1. Singapore Eye Research Institute

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    1. Mentioned In 225 Articles

    2. Normative data and associations of Optical Coherence Tomography Angiography measurements of the macula: The Singapore Malay Eye Study

      Normative data and associations of Optical Coherence Tomography Angiography measurements of the macula: The Singapore Malay Eye Study
      Objective: To describe the normative quantitative parameters of macular retinal vasculature and their systemic and ocular associations, using optical coherence tomography angiography (OCTA). Design: Population based cross sectional study SUBJECTS: Adults above 50 years old were recruited from the third examination of the population-based Singapore Malay Eye Study. Methods: All participants underwent standardized comprehensive examination and Spectral domain-OCTA (Optovue, USA) of the macula. OCTA scans with pre-existing retinal disease, macular ...
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    3. A multi-regression approach to improve optical coherence tomography diagnostic accuracy in multiple sclerosis patients without previous optic neuritis

      A multi-regression approach to improve optical coherence tomography diagnostic accuracy in multiple sclerosis patients without previous optic neuritis
      Background: Optical coherence tomography (OCT) is a retinal imaging system that may improve the diagnosis of multiple sclerosis (MS) persons, but the evidence is currently equivocal. To assess whether compensating the peripapillary retinal nerve fiber layer (pRNFL) thickness for ocular anatomical features as well as the combination with macular layers can improve the capability of OCT in differentiating non-optic neuritis eyes of relapsing-remitting MS patients from healthy controls. Methods: 74 ...
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    4. Application of Intraoperative Optical Coherence Tomography Technology in Anterior Segment Surgery

      Application of Intraoperative Optical Coherence Tomography Technology in Anterior Segment Surgery
      The use of optical coherence tomography (OCT) technology in anterior segment diseases allows for precise assessment of the changes following anterior segment surgery. Advances in microscope-integrated OCT systems have allowed the utilization of intraoperative OCT (iOCT) in anterior segment surgeries, i.e., cornea, cataract, and refractive surgery. iOCT has enabled real-time precise visualization of anterior segment tissues as well as interactions between surgical instruments and ocular tissue; thus, the device ...
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    5. A multi-regression framework to improve diagnostic ability of optical coherence tomography retinal biomarkers to discriminate mild cognitive impairment and Alzheimer’s disease

      A multi-regression framework to improve diagnostic ability of optical coherence tomography retinal biomarkers to discriminate mild cognitive impairment and Alzheimer’s disease
      Background Diagnostic performance of optical coherence tomography (OCT) to detect Alzheimers disease (AD) and mild cognitive impairment (MCI) remains limited. We assessed whether compensating the circumpapillary retinal nerve fiber layer (cpRNFL) thickness for multiple demographic and anatomical factors as well as the combination of macular layers improves the detection of MCI and AD. Methods This cross-sectional study of 62 AD ( n =92 eyes), 108 MCI ( n =158 eyes), and 55 ...
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    6. Anterior Segment Optical Coherence Tomography Angiography Following Trabecular Bypass Minimally Invasive Glaucoma Surgery

      Anterior Segment Optical Coherence Tomography Angiography Following Trabecular Bypass Minimally Invasive Glaucoma Surgery
      Objective: To assess anterior segment optical coherence tomography angiography (AS-OCTA) imaging of the episcleral vessels before and after trabecular bypass minimally invasive glaucoma surgery (MIGS). Design: A prospective, clinical, single-centre, single-arm pilot feasibility study conducted at National University Hospital, Singapore. Subjects: Patients with primary glaucomatous optic neuropathy undergoing Hydrus Microstent (Ivantis Inc., Irvine, CA, USA) implantation, who require at least one intra-ocular pressure-lowering medication. One or two eyes per patient ...
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    7. Angle closure extent, anterior segment dimensions and intraocular pressure

      Angle closure extent, anterior segment dimensions and intraocular pressure
      Aim To investigate the association between the extent of iridotrabecular contact and other quantitative anterior segment dimensions measured by swept-source optical coherence tomography (SS-OCT; CASIA SS-1000, Tomey, Nagoya, Japan) with intraocular pressure (IOP). Methods Cross-sectional study. All subjects who were 50 years with no history of glaucoma, ocular surgery or trauma, underwent SS-OCT imaging (eight equally spaced radial scans), Goldman applanation tonometry and gonioscopy on the same day. We measured ...
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    8. The Three-Dimensional Structural Configuration of the Central Retinal Vessel Trunk and Branches as a Glaucoma Biomarker

      The Three-Dimensional Structural Configuration of the Central Retinal Vessel Trunk and Branches as a Glaucoma Biomarker
      Purpose : To assess whether the three-dimensional (3D) structural configuration of the central retinal vessel trunk and its branches (CRVTB) could be used as a diagnostic marker for glaucoma. Design : Retrospective, deep-learning approach diagnosis study. Method : We trained a deep learning network to automatically segment the CRVTB from the B-scans of the optical coherence tomography (OCT) volume of the optic nerve head (ONH). Subsequently, two different approaches were used for glaucoma ...
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    9. Recommendations for OCTA reporting in retinal vascular disease: A Delphi approach by International Experts

      Recommendations for OCTA reporting in retinal vascular disease: A Delphi approach by International Experts
      Purpose: To develop a consensus nomenclature for reporting optical coherence tomography angiography (OCTA) findings in retinal vascular disease (e.g., diabetic retinopathy, retinal vein occlusion) by international experts. Design: Delphi-based survey SUBJECTS, PARTICIPANTS AND/OR CONTROLS: Twenty-five retinal vascular disease and OCTA imaging experts METHODS, INTERVENTION, OR TESTING: A Delphi method of consensus development was used, comprising two rounds of online questionnaires, followed by a face-to-face meeting conducted virtually. Twenty-five ...
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    10. Associations Between Retinal Nerve Fiber Layer and Ganglion Cell Layer in Middle Age and Cognition From Childhood to Adulthood

