1. Stephen A. Boppart

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    1. Mentioned In 174 Articles

    2. Intraoperative assessment of tumor margins with a new optical imaging technology: A multi-center, randomized, blinded clinical trial

      Intraoperative assessment of tumor margins with a new optical imaging technology: A multi-center, randomized, blinded clinical trial

      Background: Partial mastectomy is the most commonly performed procedure for invasive breast cancer and is associated with a reexcision rate commonly ranging from 20% to 40% in the literature. This high rate of reexcision is associated with significant additional cost (estimated over $4,000 per reexcision) and lower quality outcomes. Optical coherence tomography (OCT) is a high-resolution imaging technology that images tissue structure with micron-scale resolution – on the same scale as histopathology. It is similar to ultrasound except it uses near infra-red light waves instead of sound waves to create detailed images several millimeters deep into tissue. Although widely used ...

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    3. Feature Of The Week 12/9/12: University of Illinois at Urbana Champaign Researchers Extend Astronomical Guide-Star Techniques to Computational OCT Imaging

      Feature Of The Week 12/9/12: University of Illinois at Urbana Champaign Researchers Extend Astronomical Guide-Star Techniques to Computational OCT Imaging

      Researchers at the University of Illinois at Urbana-Champaign have a long history of novel work in the field of OCT and related fields.  This includes the very promising area of computational adaptive optics and related methods that offer the promise of dramatically improved images in a wide variety of settings by performing post-acquisition processing of magnitude and phase data.  Below is a summary of some of their recent work.  Aberrations degrade resolution, contrast, and signal-to-noise ratio in optical microscopy. In optical coherence tomography (OCT), aberrations limit the resolution of diagnostic features, notably in retinal OCT. With optical coherence microscopy, which ...

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    4. Guide-star-based computational adaptive optics for broadband interferometric tomography

      Guide-star-based computational adaptive optics for broadband interferometric tomography

      We present a method for the numerical correction of optical aberrations based on indirect sensing of the scattered wavefront from point-like scatterers (“guide stars”) within a three-dimensional broadband interferometric tomogram. This method enables the correction of high-order monochromatic and chromatic aberrations utilizing guide stars that are revealed after numerical compensation of defocus and low-order aberrations of the optical system. Guide-star-based aberration correction in a silicone phantom with sparse sub-resolution-sized scatterers demonstrates improvement of resolution and signal-to-noise ratio over a large isotome. Results in highly scattering muscle tissue showed improved resolution of fine structure over an extended volume. Guide-star-based computational adaptive ...

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    5. Caries Detection Using Light-Based Diagnostic Tool

      Caries Detection Using Light-Based Diagnostic Tool

      Modern caries treatment concepts like caries management by risk assessment—CAMBRA—entail diagnosing early caries lesions in a precavitated stage to make it possible to reverse the caries process with remineralization and bacteria reduction efforts. Newer, sensitive caries diagnostic tools can serve not only for early detection but also for monitoring of caries lesions to confirm the success of prevention and remineralization efforts. This article describes light-based caries diagnostic tools, with emphasis on fluorescence-based techniques, and compares the most common available fluorescence-based tools with a standardized visual caries inspection system—the International Caries Detection and Assessment System (ICDAS II). Fluorescence ...

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    6. Segmentation, co-registration, and correlation of optical coherence tomography and X-ray images for breast cancer diagnostics (Thesis)

      Segmentation, co-registration, and correlation of optical coherence tomography and X-ray images for breast cancer diagnostics (Thesis)

      In this thesis, x-ray imaging is evaluated and compared with optical coherence tomography (OCT). It is shown that each individual modality provides information about a sample through different physical characteristics. The preclinical variant of x-ray imaging is explored in the context of breast cancer detection and diagnosis because their clinical use could be augmented by OCT. After comparing them, each modality showed its specialized usage. Micro-CT is useful in detecting microcalcifications, the most apparent target of the screening mammogram. OCT can be utilized in the specific cases where high resolution is desired and penetration depth does not need to be ...

