1. Simon Fraser University

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    1. Mentioned In 48 Articles

    2. Strip-based registration of serially acquired optical coherence tomography angiography

      Strip-based registration of serially acquired optical coherence tomography angiography
      The visibility of retinal microvasculature in optical coherence tomography angiography (OCT-A) images is negatively affected by the small dimension of the capillaries, pulsatile blood flow, and motion artifacts. Serial acquisition and time-averaging of multiple OCT-A images can enhance the definition of the capillaries and result in repeatable and consistent visualization. We demonstrate an automated method for registration and averaging of serially acquired OCT-A images. Ten OCT-A volumes from six normal ...
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    3. Anterior Segment Optical Coherence Tomography for Targeted Transconjunctival Suture Placement in Overfiltering Trabeculectomy Blebs

      Anterior Segment Optical Coherence Tomography for Targeted Transconjunctival Suture Placement in Overfiltering Trabeculectomy Blebs
      Purpose: To demonstrate the utility of swept-source anterior segment optical coherence tomography (SS-AS-OCT) in guiding placement of transconjunctival sutures in hypotonous patients after a trabeculectomy. Patients and Methods: This is a longitudinal case series of 10 eyes from 10 patients who required transconjunctival sutures after a trabeculectomy. SS-AS-OCT was used to aid in the placement of the sutures to improve the function of the overfiltering bleb. Results: SS-AS-OCT reliably identified ...
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    4. Correlation between polarization sensitive optical coherence tomography and SHG microscopy in articular cartilage

      Correlation between polarization sensitive optical coherence tomography and SHG microscopy in articular cartilage
      Polarization-sensitive optical coherence tomography (PS-OCT) and second harmonic generation (SHG) microscopy are two imaging modalities with different resolutions, field-of-views (FOV), and contrasts, while they both have the capability of imaging collagen fibers in biological tissues. PS-OCT can measure the tissue birefringence which is induced by highly organized fibers while SHG can image the collagen fiber organization with high resolution. Articular cartilage, with abundant structural collagen fibers, is a suitable sample ...
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    5. Aortic and Cardiac Structure and Function Using High-Resolution Echocardiography and Optical Coherence Tomography in a Mouse Model of Marfan Syndrome

      Aortic and Cardiac Structure and Function Using High-Resolution Echocardiography and Optical Coherence Tomography in a Mouse Model of Marfan Syndrome
      Marfan syndrome (MFS) is an autosomal-dominant disorder of connective tissue caused by mutations in the fibrillin-1 (FBN1) gene. Mortality is often due to aortic dissection and rupture. We investigated the structural and functional properties of the heart and aorta in a [ Fbn1 C1039G/+ ] MFS mouse using high-resolution ultrasound (echo) and optical coherence tomography (OCT). Echo was performed on 6- and 12-month old wild type (WT) and MFS mice (n = 8 ...
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    6. Multi-GPU accelerated real-time retinal image segmentation (Thesis)

      Multi-GPU accelerated real-time retinal image segmentation (Thesis)
      In recent years, Optical Coherence Tomography (OCT) has become one of the dominant imaging technologies for ophthalmic diagnostics and vision research. The fast and high-resolution cross-sectional data that OCT provides has brought a new possibility in the role of intra-operative imaging. However, existing commercial OCT systems lack the automated real-time functionality for providing immediate feedback of changes in anatomical configuration as the result of surgical actions. The predominant reason for ...
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    7. Atlas-based shape analysis and classification of retinal optical coherence tomography images using the functional shape (fshape) framework

      Atlas-based shape analysis and classification of retinal optical coherence tomography images using the functional shape (fshape) framework
      We propose a novel approach for quantitative shape variability analysis in retinal optical coherence tomography images using the functional shape (fshape) framework. The fshape framework uses surface geometry together with functional measures, such as retinal layer thickness defined on the layer surface, for registration across anatomical shapes. This is used to generate a population mean template of the geometry-function measures from each individual. Shape variability across multiple retinas can be ...
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    8. Quantitative Optical Coherence Tomography Angiography of Radial Peripapillary Capillaries in Glaucoma, Glaucoma Suspect and Normal Eyes

      Quantitative Optical Coherence Tomography Angiography of Radial Peripapillary Capillaries in Glaucoma, Glaucoma Suspect and Normal Eyes
      Purpose To evaluate the quantitative characteristics of the radial peripapillary capillary (RPC) network in glaucoma, glaucoma suspect and normal eyes using speckle variance optical coherence tomography angiography (OCT-A). To determine correlations between RPC density, nerve fibre layer (NFL) thickness and visual field indices. Design Cross sectional study. Methods OCT-A images of RPCs were acquired at a single institution using a custom-built 1060nm system from three groups: unilateral glaucoma (10 eyes ...
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    9. Lens-based wavefront sensorless adaptive optics swept source OCT