      Associations Between Retinal Nerve Fiber Layer and Ganglion Cell Layer in Middle Age and Cognition From Childhood to Adulthood
      Importance The retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) have been proposed as potential biomarkers for Alzheimer disease (AD). Although a number of studies have shown that knowing the thickness of RNFL and GCL can help differentiate between patients with AD and healthy controls, it is unclear whether these associations are observable earlier in life. Objective To examine whether RNFL and GCL thickness was associated with global ...
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    11. Combining retinal and choroidal microvascular metrics improves discriminative power for diabetic retinopathy

      Combining retinal and choroidal microvascular metrics improves discriminative power for diabetic retinopathy
      Purpose To use optical coherence tomography angiography (OCTA) parameters from both the retinal and choroidal microvasculature to detect the presence and severity of diabetic retinopathy (DR). Method This is a cross-sectional casecontrol study. OCTA parameters from retinal vasculature, fovea avascular zone (FAZ) and choriocapillaris were evaluated from 33 mm 2 fovea-centred scans. Areas under the receiver operating characteristic (ROC) curve were used to compare the discriminative power on the presence ...
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    12. Multi-task learning approach for volumetric segmentation and reconstruction in 3D OCT images

      Multi-task learning approach for volumetric segmentation and reconstruction in 3D OCT images
      The choroid is the vascular layer of the eye that supplies photoreceptors with oxygen. Changes in the choroid are associated with many pathologies including myopia where the choroid progressively thins due to axial elongation. To quantize these changes, there is a need to automatically and accurately segment the choroidal layer from optical coherence tomography (OCT) images. In this paper, we propose a multi-task learning approach to segment the choroid from ...
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    13. Optical Coherence Tomography Classification Systems for Diabetic Macular Edema and Their Associations With Visual Outcome and Treatment Responses

      Optical Coherence Tomography Classification Systems for Diabetic Macular Edema and Their Associations With Visual Outcome and Treatment Responses
      Optical coherence tomography (OCT) is an invaluable imaging tool in detecting and assessing diabetic macular edema (DME). Over the past decade, there have been different proposed OCT-based classification systems for DME. In this review, we present an update of spectral-domain OCT (SDOCT)-based DME classifications over the past 5 years. In addition, we attempt to summarize the proposed OCT qualitative and quantitative parameters from different classification systems in relation to ...
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    14. Non-optical coherence tomography modalities for assessment of angle closure

      Non-optical coherence tomography modalities for assessment of angle closure
      Primary angle closure glaucoma is a leading cause of irreversible blindness, particularly in Asia. Its pathophysiology is based in the closure of the anterior chamber angle (ACA). In addition to gonioscopy (current reference standard), in the past decade, anterior segment optical coherence tomography (AS-OCT) has been incorporated in routine ophthalmic practice to help assess the configuration of the ACA. Especially in nonspecialist ophthalmology practice, gonioscopy may be less frequently performed ...
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    15. Combining OCT and OCTA for Focal Structure-Function Modeling in Early Primary Open-Angle Glaucoma

      Combining OCT and OCTA for Focal Structure-Function Modeling in Early Primary Open-Angle Glaucoma
      Purpose: To investigate modeling of the focal visual field (VF) loss by combining structural measurements and vascular measurements in eyes with early primary open-angle glaucoma (POAG). Methods: In this cross-sectional study, subjects with early glaucoma (VF mean deviation, -6 dB) underwent optical coherence tomography (OCT) imaging, optical coherence tomography angiography (OCTA) imaging, and Humphrey 24-2 VF tests. Capillary perfusion densities (CPDs) were calculated after the removal of large vessels in ...
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    16. The Application of Optical Coherence Tomography Angiography in Systemic Hypertension: A Meta-Analysis

      The Application of Optical Coherence Tomography Angiography in Systemic Hypertension: A Meta-Analysis
      Objective: Multiple studies have compared various optical coherence tomography angiography (OCTA) parameters in participants with systemic hypertension vs. controls and have presented discordant findings. We conducted a meta-analysis to pool together data from different studies to generate an overall effect size and find out whether OCTA parameter(s) significantly differed in participants with systemic hypertension as compared to controls. Methods: We conducted a literature search through a search of electronic ...
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  2. About Singapore Eye Research Institute

    Singapore Eye Research Institute

    Singaore Eye Research Institute (SERI) is the national research institute for ophthalmic and vision research in Singapore. Serving as the research institute of the Singapore National Eye Centre, and directly affiliated to the Yong Loo Lin School of Medicine, National University of Singapore, as well the Duke-NUS Graduate Medical School, SERI undertakes vision research in collaboration with local clinical ophthalmic centres and biomedical research institutions, as well as major eye centers and research institutes throughout the world. 
     
    SERI’s core facilities are housed in a state-of-the-art complex located at the Singapore National Eye Centre. It possesses 8 laboratories i.e. Visual Psychophysics Labs, Cell and Molecular Biology Labs, Tissue Culture Labs, Proteomics and Microanalytical Chemistry Lab, Human Ocular Surface Stem Cell Lab and an Ocular Genetics Lab. Additionally, SERI boast of a clinical trials pharmacy, several research clinics with specialist research equipment and facilities, as well as a dedicated team of clinical staff and research scientists drawn from leading institutions around the world.