1. Srinivas R. Sadda

    0 Comments Leave a Comment

    1-15 of 80 1 2 3 4 5 6 »
    1. Mentioned In 80 Articles

    2. Quantitative Analysis of Diabetic Macular Ischemia using Optical Coherence Tomography

      Quantitative Analysis of Diabetic Macular Ischemia using Optical Coherence Tomography

      Purpose: To describe the optical coherence tomography (OCT) features of diabetic macular ischemia (DMI), and correlate these findings with visual acuity (VA). Methods: Clinical and imaging data were collected from 100 patients with type 2 diabetes. Qualitative grading of DMI severity was determined according to criteria defined by the Early Treatment Diabetic Retinopathy Study. Quantitative analysis of foveal avascular zone (FAZ), and OCT images were performed using custom software. Results: In all eyes, the outer retina was thicker in eyes with DMI, (167.4 ± 18.5 µm) versus (150.4 ± 31.4 µm) (p=0.04). However, sub analysis of ...

      Read Full Article
    3. Atypical Outer Retinal Fluid Accumulation in Choroidal Neovascularization: A Novel OCT Finding

      Atypical Outer Retinal Fluid Accumulation in Choroidal Neovascularization: A Novel OCT Finding

      BACKGROUND AND OBJECTIVE: To report a novel optical coherence tomography (OCT) finding in choroidal neovascularization (CNV). PATIENTS AND METHODS: The authors identified seven eyes with CNV demonstrating the atypical pattern of fluid accumulation within the outer retina on OCT. Patient demographics, best corrected visual acuity and spectral-domain OCT (SD-OCT) images were collected for all available follow-up visits. Volume and area of the fluid were measured on SD-OCT. Microperimetry was performed in one case. RESULTS: The outer retinal fluid was located between the external limiting membrane (ELM) and the outer photoreceptor band on SD-OCT. Within this area, the outer segments of ...

      Read Full Article
    4. Segmentation of the Geographic Atrophy in Spectral-domain Optical Coherence Tomography and Fundus Autofluorescene Images

      Segmentation of the Geographic Atrophy in Spectral-domain Optical Coherence Tomography and Fundus Autofluorescene Images

      Purpose: The purpose is to develop a geographic atrophy segmentation approach in both spectral-domain optical coherence tomography (SD-OCT) and fundus autofluorescence (FAF) images and compare the segmentation performance. Methods: To identify GA in SD-OCT images, three surfaces were first segmented using graph search. A 2-D partial OCT projection image was created from the segmented choroid layer. A level-set approach was applied to segment GA in the partial OCT projection image. The algorithm was also applied to FAF images. Twenty randomly chosen macular SD-OCT (Zeiss Cirrus) volumes and twenty corresponding FAF (Heidelberg Spectralis) images were obtained from twenty subjects with GA ...

      Read Full Article
    5. Optical Coherence Tomographic Correlates of Angiographic Subtypes of Occult Choroidal Neovascularization

      Optical Coherence Tomographic Correlates of Angiographic Subtypes of Occult Choroidal Neovascularization

      Purpose: To compare the optical coherence tomographic (OCT) correlates of two previously described angiographic subtypes of occult choroidal neovascularization (CNV). Methods: We retrospectively analyzed 17 consecutive patients with previously untreated occult CNV who had both fluorescein angiography (FA) and volume spectral domain (SD) OCT images obtained on the same visit. Planimetric grading was performed on the FA images by certified reading center graders to precisely outline the boundaries of the fibrovascular pigment epithelial detachment (FVPED) and/or late leakage of undetermined source (LLUS) components of occult CNV for each case. In the SDOCT images, the inner retinal pigment epithelial (RPE ...

