A method for increasing the imaging rate for an optical coherence tomography system is disclosed. The method comprises generating an interferometric signal by interrogating each of M image points on a sample with a plurality of wavelength bands that are collectively spectrally interleaved, time encoding the interferometric signal, and sampling the time-encoded interferometric signal at a single detector.

Purpose: To report four examples of a novel optical coherence tomography finding, which appears to be characteristic of inflammatory choroidal neovascularization. Methods: Retrospective observational case series. Results: Four eyes of four patients were diagnosed clinically with inflammatory choroidal neovascularization and underwent optical coherence tomography. In each case, imaging revealed multiple, distinctive finger-like projections extending from the area of active choroidal neovascularization into the outer retina-the "pitchfork sign"-a finding not typically seen in Type 2 neovascularization due to other etiologies. Conclusion: The pitchfork sign may help distinguish inflammatory choroidal neovascularization from other causes of Type 2 neovascularization

Background: Frequency-domain optical coherence tomography (FD-OCT) is an intravascular imaging technique now available in the United States. However, the importance of level of training required for analysis using intravascular ultrasound (IVUS) and FD-OCT is unclear. The aim of this study was to evaluate inter- and intra-observer variability between expert and beginner analysts interpreting IVUS and FD-OCT images. Methods and results : Two independent expert analysts and two independent beginner analysts evaluated a total of 226±2 stent cross-sections with IVUS and 232±2 stent cross-sections with FD-OCT in 14 patients after stenting. Inter- and intra-observer variability for determining stent volume index ...

Using a generalized design for a polarization-sensitive optical coherence tomography (PS-OCT) system with a single input polarization state (SIPS), we prove the existence of an infinitely large design space over which it is possible to develop simple PS-OCT systems that yield closed form expressions for birefringence. Through simulation and experiment, we validate this analysis by demonstrating new configurations for PS-OCT systems, and present guidelines for the general design of such systems in light of their inherent inaccuracies. After accounting for systemic errors, alternative designs exhibit similar performance on average to the traditional SIPS PS-OCT system. This analysis could be extended ...