1. Stephen A. Boppart

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    1. Mentioned In 199 Articles

    2. Inverse scattering for frequency-scanned full-field optical coherence tomography

      Inverse scattering for frequency-scanned full-field optical coherence tomography
      Full-field optical coherence tomography (OCT) is able to image an entire en face plane of scatterers simultaneously, but typically the focus is scanned through the volume to acquire three-dimensional structure. By solving the inverse scattering problem for full-field OCT, we show it is possible to computationally reconstruct a three-dimensional volume while the focus is fixed at one plane inside the sample. While a low-numerical-aperture (NA) OCT system can tolerate defocus ...
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    3. A Mosaicking Approach for In Vivo Thickness Mapping of the Human Tympanic Membrane Using Low Coherence Interferometry

      A Mosaicking Approach for In Vivo Thickness Mapping of the Human Tympanic Membrane Using Low Coherence Interferometry
      The thickness of the human tympanic membrane (TM) is known to vary considerably across different regions of the TM. Quantitative determination of the thickness distribution and mapping of the TM is of significant importance in hearing research, particularly in mathematical modeling of middle-ear dynamics. Change in TM thickness is also associated with several middle-ear pathologies. Determination of the TM thickness distribution could therefore also enable a more comprehensive diagnosis of ...
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    4. Filtering for unwrapping noisy Doppler optical coherence tomography images for extended microscopic fluid velocity measurement range

      Filtering for unwrapping noisy Doppler optical coherence tomography images for extended microscopic fluid velocity measurement range
      ..., USA *Corresponding author: Carney@illinois.edu Yang Xu, Donald Darga, Jason Smid, Adam M. Zysk, Daniel Teh, Stephen A. Boppart, and P. Scott Carney, "Filtering for unwrapping noisy Doppler optical coherence tomography ...
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    5. Automated computational aberration correction method for broadband interferometric imaging techniques

      Automated computational aberration correction method for broadband interferometric imaging techniques
      Numerical correction of optical aberrations provides an inexpensive and simpler alternative to the traditionally used hardware-based adaptive optics techniques. In this Letter, we present an automated computational aberration correction method for broadband interferometric imaging techniques. In the proposed method, the process of aberration correction is modeled as a filtering operation on the aberrant image using a phase filter in the Fourier domain. The phase filter is expressed as a linear ...
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    6. Swept Source Optical Coherence Tomography Imaging of the Middle Ear Cavity (Thesis)

      Swept Source Optical Coherence Tomography Imaging of the Middle Ear Cavity (Thesis)
      Otitis media (OM), a bacterial infection of the middle ear, is a common pediatric disease. Chronic and recurrent OM is often treated with the surgical placement of tympanostomy tubes in the tympanic membrane (TM), which is the most common reason for pediatric surgery and anesthesia. Antibiotic treatment for chronic OM (COM) is often ineffective, which is explained by the hypothesis that OM is a biofilm-related disease. Recent studies in humans ...
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    7. UIUC Receives NIH Grant for Intraoperative Label-Free Optical Molecular Imaging of Breast Tumor Margins.

      UIUC Receives  NIH Grant for Intraoperative Label-Free Optical Molecular Imaging of Breast Tumor Margins.
      ...r Intraoperative Label-Free Optical Molecular Imaging of Breast Tumor Margins. The principal investiagator is Stephen Boppart. The program began in 2012 and ends in 2017. Below is a summary of the proposed work.

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    8. Detection of retinal blood vessel changes in multiple sclerosis with optical coherence tomography

      Detection of retinal blood vessel changes in multiple sclerosis with optical coherence tomography
      Although retinal vasculitis is common in multiple sclerosis (MS), it is not known if MS is associated with quantitative abnormalities in retinal blood vessels (BVs). Optical coherence tomography (OCT) is suitable for examining the integrity of the anterior visual pathways in MS. In this paper we have compared the size and number of retinal blood vessels in patients with MS, with and without a history of optic neuritis (ON), and ...
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    9. Non-Invasive Optical Assessment of Viscosity of Middle Ear Effusions in Otitis Media