      Read Full Article
    6. Relationship between Visual Acuity and Spectral Domain Optical Coherence Tomography Retinal Parameters in Neovascular Age-Related Macular Degeneration

      Relationship between Visual Acuity and Spectral Domain Optical Coherence Tomography Retinal Parameters in Neovascular Age-Related Macular Degeneration

      Purpose: Relationship between spectral domain optical coherence tomography (SD-OCT) and visual acuity (VA) in neovascular age-related macular degeneration (NVAMD). Procedures: VA and SD-OCTs of 64 treatment-naive eyes with NVAMD were retrospectively collected at baseline and 1 year (n = 30). Retinal and subretinal spaces were manually analyzed. Volume and thickness measurements were correlated with VA. Results: At baseline, lower VA correlated with increased volume of subretinal hyperreflective material (R = 0.4, p < 0.001) and with decreased volume of the photoreceptor layer (PRL, R = -0.4, p < 0.01). At 1 year, lower VA correlated with decreased volume of the retina ...

      Read Full Article
    7. Drusen Measurements Comparison By Fundus Photograph Manual Delineation Versus Optical Coherence Tomography Retinal Pigment Epithelial Segmentation Automated Analysis

      Drusen Measurements Comparison By Fundus Photograph Manual Delineation Versus Optical Coherence Tomography Retinal Pigment Epithelial Segmentation Automated Analysis

      Purpose: To compare drusen measurements obtained from color fundus and infrared retromode photographs with those derived from spectral-domain optical coherence tomography. Methods: Drusen lesions identified on the planar (color and infrared) imaging modalities were manually segmented by two independent graders using previously described reading center software to produce quantitative measurements of drusen area and number. The corresponding volume Cirrus OCT datasets were analyzed using commercial retinal pigment epithelium analysis algorithms to segment the retinal pigment epithelium band and estimated the drusen area. Drusen numbers were extracted from retinal pigment epithelium elevation maps. Intraclass correlation coefficients assessed agreement between graders; graders ...

      Read Full Article
    8. SD-OCT Thickness Measurements of Various Retinal Layers in Patients with Autosomal Dominant Optic Atrophy due to OPA1 Mutations

      SD-OCT Thickness Measurements of Various Retinal Layers in Patients with Autosomal Dominant Optic Atrophy due to OPA1 Mutations

      Purpose. To specify thickness values of various retinal layers onmacular spectral domainOptical Coherence Tomography (SDOCT) scans in patients with autosomal dominant optic atrophy (ADOA) compared to healthy controls. Methods. SDOCT volume scans of 7 patients with ADOA (OPA-1 mutation) and 14 healthy controls were quantitatively analyzed using manual grading software. Mean thickness values for the ETDRS grid subfields 5&ndash;8 were calculated for the spaces neurosensory retina, retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), a combined space of inner plexiform layer/outer plexiform layer/inner nuclear layer (IPL+INL+OPL), and a combined space of outer nuclear ...

      Read Full Article
    9. The Retinal Disease Screening Study: Retrospective Comparison of Nonmydriatic Fundus Photography and Three-Dimensional Optical Coherence Tomography for Detection of Retinal Irregularities

      The Retinal Disease Screening Study: Retrospective Comparison of Nonmydriatic Fundus Photography and Three-Dimensional Optical Coherence Tomography for Detection of Retinal Irregularities
      ... Trust, and University College London Institute of Ophthalmology, London, United Kingdom 1. Correspondence: Srinivas R. Sadda, Doheny Eye Institute, 1450 San Pablo Street, Los Angeles, CA 90033; SSadda{at}doheny.org. ...
      Read Full Article
    10. Pilot Study of Doppler optical coherence tomography of retinal blood flow following laser photocoagulation in poorly controlled diabetic patients

      Pilot Study of Doppler optical coherence tomography of retinal blood flow following laser photocoagulation in poorly controlled diabetic patients

      Purpose: To investigate the effect of panretinal photocoagulation (PRP) on retinal blood flow and shear rate using Doppler Fourier-domain optical coherence tomography (FD-OCT) in poorly controlled diabetics with proliferative diabetic retinopathy (PDR). Methods: Prospective interventional pilot study in patients with a new clinical diagnosis of PDR. Retinal blood flow and vessel diameter was measured using Doppler FD-OCT according to a previously described method, immediately before PRP treatment and 7-8 weeks after the last PRP session. Results:10 patients with poorly controlled PDR (mean hemoglobin A1c= 9.2 +/-2.0%) and 10 control subjects were included in the study. PDR patients ...

