1. Singapore Eye Research Institute

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    1. Mentioned In 159 Articles

    2. Beyond Fourier transform: break the axial resolution limit in optical coherence tomography

      Beyond Fourier transform: break the axial resolution limit in optical coherence tomography
      Optical coherence tomography (OCT) is a volumetric imaging modality that empowers the clinicians and scientists to noninvasively visualize and examine the microscopic cross-sectional architectures of biological samples. By taking advantages of the coherence gating, OCT could achieve micrometer-level axial sectioning with high sensitivity. In the past decade, substantial efforts have been made to push the axial resolution of Fourier-domain OCT (FD-OCT) further into the sub-micron regime via physically extending the ...
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    3. NTU and SERI launch joint laboratory to develop advanced ocular imaging technologies

      NTU and SERI launch joint laboratory to develop advanced ocular imaging technologies
      ...inister for Health Award for public health. Three clinician scientists from Singapore National Eye Centre and Singapore Eye Research Institute were awarded the prestigious President's Science and Technology Award in 2009...
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    4. Anterior Segment Optical Coherence Tomography: Is There a Clinical Role in the Management of Primary Angle Closure Disease?

      Anterior Segment Optical Coherence Tomography: Is There a Clinical Role in the Management of Primary Angle Closure Disease?
      Primary angle closure disease (PACD) covers a spectrum that includes primary angle closure suspect, primary angle closure, primary angle closure glaucoma, and acute primary angle closure. Accumulating evidence suggests that the pathogenesis of PACD is complex, with multiple contributory factors including variations in the anatomic or biometric characteristics of the angle segment structures. Advances in anterior segment optical coherence tomography technology have further enhanced our understanding of the risk factors ...
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    5. DIABETIC MACULAR ISCHEMIA Correlation of Retinal Vasculature Changes by Optical Coherence Tomography Angiography and Functional Deficit

      DIABETIC MACULAR ISCHEMIA Correlation of Retinal Vasculature Changes by Optical Coherence Tomography Angiography and Functional Deficit
      Purpose: To examine the relationship between macular microvasculature parameters and functional changes in persons with diabetic retinopathy (DR). Methods: Cross-sectional study of 76 eyes with varying levels of DR. Optical coherence tomography angiography (OCTA) quantified superficial and deep perifoveal vessel densities and foveal avascular zone areas. Retinal sensitivity was measured using microperimetry . Optical coherence tomography angiography parameters and retinal sensitivity were correlated. Results: Deep perifoveal vessel density decreased with increasing ...
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    6. Optical Coherence Tomography Angiography Imaging to monitor Anti-VEGF treatment of Corneal Vascularization in a Rabbit Mode

      Optical Coherence Tomography Angiography Imaging to monitor Anti-VEGF treatment of Corneal Vascularization in a Rabbit Mode
      Optical coherence tomography angiography (OCTA) is a well-established non-invasive retinal vascular imaging technique. It has been recently adapted to image the anterior segment and has shown good potential to image corneal vascularisation. The purpose of the study is to evaluate the usefulness of OCTA to monitor regression of corneal vessels following anti-VEGF (vascular endothelial growth factor) treatment using a previously established corneal vascularisation rabbit model. The regression of vessels following ...
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    7. Optical coherence tomography angiography in diabetic retinopathy: a review of current applications

      Optical coherence tomography angiography in diabetic retinopathy: a review of current applications
      Background Diabetic retinopathy (DR) is a leading cause of vision loss in adults. Currently, the standard imaging technique to monitor and prognosticate DR and diabetic maculopathy is dye-based angiography. With the introduction of optical coherence tomography angiography (OCTA), it may serve as a potential rapid, non-invasive imaging modality as an adjunct. Main text Recent studies on the role of OCTA in DR include the use of vascular parameters e.g ...
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    8. Recent advances in anterior chamber angle imaging

      Recent advances in anterior chamber angle imaging
      Differentiating the two main forms of primary glaucoma (open-angle and closed-angle glaucoma) depends on the correct assessment of the anterior chamber angle (ACA). This assessment will determine the management plan and prognosis for the disease. The standard method of examining the angle has been, for many years, slit-lamp gonioscopy. This method, although clinically still useful, is less robust for patient follow up and clinical research, given its low reproducibility. Several ...
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    9. Role of Optical Coherence Tomography in the Prognosis of Vogt–Koyanagi–Harada Disease

      Role of Optical Coherence Tomography in the Prognosis of Vogt–Koyanagi–Harada Disease
      Purpose : To evaluate the prognostic value of OCT in acute VKH disease Methods : Retrospective series of consecutive VKH patients seen with the first presentation, a minimum follow-up of 1 year and serial OCT imaging. The primary outcome was the clinical activity phase at 1, 2 and 3 years. Results : Among 29 subjects, 7 resolved, 17 became chronic, and 5 developed chronic recurrent VKH. Median RNFL measurement obtained 2 months post-treatment ...
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    10. Optical coherence tomography angiography for the assessment of choroidal vasculature in high myopia

