1. Stephen A. Boppart

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    1. Mentioned In 233 Articles

    2. Coherent optical imaging and guided interventions in breast cancer: translating technology into clinical applications

      ...Stephen A. Boppart, Freddy T. Nguyen, Adam M. Zysk et al. Breast cancer continues to be one of the most widely diagnosed forms of cancer in women and the second leading type of cancer deaths for women. The me...
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    3. Stabilization of continuum generation from normally dispersive nonlinear optical fibers for a tunable broad bandwidth source for optical coherence tomography

      ...007 Revised Manuscript: April 30, 2007 Published: July 9, 2007 Citation H. Tu, D. L. Marks, Y. L. Koh, and S. A. Boppart, "Stabilization of continuum generation from normally dispersive nonlinear optical fibers for a ...
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    4. Interferometric synthetic aperture microscopy: tissue structure inferred by computed imaging techniques

      Interferometric synthetic aperture microscopy: tissue structure inferred by computed imaging techniques
      Daniel L. Marks, Tyler S. Ralston, Brynmor J. Davis et al. Interferometric Synthetic Aperture Microscopy (ISAM) is an optical microscopy computed-imaging technique for measuring the optical properties of three-dimensional structures and biological tissues. In this work, the principle of ISAM is reviewed, and its application to imaging tissue properties in v ... [Proc. SPIE Int. Soc. Opt. Eng. 6864, 686407 (2008)] published Fri Feb 15, 2008.
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    5. Magnetic protein microspheres as dynamic contrast agents for magnetomotive optical coherence tomography

      Freddy T. Nguyen, Elizabeth M. Dibbern, Eric J. Chaney et al. Optical coherence tomography (OCT) is an emerging biomedical imaging modality that has been developed over the last 15 years. More recently, OCT has been used for the intraoperative imaging of tumor margins in breast cancer and axillary lymph nodes providing a real time in-vivo assessment of the tis ... [Proc. SPIE Int. Soc. Opt. Eng. 6867, 68670F (2008)] published Wed ...
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    6. Plasmon-resonant gold nanorods provide spectroscopic OCT contrast in excised human breast tumors

      Amy L. Oldenburg, Matthew N. Hansen, Alexander Wei et al. Plasmon-resonant gold nanorods have been demonstrated recently as contrast agents for optical coherence tomography (OCT). To evaluate their ability to produce contrast in a structurally heterogeneous environment, nanorods were injected at discrete locations into an excised sample of human breast inv ... [Proc. SPIE Int. Soc. Opt. Eng. 6867, 68670E (2008)] published Wed Feb 13, 2008.
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    7. Spectroscopic Optical Coherence Tomography and Microscopy

      Imaging biological tissues using optical coherence tomography is enhanced with spectroscopic analysis, providing new metrics for functional imaging. Recent advances in spectroscopic optical coherence tomography (SOCT) include techniques for the discrimination of endogenous tissue types and for the detection of exogenous contrast agents. In this paper, we review these techniques and their associated signal processing algorithms, while highlighting their potential for biomedical applications. We unify the theoretical framework for time- ...
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    8. In vivo ultrahigh-resolution optical coherence tomography.

      Ultrahigh-resolution optical coherence tomography (OCT) by use of state of the art broad-bandwidth femtosecond laser technology is demonstrated and applied to in vivo subcellular imaging. Imaging is performed with a Kerr-lens mode-locked Ti:sapphire laser with double-chirped mirrors that emits sub-two-cycle pulses with bandwidths of up to 350 nm, centered at 800 nm. Longitudinal resolutions of ~1mum and transverse resolution of 3mum, with a 110-dB dynamic range, are achieved in ...
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    9. Optical coherence tomography: a review of clinical development from bench to bedside

      Adam M. Zysk, Freddy T. Nguyen, Amy L. Oldenburg et al. Since its introduction, optical coherence tomography (OCT) technology has advanced from the laboratory bench to the clinic and back again. Arising from the fields of low coherence interferometry and optical time- and frequency-domain reflectometry, OCT was initially demonstrated for retinal imaging ... [J. Biomed. Opt. 12, 051403 (2007)] published Wed Oct 24, 2007.
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    10. Optical contrast agents for optically modifying incident radiation

      A method of enhancing the contrast of an image of a sample, comprises forming an image of a mixture, by exposing the mixture to electromagnetic radiation. The mixture comprises the sample and microparticles. The enhancement is particularly suitable for optical coherence tomography.
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    11. 211-225 of 233 « 1 2 ... 12 13 14 15 16 »
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  2. About Stephen A. Boppart

