1. Srinivas R. Sadda

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    1. Mentioned In 96 Articles

    2. Arvo Special Interest Group Meeting on Optical Coherence Tomography Angiography of the Eye

      Arvo Special Interest Group Meeting on Optical Coherence Tomography Angiography of the Eye

      The ARVO Special Interest Group meeting on "Optical Coherence Tomography Angiography of the Eye" wwill take place during ARVO 2015 meeting, in Denver Colorado. SIG Session Number: 125 Session Date/Start Time: M ay 3, 2015 from 1:30 PM to 3:00 PM Room: 2C/3C Mile High Ballroom Organizers: David Huang, Philip Rosenfeld, Moderators: Carmen Puliafito, James Fujimoto Participating in the Technology panel: David Huang, Yoshiaki Yasuno, Ruikang Wang, Yali Jia. Clinical panel 1: Phil Rosenfeld, SriniVas Sadda, Jay Duker, Ching-Jygh Chen, Bruno Lumbroso Clinical panel 2: Marco Rispoli, Andre Romano, Richard Rosen, Richard Spaide, Giovanni Staurenghi, Nadia ...

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    3. Comparison of Retinal Thicknesses Measured Using Swept-Source and Spectral-Domain Optical Coherence Tomography Devices

      Comparison of Retinal Thicknesses Measured Using Swept-Source and Spectral-Domain Optical Coherence Tomography Devices

      To compare retinal thicknesses measured using swept-source optical coherence tomography (SS-OCT) and spectral-domain (SD) OCT devices. PATIENTS AND METHODS: In a cohort study of 76 healthy eyes and 21 eyes with high myopia, mean retinal thicknesses in ETDRS subfields were compared between OCT scans obtained from the Topcon DRI OCT-1 (Topcon, Tokyo, Japan), Spectralis OCT (Heidelberg Engineering, Heidelberg, Germany), and Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA). RESULTS: Central retinal thickness measurements differed significantly among the three OCT devices (Spectralis: 271 µm; Cirrus: 254 µm; DRI OCT-1: 238 µm; P < .001), with mean differences ranging from 15.6 µm to ...

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    4. Measurement of retinal blood flow in normal Chinese American subjects by Doppler Fourier-domain optical coherence tomography

      Measurement of retinal blood flow in normal Chinese American subjects by Doppler Fourier-domain optical coherence tomography

      PURPOSE: To measure total retinal blood flow (TRBF) in normal, healthy Chinese-Americans using semi-automated analysis of Doppler Fourier-domain optical coherence tomography (FD-OCT) scans. METHODS: Two hundred sixty-six normal, healthy Chinese-American participants (266 eyes) were enrolled from The Chinese American Eye Study (CHES). All participants underwent complete ophthalmic examination, including best-corrected visual acuity, indirect ophthalmoscopy and Doppler FD-OCT imaging, using the circumpapillary double circular scan protocol. TRBF and other vascular parameters (e.g. venous and arterial cross-sectional area and their velocities) were calculated using Doppler OCT of Retinal Circulation software. Associations between TRBF and other clinical parameters were assessed using bivariate ...

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    5. TYPE 3 NEOVASCULARIZATION: Evolution, Association With Pigment Epithelial Detachment, and Treatment Response as Revealed by Spectral Domain Optical Coherence Tomography

      TYPE 3 NEOVASCULARIZATION: Evolution, Association With Pigment Epithelial Detachment, and Treatment Response as Revealed by Spectral Domain Optical Coherence Tomography

      Purpose: To demonstrate the evolution and treatment response of Type 3 neovascularization using spectral domain optical coherence tomography. Methods: We retrospectively analyzed 40 eyes treated with intravitreal anti-vascular endothelial growth factor therapy for Type 3 neovascularization over a variable follow-up period. Results: In 17 eyes, spectral domain optical coherence tomography captured the development of Type 3 neovascularization from punctate hyperreflective foci that preceded any outer retinal defect. The more mature Type 3 lesions were associated with outer retinal disruption and adjacent cystoid macular edema. In addition, 37 of 40 Type 3 lesions (93%) were associated with an underlying pigment epithelial ...

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    6. Change in Drusen Area Over Time Compared Using Spectral Domain Optical Coherence Tomagraphy and Color Fundus Imaging

      Change in Drusen Area Over Time Compared Using Spectral Domain Optical Coherence Tomagraphy and Color Fundus Imaging

      Purpose: To investigate the relationship between drusen area measurements from color fundus images (CFIs) and spectral domain optical coherence tomography (SDOCT) datasets. Methods: Forty-two eyes from thirty Patients with drusen in the absence of geographic atrophy were recruited into a prospective study. Digital color fundus images and SDOCT images (CirrusTM HD-OCT) were obtained at baseline and at follow-up visits at 3 and 6 months. Registered, matched circles centered on the fovea with diameters of 3 mm and 5 mm were identified on both the CFIs and the SDOCT images. SDOCT drusen measurements were obtained using a commercially available proprietary algorithm ...

