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1. Mentioned In 69 Articles
2. RETOUCH: The Retinal OCT Fluid Detection and Segmentation Benchmark and Challenge
  
  Explore IEEE Xplore Aug 1 2019 Ophthalmology
  
  Retinal swelling due to the accumulation of fluid is associated with the most vision-threatening retinal diseases. Optical coherence tomography (OCT) is the current standard of care in assessing the presence and quantity of retinal fluid and image-guided treatment management. Deep learning methods have made their impact across medical imaging, and many retinal OCT analysis methods have been proposed. However, it is currently not clear how successful they are in interpreting ...
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  Mentions: University of Central Florida Simon Fraser University Nanjing University of Science and Technology
3. Directional optical coherence tomography reveals melanin concentration-dependent scattering properties of retinal pigment epithelium
  
  Explore SPIE Digital Library Jul 6 2019 Ophthalmology
  
  Optical coherence tomography (OCT) is a powerful tool in ophthalmology that provides in vivo morphology of the retinal layers and their light scattering properties. The directional (angular) reflectivity of the retinal layers was investigated with focus on the scattering from retinal pigment epithelium (RPE). The directional scattering of the RPE was studied in three mice strains with three distinct melanin concentrations: albino (BALB/c), agouti (129S1/SvlmJ), and strongly pigmented ...
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  Mentions: Oregon Health & Science University UC Davis Robert J. Zawadzki
4. Multi-scale and -contrast sensorless adaptive optics optical coherence tomography
  
  Explore Home May 28 2019 Ophthalmology
  
  Background: The roles of the retinal microvasculature and the retinal pigment epithelium (RPE) in maintaining the health and metabolic activity of the retina lend great clinical value to their high-resolution visualization. Methods: By integrating polarization diversity detection (PDD) into multi-scale and -contrast sensorless adaptive optics optical coherence tomography (MSC-SAO-OCT), we have developed a novel multi-contrast SAO OCT system for imaging pigment in the RPE as well as flow in the ...
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  Mentions: Shuichi Makita Yoshiaki Yasuno Oregon Health & Science University
5. Slope-based segmentation of articular cartilage using polarization-sensitive optical coherence tomography phase retardation image
  
  Explore SPIE Digital Library Mar 19 2019
  
  A segmentation method based on phase retardation measurements from polarization-sensitive optical coherence tomography (PS-OCT) is developed to differentiate the structural zones of articular cartilage. The organization of collagen matrix in articular cartilage varies over the different structural zones, generating different tissue birefringence. Analyzing the slope of the accumulated phase retardation at different depths can detect the variation in tissue birefringence and be used to segment the structural zones. The method ...
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  Mentions: University of British Columbia Simon Fraser University Myeong Jin Ju
6. Deep-Learning based Multiclass Retinal Fluid Segmentation and Detection in Optical Coherence Tomography Images using a Fully Convolutional Neural Network
  
  Explore ScienceDirect Feb 26 2019 Ophthalmology
  
  As a non-invasive imaging modality, optical coherence tomography (OCT) can provide micrometer-resolution 3D images of retinal structures. These images can help reveal disease-related alterations below the surface of the retina, such as the presence of edema, or accumulation of fluid which can distort vision, and are an indication of disruptions in the vasculature of the retina. In this paper, a new framework is proposed for multiclass fluid segmentation and detection ...
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  Mentions: University of British Columbia Marinko V. Sarunic Simon Fraser University
7. EN FACE OPTICAL COHERENCE TOMOGRAPHY AND OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF INNER RETINAL DIMPLES AFTER INTERNAL LIMITING MEMBRANE PEELING FOR FULL-THICKNESS MACULAR HOLES
  
  Explore LWW Online Jan 28 2019 Ophthalmology
  
  Purpose: To quantitatively and qualitatively evaluate the microvascular and structural abnormalities associated with inner retinal dimpling after internal limiting membrane peeling for full-thickness macular holes using sequential en face optical coherence tomography ( OCT ) and OCT angiography. Methods: Thirteen eyes of 13 patients with idiopathic full-thickness macular holes were enrolled in the study. Patients were treated with pars plana vitrectomy , internal limiting membrane peeling, and gas tamponade. Subjects were evaluated preoperatively ...
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  Mentions: University of British Columbia Marinko V. Sarunic Simon Fraser University
8. Aperture phase modulation with adaptive optics
  
  Explore OSA | OSA Publishing Jan 16 2019
  
  Speckle is an inevitable consequence of the use of coherent light in imaging and acts as noise that corrupts image formation in most applications. Optical coherence tomographic imaging, as a technique employing coherence time gating, suffers from speckle. We present here a novel method of suppressing speckle noise intrinsically compatible with adaptive optics (AO) for confocal coherent imaging: modulation of the phase in the system pupil aperture with a segmented ...
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  Mentions: Oregon Health & Science University UC Davis Robert J. Zawadzki
9. Automated identification of cone photoreceptors in adaptive optics optical coherence tomography images using transfer learning
  
