1. Stanford University

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    1. Mentioned In 215 Articles

    2. Visible light optical coherence microscopy imaging of the mouse cortex with femtoliter volume resolution

      Visible light optical coherence microscopy imaging of the mouse cortex with femtoliter volume resolution
      Most flying-spot Optical Coherence Tomography (OCT) and Optical Coherence Microscopy (OCM) systems use a symmetric confocal geometry, where the detection path retraces the illumination path starting from and ending with the spatial mode of a single mode optical fiber. Here, we describe a visible light OCM instrument that breaks this symmetry to improve transverse resolution without sacrificing collection efficiency in scattering tissue. This was achieved by overfilling a 0.3 ...
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    3. Optical coherence tomography of lymphatic vessel endothelial hyaluronan receptors in vivo

      Optical coherence tomography of lymphatic vessel endothelial hyaluronan receptors in vivo
      Optical Coherence Tomography (OCT) imaging of living subjects offers millimeters depth of penetration into tissue while maintaining high spatial resolution. However, because most molecular biomarkers do not produce inherent OCT contrast signals, exogenous contrast agents must be employed to achieve molecular imaging. Here we demonstrate that microbeads (Bs) can be used as effective contrast agents to target cellular biomarkers in lymphatic vessels and can be detected by OCT using a ...
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    4. Optical Coherence Tomography Angiography in Retinal Vein Occlusion: Quantifying Macular Ischemia

      Optical Coherence Tomography Angiography in Retinal Vein Occlusion: Quantifying Macular Ischemia
      Purpose of Review Optical coherence tomography angiography (OCTA) is a new imaging modality that has the ability to image the retinal vasculature without the use of intravenous dye. This review aims to explore the role of OCTA when used to measure macular ischemia in patients with retinal vein occlusion (RVO). Recent Findings OCTA and fluorescein angiography are highly correlated in their findings related to macular perfusion status in patients with ...
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    5. Visible Light Optical Coherence Microscopy of the Brain with Isotropic Femtoliter Resolution In Vivo

      Visible Light Optical Coherence Microscopy of the Brain with Isotropic Femtoliter Resolution In Vivo
      Most flying-spot Optical Coherence Tomography (OCT) and Optical Coherence Microscopy (OCM) systems use a symmetric confocal geometry, where the detection path retraces the illumination path starting from and ending with the spatial mode of a single mode optical fiber. Here, we describe a visible light OCM instrument that breaks this symmetry to improve transverse resolution without sacrificing collection efficiency. This was achieved by overfilling a water immersion objective on the ...
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    6. ELHnet: a convolutional neural network for classifying cochlear endolymphatic hydrops imaged with optical coherence tomography

      ELHnet: a convolutional neural network for classifying cochlear endolymphatic hydrops imaged with optical coherence tomography
      Detection of endolymphatic hydrops is important for diagnosing Menieres disease, and can be performed non-invasively using optical coherence tomography (OCT) in animal models as well as potentially in the clinic. Here, we developed ELHnet, a convolutional neural network to classify endolymphatic hydrops in a mouse model using learned features from OCT images of mice cochleae. We trained ELHnet on 2159 training and validation images from 17 mice, using only the ...
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    7. Method and system for evaluating progression of age-related macular degeneration

      Method and system for evaluating progression of age-related macular degeneration
      Disclosed is a method for analyzing retinal image data obtained using spectral-domain optical coherence tomography (SD-OCT). The image data comprise a cross-section of the retina and an en face image of the retina of a subject having AMD (age-related macular degeneration). The image data are processed to obtain an accurate structure showing locations, shape, size, and other data on drusen (deposits under the retina). This structural information is processed to ...
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    8. Optical Coherence Tomography Characterization of Coronary Lithoplasty for Treatment of Calcified Lesions: First Description

      Optical Coherence Tomography Characterization of Coronary Lithoplasty for Treatment of Calcified Lesions: First Description
      Objectives This study sought to determine the mechanistic effects of a novel balloon-based lithoplasty system on heavily calcified coronary lesions and subsequent stent placement using optical coherence tomography (OCT). Background The Shockwave Coronary Rx Lithoplasty System (Shockwave Medical, Fremont, California) delivers localized, lithotripsy-enhanced disruption of calcium within the target lesion (i.e., lithoplasty) for vessel preparation before stent implantation. Methods We analyzed OCT findings in 31 patients in whom lithoplasty ...
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    9. Evaluation of macular and peripapillary vessel flow density in eyes with no known pathology using optical coherence tomography angiography

      Evaluation of macular and peripapillary vessel flow density in eyes with no known pathology using optical coherence tomography angiography
      Purpose To assess normal vessel flow density (VFD) in macular and peripapillary regions of eyes with no known ocular pathology using optical coherence tomography angiography (OCTA). Methods AngioVue (Optovue, Fremont, CA, USA) was used to capture OCTA images. A 3 3 mm grid and a 4.5 4.5 mm grid was used to scan parafoveal and peripapillary regions, respectively. ReVue software was utilized to measure VFD in five sectors ...
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    10. Speckle-free OCT

      Speckle-free OCT
      Optical coherence tomography (OCT) is a well-established method for in vivo imaging and is widely used in the field of opthamology. Like all coherent imaging techniques, OCT image quality can be reduced by the presence of speckle noise that arises from light scattering within turbid specimens. To reduce speckle noise in OCT, Liba et al . developed an approach called speckle-modulating OCT (SM-OCT). SM-OCT overcomes speckle noise by creating and averaging ...
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    11. Computer-aided detection and quantification of endolymphatic hydrops within the mouse cochlea in vivo using optical coherence tomography

      Computer-aided detection and quantification of endolymphatic hydrops within the mouse cochlea in vivo using optical coherence tomography
      Diseases that cause hearing loss and/or vertigo in humans such as Menieres disease are often studied using animal models. The volume of endolymph within the inner ear varies with these diseases. Here, we used a mouse model of increased endolymph volume, endolymphatic hydrops, to develop a computer-aided objective approach to measure endolymph volume from images collected in vivo using optical coherence tomography. The displacement of Reissners membrane from its ...
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    12. University of California at Berkeley Receives NIH Grant for Interferometric Optophysiology of the Human Retina

      University of California at Berkeley Receives NIH Grant for Interferometric Optophysiology of the Human Retina
      ..., combined with large-scale multi-electrode physiological measurements in primate retina (Chichilnisky Lab at Stanford University) to validate and tune the optical measurements. Ultimately, the innovation at each step fo...
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    13. 1-15 of 215 1 2 3 4 ... 13 14 15 »
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  2. About Stanford University

    Stanford University

    Stanford University was founded in 1891 by Leland and Jane Stanford to "promote the public welfare by exercising an influence on behalf of humanity and civilization." More than a century later, Stanford remains dedicated to finding solutions to the great challenges of the day and to preparing our students for leadership in today's complex world.