1. Simon Fraser University

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    1. Mentioned In 90 Articles

    2. Effects of Myopia and Glaucoma on the Neural Canal and Lamina Cribrosa using Optical Coherence Tomography

      Effects of Myopia and Glaucoma on the Neural Canal and Lamina Cribrosa using Optical Coherence Tomography
      Prcis: Glaucoma was associated with axial bowing and rotation of BMO and ALI, skewed neural canal, and deeper ALCS. Longer axial length was associated with wider, longer, and more skewed neural canal and flatter ALCS. Purpose: Investigate the effects of myopia and glaucoma in the prelaminar neural canal and anterior lamina cribrosa using 1060-nm swept-source optical coherence tomography . Patients: 19 control (38 eyes) and 38 glaucomatous subjects (63 eyes). Methods ...
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    3. Numerical calibration method for a multiple spectrometer-based OCT system

      Numerical calibration method for a multiple spectrometer-based OCT system
      The present paper introduces a numerical calibration method for the easy and practical implementation of multiple spectrometer-based spectral-domain optical coherence tomography (SD-OCT) systems. To address the limitations of the traditional hardware-based spectrometer alignment across more than one spectrometer, we applied a numerical spectral calibration algorithm where the pixels corresponding to the same wavelength in each unit are identified through spatial- and frequency-domain interferometric signatures of a mirror sample. The utility ...
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    4. Volumetric directional optical coherence tomography

      Volumetric directional optical coherence tomography
      Photoreceptor loss and resultant thinning of the outer nuclear layer (ONL) is an important pathological feature of retinal degenerations and may serve as a useful imaging biomarker for age-related macular degeneration. However, the demarcation between the ONL and the adjacent Henles fiber layer (HFL) is difficult to visualize with standard optical coherence tomography (OCT). A dedicated OCT system that can precisely control and continuously and synchronously update the imaging beam ...
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    5. 105° field of view non-contact handheld swept-source optical coherence tomography

      105° field of view non-contact handheld swept-source optical coherence tomography
      We demonstrate a handheld swept-source optical coherence tomography (OCT) system with a 400 kHz vertical-cavity surface-emitting laser (VCSEL) light source, a non-contact approach, and an unprecedented single shot 105 field of view (FOV). We also implemented a spiral scanning pattern allowing real-time visualization with improved scanning efficiency. To the best of our knowledge, this is the widest FOV achieved in a portable non-contact OCT retinal imaging system to date. Improvements ...
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    6. Effect of optical coherence tomography and angiography sampling rate towards diabetic retinopathy severity classification

      Effect of optical coherence tomography and angiography sampling rate towards diabetic retinopathy severity classification
      Optical coherence tomography (OCT) and OCT angiography (OCT-A) may benefit the screening of diabetic retinopathy (DR). This study investigated the effect of laterally subsampling OCT/OCT-A en face scans by up to a factor of 8 when using deep neural networks for automated referable DR classification. There was no significant difference in the classification performance across all evaluation metrics when subsampling up to a factor of 3, and only minimal ...
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    7. LF-UNet - A Novel Anatomical-Aware Dual-Branch Cascaded Deep Neural Network for Segmentation of Retinal Layers and Fluid from Optical Coherence Tomography Images

      LF-UNet - A Novel Anatomical-Aware Dual-Branch Cascaded Deep Neural Network for Segmentation of Retinal Layers and Fluid from Optical Coherence Tomography Images
      Computer-assistant diagnosis of retinal disease relies heavily on the accurate detection of retinal boundaries and other pathological features such as fluid accumulation. Optical coherence tomography (OCT) is a non-invasive ophthalmological imaging technique that has become a standard modality in the field due to its ability to detect cross-sectional retinal pathologies at the micrometer level. In this work, we presented a novel framework to achieve simultaneous retinal layers and fluid segmentation ...
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    8. Long-term assessment of internal limiting membrane peeling for full-thickness macular hole using en face adaptive optics and conventional optical coherence tomography

      Long-term assessment of internal limiting membrane peeling for full-thickness macular hole using en face adaptive optics and conventional optical coherence tomography
      Objective: To evaluate the long-term structural and microvascular retinal effects of internal limiting membrane peeling for full-thickness macular hole (FTMH) using en face adaptive optics optical coherence tomography (AO-OCT), conventional OCT, and OCT angiography (OCTA). Design: Interventional case series. Participants: Patients with FTMH treated with vitrectomy, internal limiting membrane peeling, and gas tamponade. Methods: Eleven eyes with FTMH that had at least 12 months of postoperative follow-up were enrolled in ...
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    9. High-speed and widefield handheld swept-source OCT angiography with a VCSEL light source