      Lens-based wavefront sensorless adaptive optics swept source OCT
      Optical coherence tomography (OCT) has revolutionized modern ophthalmology, providing depth resolved images of the retinal layers in a system that is suited to a clinical environment. Although the axial resolution of OCT system, which is a function of the light source bandwidth, is sufficient to resolve retinal features at a micrometer scale, the lateral resolution is dependent on the delivery optics and is limited by ocular aberrations. Through the combination ...
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    10. Retinal optical coherence tomography at 1  μm with dynamic focus control and axial motion tracking

      Retinal optical coherence tomography at 1  μm with dynamic focus control and axial motion tracking
      High-resolution optical coherence tomography (OCT) retinal imaging is important to noninvasively visualize the various retinal structures to aid in better understanding of the pathogenesis of vision-robbing diseases. However, conventional OCT systems have a trade-off between lateral resolution and depth-of-focus. In this report, we present the development of a focus-stacking OCT system with automatic focus optimization for high-resolution, extended-focal-range clinical retinal imaging by incorporating a variable-focus liquid lens into the sample ...
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    11. In vivo wide-field multispectral scanning laser ophthalmoscopy–optical coherence tomography mouse retinal imager: longitudinal imaging of ganglion cells, microglia, and Müller glia, and mapping of the mouse retinal and choroidal vasculature

      In vivo wide-field multispectral scanning laser ophthalmoscopy–optical coherence tomography mouse retinal imager: longitudinal imaging of ganglion cells, microglia, and Müller glia, and mapping of the mouse retinal and choroidal vasculature
      Scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT) provide complementary views of the retina, with the former collecting fluorescence data with good lateral but relatively low-axial resolution, and the latter collecting label-free backscattering data with comparable lateral but much higher axial resolution. To take maximal advantage of the information of both modalities in mouse retinal imaging, we have constructed a compact, four-channel, wide-field ( 50 deg ) system that simultaneously acquires ...
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    12. Quantitative Noninvasive Angiography of the Fovea Centralis Using Speckle Variance Optical Coherence Tomography

      Quantitative Noninvasive Angiography of the Fovea Centralis Using Speckle Variance Optical Coherence Tomography
      Purpose : To demonstrate the utility of speckle variance optical coherence tomography (svOCT), a noninvasive angiographic technique, for evaluating the foveal vasculature. Methods : Twelve normal human eyes were imaged with svOCT (1060-nm, 100-kHz custom-built system) and fluorescein angiography (FA; Topcon TRC-50DX with 5.0 megapixel resolution camera). Manual tracing techniques were used to quantify the foveal vasculature, including foveal avascular zone (FAZ) metrics (area, perimeter, greatest diameter, and lowest diameter). Reproducibility ...
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    13. En face projection imaging of the human choroidal layers with tracking SLO and swept source OCT angiography methods

      En face projection imaging of the human choroidal layers with tracking SLO and swept source OCT angiography methods
      We tested and compared the capability of multiple optical coherence tomography (OCT) angiography methods: phase variance, amplitude decorrelation and speckle variance, with application of the split spectrum technique, to image the choroiretinal complex of the human eye. To test the possibility of OCT imaging stability improvement we utilized a real-time tracking scanning laser ophthalmoscopy (TSLO) system combined with a swept source OCT setup. In addition, we implemented a post- processing ...
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    14. In vivo optical imaging of human retinal capillary networks using speckle variance optical coherence tomography with quantitative clinico-histological correlation

      In vivo optical imaging of human retinal capillary networks using speckle variance optical coherence tomography with quantitative clinico-histological correlation
      ...Ophthalmology and Visual Sciences, University of British Columbia, Canada * ^d School of Engineering Science, Simon Fraser University, Burnaby, BC, Canada Accepted 19 April 2015, Available online 24 April 2015 Highl...
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    15. System and method for rapid OCT image acquisition using compressive sampling

      System and method for rapid OCT image acquisition using compressive sampling
      A method for rapid OCT image acquisition includes acquiring by OCT a plurality of compressive measurements (y) representing a set of under-sampled OCT data in a Dirac domain below a Nyquist rate by sampling an object of interest at randomly spaced vertical and horizontal lines in a Cartesian geometry using a raster scan, and recovering a 3D volumetric OCT image (f) from the compressive measurements (y) using compressive sampling. The ...
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  2. About Simon Fraser University

    Simon Fraser University

    Simon Fraser University is a Canadian comprehensive university with campuses located in Burnaby Mountain in Burnaby, British Columbia, Vancouver, British Columbia , and Surrey, British Columbia. It was established in 1965 and presently has 24,000 students. It is named after Simon Fraser, explorer of the Vancouver area.