1. Singapore Eye Research Institute

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    1. Mentioned In 186 Articles

    2. Effect of spectral leakage on the image formation of Fourier-domain optical coherence tomography

      Effect of spectral leakage on the image formation of Fourier-domain optical coherence tomography
      We report on the investigation of spectral leakages impact on the reconstruction of Fourier-domain optical coherence tomography (FD-OCT). We discuss the shift-variant nature introduced by the spectral leakage and develop a novel spatial-domain FD-OCT image formation model. A proof-of-concept phantom experiment is conducted to validate our model. Compared with previous models, the proposed framework could better describe the image formation process, especially when the fineness of the axial structure approaches ...
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    3. DIABETIC MACULAR ISCHEMIA: Correlation of Retinal Vasculature Changes by Optical Coherence Tomography Angiography and Functional Deficit

      DIABETIC MACULAR ISCHEMIA: Correlation of Retinal Vasculature Changes by Optical Coherence Tomography Angiography and Functional Deficit
      Purpose: To examine the relationship between macular microvasculature parameters and functional changes in persons with diabetic retinopathy (DR). Methods: Cross-sectional study of 76 eyes with varying levels of DR. Optical coherence tomography angiography (OCTA) quantified superficial and deep perifoveal vessel densities and foveal avascular zone areas. Retinal sensitivity was measured using microperimetry . Optical coherence tomography angiography parameters and retinal sensitivity were correlated. Results: Deep perifoveal vessel density decreased with increasing ...
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    4. Differential reperfusion patterns in retinal vascular plexuses following increase in intraocular pressure an OCT angiography study

      Differential reperfusion patterns in retinal vascular plexuses following increase in intraocular pressure an OCT angiography study
      To describe patterns of reperfusion in the superficial vascular plexus (SVP), deep capillary plexus (DCP) and choriocapillaris (CC) as detected on optical coherence tomography (OCTA) in cynomogulus macaque monkey model following increase in intraocular pressure by an intravitreal injection. Animal imaging study. Two cynomogulus macaque monkeys. A 100 L intravitreal injection (IVI) of saline was given in one eye of each monkey. Serial OCTA using a Zeiss Plex Elite 9000 ...
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    5. Deep learning algorithms to isolate and quantify the structures of the anterior segment in optical coherence tomography images

      Deep learning algorithms to isolate and quantify the structures of the anterior segment in optical coherence tomography images
      Background/Aims Accurate isolation and quantification of intraocular dimensions in the anterior segment (AS) of the eye using optical coherence tomography (OCT) images is important in the diagnosis and treatment of many eye diseases, especially angle-closure glaucoma. Method In this study, we developed a deep convolutional neural network (DCNN) for the localisation of the scleral spur; moreover, we introduced an information-rich segmentation approach for this localisation problem. An ensemble of ...
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    6. Detection of features associated with neovascular age-related macular degeneration in ethnically distinct data sets by an optical coherence tomography: trained deep learning algorithm

      Detection of features associated with neovascular age-related macular degeneration in ethnically distinct data sets by an optical coherence tomography: trained deep learning algorithm
      Background The ability of deep learning (DL) algorithms to identify eyes with neovascular age-related macular degeneration (nAMD) from optical coherence tomography (OCT) scans has been previously established. We herewith evaluate the ability of a DL model, showing excellent performance on a Korean data set, to generalse onto an American data set despite ethnic differences. In addition, expert graders were surveyed to verify if the DL model was appropriately identifying lesions ...
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    7. Longitudinal assessment of optic nerve head changes using optical coherence tomography in a primate microbead model of ocular hypertension

      Longitudinal assessment of optic nerve head changes using optical coherence tomography in a primate microbead model of ocular hypertension
      In humans, the longitudinal characterisation of early optic nerve head (ONH) damage in ocular hypertension (OHT) is difficult as patients with glaucoma usually have structural ONH damage at the time of diagnosis. Previous studies assessed glaucomatous ONH cupping by measuring the anterior lamina cribrosa depth (LCD) and minimal rim width (MRW) using optical coherence tomography (OCT). In this study, we induced OHT by repeated intracameral microbead injections in 16 cynomolgus ...
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    8. Anterior segment optical coherence tomography angiography for iris vasculature in pigmented eyes

      Anterior segment optical coherence tomography angiography for iris vasculature in pigmented eyes
      Purpose To compare anterior segment optical coherence tomography angiography (AS-OCTA) systems in delineating normal iris vessels and iris neovascularisation (NVI) in eyes with pigmented irides. Methods Prospective study from January 2019 to June 2019 of 10 consecutive patients with normal pigmented iris, had AS-OCTA scans with a described illumination technique, before using the same protocol in five eyes with NVI (clinical stages 13). All scans were sequentially performed using a ...
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    9. Novel Approaches for Imaging-Based Diagnosis of Ocular Surface Disease

      Novel Approaches for Imaging-Based Diagnosis of Ocular Surface Disease
      Imaging has become indispensable in the diagnosis and management of diseases in the posterior part of the eye. In recent years, imaging techniques for the anterior segment are also gaining importance and are nowadays routinely used in clinical practice. Ocular surface disease is often synonymous with dry eye disease, but also refers to other conditions of the ocular surface, such as Meibomian gland dysfunction or keratitis and conjunctivitis with different ...
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    10. Objective Imaging Diagnostics for Dry Eye Disease

