1. Simon Fraser University

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    1. Mentioned In 67 Articles

    2. Multi-scale and -contrast sensorless adaptive optics optical coherence tomography

      Explore Home Ophthalmology
      Multi-scale and -contrast sensorless adaptive optics optical coherence tomography
      Background: The roles of the retinal microvasculature and the retinal pigment epithelium (RPE) in maintaining the health and metabolic activity of the retina lend great clinical value to their high-resolution visualization. Methods: By integrating polarization diversity detection (PDD) into multi-scale and -contrast sensorless adaptive optics optical coherence tomography (MSC-SAO-OCT), we have developed a novel multi-contrast SAO OCT system for imaging pigment in the RPE as well as flow in the ...
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      Mentions: Shuichi Makita Yoshiaki Yasuno Oregon Health & Science University

    3. Slope-based segmentation of articular cartilage using polarization-sensitive optical coherence tomography phase retardation image

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      Slope-based segmentation of articular cartilage using polarization-sensitive optical coherence tomography phase retardation image
      A segmentation method based on phase retardation measurements from polarization-sensitive optical coherence tomography (PS-OCT) is developed to differentiate the structural zones of articular cartilage. The organization of collagen matrix in articular cartilage varies over the different structural zones, generating different tissue birefringence. Analyzing the slope of the accumulated phase retardation at different depths can detect the variation in tissue birefringence and be used to segment the structural zones. The method ...
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      Mentions: University of British Columbia Simon Fraser University Myeong Jin Ju

    4. Deep-Learning based Multiclass Retinal Fluid Segmentation and Detection in Optical Coherence Tomography Images using a Fully Convolutional Neural Network

      Explore ScienceDirect Ophthalmology
      Deep-Learning based Multiclass Retinal Fluid Segmentation and Detection in Optical Coherence Tomography Images using a Fully Convolutional Neural Network
      As a non-invasive imaging modality, optical coherence tomography (OCT) can provide micrometer-resolution 3D images of retinal structures. These images can help reveal disease-related alterations below the surface of the retina, such as the presence of edema, or accumulation of fluid which can distort vision, and are an indication of disruptions in the vasculature of the retina. In this paper, a new framework is proposed for multiclass fluid segmentation and detection ...
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      Mentions: University of British Columbia Marinko V. Sarunic Simon Fraser University

    5. EN FACE OPTICAL COHERENCE TOMOGRAPHY AND OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF INNER RETINAL DIMPLES AFTER INTERNAL LIMITING MEMBRANE PEELING FOR FULL-THICKNESS MACULAR HOLES

      Explore LWW Online Ophthalmology
      EN FACE OPTICAL COHERENCE TOMOGRAPHY AND OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF INNER RETINAL DIMPLES AFTER INTERNAL LIMITING MEMBRANE PEELING FOR FULL-THICKNESS MACULAR HOLES
      Purpose: To quantitatively and qualitatively evaluate the microvascular and structural abnormalities associated with inner retinal dimpling after internal limiting membrane peeling for full-thickness macular holes using sequential en face optical coherence tomography ( OCT ) and OCT angiography. Methods: Thirteen eyes of 13 patients with idiopathic full-thickness macular holes were enrolled in the study. Patients were treated with pars plana vitrectomy , internal limiting membrane peeling, and gas tamponade. Subjects were evaluated preoperatively ...
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      Mentions: University of British Columbia Marinko V. Sarunic Simon Fraser University

    6. Aperture phase modulation with adaptive optics

      Explore OSA | OSA Publishing
      Aperture phase modulation with adaptive optics
      Speckle is an inevitable consequence of the use of coherent light in imaging and acts as noise that corrupts image formation in most applications. Optical coherence tomographic imaging, as a technique employing coherence time gating, suffers from speckle. We present here a novel method of suppressing speckle noise intrinsically compatible with adaptive optics (AO) for confocal coherent imaging: modulation of the phase in the system pupil aperture with a segmented ...
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      Mentions: Oregon Health & Science University UC Davis Robert J. Zawadzki

    7. Automated identification of cone photoreceptors in adaptive optics optical coherence tomography images using transfer learning

      Explore OSA | OSA Publishing Ophthalmology
      Automated identification of cone photoreceptors in adaptive optics optical coherence tomography images using transfer learning
      Automated measurements of the human cone mosaic requires the identification of individual cone photoreceptors. The current gold standard, manual labeling, is a tedious process and can not be done in a clinically useful timeframe. As such, we present an automated algorithm for identifying cone photoreceptors in adaptive optics optical coherence tomography (AO-OCT) images. Our approach fine-tunes a pre-trained convolutional neural network originally trained on AO scanning laser ophthalmoscope (AO-SLO) images ...
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      Mentions: University of British Columbia Marinko V. Sarunic Simon Fraser University

    8. Visible light sensorless adaptive optics for retinal structure and fluorescence imaging

      Explore OSA | OSA Publishing Ophthalmology
      Visible light sensorless adaptive optics for retinal structure and fluorescence imaging
      Optical coherence tomography (OCT) has emerged as a powerful imaging instrument and technology in biomedicine. OCT imaging is predominantly performed using wavelengths in the near infrared; however, visible light (VIS) has been recently employed in OCT systems with encouraging results for high-resolution retinal imaging. Using a broadband supercontinuum VIS source, we present a sensorless adaptive optics (SAO) multimodal imaging system driven by VIS-OCT for volumetric retinal structural imaging, followed by ...
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      Mentions: Oregon Health & Science University Marinko V. Sarunic Simon Fraser University

    9. Aperture Phase Modulation with Adaptive Optics: A Novel Approach for Speckle Reduction and Structure Extraction in Optical Coherence Tomography

