1. Singapore Eye Research Institute

    0 Comments Leave a Comment

    1-15 of 134 1 2 3 4 5 6 7 8 9 »
    1. Mentioned In 134 Articles

    2. 250 kHz, 1.5 µm resolution SD-OCT for in-vivo cellular imaging of the human cornea

      250 kHz, 1.5 µm resolution SD-OCT for in-vivo cellular imaging of the human cornea
      We present the first spectral domain optical coherence tomography (SD-OCT) system that combines an isotropic imaging resolution of ~1.5 m in biological tissue with a 250 kHz image acquisition rate, for in vivo non-contact, volumetric imaging of the cellular structure of the human cornea. OCT images of the healthy human cornea acquired with this system reveal the cellular structure of the corneal epithelium, cellular debris and mucin clusters in ...
      Read Full Article
    3. Assessment of Circumferential Angle Closure with Swept-Source Optical Coherence Tomography: a community based study

      Assessment of Circumferential Angle Closure with Swept-Source Optical Coherence Tomography: a community based study
      Purpose To evaluate the diagnostic performance of swept-source optical coherence tomography (SS-OCT, CASIA SS-1000, Tomey Corporation, Nagoya, Japan) for angle closure detection, in comparison with gonioscopy in a community setting. Design Reliability analysis. Methods A total of 2027 phakic subjects aged 50 years, with no previous history of glaucoma, laser (including peripheral iridotomy), intraocular surgery or ocular trauma, were consecutively recruited from a community polyclinic in Singapore. Gonioscopy was performed ...
      Read Full Article
    4. Artificial intelligence and deep learning in ophthalmology

      Artificial intelligence and deep learning in ophthalmology
      Artificial intelligence (AI) based on deep learning (DL) has sparked tremendous global interest in recent years. DL has been widely adopted in image recognition, speech recognition and natural language processing, but is only beginning to impact on healthcare. In ophthalmology, DL has been applied to fundus photographs, optical coherence tomography and visual fields, achieving robust classification performance in the detection of diabetic retinopathy and retinopathy of prematurity, the glaucoma-like disc ...
      Read Full Article
    5. Predicting the outcome of laser peripheral iridotomy for primary angle closure suspect eyes using anterior segment optical coherence tomography

      Predicting the outcome of laser peripheral iridotomy for primary angle closure suspect eyes using anterior segment optical coherence tomography
      Purpose Develop an algorithm to predict the success of laser peripheral iridotomy (LPI) in primary angle closure suspect (PACS), using pretreatment anterior segment optical coherence tomography (ASOCT) scans. Methods A total of 69 eyes with PACS underwent LPI and time‐domain ASOCT scans (temporal and nasal cuts) were performed before and after LPI. After LPI, success is defined as one or more angles changed from closed to open. All the ...
      Read Full Article
    6. Quantification of the Posterior Cornea Using Swept Source Optical Coherence Tomography

      Quantification of the Posterior Cornea Using Swept Source Optical Coherence Tomography
      Purpose : We define optical coherence tomography (OCT) measurement parameters of the corneal endothelium/Descemet's membrane (DM) complex and peripheral transition zone (TZ) and describe these measurements in an ethnically Chinese population. Methods : OCT images of the anterior segment and iridocorneal angle were obtained from 129 healthy Chinese subjects (129 eyes), aged 40 to 81 years. The scleral spur (SS) and Schwalbe's line (SL) were identified in each image ...
      Read Full Article
    7. Correlation of Color Fundus Photograph Grading with Risks of Early Age-related Macular Degeneration by using Automated OCT-derived Drusen Measurements

      Correlation of Color Fundus Photograph Grading with Risks of Early Age-related Macular Degeneration by using Automated OCT-derived Drusen Measurements
      We evaluated automated OCT-derived drusen volume measures in a population-based study (n=4,512) aged 40 years, and its correlation with conventional color fundus photographs (CFP)-derived early AMD features. Participants had protocol-based assessment to capture medical and ocular history, genotyping for SNPs in CFH , ARMS2 , and CETP , CFP-based AMD grading and automated drusen volume based on SD-OCT using built-in software (Cirrus OCT advanced RPE analysis software). Significantly fewer eyes ...
      Read Full Article
    8. Imaging Of Pigment Epithelial Detachments With Optical Coherence Tomography Angiography

      Imaging Of Pigment Epithelial Detachments With Optical Coherence Tomography Angiography
      Purpose: To investigate the utility of optical coherence tomography angiography (OCTA) for detecting pathologic vascularization within pigment epithelial detachments (PEDs). Methods: This was a retrospective, cross-sectional, consecutive case series. Multimodal imaging (structural OCT, fluorescein, and indocyanine green angiography) was used as the gold standard to classify PEDs as nonvascularized or vascularized. Optical coherence tomography angiography imaging of the PED was subsequently and independently evaluated to classify PEDs as vascularized or ...
      Read Full Article
    9. Comparison Of Optical Coherence Tomography Angiographic Changes After Anti–Vascular Endothelial Growth Factor Therapy Alone Or In Combination With Photodynamic Therapy In Polypoidal Choroidal Vasculopathy

