1. Simon Fraser University

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    1. Mentioned In 87 Articles

    2. 105° field of view non-contact handheld swept-source optical coherence tomography

      105° field of view non-contact handheld swept-source optical coherence tomography
      We demonstrate a handheld swept-source optical coherence tomography (OCT) system with a 400 kHz vertical-cavity surface-emitting laser (VCSEL) light source, a non-contact approach, and an unprecedented single shot 105 field of view (FOV). We also implemented a spiral scanning pattern allowing real-time visualization with improved scanning efficiency. To the best of our knowledge, this is the widest FOV achieved in a portable non-contact OCT retinal imaging system to date. Improvements ...
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    3. Effect of optical coherence tomography and angiography sampling rate towards diabetic retinopathy severity classification

      Effect of optical coherence tomography and angiography sampling rate towards diabetic retinopathy severity classification
      Optical coherence tomography (OCT) and OCT angiography (OCT-A) may benefit the screening of diabetic retinopathy (DR). This study investigated the effect of laterally subsampling OCT/OCT-A en face scans by up to a factor of 8 when using deep neural networks for automated referable DR classification. There was no significant difference in the classification performance across all evaluation metrics when subsampling up to a factor of 3, and only minimal ...
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    4. LF-UNet - A Novel Anatomical-Aware Dual-Branch Cascaded Deep Neural Network for Segmentation of Retinal Layers and Fluid from Optical Coherence Tomography Images

      LF-UNet - A Novel Anatomical-Aware Dual-Branch Cascaded Deep Neural Network for Segmentation of Retinal Layers and Fluid from Optical Coherence Tomography Images
      Computer-assistant diagnosis of retinal disease relies heavily on the accurate detection of retinal boundaries and other pathological features such as fluid accumulation. Optical coherence tomography (OCT) is a non-invasive ophthalmological imaging technique that has become a standard modality in the field due to its ability to detect cross-sectional retinal pathologies at the micrometer level. In this work, we presented a novel framework to achieve simultaneous retinal layers and fluid segmentation ...
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    5. Long-term assessment of internal limiting membrane peeling for full-thickness macular hole using en face adaptive optics and conventional optical coherence tomography

      Long-term assessment of internal limiting membrane peeling for full-thickness macular hole using en face adaptive optics and conventional optical coherence tomography
      Objective: To evaluate the long-term structural and microvascular retinal effects of internal limiting membrane peeling for full-thickness macular hole (FTMH) using en face adaptive optics optical coherence tomography (AO-OCT), conventional OCT, and OCT angiography (OCTA). Design: Interventional case series. Participants: Patients with FTMH treated with vitrectomy, internal limiting membrane peeling, and gas tamponade. Methods: Eleven eyes with FTMH that had at least 12 months of postoperative follow-up were enrolled in ...
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    6. High-speed and widefield handheld swept-source OCT angiography with a VCSEL light source

      High-speed and widefield handheld swept-source OCT angiography with a VCSEL light source
      Optical coherence tomography (OCT) and OCT angiography (OCTA) enable noninvasive structural and angiographic imaging of the eye. Portable handheld OCT/OCTA systems are required for imaging patients in the supine position. Examples include infants in the neonatal intensive care unit (NICU) and operating room (OR). The speed of image acquisition plays a pivotal role in acquiring high-quality OCT/OCTA images, particularly with the handheld system, since both the operator hand ...
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    7. Optimizing 3D retinal vasculature imaging in diabetic retinopathy using registration and averaging of OCT-A

      Optimizing 3D retinal vasculature imaging in diabetic retinopathy using registration and averaging of OCT-A
      High resolution visualization of optical coherence tomography (OCT) and OCT angiography (OCT-A) data is required to fully take advantage of the imaging modality's three-dimensional nature. However, artifacts induced by patient motion often degrade OCT-A data quality. This is especially true for patients with deteriorated focal vision, such as those with diabetic retinopathy (DR). We propose a novel methodology for software-based OCT-A motion correction achieved through serial acquisition, volumetric registration ...
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    8. Use of the Retinal Vascular Histology to Validate an Optical Coherence Tomography Angiography Technique

      Use of the Retinal Vascular Histology to Validate an Optical Coherence Tomography Angiography Technique
      Purpose: To determine the fidelity of optical coherence tomography angiography (OCTA) techniques by direct comparison of the retinal capillary network images obtained from the same region as imaged by OCTA and high-resolution confocal microscope. Method: Ten porcine eyes were perfused with red blood cells for OCTA image acquisition from the area centralis and then perfusion-fixed, and the vessels were labeled for confocal imaging. Two approaches involving post-processing of two-dimensional projection ...
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    9. Quantitative multi-contrast in vivo mouse imaging with polarization diversity optical coherence tomography and angiography

