1. South China Normal University

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    1. Mentioned In 49 Articles

    2. Fluorescein Leakage and Optical Coherence Tomography Angiography Features of Microaneurysms in Diabetic Retinopathy

      Fluorescein Leakage and Optical Coherence Tomography Angiography Features of Microaneurysms in Diabetic Retinopathy
      Background and Objective. To correlate optical coherence tomography angiography (OCTA) characteristics of diabetic microaneurysms (MAs) with leakage status on fluorescein angiography (FA). Patients and Methods. 167 MAs from 39 diabetic eyes were analyzed using OCTA and FA simultaneously. The characteristics of MAs on OCTA en face, OCT en face, and OCT B-scan with flow overlay were evaluated and correlated with fluorescein leakage status. Results. Thirty-six, fifty-two, and seventy-nine MAs showed ...
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    3. Carbon Dots with Intrinsic Bioactivities for Photothermal Optical Coherence Tomography, tumor-specific Therapy and Postoperative Wound Management

      Carbon Dots with Intrinsic Bioactivities for Photothermal Optical Coherence Tomography, tumor-specific Therapy and Postoperative Wound Management
      Carbon dots (CDs) have been considered as promising candidates with superior biocompatibilities for multimodel cancer theranostics. However, incorporation of exogenous components, such as targeting molecules and chemo/photo therapeutic drugs, are often required to improve the therapeutic efficacy. Herein, we propose an "all-in-one" CDs that exhibit intrinsic bioactivities for bioimaging, potent tumor therapy and postoperative management. The multifunctional CDs derived from gallic acid and tyrosine (GT-CDs) consist of a graphitized ...
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    4. Pulse photothermal optical coherence tomography for multimodal hemodynamic imaging

      Pulse photothermal optical coherence tomography for multimodal hemodynamic imaging
      To realize multimodal hemodynamic imaging, pulse photothermal optical coherence tomography (P-PTOCT) is proposed in this Letter to solve the separation problem of photothermal phase and Doppler phase, which is difficult to solve in traditional PTOCT. This technique can obtain blood flow distribution, light absorption distribution, and concentration images simultaneously. Based on the difference between pulse photothermal phase and Doppler phase, we propose an even number differential demodulation algorithm that can ...
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    5. Low-Reflectivity Drusen With Overlying RPE Damage Revealed by Spectral-Domain OCT: Hint for the Development of Age-Related Macular Degeneration

      Low-Reflectivity Drusen With Overlying RPE Damage Revealed by Spectral-Domain OCT: Hint for the Development of Age-Related Macular Degeneration
      Purpose: To observe the relationship between the characteristic changes in the drusen morphology revealed by the spectral-domain optical coherence tomography (SD-OCT) and the progression of age-related macular degeneration (AMD). Methods: A total of 380 drusen in 45 eyes in 35 patients with the intermediate drusen were longitudinally followed up every 6 months by SD-OCT for a period of 24 months. The drusen were divided into the dynamic group and stable ...
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    6. The effects of electrical pulses-mediated gold and silver nanoparticles on the optical properties of ex vivo human femoral head tissue with optical coherence tomography

      The effects of electrical pulses-mediated gold and silver nanoparticles on the optical properties of ex vivo human femoral head tissue with optical coherence tomography
      This study aims to monitor and assess the penetration and accumulation of gold nanoparticles (Au NPs) or silver nanoparticles (Ag NPs) (average particle size 40 nm) and the penetration of the Au NPs or Ag NPs assisted by electrical impulses (EP) in human normal femoral head (NFH) and pathological femoral head (PFH) tissues. The results show that optical coherence tomography images can easily distinguish NFH from PFH tissues. The control ...
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    7. Optical coherence hyperspectral microscopy with a single supercontinuum light source

      Optical coherence hyperspectral microscopy with a single supercontinuum light source
      In the paper, we have developed an optical coherence hyperspectral microscopy with a single supercontinuum light source. The microscopy consists of optical coherence tomography (OCT) and hyperspectral imaging (HSI), which can visualize the structural and functional characteristics of biological tissues. The 500-700 nm band is selected for HSI and OCT imaging, where HSI enables imaging of oxygen saturation and hemoglobin (Hb) content, while OCT acquires structural characteristics to assess the ...
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    8. Retinal cross‐section motion correction in three‐dimensional retinal optical coherence tomography

      Retinal cross‐section motion correction in three‐dimensional retinal optical coherence tomography
      Motion correction is an important issue in ophthalmic optical coherence tomography (OCT), and can improve the ability of datasets to reflect the physiological structures of tissues and make visualization and subsequent analysis easier. In this study, we present a novel method to correct the cross-sectional motion artifacts in retinal OCT volumes. Motion along the x-direction (fast-scan direction) is corrected through the normalized cross-correlation algorithm, while axial motion compensation is performed ...
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    9. Redox responsive nanoparticle encapsulating black phosphorus quantum dots for cancer theranostics

      Redox responsive nanoparticle encapsulating black phosphorus quantum dots for cancer theranostics
      Effective cancer treatment puts high demands for cancer theranostics. For cancer diagnostics, optical coherence tomography (OCT) technology (including photothermal optical coherence tomography (PT-OCT)) has been widely investigated since it induces changes in optical phase transitions in tissue through environmental changes (such as temperature change for PT-OCT). In this report, redox responsive nanoparticle encapsulating black phosphorus quantum dots was developed as a robust PT-OCT agent. Briefly, black phosphorus quantum dots (BPQDs ...
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    10. Towards quantitative assessment of burn based on photoacoustic and optical coherence tomography