      Explore bioRxiv.org Ophthalmology
      Aperture Phase Modulation with Adaptive Optics: A Novel Approach for Speckle Reduction and Structure Extraction in Optical Coherence Tomography
      Speckle is an inevitable consequence of the use of coherent light in optical coherence tomography (OCT), and often acts as noise that obscures micro-structures of biological tissue. We here present a novel method of suppressing speckle noise intrinsically compatible with adaptive optics (AO) in OCT system: by modulating the phase inside the imaging system pupil aperture with a segmented deformable mirror, thus producing minor perturbations in the point spread function ...
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      Mentions: Oregon Health & Science University UC Davis Robert J. Zawadzki

    10. Label‐free volumetric imaging of conjunctival collecting lymphatics ex vivo by optical coherence tomography lymphangiography

      Explore Wiley Online Library
      Label‐free volumetric imaging of conjunctival collecting lymphatics ex vivo by optical coherence tomography lymphangiography
      We employ optical coherence tomography (OCT) and optical coherence microscopy (OCM) to study conjunctival lymphatics in porcine eyes ex vivo . This study is a precursor to the development of in vivo imaging of the collecting lymphatics for potentially guiding and monitoring glaucoma filtration surgery. OCT scans at 1300 nm and higher‐resolution OCM scans at 785 nm reveal the lymphatic vessels via their optical transparency. Equivalent signal characteristics are also ...
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      Mentions: David D. Sampson University of Western Australia Qiang Wang

    11. Effective bidirectional scanning pattern for optical coherence tomography angiography

      Explore OSA | OSA Publishing Ophthalmology
      Effective bidirectional scanning pattern for optical coherence tomography angiography
      We demonstrate the utility of a novel scanning method for optical coherence tomography angiography (OCTA). Although raster scanning is commonly used for OCTA imaging, a bidirectional approach would lessen the distortion caused by galvanometer-based scanners as sources continue to increase sweep rates. As shown, a unidirectional raster scan approach has a lower effective scanning time than bidirectional approaches; however, a strictly bidirectional approach causes contrast variation along the B-scan direction ...
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      Mentions: Marinko V. Sarunic Simon Fraser University Myeong Jin Ju

    12. Investigation of the effect of directional (off-axis) illumination on the reflectivity of retina layers in mice using swept-source optical coherence tomography

      Explore SPIE Digital Library Ophthalmology
      Investigation of the effect of directional (off-axis) illumination on the reflectivity of retina layers in mice using swept-source optical coherence tomography
      Changes in visibility of the Henle fiber layer and photoreceptor bands of the human retina with illumination directionality have been reported in OCT clinical imaging. These are a direct consequence of the changes in back scattering due to fibrous tissue orientation and to waveguiding properties of the photoreceptors respectively. Here we report the preliminary results of a study on the effects of retinal images acquired with OCT of illumination directionality ...
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      Mentions: UC Davis Robert J. Zawadzki Marinko V. Sarunic

    13. Adaptive optics with combined optical coherence tomography and scanning laser ophthalmoscopy for in vivo mouse retina imaging

      Explore SPIE Digital Library Ophthalmology
      Adaptive optics with combined optical coherence tomography and scanning laser ophthalmoscopy for in vivo mouse retina imaging
      Optical coherence tomography (OCT) and scanning laser ophthalmoscopy (SLO) are two state-of-the-art imaging technologies commonly used to study retina. Adaptive Optics (AO) methodologies enable high-fidelity correction of ocular aberrations, resulting in improved resolution and sensitivity for both SLO and OCT systems. Here we present work integrating OCT into a previously described mouse retinal AO-SLO system, allowing simultaneous reflectance and fluorescence imaging. The new system allows simultaneous data acquisition of AO-SLO ...
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      Mentions: UC Davis Robert J. Zawadzki Marinko V. Sarunic

    14. Comparisons Between Histology and Optical Coherence Tomography Angiography of the Periarterial Capillary-Free Zone

      Explore American Journal of Ophthalmology Ophthalmology
      Comparisons Between Histology and Optical Coherence Tomography Angiography of the Periarterial Capillary-Free Zone
      Purpose To use the capillary-free zone along retinal arteries, a physiologic area of superficial avascularization, as an anatomic paradigm to investigate the reliability of optical coherence tomographic angiography (OCTA) for visualizing the deep retinal circulation. Design Validity analysis and laboratory investigation. Methods Five normal human donor eyes (mean age 69.8 years) were perfusion-labelled with endothelial antibodies and the capillary networks of the perifovea were visualized using confocal scanning laser ...
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      Mentions: Marinko V. Sarunic Simon Fraser University K. Bailey Freund

    15. Quantitative comparisons between optical coherence tomography angiography and matched histology in the human eye

      Explore ScienceDirect Ophthalmology
      Quantitative comparisons between optical coherence tomography angiography and matched histology in the human eye
      The aim was to quantitatively compare retinal vascular detail as seen on optical coherence tomography angiography (OCTA) and matched histology in the human eye. 13 normal human donor eyes were used. The central retinal artery was cannulated after which human packed red blood cells were perfused through the retinal vasculature. Retinal vessels were imaged using a custom-built OCTA device during red blood cell perfusion. The eye was subsequently perfused with ...
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      Mentions: University of Western Australia Marinko V. Sarunic Simon Fraser University
    17. 1-15 of 67 1 2 3 4 5 »
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  4. About Simon Fraser University

    Simon Fraser University

    Simon Fraser University is a Canadian comprehensive university with campuses located in Burnaby Mountain in Burnaby, British Columbia, Vancouver, British Columbia , and Surrey, British Columbia. It was established in 1965 and presently has 24,000 students. It is named after Simon Fraser, explorer of the Vancouver area.

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