1. Singapore Eye Research Institute

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    1. Mentioned In 121 Articles

    2. Postdoctoral Research Fellow Position in the Ocular Imaging Program at the Singapore Eye Research Institute

      Postdoctoral Research Fellow Position in the Ocular Imaging Program at the Singapore Eye Research Institute
      ...ional qualification, career history, current and expected salaries, contact number(s) and e-mail address to: Singapore Eye Research Institute 11 Third Hospital Avenue #05-00 Singapore 168751 Email: hr@seri.com.sg ...
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    3. Clinical Use of Optical Coherence Tomography Angiography in Diabetic Retinopathy Treatment Ready for Showtime?

      Clinical Use of Optical Coherence Tomography Angiography in Diabetic Retinopathy Treatment Ready for Showtime?
      Diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR) are the 2 advanced stages of diabetic retinopathy (DR) that are the main causes for visual loss in patients with diabetes. Both DME and PDR can be readily diagnosed with clinical examination and, increasingly, by the noninvasive use of optical coherence tomography. However, another, less commonly recognized cause of visual loss in patients with diabetes is diabetic macular ischemia (DMI) in ...
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    4. Swept-Source Optical Coherence Tomography A Color Atlas (Textbook)

      Swept-Source Optical Coherence Tomography A Color Atlas  (Textbook)
      This book is written for retinal specialists and clinicians with a special interest in retinal diseases. It presents a collection of images and brief annotations of the microstructures of both the normal and diseased eye captured on swept source optical coherence tomography. The swept-source OCT is a relatively new form of imaging and is able to capture structures and details which previous generations of OCT machines cannot. This type of ...
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    5. DRUNET: A Dilated-Residual U-Net Deep Learning Network to Digitally Stain Optic Nerve Head Tissues in Optical Coherence Tomography Images

      DRUNET: A Dilated-Residual U-Net Deep Learning Network to Digitally Stain Optic Nerve Head Tissues in Optical Coherence Tomography Images
      Given that the neural and connective tissues of the optic nerve head (ONH) exhibit complex morphological changes with the development and progression of glaucoma, their simultaneous isolation from optical coherence tomography (OCT) images may be of great interest for the clinical diagnosis and management of this pathology. A deep learning algorithm was designed and trained to digitally stain (i.e. highlight) 6 ONH tissue layers by capturing both the local ...
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    6. Optical coherence tomography angiography: a review of current and future clinical applications

      Optical coherence tomography angiography: a review of current and future clinical applications
      Optical coherence tomography angiography is a non-invasive imaging technique that now allows for simultaneous in vivo imaging of the morphology as well as the vasculature in the eye. In this review, we provide an update on the existing clinical applications of optical coherence tomography angiography technology from the anterior to posterior segment of the eye. We also discuss the limitations of optical coherence tomography angiography technology, as well as the ...
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    7. Imaging of the lamina cribrosa and its role in glaucoma: a review

      Imaging of the lamina cribrosa and its role in glaucoma: a review
      The lamina cribrosa of the optic nerve head serves two contrasting roles; it must be porous to allow retinal ganglion cell axons to pass through, and yet at the same time, it must also provide adequate structural support to withstand the stresses and strains across it. Improvements in imaging such as optical coherence tomography image capture and image processing have allowed detailed in vivo studies of lamina cribrosa macro- and ...
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    8. Role of anterior segment optical coherence tomography in angle closure disease: a review

      Role of anterior segment optical coherence tomography in angle closure disease: a review
      This article aims to review the published literature pertaining to the use of anterior segment optical coherence tomography (AS-OCT) in the evaluation of angle closure disease. Searches on the available published literature were last conducted on June 15, 2017. Rated as Level I evidence, we found that AS-OCT has shown good sensitivity and moderate diagnostic accuracy to detect narrow angles when compared with gonioscopy. AS-OCT quantitative and qualitative parameters demonstrated ...
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    9. Plateau Iris Distribution Across Anterior Segment Optical Coherence Tomography Defined Subgroups of Subjects With Primary Angle Closure Glaucoma

      Plateau Iris Distribution Across Anterior Segment Optical Coherence Tomography Defined Subgroups of Subjects With Primary Angle Closure Glaucoma
      Purpose : We previously identified three distinct subgroups of patients with primary angle closure glaucoma (PACG) based on anterior segment optical coherence tomography (ASOCT) imaging. Group 1 was characterized by a large iris area with deepest anterior chambers, group 2 by a large lens vault (LV) and shallow anterior chamber depth (ACD), and group 3 displayed intermediate values across iris area, LV, and ACD. The purpose of the present study was ...
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    10. Swept-source Optical Coherence Tomography : A Color Atlas (Textbook)