      Non-Invasive Optical Assessment of Viscosity of Middle Ear Effusions in Otitis Media
      In vivo Optical Coherence Tomography (OCT) image of a human tympanic membrane and Middle Ear Effusion (MEE) (top), with a CCD image of the tympanic membrane surface (inset). Below is the corresponding time-lapse M-mode OCT data acquired along the white dotted line over time, which can be analyzed to determine the StokesEinstein diffusion coefficient of the effusion. Eustachian tube dysfunction can cause fluid to collect within the middle ear cavity ...
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    10. Non-invasive optical assessment of viscosity of middle ear effusions in otitis media

      Non-invasive optical assessment of viscosity of middle ear effusions in otitis media
      In vivo Optical Coherence Tomography (OCT) image of a human tympanic membrane and Middle Ear Effusion (MEE) (top), with a CCD image of the tympanic membrane surface (inset). Below is the corresponding time-lapse M-mode OCT data acquired along the white dotted line over time, which can be analyzed to determine the StokesEinstein diffusion coefficient of the effusion. Eustachian tube dysfunction can cause fluid to collect within the middle ear cavity ...
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    11. Computational adaptive optics of the human retina

      Computational adaptive optics of the human retina
      It is well known that patient-specific ocular aberrations limit imaging resolution in the human retina. Previously, hardware adaptive optics (HAO) has been employed to measure and correct these aberrations to acquire high-resolution images of various retinal structures. While the resulting aberration-corrected images are of great clinical importance, clinical use of HAO has not been widespread due to the cost and complexity of these systems. We present a technique termed computational ...
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    12. Automated interferometric synthetic aperture microscopy and computational adaptive optics for improved optical coherence tomography

      Automated interferometric synthetic aperture microscopy and computational adaptive optics for improved optical coherence tomography
      ...ngfield Avenue, Urbana, Illinois 61801, USA *Corresponding author: Carney@illinois.edu Yang Xu, Yuan-Zhi Liu, Stephen A. Boppart, and P. Scott Carney, "Automated interferometric synthetic aperture microscopy and computat...
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    13. Intraoperative optical coherence tomography for assessing human lymph nodes for metastatic cancer

      Intraoperative optical coherence tomography for assessing human lymph nodes for metastatic cancer
      Background Evaluation of lymph node (LN) status is an important factor for detecting metastasis and thereby staging breast cancer. Currently utilized clinical techniques involve the surgical disruption and resection of lymphatic structure, whether nodes or axillary contents, for histological examination. While reasonably effective at detection of macrometastasis , the majority of the resected lymph nodes are histologically negative. Improvements need to be made to better detect micrometastasis , minimize or eliminate lymphatic ...
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    14. Response of simulated drinking water biofilm mechanical and structural properties to long-term disinfectant exposure

      Response of simulated drinking water biofilm mechanical and structural properties to long-term disinfectant exposure
      Mechanical and structural properties of biofilms influence the accumulation and release of pathogens in drinking water distribution systems (DWDS). Thus, understanding how long-term residual disinfectants exposure affects biofilm mechanical and structural properties is a necessary aspect for pathogen risk assessment and control. In this study, elastic modulus and structure of groundwater biofilms was monitored by atomic force microscopy (AFM) and optical coherence tomography (OCT) during three months of exposure to ...
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    15. Polarization-sensitive interferometric synthetic aperture microscopy

      Polarization-sensitive interferometric synthetic aperture microscopy
      Three-dimensional optical microscopy suffers from the well-known compromise between transverse resolution and depth-of-field. This is true for both structural imaging methods and their functional extensions. Interferometric synthetic aperture microscopy (ISAM) is a solution to the 3D coherent microscopy inverse problem that provides depth-independent transverse resolution. We demonstrate the extension of ISAM to polarization sensitive imaging, termed polarization-sensitive interferometric synthetic aperture microscopy (PS-ISAM). This technique is the first functionalization of the ...
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    16. 1-15 of 199 1 2 3 4 ... 12 13 14 »
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  2. About Stephen A. Boppart

    Stephen A. Boppart

    Stephen A. Boppart is a professor in the Biophotonics Imaging Laboratory at the University of Illinois Urbana Champaign.  Dr. Boppart received his Ph.D. from the Massachusetts Institute of Technology in 1998, followed by a M.D. from Harvard Medical School in 2000. Currently Prof. Boppart is a full-time faculty member in the Beckman Institute Nanoelectronics and Biophotonics Group as well as an associate professor in the UIUC Department of Electrical and Computer Engineering and the Bioengineering Department. In January 2007, he was named the Founding Director of the Mills Breast Cancer Institute at Carle Foundation Hospital. Dr. Boppart is also a Clinical Research Physician in the UI College of Medicine-Urbana. His fields of professional interest include optical imaging (specifically in Optical Coherence Tomography) and biophotonics in medicine and biology.