      Quantitative multi-contrast in vivo mouse imaging with polarization diversity optical coherence tomography and angiography
      Retinal microvasculature and the retinal pigment epithelium (RPE) play vital roles in maintaining the health and metabolic activity of the eye. Visualization of these retina structures is essential for pre-clinical studies of vision-robbing diseases, such as age-related macular degeneration (AMD). We have developed a quantitative multi-contrast polarization diversity OCT and angiography (QMC-PD-OCTA) system for imaging and visualizing pigment in the RPE using degree of polarization uniformity (DOPU), along with flow ...
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    10. Feasibility of combined optical coherence tomography and autofluorescence imaging for visualization of needle biopsy placement

      Feasibility of combined optical coherence tomography and autofluorescence imaging for visualization of needle biopsy placement
      Significance: Diagnosis of suspicious lung nodules requires precise collection of relevant biopsies for histopathological analysis. Using optical coherence tomography and autofluorescence imaging (OCT-AFI) to improve diagnostic yield in parts of the lung inaccessible to larger imaging methods may allow for reducing complications related to the alternative of computed tomography-guided biopsy. Aim: Feasibility of OCT-AFI combined with a commercially available lung biopsy needle was demonstrated for visualization of needle puncture sites ...
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    11. Real-time retinal layer segmentation of OCT volumes with GPU accelerated inferencing using a compressed, low-latency neural network

      Real-time retinal layer segmentation of OCT volumes with GPU accelerated inferencing using a compressed, low-latency neural network
      Segmentation of retinal layers in optical coherence tomography (OCT) is an essential step in OCT image analysis for screening, diagnosis, and assessment of retinal disease progression. Real-time segmentation together with high-speed OCT volume acquisition allows rendering of en face OCT of arbitrary retinal layers, which can be used to increase the yield rate of high-quality scans, provide real-time feedback during image-guided surgeries, and compensate aberrations in adaptive optics (AO) OCT ...
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    12. Ensemble Deep Learning for Diabetic Retinopathy Detection Using Optical Coherence Tomography Angiography

      Ensemble Deep Learning for Diabetic Retinopathy Detection Using Optical Coherence Tomography Angiography
      Purpose : To evaluate the role of ensemble learning techniques with deep learning in classifying diabetic retinopathy (DR) in optical coherence tomography angiography (OCTA) images and their corresponding co-registered structural images. Methods : A total of 463 volumes from 380 eyes were acquired using the 3 3-mm OCTA protocol on the Zeiss Plex Elite system. Enface images of the superficial and deep capillary plexus were exported from both the optical coherence tomography ...
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    13. Retinal capillary perfusion heterogeneity in diabetic retinopathy detected by optical coherence tomography angiography

      Retinal capillary perfusion heterogeneity in diabetic retinopathy detected by optical coherence tomography angiography
      Purpose : To investigate the ability of a commercially available optical coherence tomography angiography (OCTA) machine to describe retinal capillary perfusion heterogeneity in diabetic retinopathy (DR) patients. Methods : Ten consecutive en face 6x6mm foveal OCTA images were obtained from both eyes of 13 DR patients and 5 healthy controls using a Zeiss PLEX Elite 9000. Fifteen DR and eight healthy eyes met the inclusion criteria: a centered fovea, little motion artifacts ...
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    14. Sensorless adaptive-optics optical coherence tomographic angiography

      Sensorless adaptive-optics optical coherence tomographic angiography
      Optical coherence tomographic angiography (OCTA) can image the retinal blood flow but visualization of the capillary caliber is limited by the low lateral resolution. Adaptive optics (AO) can be used to compensate ocular aberrations when using high numerical aperture (NA), and thus improve image resolution. However, previously reported AO-OCTA instruments were large and complex, and have a small sub-millimeter field of view (FOV) that hinders the extraction of biomarkers with ...
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    15. 1-15 of 87 1 2 3 4 5 6 »
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  2. About Simon Fraser University

    Simon Fraser University

    Simon Fraser University is a Canadian comprehensive university with campuses located in Burnaby Mountain in Burnaby, British Columbia, Vancouver, British Columbia , and Surrey, British Columbia. It was established in 1965 and presently has 24,000 students. It is named after Simon Fraser, explorer of the Vancouver area.