      Comparison Of Optical Coherence Tomography Angiographic Changes After Anti–Vascular Endothelial Growth Factor Therapy Alone Or In Combination With Photodynamic Therapy In Polypoidal Choroidal Vasculopathy
      Purpose: To compare changes in optical coherence tomography angiography in eyes with polypoidal choroidal vasculopathy after treatment with antivascular endothelial growth factor monotherapy or combined with photodynamic therapy . Methods: This is a longitudinal case-controlled study. The authors performed optical coherence tomography angiography at baseline and Month 3 in patients with treatment-naive polypoidal choroidal vasculopathy undergoing monotherapy (n = 10) or combination therapy (n = 13). We analyzed flow signal within the outer ...
      Read Full Article
    10. Spectral Domain-Optical Coherence Tomography Measurements in Alzheimer’s Disease: A Systematic Review and Meta-analysis

      Spectral Domain-Optical Coherence Tomography Measurements in Alzheimer’s Disease: A Systematic Review and Meta-analysis
      Topic Optical coherence tomography (OCT) is a non-invasive tool to measure specific retinal layers in the eye. The relationship of retinal spectral domain-OCT (SD-OCT) measurements with Alzheimers Disease (AD) and mild cognitive impairment (MCI) remains unclear. Hence, we conducted a systematic review and meta-analysis to examine the SD-OCT measurements in AD and MCI. Clinical Relevance Current methods of diagnosing early AD are expensive and invasive. Retinal measurements of SD-OCT, which ...
      Read Full Article
    11. Novel application of In Vivo Micro-Optical Coherence Tomography to assess Cornea scarring in an Animal Model

      Novel application of In Vivo Micro-Optical Coherence Tomography to assess Cornea scarring in an Animal Model
      This pilot study uses a micro-optical coherence tomography (micro-OCT) system with ~1m axial resolution specifically to image the cornea and corneal scars in vivo . We used an established murine corneal scar model by irregular phototherapeutic keratectomy in ten C57BL/6 mice, with serial imaging using the micro-OCT and compared to anterior segment (AS-OCT) (RTvue, Optovue, Fremont, CA) before and after scar induction. Main outcome was agreement between the AS-OCT and ...
      Read Full Article
    12. DRUNET: a dilated-residual U-Net deep learning network to segment optic nerve head tissues in optical coherence tomography images

      DRUNET: a dilated-residual U-Net deep learning network to segment optic nerve head tissues in optical coherence tomography images
      Given that the neural and connective tissues of the optic nerve head (ONH) exhibit complex morphological changes with the development and progression of glaucoma, their simultaneous isolation from optical coherence tomography (OCT) images may be of great interest for the clinical diagnosis and management of this pathology. A deep learning algorithm (custom U-NET) was designed and trained to segment 6 ONH tissue layers by capturing both the local (tissue texture ...
      Read Full Article
    13. IMPROVED DETECTION AND DIAGNOSIS OF POLYPOIDAL CHOROIDAL VASCULOPATHY USING A COMBINATION OF OPTICAL COHERENCE TOMOGRAPHY AND OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      IMPROVED DETECTION AND DIAGNOSIS OF POLYPOIDAL CHOROIDAL VASCULOPATHY USING A COMBINATION OF OPTICAL COHERENCE TOMOGRAPHY AND OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY
      Purpose: To assess the ability of optical coherence tomography (OCT) alone and in combination with OCT angiography (OCTA) to differentiate polypoidal choroidal vasculopathy (PCV) from neovascular age-related macular degeneration , as compared to fluorescein angiography and indocyanine green angiography. Methods: This is a cross-sectional study. All participants had a standardized history, clinical examination including measurement of best-corrected visual acuity, slit-lamp biomicroscopy, and indirect fundus examination, and underwent standardized imaging (color photography ...
      Read Full Article
    14. Postdoctoral Research Fellow Position in the Ocular Imaging Program at the Singapore Eye Research Institute

      Postdoctoral Research Fellow Position in the Ocular Imaging Program at the Singapore Eye Research Institute
      ...ional qualification, career history, current and expected salaries, contact number(s) and e-mail address to: Singapore Eye Research Institute 11 Third Hospital Avenue #05-00 Singapore 168751 Email: hr@seri.com.sg ...
      Read Full Article
    15. 1-15 of 134 1 2 3 4 5 6 7 8 9 »
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. About Singapore Eye Research Institute

    Singapore Eye Research Institute

    Singaore Eye Research Institute (SERI) is the national research institute for ophthalmic and vision research in Singapore. Serving as the research institute of the Singapore National Eye Centre, and directly affiliated to the Yong Loo Lin School of Medicine, National University of Singapore, as well the Duke-NUS Graduate Medical School, SERI undertakes vision research in collaboration with local clinical ophthalmic centres and biomedical research institutions, as well as major eye centers and research institutes throughout the world. 
     
    SERI’s core facilities are housed in a state-of-the-art complex located at the Singapore National Eye Centre. It possesses 8 laboratories i.e. Visual Psychophysics Labs, Cell and Molecular Biology Labs, Tissue Culture Labs, Proteomics and Microanalytical Chemistry Lab, Human Ocular Surface Stem Cell Lab and an Ocular Genetics Lab. Additionally, SERI boast of a clinical trials pharmacy, several research clinics with specialist research equipment and facilities, as well as a dedicated team of clinical staff and research scientists drawn from leading institutions around the world.