    Stephen A. Boppart

    Stephen A. Boppart is a professor in the Biophotonics Imaging Laboratory at the University of Illinois Urbana Champaign.  Dr. Boppart received his Ph.D. from the Massachusetts Institute of Technology in 1998, followed by a M.D. from Harvard Medical School in 2000. Currently Prof. Boppart is a full-time faculty member in the Beckman Institute Nanoelectronics and Biophotonics Group as well as an associate professor in the UIUC Department of Electrical and Computer Engineering and the Bioengineering Department. In January 2007, he was named the Founding Director of the Mills Breast Cancer Institute at Carle Foundation Hospital. Dr. Boppart is also a Clinical Research Physician in the UI College of Medicine-Urbana. His fields of professional interest include optical imaging (specifically in Optical Coherence Tomography) and biophotonics in medicine and biology.

  3. Quotes

    1. With advances in microscopy techniques such as ours, we hope to change the way we detect, visualize and monitor diseases that will lead to better diagnosis, treatments and outcomes.
      In IMAGING TECHNIQUE FROM BECKMAN LAB NAMED TOP 10 MICROSCOPY INNOVATION
    2. Any state of disease will alter the cells and molecules in our body...leaving a distinct optical scattering signature.” The new device senses cancer cells’ unique signatures, letting surgeons know which areas around the tumor are cancerous and which are safe to leave alone.
      In Flashlight-Sized Probe Can Spot Cancer Cells in Real Time
    3. We agree that, given the images we've seen from the hardware [adaptive optics] systems, our computational approaches are equivalent to those...In addition, we think we could do better by correcting the finer aberrations and by being able to manipulate the data post-acquisition, which gives us a lot more flexibility.
      In Bringing the human eye into focus
    4. We agree that, given the images we've seen from the hardware [adaptive optics] systems, our computational approaches are equivalent to those...In addition, we think we could do better by correcting the finer aberrations and by being able to manipulate the data post-acquisition, which gives us a lot more flexibility.
      In Bringing the human eye into focus
    5. Jim's innovation, scholarly activities, professional service, entrepreneurial efforts, and impact on the field of biomedical optics typifies the spirit of this award, and reflects the seminal changes that Britton Chance made during his lifetime...Few researchers in the world today have had such a profound impact as a result of their technological work that has literally changed our field, changed the way we practice medicine, and directly improved the lives of perhaps hundreds of thousands of patients (considering ophthalmology and cardiology).
      In Fujimoto Honored with Britton Chance Biomedical Optics Award
    6. We know that antibiotics don’t always work well if you have a biofilm, because the bacteria protect themselves and become resistant...In the presence of a chronic ear infection that has a biofilm, the bacteria may not respond to the usual antibiotics, and you need to stop them. But without being able to detect the biofilm, we have no idea whether or not it’s responding to treatment.
      In Nowhere to hide: New device sees bacteria behind the eardrum
    7. I think it's going to dramatically change things...What we hope is that diagnosis is going to get shifted closer and closer to the point of care...We’re developing techniques to get at molecular changes..So much of medicine and pathology are based on structural changes. If we think of a pathologist looking at a slide, he or she looks at the cells and tissue structures. A radiologist will look at how organs and these anatomical structures are arranged...But with a lot of these techniques, we can get the molecular changes where disease starts. So a pathologist that has molecular information, not just structural, will perhaps catch disease earlier. The same is true for Rohit’s work and Gabi’s work.
      In Positive Results: A New Era for Medical Diagnostics - News from UIUC
    8. It's the same challenge, but instead of imaging through the atmosphere, we're imaging through tissue, and instead of imaging a star, we're imaging a cell.
      In Computing the best high-resolution 3-D tissue images - News from Beckman Institute at UIUC
    9. The effectiveness is striking...Because of the aberrations of the human eye, when you look at the retina without adaptive optics you just see variations of light and dark areas that represent the rods and cones. But when you use adaptive optics, you see the rods and cones as distinct objects...are working to compute the best image possible.
      In Computing the best high-resolution 3-D tissue images - News from Beckman Institute at UIUC
    10. to emphasize the role of medical imaging and how this technology has enabled us to look into the body at many different size scales, how imaging has enabled us to diagnose disease, and how imaging has made a difference in our healthcare...Federal dollars have been used to fund technology that’s going to change and improve health care. They already have. In the area of optics and high-resolution optical imaging, there’s going to be better healthcare, economic development with new companies, new jobs, and new areas of research to investigate...We can now do real-time microscopic imaging in the operating room without waiting for pathology.
      In Boppart Presents at Congressional Briefing