      Swept-source Optical Coherence Tomography : A Color Atlas (Textbook)
      This book is written for retinal specialists and clinicians with a special interest in retinal diseases. It presents a collection of images and brief annotations of the microstructures of both the normal and diseased eye captured on swept source optical coherence tomography. The swept-source OCT is a relatively new form of imaging and is able to capture structures and details which previous generations of OCT machines cannot. This type of ...
      Read Full Article
    11. Comparison of anterior segment optical coherence tomography angiography systems for corneal vascularisation

      Comparison of anterior segment optical coherence tomography angiography systems for corneal vascularisation
      Aim To newly describe a spectral-domain (SD) optical coherence tomography angiography (OCTA) for the cornea and directly compare two OCTA system scans of the same eyes with corneal vascularisation. Methods Cross-sectional, observational, comparative case series. We performed sequential OCTA scans (10 eyes of 10 subjects with corneal vascularisation,4 scans each eye) repeated using split-spectrum amplitude decorrelation algorithm angiography system (SSADA, AngioVue; Optovue Inc, USA) and SD OCTA (Angioscan; Nidek ...
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    12. Mapping Retinal and Choroidal Thickness in Unilateral Nongranulomatous Acute Anterior Uveitis Using Three-Dimensional 1060-nm Optical Coherence Tomography

      Mapping Retinal and Choroidal Thickness in Unilateral Nongranulomatous Acute Anterior Uveitis Using Three-Dimensional 1060-nm Optical Coherence Tomography
      Purpose : To analyze retinal thickness (RT) and choroidal thickness (ChT) changes in patients with unilateral nongranulomatous acute anterior uveitis (AAU) using three-dimensional (3D) 1060-nm optical coherence tomography (OCT). Methods : Retinal and choroidal thickness maps were statistically analyzed for 24 patients with newly diagnosed unilateral AAU before therapy. A total of 17 patients were followed until resolution of inflammatory activity (twice in the first week, then weekly). Resolution occurred in all ...
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    13. Identification of imaging features that determine quality and repeatability of retinal capillary plexus density measurements in OCT angiography

      Identification of imaging features that determine quality and repeatability of retinal capillary plexus density measurements in OCT angiography
      Purpose Optical coherence tomography angiography (OCT-A) potentially allows for rapid and non-invasive quantification of retinal capillary plexus density in various disease states. This study aims to identify the key features that influenced the repeatability of OCT-A measurements. Methods We obtained OCT-A images on two separate visits in 44 healthy eyes from 44 subjects, each imaged with using the Topcon DRI OCT Triton imaging system. The parafoveal vessel density within a ...
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    14. Segmentation and Quantification for Angle-Closure Glaucoma Assessment in Anterior Segment OCT

      Segmentation and Quantification for Angle-Closure Glaucoma Assessment in Anterior Segment OCT
      Angle-closure glaucoma is a major cause of irreversible visual impairment and can be identified by measuring the anterior chamber angle (ACA) of the eye. The ACA can be viewed clearly through anterior segment optical coherence tomography (AS-OCT), but the imaging characteristics and the shapes and locations of major ocular structures can vary significantly among different AS-OCT modalities, thus complicating image analysis. To address this problem, we propose a data-driven approach ...
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    15. A Deep Learning Approach to Digitally Stain Optical Coherence Tomography Images of the Optic Nerve Head

      A Deep Learning Approach to Digitally Stain Optical Coherence Tomography Images of the Optic Nerve Head
      Purpose. To develop a deep learning approach to digitally-stain optical coherence tomography (OCT) images of the optic nerve head (ONH). Methods. A horizontal B-scan was acquired through the center of the ONH using OCT (Spectralis) for 1 eye of each of 100 subjects (40 normal 60 glaucoma). All images were enhanced using adaptive compensation. A custom deep learning network was then designed and trained with the compensated images to digitally ...
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  2. About Singapore Eye Research Institute

    Singapore Eye Research Institute

    Singaore Eye Research Institute (SERI) is the national research institute for ophthalmic and vision research in Singapore. Serving as the research institute of the Singapore National Eye Centre, and directly affiliated to the Yong Loo Lin School of Medicine, National University of Singapore, as well the Duke-NUS Graduate Medical School, SERI undertakes vision research in collaboration with local clinical ophthalmic centres and biomedical research institutions, as well as major eye centers and research institutes throughout the world. 
     
    SERI’s core facilities are housed in a state-of-the-art complex located at the Singapore National Eye Centre. It possesses 8 laboratories i.e. Visual Psychophysics Labs, Cell and Molecular Biology Labs, Tissue Culture Labs, Proteomics and Microanalytical Chemistry Lab, Human Ocular Surface Stem Cell Lab and an Ocular Genetics Lab. Additionally, SERI boast of a clinical trials pharmacy, several research clinics with specialist research equipment and facilities, as well as a dedicated team of clinical staff and research scientists drawn from leading institutions around the world.