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    7. University of Illinois Urbana-Champaign received NIH Grant for Developing an Intraoperative Label-Free Optical Molecular Imaging of Breast Tumor Margins

      University of Illinois Urbana-Champaign received NIH Grant for Developing an Intraoperative Label-Free Optical Molecular Imaging of Breast Tumor Margins
      ...gins. The program is a multi-year program and started in 2012 and ends in 2017. The principle investigator is Stephen Boppart. A brief description of the project is given below. Margin status during the surgical treatme...
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    8. University of Illinois at Urbana-Champaign Wins NIH Grant for Developing Technology for Primary Care Imaging

      University of Illinois at Urbana-Champaign Wins NIH Grant for Developing Technology for Primary Care Imaging
      ...The program is part of a multiyear study that started in 2011 and ends in 2016. The principal investigator is Stephen Boppart. Below is a summary of the proposed work.  Primary Care Medicine, including Family Practice a...
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    9. University of Illinois at Urbana-Champaign Wins NIH Grant for Investigating Targeted Microspheres for Contract Enhancement in Optical Coherence Tomography.

      University of Illinois at Urbana-Champaign Wins NIH Grant for Investigating Targeted Microspheres for Contract Enhancement in Optical Coherence Tomography.
      ... in Optical Coherence Tomography. The program started in 2009 and ends in 2013. The principal investigator is Stephen Boppart. Below is a summary of the proposed work.  Molecular imaging is frequently performed with con...
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    10. Group refractive index reconstruction with broadband interferometric confocal microscopy

      Group refractive index reconstruction with broadband interferometric confocal microscopy

      A system and method for microscale measurement and imaging of the group refractive index of a sample. The method utilizes a broadband confocal high-numerical aperture microscope embedded into an interferometer and a spectrometric means, whereby spectral interferograms are analyzed to compute optical path delay of the beam traversing the sample as the sample is translated through the focus of an interrogating light beam. A determination of group refractive index may serve to disambiguate phase ambiguity in a measurement of refractive index at a specified wavelength. Spatial resolution of object characterization in three dimensions is achieved by imaging the object from ...

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    11. Three-dimensional Optical Coherence Tomography for Optical Biopsy of Lymph Nodes and Assessment of Metastatic Disease

      Three-dimensional Optical Coherence Tomography for Optical Biopsy of Lymph Nodes and Assessment of Metastatic Disease
      ...sease Renu John PhD, Steven G. Adie PhD, Eric J. Chaney BS, Marina Marjanovic PhD, Krishnarao V. Tangella MD, Stephen A. Boppart MD, PhD Translational Research and Biomarkers Online First ™ - June , 2012 View full articl...
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    12. Feature Of The Week 6/10/12: Computational Adaptive Optics: A New Digital Post-Processing Technique to Optimize Resolution in OCT and other Interferometric Optical Imaging Applications

      Feature Of The Week 6/10/12: Computational Adaptive Optics: A New Digital Post-Processing Technique to Optimize Resolution in OCT and other Interferometric Optical Imaging Applications
      ...volume spanning tens of Rayleigh lengths.For more information see recent Article. Courtesy of Steven Adie and Stephen Boppart from the University of Illinois at Urbana-Champaign. To share this article click Here.Referenc...
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    13. Noninvasive in vivo optical detection of biofilm in the human middle ear

      Noninvasive in vivo optical detection of biofilm in the human middle ear

      Otitis media (OM), a middle-ear infection, is the most common childhood illness treated by pediatricians. If inadequately treated, OM can result in long-term chronic problems persisting into adulthood. Children with chronic OM or recurrent OM often have conductive hearing loss and communication difficulties and require surgical treatment. Tympanostomy tube insertion, the placement of a small drainage tube in the tympanic membrane (TM), is the most common surgical procedure performed in children under general anesthesia. Recent clinical studies have shown evidence of a direct correspondence between chronic OM and the presence of a bacterial biofilm within the middle ear. Biofilms are ...

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    14. 46-60 of 174 « 1 2 3 4 5 6 7 ... 10 11 12 »
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  2. About Stephen A. Boppart

    Stephen A. Boppart

    Stephen A. Boppart is a professor in the Biophotonics Imaging Laboratory at the University of Illinois Urbana Champaign.  Dr. Boppart received his Ph.D. from the Massachusetts Institute of Technology in 1998, followed by a M.D. from Harvard Medical School in 2000. Currently Prof. Boppart is a full-time faculty member in the Beckman Institute Nanoelectronics and Biophotonics Group as well as an associate professor in the UIUC Department of Electrical and Computer Engineering and the Bioengineering Department. In January 2007, he was named the Founding Director of the Mills Breast Cancer Institute at Carle Foundation Hospital. Dr. Boppart is also a Clinical Research Physician in the UI College of Medicine-Urbana. His fields of professional interest include optical imaging (specifically in Optical Coherence Tomography) and biophotonics in medicine and biology.