  Explore OSA | OSA Publishing Oct 16 2018 Ophthalmology
  
  Automated measurements of the human cone mosaic requires the identification of individual cone photoreceptors. The current gold standard, manual labeling, is a tedious process and can not be done in a clinically useful timeframe. As such, we present an automated algorithm for identifying cone photoreceptors in adaptive optics optical coherence tomography (AO-OCT) images. Our approach fine-tunes a pre-trained convolutional neural network originally trained on AO scanning laser ophthalmoscope (AO-SLO) images ...
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  Mentions: University of British Columbia Marinko V. Sarunic Simon Fraser University
10. Visible light sensorless adaptive optics for retinal structure and fluorescence imaging
  
  Explore OSA | OSA Publishing Oct 16 2018 Ophthalmology
  
  Optical coherence tomography (OCT) has emerged as a powerful imaging instrument and technology in biomedicine. OCT imaging is predominantly performed using wavelengths in the near infrared; however, visible light (VIS) has been recently employed in OCT systems with encouraging results for high-resolution retinal imaging. Using a broadband supercontinuum VIS source, we present a sensorless adaptive optics (SAO) multimodal imaging system driven by VIS-OCT for volumetric retinal structural imaging, followed by ...
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  Mentions: Oregon Health & Science University Marinko V. Sarunic Simon Fraser University
11. Aperture Phase Modulation with Adaptive Optics: A Novel Approach for Speckle Reduction and Structure Extraction in Optical Coherence Tomography
  
  Explore bioRxiv.org Sep 29 2018 Ophthalmology
  
  Speckle is an inevitable consequence of the use of coherent light in optical coherence tomography (OCT), and often acts as noise that obscures micro-structures of biological tissue. We here present a novel method of suppressing speckle noise intrinsically compatible with adaptive optics (AO) in OCT system: by modulating the phase inside the imaging system pupil aperture with a segmented deformable mirror, thus producing minor perturbations in the point spread function ...
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  Mentions: Oregon Health & Science University UC Davis Robert J. Zawadzki
12. Label‐free volumetric imaging of conjunctival collecting lymphatics ex vivo by optical coherence tomography lymphangiography
  
  Explore Wiley Online Library Jun 19 2018
  
  We employ optical coherence tomography (OCT) and optical coherence microscopy (OCM) to study conjunctival lymphatics in porcine eyes ex vivo . This study is a precursor to the development of in vivo imaging of the collecting lymphatics for potentially guiding and monitoring glaucoma filtration surgery. OCT scans at 1300 nm and higher‐resolution OCM scans at 785 nm reveal the lymphatic vessels via their optical transparency. Equivalent signal characteristics are also ...
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  Mentions: David D. Sampson University of Western Australia Qiang Wang
13. Effective bidirectional scanning pattern for optical coherence tomography angiography
  
  Explore OSA | OSA Publishing May 1 2018 Ophthalmology
  
  We demonstrate the utility of a novel scanning method for optical coherence tomography angiography (OCTA). Although raster scanning is commonly used for OCTA imaging, a bidirectional approach would lessen the distortion caused by galvanometer-based scanners as sources continue to increase sweep rates. As shown, a unidirectional raster scan approach has a lower effective scanning time than bidirectional approaches; however, a strictly bidirectional approach causes contrast variation along the B-scan direction ...
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  Mentions: Marinko V. Sarunic Simon Fraser University Myeong Jin Ju
14. Investigation of the effect of directional (off-axis) illumination on the reflectivity of retina layers in mice using swept-source optical coherence tomography
  
  Explore SPIE Digital Library Mar 24 2018 Ophthalmology
  
  Changes in visibility of the Henle fiber layer and photoreceptor bands of the human retina with illumination directionality have been reported in OCT clinical imaging. These are a direct consequence of the changes in back scattering due to fibrous tissue orientation and to waveguiding properties of the photoreceptors respectively. Here we report the preliminary results of a study on the effects of retinal images acquired with OCT of illumination directionality ...
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  Mentions: UC Davis Robert J. Zawadzki Marinko V. Sarunic
15. Adaptive optics with combined optical coherence tomography and scanning laser ophthalmoscopy for in vivo mouse retina imaging
  
  Explore SPIE Digital Library Mar 24 2018 Ophthalmology
  
  Optical coherence tomography (OCT) and scanning laser ophthalmoscopy (SLO) are two state-of-the-art imaging technologies commonly used to study retina. Adaptive Optics (AO) methodologies enable high-fidelity correction of ocular aberrations, resulting in improved resolution and sensitivity for both SLO and OCT systems. Here we present work integrating OCT into a previously described mouse retinal AO-SLO system, allowing simultaneous reflectance and fluorescence imaging. The new system allows simultaneous data acquisition of AO-SLO ...
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  Mentions: UC Davis Robert J. Zawadzki Marinko V. Sarunic
16. Comparisons Between Histology and Optical Coherence Tomography Angiography of the Periarterial Capillary-Free Zone
  
  Explore American Journal of Ophthalmology Feb 19 2018 Ophthalmology
  
  Purpose To use the capillary-free zone along retinal arteries, a physiologic area of superficial avascularization, as an anatomic paradigm to investigate the reliability of optical coherence tomographic angiography (OCTA) for visualizing the deep retinal circulation. Design Validity analysis and laboratory investigation. Methods Five normal human donor eyes (mean age 69.8 years) were perfusion-labelled with endothelial antibodies and the capillary networks of the perifovea were visualized using confocal scanning laser ...
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  Mentions: Marinko V. Sarunic Simon Fraser University K. Bailey Freund
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