      High-speed and widefield handheld swept-source OCT angiography with a VCSEL light source
      Optical coherence tomography (OCT) and OCT angiography (OCTA) enable noninvasive structural and angiographic imaging of the eye. Portable handheld OCT/OCTA systems are required for imaging patients in the supine position. Examples include infants in the neonatal intensive care unit (NICU) and operating room (OR). The speed of image acquisition plays a pivotal role in acquiring high-quality OCT/OCTA images, particularly with the handheld system, since both the operator hand ...
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    10. Optimizing 3D retinal vasculature imaging in diabetic retinopathy using registration and averaging of OCT-A

      Optimizing 3D retinal vasculature imaging in diabetic retinopathy using registration and averaging of OCT-A
      High resolution visualization of optical coherence tomography (OCT) and OCT angiography (OCT-A) data is required to fully take advantage of the imaging modality's three-dimensional nature. However, artifacts induced by patient motion often degrade OCT-A data quality. This is especially true for patients with deteriorated focal vision, such as those with diabetic retinopathy (DR). We propose a novel methodology for software-based OCT-A motion correction achieved through serial acquisition, volumetric registration ...
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    11. Use of the Retinal Vascular Histology to Validate an Optical Coherence Tomography Angiography Technique

      Use of the Retinal Vascular Histology to Validate an Optical Coherence Tomography Angiography Technique
      Purpose: To determine the fidelity of optical coherence tomography angiography (OCTA) techniques by direct comparison of the retinal capillary network images obtained from the same region as imaged by OCTA and high-resolution confocal microscope. Method: Ten porcine eyes were perfused with red blood cells for OCTA image acquisition from the area centralis and then perfusion-fixed, and the vessels were labeled for confocal imaging. Two approaches involving post-processing of two-dimensional projection ...
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    12. Quantitative multi-contrast in vivo mouse imaging with polarization diversity optical coherence tomography and angiography

      Quantitative multi-contrast in vivo mouse imaging with polarization diversity optical coherence tomography and angiography
      Retinal microvasculature and the retinal pigment epithelium (RPE) play vital roles in maintaining the health and metabolic activity of the eye. Visualization of these retina structures is essential for pre-clinical studies of vision-robbing diseases, such as age-related macular degeneration (AMD). We have developed a quantitative multi-contrast polarization diversity OCT and angiography (QMC-PD-OCTA) system for imaging and visualizing pigment in the RPE using degree of polarization uniformity (DOPU), along with flow ...
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    13. Feasibility of combined optical coherence tomography and autofluorescence imaging for visualization of needle biopsy placement

      Feasibility of combined optical coherence tomography and autofluorescence imaging for visualization of needle biopsy placement
      Significance: Diagnosis of suspicious lung nodules requires precise collection of relevant biopsies for histopathological analysis. Using optical coherence tomography and autofluorescence imaging (OCT-AFI) to improve diagnostic yield in parts of the lung inaccessible to larger imaging methods may allow for reducing complications related to the alternative of computed tomography-guided biopsy. Aim: Feasibility of OCT-AFI combined with a commercially available lung biopsy needle was demonstrated for visualization of needle puncture sites ...
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    14. Real-time retinal layer segmentation of OCT volumes with GPU accelerated inferencing using a compressed, low-latency neural network

      Real-time retinal layer segmentation of OCT volumes with GPU accelerated inferencing using a compressed, low-latency neural network
      Segmentation of retinal layers in optical coherence tomography (OCT) is an essential step in OCT image analysis for screening, diagnosis, and assessment of retinal disease progression. Real-time segmentation together with high-speed OCT volume acquisition allows rendering of en face OCT of arbitrary retinal layers, which can be used to increase the yield rate of high-quality scans, provide real-time feedback during image-guided surgeries, and compensate aberrations in adaptive optics (AO) OCT ...
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  2. About Simon Fraser University

    Simon Fraser University

    Simon Fraser University is a Canadian comprehensive university with campuses located in Burnaby Mountain in Burnaby, British Columbia, Vancouver, British Columbia , and Surrey, British Columbia. It was established in 1965 and presently has 24,000 students. It is named after Simon Fraser, explorer of the Vancouver area.