  3. Quotes

    1. Any state of disease will alter the cells and molecules in our body...leaving a distinct optical scattering signature.” The new device senses cancer cells’ unique signatures, letting surgeons know which areas around the tumor are cancerous and which are safe to leave alone.
      In Flashlight-Sized Probe Can Spot Cancer Cells in Real Time
    2. We agree that, given the images we've seen from the hardware [adaptive optics] systems, our computational approaches are equivalent to those...In addition, we think we could do better by correcting the finer aberrations and by being able to manipulate the data post-acquisition, which gives us a lot more flexibility.
      In Bringing the human eye into focus
    3. We agree that, given the images we've seen from the hardware [adaptive optics] systems, our computational approaches are equivalent to those...In addition, we think we could do better by correcting the finer aberrations and by being able to manipulate the data post-acquisition, which gives us a lot more flexibility.
      In Bringing the human eye into focus
    4. Jim's innovation, scholarly activities, professional service, entrepreneurial efforts, and impact on the field of biomedical optics typifies the spirit of this award, and reflects the seminal changes that Britton Chance made during his lifetime...Few researchers in the world today have had such a profound impact as a result of their technological work that has literally changed our field, changed the way we practice medicine, and directly improved the lives of perhaps hundreds of thousands of patients (considering ophthalmology and cardiology).
      In Fujimoto Honored with Britton Chance Biomedical Optics Award
    5. We know that antibiotics don’t always work well if you have a biofilm, because the bacteria protect themselves and become resistant...In the presence of a chronic ear infection that has a biofilm, the bacteria may not respond to the usual antibiotics, and you need to stop them. But without being able to detect the biofilm, we have no idea whether or not it’s responding to treatment.
      In Nowhere to hide: New device sees bacteria behind the eardrum
    6. I think it's going to dramatically change things...What we hope is that diagnosis is going to get shifted closer and closer to the point of care...We’re developing techniques to get at molecular changes..So much of medicine and pathology are based on structural changes. If we think of a pathologist looking at a slide, he or she looks at the cells and tissue structures. A radiologist will look at how organs and these anatomical structures are arranged...But with a lot of these techniques, we can get the molecular changes where disease starts. So a pathologist that has molecular information, not just structural, will perhaps catch disease earlier. The same is true for Rohit’s work and Gabi’s work.
      In Positive Results: A New Era for Medical Diagnostics - News from UIUC
    7. It's the same challenge, but instead of imaging through the atmosphere, we're imaging through tissue, and instead of imaging a star, we're imaging a cell.
      In Computing the best high-resolution 3-D tissue images - News from Beckman Institute at UIUC
    8. The effectiveness is striking...Because of the aberrations of the human eye, when you look at the retina without adaptive optics you just see variations of light and dark areas that represent the rods and cones. But when you use adaptive optics, you see the rods and cones as distinct objects...are working to compute the best image possible.
      In Computing the best high-resolution 3-D tissue images - News from Beckman Institute at UIUC
    9. to emphasize the role of medical imaging and how this technology has enabled us to look into the body at many different size scales, how imaging has enabled us to diagnose disease, and how imaging has made a difference in our healthcare...Federal dollars have been used to fund technology that’s going to change and improve health care. They already have. In the area of optics and high-resolution optical imaging, there’s going to be better healthcare, economic development with new companies, new jobs, and new areas of research to investigate...We can now do real-time microscopic imaging in the operating room without waiting for pathology.
      In Boppart Presents at Congressional Briefing
    10. In the end, I expect the cost of this system will be slightly more than what it replaces, but with significantly more capabilities, I do expect the cost of this system to continue to fall as more systems are developed and demand increases...This will be a boon for poorer hospitals and Third World or developing countries...It is essentially a portable imaging system with digital data that can be sent via cell-phone networks for analysis by experts in larger cities/hospitals.
      In Scientists awarded grant to continue developing optical device for medical exams