      Towards quantitative assessment of burn based on photoacoustic and optical coherence tomography
      Accurate and timely assessment of the severity of burn is essential for the treatment of burns. Currently, although most first‐degree and third‐degree burns are easily diagnosed through visual inspection or auxiliary diagnostic methods, the second‐degree burn is still difficult to distinguish due to the ambiguity boundaries of second‐degree with first‐degree and third‐degree burns. In this study, we proposed a non‐invasive technique by combing ...
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    11. Multi-parameter characterization of atherosclerotic plaques based on optical coherence tomography, photoacoustic and viscoelasticity imaging

      Multi-parameter characterization of atherosclerotic plaques based on optical coherence tomography, photoacoustic and viscoelasticity imaging
      Detection of atherosclerotic plaque vulnerability is the critical step in prevention of acute coronary events. Fibrous cap thickness, lipid core size, and inflammation extent are three key parameters for assessing plaque vulnerability. Here, we report on multimodality imaging of mice aortic plaques using a system that integrates optical coherence tomography (OCT), photoacoustic imaging (PAI), and photoacoustic viscoelasticity imaging (PAVEI). The thickness of fibrous cap is accurately evaluated by OCT, and ...
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    12. Optical Biopsy of Melanoma and Basal Cell Carcinoma Progression by Noncontact Photoacoustic and Optical Coherence Tomography: In vivo Multi-parametric Characterizing Tumor Microenvironment

      Optical Biopsy of Melanoma and Basal Cell Carcinoma Progression by Noncontact Photoacoustic and Optical Coherence Tomography: In vivo Multi-parametric Characterizing Tumor Microenvironment
      Measuring the structural and functional status of tumor microenvironment for malignant melanoma (MM) and basal cell carcinoma (BCC) is of profound significance in understanding dermatological condition for biopsy. However, conventional optical imaging techniques are limited to visualize superficial skin features and parameter information is deficient to depict pathophysiology correlations of skin diseases. Here, we demonstrate a preclinical device, all-optically integrated photoacoustic and optical coherence tomography (AOPA/OCT), that, for the ...
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    13. Co-impulse multispectral photoacoustic microscopy and optical coherence tomography system using a single supercontinuum laser

      Co-impulse multispectral photoacoustic microscopy and optical coherence tomography system using a single supercontinuum laser
      A combination of multispectral photoacoustic microscopy (PAM) and optical coherence tomography (OCT) by a single light source was previously realized discretely; however, this is unfavorable for visualizing vital physiological and pathological activities in vivo . Here, a co-impulse dual-mode imaging system that simultaneously enables multispectral PAM and OCT using a megahertz supercontinuum pulse laser in vivo is presented. The 500600 nm band is used for functional PAM imaging, which can flexibly ...
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    14. Cross-correlation photothermal optical coherence tomography with high effective resolution

      Cross-correlation photothermal optical coherence tomography with high effective resolution
      We developed a cross-correlation photothermal optical coherence tomography (CC-PTOCT) system for photothermal imaging with high lateral and axial resolution. The CC-PTOCT system consists of a phase-sensitive OCT system, a modulated pumping laser, and a digital cross-correlator. The pumping laser was used to induce the photothermal effect in the sample, causing a slight phase modulation of the OCT signals. A spatial phase differentiation method was employed to reduce phase accumulation. The ...
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    15. Optical biopsy approach to basal cell carcinoma and melanoma based on all-optically integrated photoacoustic and optical coherence tomography

      Optical biopsy approach to basal cell carcinoma and melanoma based on all-optically integrated photoacoustic and optical coherence tomography
      Basal cell carcinoma (BCC) and melanoma (MM), with the highest morbidity and mortality, respectively, are considered as two skin cancers of concern in dermatology. Histological studies have demonstrated that vascular patterns and collagenous stroma serve as key parameters for BCC and MM classification. In this Letter, we sought to identify BCC and MM based on the dual parameters of vascular patterns and scattering structures provided by all-optically integrated photoacoustic and ...
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    16. Noninvasive monitoring of blood glucose concentration in diabetic patients with optical coherence tomography

      Noninvasive monitoring of blood glucose concentration in diabetic patients with optical coherence tomography
      Optical coherence tomography (OCT) has been used to noninvasively monitor the blood glucose concentration (BGC) in healthy subjects with good accuracy and acceptable specificity. Based on this, the paper further considered the possibility of OCT in noninvasive monitoring BGC in diabetic patients. The OCT signal slope (OCTSS) changed with variation of BGC. The correlation coefficient R between BGC and OCTSS in diabetic patients was 0.91; while the correlation coefficient ...
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  2. About South China Normal University

    South China Normal University

    South China Normal University is an institution of higher learning with a long history and a rich legacy. Situated in Guangzhou, an open metropolis in South China, the University is imbued with Lingnan’s pioneering and pragmatic spirit. It has a tradition of elegant simplicity and a favourable learning atmosphere. In the past seventy years or so, the University has all along preserved its distinguishing characteristics, mainly concentrating on teacher-education and training, and has dedicated itself to training qualified teachers and professionals of other kind, viz., outstanding personnel of moral integrity, high thinking, inventive ability, with a sense of responsibility.