1. Stephanie J. Chiu

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    1. Mentioned In 28 Articles

    2. Optical Coherence Tomography Reflective Drusen Substructures Predict Progression to Geographic Atrophy in Age-related Macular Degeneration

      Optical Coherence Tomography Reflective Drusen Substructures Predict Progression to Geographic Atrophy in Age-related Macular Degeneration
      Purpose Structural and compositional heterogeneity within drusen comprising lipids, carbohydrates, and proteins have been previously described. We sought to detect and define phenotypic patterns of drusen heterogeneity in the form of optical coherence tomographyreflective drusen substructures (ODS) and examine their associations with age-related macular degeneration (AMD)related features and AMD progression. Design Retrospective analysis in a prospective study. Participants Patients with intermediate AMD (n = 349) enrolled in the multicenter Age-Related ...
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    3. Validation of Macular Choroidal Thickness Measurements from Automated SD-OCT Image Segmentation

      Validation of Macular Choroidal Thickness Measurements from Automated SD-OCT Image Segmentation
      Purpose: Spectral domain optical coherence tomography (SD-OCT) imaging permits in vivo visualization of the choroid with micron-level resolution over wide areas and is of interest for studies of ocular growth and myopia control. We evaluated the speed, repeatability, and accuracy of a new image segmentation method to quantify choroid thickness compared to manual segmentation. Methods: Two macular volumetric scans (25 x 30[degrees]) were taken from 30 eyes of 30 ...
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    4. Kernel regression based segmentation of optical coherence tomography images with diabetic macular edema

      Kernel regression based segmentation of optical coherence tomography images with diabetic macular edema
      We present a fully automatic algorithm to identify fluid-filled regions and seven retinal layers on spectral domain optical coherence tomography images of eyes with diabetic macular edema (DME). To achieve this, we developed a kernel regression (KR)-based classification method to estimate fluid and retinal layer positions. We then used these classification estimates as a guide to more accurately segment the retinal layer boundaries using our previously described graph theory ...
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    5. Retinal Atrophy in Eyes With Resolved Papilledema Detected by Optical Coherence Tomography

      Retinal Atrophy in Eyes With Resolved Papilledema Detected by Optical Coherence Tomography
      Background: To apply automated spectral domain optical coherence tomography (SD-OCT) segmentation to eyes with resolving papilledema. Methods: Ninety-four patients with idiopathic intracranial hypertension seen at the Duke Eye Center neuro-ophthalmology clinic between November 2010 and October 2011 were reviewed. Excluded were eyes with papilledema with Frisen grade 2, other optic neuropathies or retinopathies, and those that did not have SD-OCT imaging. The remaining 43 patients were split into 2 groups ...
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    6. Segmentation and identification of layered structures in images

      Segmentation and identification of layered structures in images
      Disclosed herein are systems and method for segmentation and identification of structured features in images. According to an aspect, a method may include representing an image as a graph of nodes connected together by edges. For example, the image may be an ocular image showing layered structures or other features of the retina. The method may also include adding, to the graph, nodes adjacent to nodes along first and second ...
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    7. Pilocarpine-induced dilation of Schlemm's canal and prevention of lumen collapse at elevated intraocular pressures in living mice visualized by OCT

      Pilocarpine-induced dilation of Schlemm's canal and prevention of lumen collapse at elevated intraocular pressures in living mice visualized by OCT
      Purpose:The goal was to assess effects of intraocular pressure (IOP) and pilocarpine-induced ciliary muscle contraction on conventional outflow pathway tissues in living anesthetized mice. Methods:IOP was controlled by intracameral cannulation of mouse eyes while imaging using spectral domain optical coherence tomography (SD-OCT). Time-lapse sagittal SD-OCT sections through Schlemm's canal (SC) were acquired while changing IOP stepwise between 10 and 45 mmHg. After topical application of 1% pilocarpine ...
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    8. Characterization of the Choroid-Scleral Junction and Suprachoroidal Layer in Healthy Individuals on Enhanced-Depth Imaging Optical Coherence Tomography