      Optical coherence tomography angiography for the assessment of choroidal vasculature in high myopia
      Aims To assess specific layers of the choroid in highly myopic young adults and to examine their associations with levels of myopia. Methods We recruited 51 young myopes (n=91 eyes) from the Singapore Cohort of Risk Factors for Myopia cohort. We performed standardised optical coherence tomography (OCT) and OCT angiography imaging and developed a novel segmentation technique assessing choroidal layers thickness (overall choroidal thickness (CT), medium-vessel choroidal layer (MVCL ...
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    11. A Deep Learning Approach to Denoise Optical Coherence Tomography Images of the Optic Nerve Head

      A Deep Learning Approach to Denoise Optical Coherence Tomography Images of the Optic Nerve Head
      Optical coherence tomography (OCT) has become an established clinical routine for the in vivo imaging of the optic nerve head (ONH) tissues, that is crucial in the diagnosis and management of various ocular and neuro-ocular pathologies. However, the presence of speckle noise affects the quality of OCT images and its interpretation. Although recent frame-averaging techniques have shown to enhance OCT image quality, they require longer scanning durations, resulting in patient ...
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    12. Constrained polarization evolution simplifies depth-resolved retardation measurements with polarization-sensitive optical coherence tomography

      Constrained polarization evolution simplifies depth-resolved retardation measurements with polarization-sensitive optical coherence tomography
      We observed that the polarization state of light after round-trip propagation through a birefringent medium frequently aligns with the employed input polarization state mirrored by the horizontal plane of the Poincar sphere. We explored the predisposition for this mirror state and evidence that it constrains the evolution of polarization states as a function of the round-trip depth into weakly scattering birefringent samples, as measured with polarization-sensitive optical coherence tomography (PS-OCT ...
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    13. Understanding diagnostic disagreement in angle closure assessment between anterior segment optical coherence tomography and gonioscopy

      Understanding diagnostic disagreement in angle closure assessment between anterior segment optical coherence tomography and gonioscopy
      Background/aims Although being a more objective tool for assessment and follow-up of angle closure, reliability studies have reported a moderate diagnostic performance for anterior segment optical coherence tomography (OCT) technologies when comparing with gonioscopy as the reference standard. We aim to determine factors associated with diagnostic disagreement in angle closure when assessed by anterior segment swept source OCT (SS-OCT, CASIA SS-1000; Tomey, Nagoya, Japan) and gonioscopy. Methods Cross-sectional study ...
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    14. Anterior Segment Optical Coherence Tomography Is there a Clinical Role in Management of Primary Angle Closure Disease?

      Anterior Segment Optical Coherence Tomography Is there a Clinical Role in Management of Primary Angle Closure Disease?
      Primary angle-closure disease (PACD) covers a spectrum that includes primary angle-closure suspect (PACS), primary angle-closure (PAC), primary angle-closure glaucoma (PACG), as well as acute primary angle closure (APAC). Accumulating evidence suggests that the pathogenesis of PACD is complex, with multiple contributory factors including variations in the anatomical or biometric characteristics of the angle segment structures. Advances in anterior segment optical coherence tomography (ASOCT) technology have further enhanced our understanding of ...
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    15. Characterization of dry eye disease in a mouse model by optical coherence tomography and fluorescein staining

      Characterization of dry eye disease in a mouse model by optical coherence tomography and fluorescein staining
      A custom-built ultrahigh-resolution optical coherence tomography (UHR-OCT) system and fluorescein staining were employed for investigation of a scopolamine induced dry eye mouse model. Acquired data was used to evaluate common and complementary findings of the two modalities. Central corneal thickness as measured by UHR-OCT increased significantly over the study period of 24 hours, from 89.03.57 m to 92.24.07 m. Both techniques were able to show corneal ...
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    16. Chip-based frequency comb sources for optical coherence tomography

      Chip-based frequency comb sources for optical coherence tomography
      Optical coherence tomography (OCT) is a powerful interferometric imaging technique widely used in medical fields such as ophthalmology, cardiology and dermatology. Superluminescent diodes (SLDs) are widely used as light sources in OCT. Recently integrated chip-based frequency combs have been demonstrated in numerous platforms and the possibility of using these broadband chip-scale combs for OCT has been raised extensively over the past few years. However, the use of these chip-based frequency ...
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  2. About Singapore Eye Research Institute

    Singapore Eye Research Institute

    Singaore Eye Research Institute (SERI) is the national research institute for ophthalmic and vision research in Singapore. Serving as the research institute of the Singapore National Eye Centre, and directly affiliated to the Yong Loo Lin School of Medicine, National University of Singapore, as well the Duke-NUS Graduate Medical School, SERI undertakes vision research in collaboration with local clinical ophthalmic centres and biomedical research institutions, as well as major eye centers and research institutes throughout the world. 
     
    SERI’s core facilities are housed in a state-of-the-art complex located at the Singapore National Eye Centre. It possesses 8 laboratories i.e. Visual Psychophysics Labs, Cell and Molecular Biology Labs, Tissue Culture Labs, Proteomics and Microanalytical Chemistry Lab, Human Ocular Surface Stem Cell Lab and an Ocular Genetics Lab. Additionally, SERI boast of a clinical trials pharmacy, several research clinics with specialist research equipment and facilities, as well as a dedicated team of clinical staff and research scientists drawn from leading institutions around the world.