1. Siavash Yousefi

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    1. Mentioned In 13 Articles

    2. Gold Nanoprisms as Optical Coherence Tomography Contrast Agents in the Second Near-Infrared Window for Enhanced Angiography in Live Animals

      Gold Nanoprisms as Optical Coherence Tomography Contrast Agents in the Second Near-Infrared Window for Enhanced Angiography in Live Animals
      Optical coherence tomography angiography (OCTA) is an important tool for investigating vascular networks and microcirculation in living tissue. Traditional OCTA detects blood vessels via intravascular dynamic scattering signals derived from the movements of red blood cells (RBCs). However, the low hematocrit and long latency between RBCs in capillaries make these OCTA signals discontinuous, leading to incomplete mapping of the vascular networks. OCTA imaging of microvascular circulation is particularly challenging in ...
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    3. Optical coherence tomography of lymphatic vessel endothelial hyaluronan receptors in vivo

      Optical coherence tomography of lymphatic vessel endothelial hyaluronan receptors in vivo
      Optical Coherence Tomography (OCT) imaging of living subjects offers millimeters depth of penetration into tissue while maintaining high spatial resolution. However, because most molecular biomarkers do not produce inherent OCT contrast signals, exogenous contrast agents must be employed to achieve molecular imaging. Here we demonstrate that microbeads (Bs) can be used as effective contrast agents to target cellular biomarkers in lymphatic vessels and can be detected by OCT using a ...
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    4. In Vivo Molecular Optical Coherence Tomography of Lymphatic Vessel Endothelial Hyaluronan Receptors

      In Vivo Molecular Optical Coherence Tomography of Lymphatic Vessel Endothelial Hyaluronan Receptors
      Optical Coherence Tomography (OCT) imaging of living subjects offers increased depth of penetration while maintaining high spatial resolution when compared to other optical microscopy techniques. However, since most protein biomarkers do not exhibit inherent contrast detectable by OCT, exogenous contrast agents must be employed for imaging specific cellular biomarkers of interest. While a number of OCT contrast agents have been previously studied, demonstrations of molecular targeting with such agents in ...
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    5. Label-free optical imaging of lymphatic vessels within tissue beds in vivo

      Label-free optical imaging of lymphatic vessels within tissue beds in vivo
      Lymphatic vessels are a part of the circulatory system in vertebrates that maintain tissue fluid homeostasis and drain excess fluid and large cells that cannot easily find their way back into venous system. Due to the lack of noninvasive monitoring tools, lymphatic vessels are known as forgotten circulation. However, the lymphatic system plays an important role in diseases such as cancer and inflammatory conditions. In this paper, we start to ...
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    6. Segmentation and quantification of blood vessels for OCT-based micro-angiograms using hybrid shape/intensity compounding

      Segmentation and quantification of blood vessels for OCT-based micro-angiograms using hybrid shape/intensity compounding
      Optical coherence tomography (OCT) based microangiography is capable of visualizing 3D functional blood vessel networks within microcirculatory tissue beds in vivo. To provide the quantitative information of vasculature from the microangiograms such as vessel diameter and morphology, it is necessary to develop efficient vessel segmentation algorithms. In this paper, we propose to develop a hybrid Hessian/intensity based method to segment and quantify shape and diameter of the blood vessels ...
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    7. Improved microcirculation imaging of human skin in vivo using optical microangiography with a correlation mapping mask

      Improved microcirculation imaging of human skin in vivo using optical microangiography with a correlation mapping mask
      Optical microangiography based on optical coherence tomography (OCT) is prone to noise that arises from a static tissue region. Here, we propose a method that can significantly reduce this noise. The method is developed based on an approach that uses the magnitude information of OCT signals to produce tissue microangiograms, especially suitable for the case where a swept-source OCT system is deployed. By combined use of two existing OCT microangiography ...
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    8. Label-free optical lymphangiography: development of an automatic segmentation method applied to optical coherence tomography to visualize lymphatic vessels using Hessian filters

      Label-free optical lymphangiography: development of an automatic segmentation method applied to optical coherence tomography to visualize lymphatic vessels using Hessian filters
      Lymphatic vessels are a part of the circulatory system that collect plasma and other substances that have leaked from the capillaries into interstitial fluid (lymph) and transport lymph back to the circulatory system. Since lymph is transparent, lymphatic vessels appear as dark hallow vessel-like regions in optical coherence tomography (OCT) cross sectional images. We propose an automatic method to segment lymphatic vessel lumen from OCT structural cross sections using eigenvalues ...
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    9. Super-resolution spectral estimation of optical micro-angiography for quantifying blood flow within microcirculatory tissue beds in vivo

      Super-resolution spectral estimation of optical micro-angiography for quantifying blood flow within microcirculatory tissue beds in vivo
      In this paper, we propose a super-resolution spectral estimation technique to quantify microvascular hemodynamics using optical microangiography (OMAG) based on optical coherence tomography (OCT). The proposed OMAG technique uses both amplitude and phase information of the OCT signals which makes it sensitive to the axial and transverse flows. The scanning protocol for the proposed method is identical to three-dimensional ultrahigh sensitive OMAG, and is applicable for in vivo measurements. In ...
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    10. Automated segmentation of intramacular layers in Fourier domain optical coherence tomography structural images from normal subjects

      Automated segmentation of intramacular layers in Fourier domain optical coherence tomography structural images from normal subjects
      Segmentation of optical coherence tomography (OCT) cross-sectional structural images is important for assisting ophthalmologists in clinical decision making in terms of both diagnosis and treatment. We present an automatic approach for segmenting intramacular layers in Fourier domain optical coherence tomography (FD-OCT) images using a searching strategy based on locally weighted gradient extrema, coupled with an error-removing technique based on statistical error estimation. A two-step denoising preprocess in different directions is ...
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    11. Automatic estimation of point-spread-function for deconvoluting out-of-focus optical coherence tomographic images using information entropy-based approach

      Automatic estimation of point-spread-function for deconvoluting out-of-focus optical coherence tomographic images using information entropy-based approach
      ...optics and biotechnology : Optical coherence tomography ToC Category: Category Pending Citation Guozhong Liu, Siavash Yousefi, Zhongwei Zhi, and Ruikang K. Wang, "Automatic estimation of point-spread-function for deconvo...
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  2. About Siavash Yousefi

    Siavash Yousefi

    Siavash Yousefi gradauted from the Department of Bioengineering at the University of Washington.