Purpose: To develop and evaluate an improved method of generating en face fundus images from three-dimensional optical coherence tomography images which enhances the visualization of drusen. Methods: We describe a novel approach, the restricted summed-voxel projection (RSVP), to generate en face projection images of the retinal surface combined with an image processing method to enhance drusen visualization. The RSVP approach is an automated method that restricts the projection to the retinal pigment epithelium layer neighborhood. Additionally, drusen visualization is improved through an image processing technique that fills drusen with bright pixels. The choroid layer is also excluded when creating the ...
Objectives This first-in-human multicenter study sought to examine prospectively the safety and efficacy of a new, cobalt chromium thin-strut, coronary absorbable polymer–coated, sirolimus-eluting stent. Background Bioabsorbable polymers on drug-eluting stents may lower the long-term risks of inflammation, delayed healing, and adverse events. Methods We enrolled patients with symptomatic coronary artery disease with stable or unstable angina pectoris and >50% diameter stenosis, amenable to coverage with a ≤23-mm long stent in a vessel 2.5 to 3.5 mm in diameter. All patients received dual antiplatelet therapy after implantation. Patients, in groups of 10, underwent repeat angiography, intravascular ultrasound, and ...
Purpose: To describe the appearance of acute syphilitic posterior placoid chorioretinitis, a rare ocular manifestation of syphilis, on spectral domain optical coherence tomography (SD OCT) both before and after treatment. Methods: Ophthalmic examination and imaging studies of 30 eyes of 19 confirmed cases were analyzed both at the time of presentation and at each follow-up visit. Patients with SD OCT and fluorescein angiography at the time of presentation, and at least three documented follow-up visits after initiation of therapy, were included in the study. Standard treatment of neurosyphilis was given to each patient, including 4 million units of penicillin G ...
Stanford University Received a 2013 NIH Grant for $482,301 for Enhanced Clinical Diagnosis of Early Osteoarthr...
A method for increasing the imaging rate for an optical coherence tomography system is disclosed. The method comprises generating an interferometric signal by interrogating each of M image points on a sample with a plurality of wavelength bands that are collectively spectrally interleaved, time encoding the interferometric signal, and sampling the time-encoded interferometric signal at a single detector.
Purpose: To report four examples of a novel optical coherence tomography finding, which appears to be characteristic of inflammatory choroidal neovascularization. Methods: Retrospective observational case series. Results: Four eyes of four patients were diagnosed clinically with inflammatory choroidal neovascularization and underwent optical coherence tomography. In each case, imaging revealed multiple, distinctive finger-like projections extending from the area of active choroidal neovascularization into the outer retina-the "pitchfork sign"-a finding not typically seen in Type 2 neovascularization due to other etiologies. Conclusion: The pitchfork sign may help distinguish inflammatory choroidal neovascularization from other causes of Type 2 neovascularization
Resolution is an important figure of merit for imaging systems. We designed, fabricated and tested an optical phantom consisting of a block of SU-8 with bars etched into its surface. This phantom mimics the simplicity of the 1951 Air Force test chart but can characterize both the axial and lateral resolution of optical coherence tomography systems. The phantom was successfully used to find the axial and lateral resolutions of multiple OCT systems.
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