1. Stanford University

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    1. Mentioned In 169 Articles

    2. Spectral-Domain Optical Coherence Tomography Angiography of Central Retinal Artery Occlusion

      Spectral-Domain Optical Coherence Tomography Angiography of Central Retinal Artery Occlusion
      The authors report the use of optical coherence tomography angiography (OCTA) to determine retinal blood flow in a patient with central retinal artery occlusion (CRAO). Spectral-domain OCTA (SD-OCTA) was performed on an eye with CRAO. En face vascular images were constructed using an optical microangiography algorithm. The retinal vasculature was clearly imaged with high fidelity; areas of perfused retina were identified with exquisite detail. This study supports use of OCTA ...
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    3. Feature of the Week 04/02/2016: Contrast-Enhanced Optical Coherence Tomography with Picomolar Sensitivity for Functional in vivo Imaging (with Audio)

      Feature of the Week 04/02/2016:  Contrast-Enhanced Optical Coherence Tomography with Picomolar Sensitivity for Functional in vivo Imaging (with Audio)
      ...oRelle et al, Langmuir 31(45) (2015) For more information see recent Article . Courtesy Adam de la Zerda from Stanford . Optical Coherence Tomography (OCT) enables real-time imaging of living tissues with cellular resolu...
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    4. High-speed spectral calibration by complex FIR filter in phase-sensitive optical coherence tomography

      High-speed spectral calibration by complex FIR filter in phase-sensitive optical coherence tomography
      Swept-laser sources offer a number of advantages for Phase-sensitive Optical Coherence Tomography (PhOCT). However, inter- and intra-sweep variability leads to calibration errors that adversely affect phase sensitivity. While there are several approaches to overcoming this problem, our preferred method is to simply calibrate every sweep of the laser. This approach offers high accuracy and phase stability at the expense of a substantial processing burden. In this approach, the Hilbert phase ...
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    5. Contrast-enhanced optical coherence tomography with picomolar sensitivity for functional in vivo imaging

      Contrast-enhanced optical coherence tomography with picomolar sensitivity for functional in vivo imaging
      Optical Coherence Tomography (OCT) enables real-time imaging of living tissues at cell-scale resolution over millimeters in three dimensions. Despite these advantages, functional biological studies with OCT have been limited by a lack of exogenous contrast agents that can be distinguished from tissue. Here we report an approach to functional OCT imaging that implements custom algorithms to spectrally identify unique contrast agents: large gold nanorods (LGNRs). LGNRs exhibit 110-fold greater spectral ...
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    6. Multimodal 3D cancer-mimicking optical phantom

      Multimodal 3D cancer-mimicking optical phantom
      Three-dimensional (3D) organ-mimicking phantoms provide realistic imaging environments for testing various aspects of optical systems, including for evaluating new probe designs, characterizing the diagnostic potential of new technologies, and assessing novel image processing algorithms prior to validation in real tissue. We introduce and characterize the use of a new material, Dragon Skin (Smooth-On Inc.), and fabrication technique, air-brushing, for fabrication of a 3D phantom that mimics the appearance of a ...
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    7. Combined optical coherence tomography and hyper-spectral imaging using a double clad fiber coupler

      Combined optical coherence tomography and hyper-spectral imaging using a double clad fiber coupler
      This proceedings shows the combination of Optical Coherence Tomography (OCT) and Hyper-Spectral Imaging (HSI) using a double-clad optical fiber. The single mode core of the fiber is used to transmit OCT signals, while the cladding, with its large collection area, provides an efficient way to capture the reflectance spectrum of the sample. The combination of both methods enables three-dimensional acquisition of sample morphology with OCT, enhanced by the molecular information ...
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    8. Phase-sensitive optical coherence tomography-based vibrometry using a highly phase-stable akinetic swept laser source

      Phase-sensitive optical coherence tomography-based vibrometry using a highly phase-stable akinetic swept laser source
      Phase-sensitive Optical Coherence Tomography (PhOCT) is an emerging tool for in vivo investigation of the vibratory function of the intact middle and inner ear. PhOCT is able to resolve micron scale tissue morphology in three dimensions as well as measure picometer scale motion at each spatial position. Most PhOCT systems to date have relied upon the phase stability offered by spectrometer detection. On the other hand swept laser source based ...
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    9. Iterative re-weighted approach to high-resolution optical coherence tomography with narrow-band sources

      Iterative re-weighted approach to high-resolution optical coherence tomography with narrow-band sources
      Optical coherence tomography (OCT) is a non-invasive optical imaging modality capable of high resolution imaging of internal tissue structures. It is widely believed that the high axial resolution in OCT systems requires a wide-bandwidth light source. As a result, often the potential advantages of narrow-bandwidth sources (in terms of cost and/or imaging speed) are understood to come at the cost of significant reduction in imaging resolution. In this paper ...
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    10. Quantitative contrast-enhanced optical coherence tomography

      Quantitative contrast-enhanced optical coherence tomography
      We have developed a model to accurately quantify the signals produced by exogenous scattering agents used for contrast-enhanced Optical Coherence Tomography (OCT). This model predicts distinct concentration-dependent signal trends that arise from the underlying physics of OCT detection. Accordingly, we show that real scattering particles can be described as simplified ideal scatterers with modified scattering intensity and concentration. The relation between OCT signal and particle concentration is approximately linear at ...
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    11. Automated segmentation of optic disc in SD-OCT images and cup-to-disc ratios quantification by patch searching-based neural canal opening detection

      Automated segmentation of optic disc in SD-OCT images and cup-to-disc ratios quantification by patch searching-based neural canal opening detection
      Glaucoma is one of the most common causes of blindness worldwide. Early detection of glaucoma is traditionally based on assessment of the cup-to-disc (C/D) ratio, an important indicator of structural changes to the optic nerve head. Here, we present an automated optic disc segmentation algorithm in 3-D spectral domain optical coherence tomography (SD-OCT) volumes to quantify this ratio. The proposed algorithm utilizes a two-stage strategy. First, it detects the ...
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    12. Automated, Depth-Resolved Estimation of the Attenuation Coefficient From Optical Coherence Tomography Data

      Automated, Depth-Resolved Estimation of the Attenuation Coefficient From Optical Coherence Tomography Data
      We present a method for automated, depth-resolved extraction of the attenuation coefficient from Optical Coherence Tomography (OCT) data. In contrast to previous automated, depth-resolved methods, the Depth-Resolved Confocal (DRC) technique derives an invertible mapping between the measured OCT intensity data and the attenuation coefficient while considering the confocal function and sensitivity fall-off, which are critical to ensure accurate measurements of the attenuation coefficient in practical settings (e.g., clinical endoscopy ...
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    13. Methods of Melanoma Detection

      Methods of Melanoma Detection
      Detection and removal of melanoma, before it has metastasized, dramatically improves prognosis and survival. The purpose of this chapter is to (1) summarize current methods of melanoma detection and (2) review state-of-the-art detection methods and technologies that have the potential to reduce melanoma mortality. Current strategies for the detection of melanoma range from population-based educational campaigns and screening to the use of algorithm-driven imaging technologies and performance of assays that ...
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    14. 1-15 of 169 1 2 3 4 ... 10 11 12 »
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  2. About Stanford University

    Stanford University

    Stanford University was founded in 1891 by Leland and Jane Stanford to "promote the public welfare by exercising an influence on behalf of humanity and civilization." More than a century later, Stanford remains dedicated to finding solutions to the great challenges of the day and to preparing our students for leadership in today's complex world.