      Read Full Article
    11. Optical Coherence Tomography Device, Method, And System

      Optical Coherence Tomography Device, Method, And System

      In accordance with one aspect of the present invention, an optical coherence tomography instrument comprises an eyepiece for receiving at least one eye of a user is provided; a light source that outputs light that is directed through the eyepiece into the user's eye; an interferometer configured to produce optical interference using light reflected from the user's eye; an optical detector disposed so as to detect said optical interference; and electronics coupled to the detector. The electronics can be configured to perform a risk assessment analysis based on optical coherence tomography measurements obtained using the interferometer. An output ...

      Read Full Article
    12. Comparison of Non-Mydriatic Fundus Photography and Three Dimensional Optical Coherence Tomography for Detection of Retinal Irregularities

      Comparison of Non-Mydriatic Fundus Photography and Three Dimensional Optical Coherence Tomography for Detection of Retinal Irregularities

      Purpose:To determine the sensitivity of detection for retinal abnormalities using 3D-OCT versus single field fundus imaging. Methods:Images from consecutive patients in a retina clinic undergoing simultaneous 3D-OCT (512x128) and single, foveal non-mydriatic 45 degree color fundus imaging with 3D-OCT-1000 (Topcon Corp, Tokyo, Japan) in a 4 months period were retrospectively collected. Findings for each modality were graded independently by two graders as present, questionable or absent. Findings were separated into 3 categories for intermodality comparisons: epiretinal, retinal/subretinal, and RPE/choroidal. The approximate location of findings in relation to the 3D-OCT field was noted as infield and out ...

      Read Full Article
    13. Multiple layer segmentation and analysis in three-dimensional spectral-domain optical coherence tomography volume scans

      Multiple layer segmentation and analysis in three-dimensional spectral-domain optical coherence tomography volume scans
      ...reference for subsequent adaptations in eyes with diseases. Zhihong Hu ; Xiaodong Wu ; Amirhossein Hariri and Srinivas R. Sadda "Multiple layer segmentation and analysis in three-dimensional spectral-domain optical coher...
      Read Full Article
    14. Evaluation of retinal pigment epithelium-Bruch's membrane complex thickness in dry age-related macular degeneration using optical coherence tomography

      Evaluation of retinal pigment epithelium-Bruch's membrane complex thickness in dry age-related macular degeneration using optical coherence tomography

      Aim To compare retinal pigment epithelium–Bruch's membrane (RPE–BM) complex thickness in patients with early and intermediate dry age-related macular degeneration (AMD) and age-matched controls using spectral domain optical coherence tomography (SD-OCT). Methods In this retrospective, cross-sectional study, 25 patients with dry AMD and 25 controls were recruited. SD-OCT scans were manually segmented by two independent investigators. Thickness values were calculated for the nine Early Treatment Diabetic Retinopathy Study (ETDRS) subfields. Results RPE–BM thickness was significantly thicker in the dry AMD group (32.3, 30.6 and 28.4 μm for central, inner and outer subfields, respectively ...

      Read Full Article
    15. 1-15 of 80 1 2 3 4 5 6 »
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources, Velocimetry
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. About Srinivas R. Sadda

    Srinivas R. Sadda

    Srinivas R. Sadda, MD, Assistant Professor of Ophthalmology, Doheny Image Reading Center, Doheny Eye Institute, Keck School of Medicine of the University of Southern California.

  3. Quotes

    1. With CIRRUS FastTrac, I can place a highest resolution 20x B-Scan precisely on the area I am treating at each successive visit to see the fine details of the patient’s response to treatment...It’s also very helpful for removing any eye motion from the larger cube scans without disturbing my patient flow because it works so quickly. My initial experience is that FastTrac is about 30 percent faster than other tracking methods I have used.
      In Modernized new OCT platforms span full spectrum of multi-modality imaging for glaucoma and retinal disease