honored with Britton Chance Biomedical Optics Award
    2. We know that antibiotics don’t always work well if you have a biofilm, because the bacteria protect themselves and become resistant...In the presence of a chronic ear infection that has a biofilm, the bacteria may not respond to the usual antibiotics, and you need to stop them. But without being able to detect the biofilm, we have no idea whether or not it’s responding to treatment.
      In Nowhere to hide: New device sees bacteria behind the eardrum
    3. I think it's going to dramatically change things...What we hope is that diagnosis is going to get shifted closer and closer to the point of care...We’re developing techniques to get at molecular changes..So much of medicine and pathology are based on structural changes. If we think of a pathologist looking at a slide, he or she looks at the cells and tissue structures. A radiologist will look at how organs and these anatomical structures are arranged...But with a lot of these techniques, we can get the molecular changes where disease starts. So a pathologist that has molecular information, not just structural, will perhaps catch disease earlier. The same is true for Rohit’s work and Gabi’s work.
      In Positive Results: A New Era for Medical Diagnostics - News from UIUC
    4. It's the same challenge, but instead of imaging through the atmosphere, we're imaging through tissue, and instead of imaging a star, we're imaging a cell.
      In Computing the best high-resolution 3-D tissue images - News from Beckman Institute at UIUC
    5. The effectiveness is striking...Because of the aberrations of the human eye, when you look at the retina without adaptive optics you just see variations of light and dark areas that represent the rods and cones. But when you use adaptive optics, you see the rods and cones as distinct objects...are working to compute the best image possible.
      In Computing the best high-resolution 3-D tissue images - News from Beckman Institute at UIUC
    6. to emphasize the role of medical imaging and how this technology has enabled us to look into the body at many different size scales, how imaging has enabled us to diagnose disease, and how imaging has made a difference in our healthcare...Federal dollars have been used to fund technology that’s going to change and improve health care. They already have. In the area of optics and high-resolution optical imaging, there’s going to be better healthcare, economic development with new companies, new jobs, and new areas of research to investigate...We can now do real-time microscopic imaging in the operating room without waiting for pathology.
      In Boppart Presents at Congressional Briefing
    7. In the end, I expect the cost of this system will be slightly more than what it replaces, but with significantly more capabilities, I do expect the cost of this system to continue to fall as more systems are developed and demand increases...This will be a boon for poorer hospitals and Third World or developing countries...It is essentially a portable imaging system with digital data that can be sent via cell-phone networks for analysis by experts in larger cities/hospitals.
      In Scientists awarded grant to continue developing optical device for medical exams
    8. The result of this – if successful, could really reduce our health care costs and streamline our delivery of health care.
      In NIH Awards Stephen Boppart $5M For A Bioengineering Research Partnership to Develop Handheld Optical Imaging Technology
    9. We are trying to build a small, handheld unit that has multiple tips...What’s collected is 3D digital data that can image several millimeters into tissue and at micron-scale resolution...The primary care physician is the best person to screen the general population for disease...“We think that it’s going to completely change the way we treat ear infections.
      In NIH Awards Stephen Boppart $5M For A Bioengineering Research Partnership to Develop Handheld Optical Imaging Technology
    10. The diagnosis is made based on very subjective interpretation – how the cells are laid out, the structure, the morphology...This is what we call the gold standard for diagnosis. We want to make the process of medical diagnostics more quantitative and more rapid.
      In New imaging technique accurately finds cancer cells, fast