      Characterization of the Choroid-Scleral Junction and Suprachoroidal Layer in Healthy Individuals on Enhanced-Depth Imaging Optical Coherence Tomography
      Importance Accurate measurements of choroidal thickness (CT) using enhanced-depth imaging optical coherence tomography (EDI-OCT) require a well-defined choroid-scleral junction (CSJ), which may appear in some eyes as a hyporeflective band corresponding to the suprachoroidal layer (SCL). Objective To identify factors associated with the presence and thickness of the SCL in healthy participants and determine how different CSJ boundary definitions impact CT measurements. Design, Setting, and Participants Secondary analysis of EDI-OCT ...
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    9. Fully Automatic Software for Retinal Thickness in Eyes with Diabetic Macular Edema from Images Acquired by Cirrus and Spectralis Systems

      Fully Automatic Software for Retinal Thickness in Eyes with Diabetic Macular Edema from Images Acquired by Cirrus and Spectralis Systems
      Purpose: To determine whether a novel automatic segmentation program, the Duke Optical Coherence Tomography Retinal Analysis Program (DOCTRAP), can be applied to spectral domain optical coherence tomography (SD-OCT) images obtained from different commercially available SD-OCT in eyes with diabetic macular edema (DME). Methods: A novel segmentation framework was used to segment the retina, inner retinal pigment epithelium, and Bruch's membrane on images from eyes with DME acquired by one ...
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    10. Macular Findings in Healthy Full-term Hispanic Newborns Observed by Hand-held Spectral-Domain Optical Coherence Tomography

      Macular Findings in Healthy Full-term Hispanic Newborns Observed by Hand-held Spectral-Domain Optical Coherence Tomography
      BACKGROUND AND OBJECTIVE: To enhance understanding of ethnically diverse normal newborn retinal morphology, the authors report spectral-domain optical coherence tomography (SD-OCT) macular findings in healthy Hispanic newborns. PATIENTS AND METHODS: In this IRB-approved prospective, observational case series, 20 full-term Hispanic newborns had dilated retinal examinations and imaging by hand-held SD-OCT without sedation at the Duke Birthing Center. RESULTS: Of 20 newborns imaged (35% male; median gestational age: 39 weeks; range ...
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    11. Automated non-rigid registration and mosaicing for robust imaging of distinct retinal capillary beds using speckle variance optical coherence tomography

      Automated non-rigid registration and mosaicing for robust imaging of distinct retinal capillary beds using speckle variance optical coherence tomography
      Variance processing methods in Fourier domain optical coherence tomography (FD-OCT) have enabled depth-resolved visualization of the capillary beds in the retina due to the development of imaging systems capable of acquiring A-scan data in the 100 kHz regime. However, acquisition of volumetric variance data sets still requires several seconds of acquisition time, even with high speed systems. Movement of the subject during this time span is sufficient to corrupt visualization ...
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    12. Choroid Development and Feasibility of Choroidal Imaging in the Preterm and Term Infants Utilizing SDOCT

      Choroid Development and Feasibility of Choroidal Imaging in the Preterm and Term Infants Utilizing SDOCT
      Purpose: To determine whether choroidal imaging is feasible in preterm and term infants using an 840-nm portable spectral domain optical coherence tomography (SDOCT) system without the use of enhanced- depth imaging techniques and to assess choroidal development by comparing choroidal thickness of preterm infants, term infants, and adults. Methods: SDOCT images were obtained from 86 preterm infants, 59 term infants and 9 adults using a portable SDOCT (Bioptigen, Inc., NC ...
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    13. Photoreceptor and Choroid Development Assessed with Handheld SD-OCT

      Photoreceptor and Choroid Development Assessed with Handheld SD-OCT
      Objective: Optical coherence tomography (OCT) allows examination of the human retina. While conventional OCT devices are limited mainly to adults, the availability of a handheld system has expanded the use of this technique to pediatric populations, with the primary clinical applications being shaken baby syndrome and retinopathy of prematurity. We sought to apply OCT imaging to neonatal population to assess retinal development. Methods: Subjects imaged at the Duke Neonatal Intensive ...
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    14. Maturation of the Human Fovea: Correlation of Spectral-Domain Optical Coherence Tomography Findings With Histology

      Maturation of the Human Fovea: Correlation of Spectral-Domain Optical Coherence Tomography Findings With Histology
      ...* Daniel Possin Affiliations + Department of Ophthalmology, University of Washington, Seattle, Washington , * Stephanie J. Chiu Affiliations + Department of Biomedical Engineering, Pratt School of Engineering, Durham, No...
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  2. About Stephanie J. Chiu

    Stephanie J. Chiu

    Stephanie Chiu is a student in Biomedical Engineering at Duke University.