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    7. Effect of Angle of Incidence on Anterior Chamber Angle Metrics From Optical Coherence Tomography

      Effect of Angle of Incidence on Anterior Chamber Angle Metrics From Optical Coherence Tomography

      Purpose: To evaluate the local variability of anterior chamber angle (ACA) metrics obtained by time domain (TD) and spectral domain (SD) optical coherence tomography (OCT). Materials and Methods: Anterior-segment OCT imaging was performed on 30 normal eyes using Visante TD-OCT and 40 normal eyes using Cirrus SD-OCT. For Visante OCT, a single 16-mm line scan of the inferior angle with 3 slightly different rotations of 265, 270, and 275 degrees was performed. For Cirrus OCT, a 5-line raster of the inferior angle was performed, centering the third scan line at the 6 o'clock position, with 0.25 mm between ...

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    8. Reproducibility of Anterior Segment Angle Metrics Measurements Derived From Cirrus Spectral Domain Optical Coherence Tomography

      Reproducibility of Anterior Segment Angle Metrics Measurements Derived From Cirrus Spectral Domain Optical Coherence Tomography

      Purpose: To investigate the reproducibility of anterior segment angle (ACA) metrics measurements in normal subjects on Cirrus spectral domain optical coherence tomography (SD-OCT). Methods: 40 eyes from 20 healthy, normal subjects underwent anterior segment imaging using a Cirrus SD-OCT. For each eye, 2 acquisitions of 5-line raster scans were performed perpendicularly on the inferior (270 degrees) angle. The Schwalbe's line-angle opening distance (SL-AOD) and Schwalbe's line-trabecular-iris space area (SL-TISA) measurements were performed by masked certified reading center graders using customized grading software. Intra-acquisition, intergrader, and intragrader reproducibility of SL-AOD and SL-TISA measurements were evaluated by intraclass correlation coefficients ...

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    9. Advanced Optical Coherence Tomography Applications for the Retina Specialist (CME Webinar Seires)

      Advanced Optical Coherence Tomography Applications for the Retina Specialist (CME Webinar Seires)

      Advances in retinal pharmacology have significantly improved outcomes for patients with a range of chronic retinal conditions, including age-related macular degeneration, macular edema, retinal vascular disorders and diseases of the vitreomacular interface. Maximizing the efficacy of available treatments requires the appropriate use of optical coherence tomography (OCT) to diagnose these conditions and to monitor the efficacy of treatment. In this webinar series, leading clinicians and researchers will discuss the role of OCT in detecting structural changes associated with a range of retinal diseases and provide clinical pearls on using tools such as thickness maps, automated change analysis and angiography in ...

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    10. Dual-Angle Protocol for Doppler Optical Coherence Tomography to Improve Retinal Blood Flow Measurement

      Dual-Angle Protocol for Doppler Optical Coherence Tomography to Improve Retinal Blood Flow Measurement

      Purpose: To compare the performance of two different multiple-scan protocols for total retinal blood flow (TRBF) measurement using Doppler optical coherence tomography (OCT). Methods: In the “single-angle” protocol, five Doppler scans were acquired at a single beam angle. In the “dual-angle” protocol, three scans were obtained with the OCT beam passing through the supranasal portion of the pupil and three through the infranasal portion. The data were analyzed using a custom software termed “Doppler OCT of Retinal Circulation” (DOCTORC) to generate TRBF measurements. In DOCTORC, the measurement of a vein was considered unreliable if the Doppler angle was less than ...

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    11. Grader learning effect and reproducibility of Doppler Spectral‐Domain Optical Coherence Tomography derived retinal blood flow measurements

      Grader learning effect and reproducibility of Doppler Spectral‐Domain Optical Coherence Tomography derived retinal blood flow measurements
      ...alpana Rose^1, 2. Monica Jong^2, 3. Firdaus Yusof^1,3, 4. Faryan Tayyari^1, 5. Ou Tan^4, 6. David Huang^4, 7. Srinivas R Sadda^5, 8. John G Flanagan^1,2 and 9. Christopher Hudson^1,2,* Article first published online: 6...
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    12. Reproducibility of Angle Metrics Using the Time-Domain Anterior Segment Optical Coherence Tomography: Intra-Observer and Inter-Observer Variability

      Reproducibility of Angle Metrics Using the Time-Domain Anterior Segment Optical Coherence Tomography: Intra-Observer and Inter-Observer Variability

      Purpose : To evaluate the reproducibility of anterior chamber angle measurements obtained by the Zeiss Visante anterior segment optical coherence tomography (AS-OCT). Methods : Twenty eyes from 20 normal subjects with open anterior chamber angles were studied. The anterior chamber angle was imaged using the Visante AS-OCT. The angle-opening distance (AOD 500, AOD 750), trabercular iris space area (TISA 500, TISA 750) and scleral spur angle (SS angle) at the inferior angle location were measured. All the subjects underwent imaging in a darkened room (1 foot candles measured at the eye). Images were graded in a masked fashion by certified Doheny Image ...

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  2. About Srinivas R. Sadda

    Srinivas R. Sadda

    Srinivas R. Sadda, MD, Assistant Professor of Ophthalmology, Doheny Image Reading Center, Doheny Eye Institute, Keck School of Medicine of the University of Southern California.

  3. Quotes

    1. With CIRRUS FastTrac, I can place a highest resolution 20x B-Scan precisely on the area I am treating at each successive visit to see the fine details of the patient’s response to treatment...It’s also very helpful for removing any eye motion from the larger cube scans without disturbing my patient flow because it works so quickly. My initial experience is that FastTrac is about 30 percent faster than other tracking methods I have used.
      In Modernized new OCT platforms span full spectrum of multi-modality imaging for glaucoma and retinal disease