BACKGROUND AND OBJECTIVE: To report a novel optical coherence tomography (OCT) finding in choroidal neovascularization (CNV). PATIENTS AND METHODS: The authors identified seven eyes with CNV demonstrating the atypical pattern of fluid accumulation within the outer retina on OCT. Patient demographics, best corrected visual acuity and spectral-domain OCT (SD-OCT) images were collected for all available follow-up visits. Volume and area of the fluid were measured on SD-OCT. Microperimetry was performed in one case. RESULTS: The outer retinal fluid was located between the external limiting membrane (ELM) and the outer photoreceptor band on SD-OCT. Within this area, the outer segments of ...

Purpose: The purpose is to develop a geographic atrophy segmentation approach in both spectral-domain optical coherence tomography (SD-OCT) and fundus autofluorescence (FAF) images and compare the segmentation performance. Methods: To identify GA in SD-OCT images, three surfaces were first segmented using graph search. A 2-D partial OCT projection image was created from the segmented choroid layer. A level-set approach was applied to segment GA in the partial OCT projection image. The algorithm was also applied to FAF images. Twenty randomly chosen macular SD-OCT (Zeiss Cirrus) volumes and twenty corresponding FAF (Heidelberg Spectralis) images were obtained from twenty subjects with GA ...

Purpose: To compare the optical coherence tomographic (OCT) correlates of two previously described angiographic subtypes of occult choroidal neovascularization (CNV). Methods: We retrospectively analyzed 17 consecutive patients with previously untreated occult CNV who had both fluorescein angiography (FA) and volume spectral domain (SD) OCT images obtained on the same visit. Planimetric grading was performed on the FA images by certified reading center graders to precisely outline the boundaries of the fibrovascular pigment epithelial detachment (FVPED) and/or late leakage of undetermined source (LLUS) components of occult CNV for each case. In the SDOCT images, the inner retinal pigment epithelial (RPE ...

Purpose: Relationship between spectral domain optical coherence tomography (SD-OCT) and visual acuity (VA) in neovascular age-related macular degeneration (NVAMD). Procedures: VA and SD-OCTs of 64 treatment-naive eyes with NVAMD were retrospectively collected at baseline and 1 year (n = 30). Retinal and subretinal spaces were manually analyzed. Volume and thickness measurements were correlated with VA. Results: At baseline, lower VA correlated with increased volume of subretinal hyperreflective material (R = 0.4, p < 0.001) and with decreased volume of the photoreceptor layer (PRL, R = -0.4, p < 0.01). At 1 year, lower VA correlated with decreased volume of the retina ...

Purpose: To compare drusen measurements obtained from color fundus and infrared retromode photographs with those derived from spectral-domain optical coherence tomography. Methods: Drusen lesions identified on the planar (color and infrared) imaging modalities were manually segmented by two independent graders using previously described reading center software to produce quantitative measurements of drusen area and number. The corresponding volume Cirrus OCT datasets were analyzed using commercial retinal pigment epithelium analysis algorithms to segment the retinal pigment epithelium band and estimated the drusen area. Drusen numbers were extracted from retinal pigment epithelium elevation maps. Intraclass correlation coefficients assessed agreement between graders; graders ...

Purpose. To specify thickness values of various retinal layers onmacular spectral domainOptical Coherence Tomography (SDOCT) scans in patients with autosomal dominant optic atrophy (ADOA) compared to healthy controls. Methods. SDOCT volume scans of 7 patients with ADOA (OPA-1 mutation) and 14 healthy controls were quantitatively analyzed using manual grading software. Mean thickness values for the ETDRS grid subfields 5&ndash;8 were calculated for the spaces neurosensory retina, retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), a combined space of inner plexiform layer/outer plexiform layer/inner nuclear layer (IPL+INL+OPL), and a combined space of outer nuclear ...

Purpose: To investigate the effect of panretinal photocoagulation (PRP) on retinal blood flow and shear rate using Doppler Fourier-domain optical coherence tomography (FD-OCT) in poorly controlled diabetics with proliferative diabetic retinopathy (PDR). Methods: Prospective interventional pilot study in patients with a new clinical diagnosis of PDR. Retinal blood flow and vessel diameter was measured using Doppler FD-OCT according to a previously described method, immediately before PRP treatment and 7-8 weeks after the last PRP session. Results:10 patients with poorly controlled PDR (mean hemoglobin A1c= 9.2 +/-2.0%) and 10 control subjects were included in the study. PDR patients ...

Purpose:To determine the sensitivity of detection for retinal abnormalities using 3D-OCT versus single field fundus imaging. Methods:Images from consecutive patients in a retina clinic undergoing simultaneous 3D-OCT (512x128) and single, foveal non-mydriatic 45 degree color fundus imaging with 3D-OCT-1000 (Topcon Corp, Tokyo, Japan) in a 4 months period were retrospectively collected. Findings for each modality were graded independently by two graders as present, questionable or absent. Findings were separated into 3 categories for intermodality comparisons: epiretinal, retinal/subretinal, and RPE/choroidal. The approximate location of findings in relation to the 3D-OCT field was noted as infield and out ...

Aim To compare retinal pigment epithelium–Bruch's membrane (RPE–BM) complex thickness in patients with early and intermediate dry age-related macular degeneration (AMD) and age-matched controls using spectral domain optical coherence tomography (SD-OCT). Methods In this retrospective, cross-sectional study, 25 patients with dry AMD and 25 controls were recruited. SD-OCT scans were manually segmented by two independent investigators. Thickness values were calculated for the nine Early Treatment Diabetic Retinopathy Study (ETDRS) subfields. Results RPE–BM thickness was significantly thicker in the dry AMD group (32.3, 30.6 and 28.4 μm for central, inner and outer subfields, respectively ...

Purpose. To compare color fundus photography (FP), fluorescein angiography (FA), and spectral domain optical coherence tomography (SDOCT) for the detection of age-related macular degeneration (AMD), choroidal neovascularisation (CNV), and CNV activity. Methods. FPs, FAs, and SDOCT volume scans from 120 eyes of 66 AMD and control patients were randomly collected. Control eyes were required to show no AMD, but other retinal pathology was allowed. The presence of drusen, pigmentary changes, CNV, and signs for CNV activity was independently analyzed for all imaging modalities. Results. AMD was diagnosed based on FP in 75 eyes. SDOCT and FA showed sensitivity (specificity) of ...