  3. Quotes

    1. Jim's innovation, scholarly activities, professional service, entrepreneurial efforts, and impact on the field of biomedical optics typifies the spirit of this award, and reflects the seminal changes that Britton Chance made during his lifetime...Few researchers in the world today have had such a profound impact as a result of their technological work that has literally changed our field, changed the way we practice medicine, and directly improved the lives of perhaps hundreds of thousands of patients (considering ophthalmology and cardiology).
      In Fujimoto Honored with Britton Chance Biomedical Optics Award
    2. We know that antibiotics don’t always work well if you have a biofilm, because the bacteria protect themselves and become resistant...In the presence of a chronic ear infection that has a biofilm, the bacteria may not respond to the usual antibiotics, and you need to stop them. But without being able to detect the biofilm, we have no idea whether or not it’s responding to treatment.
      In Nowhere to hide: New device sees bacteria behind the eardrum
    3. I think it's going to dramatically change things...What we hope is that diagnosis is going to get shifted closer and closer to the point of care...We’re developing techniques to get at molecular changes..So much of medicine and pathology are based on structural changes. If we think of a pathologist looking at a slide, he or she looks at the cells and tissue structures. A radiologist will look at how organs and these anatomical structures are arranged...But with a lot of these techniques, we can get the molecular changes where disease starts. So a pathologist that has molecular information, not just structural, will perhaps catch disease earlier. The same is true for Rohit’s work and Gabi’s work.
      In Positive Results: A New Era for Medical Diagnostics - News from UIUC
    4. It's the same challenge, but instead of imaging through the atmosphere, we're imaging through tissue, and instead of imaging a star, we're imaging a cell.
      In Computing the best high-resolution 3-D tissue images - News from Beckman Institute at UIUC
    5. The effectiveness is striking...Because of the aberrations of the human eye, when you look at the retina without adaptive optics you just see variations of light and dark areas that represent the rods and cones. But when you use adaptive optics, you see the rods and cones as distinct objects...are working to compute the best image possible.
      In Computing the best high-resolution 3-D tissue images - News from Beckman Institute at UIUC
    6. to emphasize the role of medical imaging and how this technology has enabled us to look into the body at many different size scales, how imaging has enabled us to diagnose disease, and how imaging has made a difference in our healthcare...Federal dollars have been used to fund technology that’s going to change and improve health care. They already have. In the area of optics and high-resolution optical imaging, there’s going to be better healthcare, economic development with new companies, new jobs, and new areas of research to investigate...We can now do real-time microscopic imaging in the operating room without waiting for pathology.
      In Boppart Presents at Congressional Briefing
    7. In the end, I expect the cost of this system will be slightly more than what it replaces, but with significantly more capabilities, I do expect the cost of this system to continue to fall as more systems are developed and demand increases...This will be a boon for poorer hospitals and Third World or developing countries...It is essentially a portable imaging system with digital data that can be sent via cell-phone networks for analysis by experts in larger cities/hospitals.
      In Scientists awarded grant to continue developing optical device for medical exams
    8. The result of this – if successful, could really reduce our health care costs and streamline our delivery of health care.
      In NIH Awards Stephen Boppart $5M For A Bioengineering Research Partnership to Develop Handheld Optical Imaging Technology
    9. We are trying to build a small, handheld unit that has multiple tips...What’s collected is 3D digital data that can image several millimeters into tissue and at micron-scale resolution...The primary care physician is the best person to screen the general population for disease...“We think that it’s going to completely change the way we treat ear infections.
      In NIH Awards Stephen Boppart $5M For A Bioengineering Research Partnership to Develop Handheld Optical Imaging Technology
    10. The diagnosis is made based on very subjective interpretation – how the cells are laid out, the structure, the morphology...This is what we call the gold standard for diagnosis. We want to make the process of medical diagnostics more quantitative and more rapid.
      In New imaging technique accurately finds cancer cells, fast