      Objective Imaging Diagnostics for Dry Eye Disease
      Traditional diagnostic tests for dry eye disease (DED), such as fluorescein tear film break-up time and the Schirmer test, are often associated with poor reproducibility and reliability, which make the diagnosis, follow-up, and management of the disease challenging. Advances in ocular imaging technology enables objective and reproducible measurement of changes in the ocular surface, tear film, and optical quality associated with DED. In this review, the authors will discuss the ...
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    11. Imaging the Choroid: From Indocyanine Green Angiography to Optical Coherence Tomography Angiography

      Imaging the Choroid: From Indocyanine Green Angiography to Optical Coherence Tomography Angiography
      The choroid is the vascular structure nourishing the retinal pigment epithelium and the outer retina and it plays a key role in the homeostasis of the eye both under physiological and pathological conditions. In the last 20 years we have moved from guessing what was happening beyond the retinal pigment epithelium to actually visualize structural and functional changes of the choroid in vivo noninvasively. In this review we describe the ...
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    12. Stable complex conjugate artifact removal in OCT using circularly polarized light as reference

      Stable complex conjugate artifact removal in OCT using circularly polarized light as reference
      In Fourier domain optical coherence tomography (FDOCT), the depth profile is mirrored about the zero delay between the sample and reference optical paths, limiting the imaging depth to half of the entire ranging space and undermining the optimal sensitivity window. We present a new method, to the best of our knowledge, to remove the complex conjugate artifact by using circularly polarized light as reference. Quadrature detection of the complex fringe ...
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    13. Are choriocapillaris flow void features robust to diurnal variations? A swept-source optical coherence tomography angiography (OCTA) study

      Are choriocapillaris flow void features robust to diurnal variations? A swept-source optical coherence tomography angiography (OCTA) study
      We evaluated the impact of diurnal variation on choroidal and retinal microvasculature and structural measurements using a swept-source optical coherence tomography angiography machine (SS-OCTA; PLEX Elite 9,000, Carl Zeiss Meditec, Inc., Dublin, USA). Fourteen participants who were without ocular diseases underwent SS-OCTA imaging using 33-mm 2 macular scan pattern on two separate days at five time points. Choriocapillaris flow voids were generated to determine its density (percentage), size (m ...
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    14. Prevalence, risk factors and impact of posterior staphyloma diagnosed from wide‐field optical coherence tomography in Singapore adults with high myopia

      Prevalence, risk factors and impact of posterior staphyloma diagnosed from wide‐field optical coherence tomography in Singapore adults with high myopia
      Purpose To investigate the prevalence and risk factors of posterior staphyloma using wide‐field optical coherence tomography (WF‐OCT) in adults with high myopia in Singapore. Design Population‐based cross‐sectional study. Methods Adults with spherical equivalent (SE) 5D in either eye at the first visit of Singapore Epidemiology of Eye Diseases study and Singapore Prospective Study Program study were recruited. Posterior staphyloma was diagnosed using WF‐OCT (PLEX Elite9000 ...
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    15. Longitudinal Structural and Microvascular Observation in RCS Rat Eyes Using Optical Coherence Tomography Angiography

      Longitudinal Structural and Microvascular Observation in RCS Rat Eyes Using Optical Coherence Tomography Angiography
      Purpose : To evaluate the change of retinal thickness and ocular microvasculature in a rat model of retinitis pigmentosa using swept source optical coherence tomography angiography (SS-OCTA) Methods : Three-weeks-old Royal College of Surgeons (RCS) rats ( n = 8) and age-matched control rats ( n = 14) were imaged by a prototype SS-OCTA system. Follow-up measurements occurred every three weeks on six RCS rats until week 18, and cross-sectional measurements were conducted on control rats ...
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    16. Systemic hypertension associated retinal microvascular changes can be detected with optical coherence tomography angiography

      Systemic hypertension associated retinal microvascular changes can be detected with optical coherence tomography angiography
      A major complication of hypertension is microvascular damage and capillary rarefaction is a known complication of hypertensive end-organ damage which confers a higher risk of systemic disease such as stroke and cardiovascular events. Our aim was to study the effect of hypertension on the retinal microvasculature using non-invasive optical coherence tomography angiography (OCTA). We performed a case-control study of 94 eyes of 94 participants with systemic hypertension and 46 normal ...
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  2. About Singapore Eye Research Institute

    Singapore Eye Research Institute

    Singaore Eye Research Institute (SERI) is the national research institute for ophthalmic and vision research in Singapore. Serving as the research institute of the Singapore National Eye Centre, and directly affiliated to the Yong Loo Lin School of Medicine, National University of Singapore, as well the Duke-NUS Graduate Medical School, SERI undertakes vision research in collaboration with local clinical ophthalmic centres and biomedical research institutions, as well as major eye centers and research institutes throughout the world. 
     
    SERI’s core facilities are housed in a state-of-the-art complex located at the Singapore National Eye Centre. It possesses 8 laboratories i.e. Visual Psychophysics Labs, Cell and Molecular Biology Labs, Tissue Culture Labs, Proteomics and Microanalytical Chemistry Lab, Human Ocular Surface Stem Cell Lab and an Ocular Genetics Lab. Additionally, SERI boast of a clinical trials pharmacy, several research clinics with specialist research equipment and facilities, as well as a dedicated team of clinical staff and research scientists drawn from leading institutions around the world.