1. Shuichi Makita

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    1. Mentioned In 59 Articles

    2. Simultaneous Investigation of Vascular and Retinal Pigment Epithelial Pathologies of Exudative Macular Diseases by Multi-Functional Optical Coherence Tomography

      Simultaneous Investigation of Vascular and Retinal Pigment Epithelial Pathologies of Exudative Macular Diseases by Multi-Functional Optical Coherence Tomography

      Purpose: To investigate exudative macular disease, multi-functional optical coherence tomography (MF-OCT) using a 1-μm probe band was developed. The clinical utility of MF-OCT was examined in a descriptive case series. Methods: Ten eyes of nine subjects with exudative macular disease, including one eye with age-related macular degeneration (AMD), one eye with idiopathic neovascular maculopathy, and eight eyes with polypoidal choroidal vasculopathy (PCV), were investigated. Areas of 6 × 6 mm 2 around the pathologic region were scanned with 512 × 1024 depth scans in 6.6 seconds. Structural OCT, Doppler optical coherence angiography (OCA) and cumulative phase retardation images were obtained ...

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    3. Advanced multi-contrast Jones matrix optical coherence tomography for Doppler and polarization sensitive imaging

      Advanced multi-contrast Jones matrix optical coherence tomography for Doppler and polarization sensitive imaging

      An advanced version of Jones matrix optical coherence tomography (JMT) is demonstrated for Doppler and polarization sensitive imaging of the posterior eye. JMT is capable of providing localized flow tomography by Doppler detection and investigating the birefringence property of tissue through a three-dimensional (3-D) Jones matrix measurement. Owing to an incident polarization multiplexing scheme based on passive optical components, this system is stable, safe in a clinical environment, and cost effective. Since the properties of this version of JMT provide intrinsic compensation for system imperfection, the system is easy to calibrate. Compared with the previous version of JMT, this advanced ...

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    4. Noninvasive Investigation of Deep Vascular Pathologies of Exudative Macular Diseases by High Penetration Optical Coherence Angiography

      Noninvasive Investigation of Deep Vascular Pathologies of Exudative Macular Diseases by High Penetration Optical Coherence Angiography

      Purpose: A newly developed high-penetration Doppler optical coherence angiography (HP-OCA) with a 1-μm probe beam for non-invasive investigation of vascular pathology of exudative macular diseases is introduced. A descriptive case series is presented to discuss the clinical utility of HP-OCA. Methods: Eleven eyes of 10 subjects with exudative macular disease, including 2 eyes with myopic choroidal neovascularization (mCNV), 4 eyes with age-related macular degeneration (AMD) and 5 eyes with polypoidal choroidal vasculopathy (PCV), were investigated. Two Doppler scanning modes (bi-directional and high-sensitive) of HP-OCA were used for the investigation. HP-OCA provides depth resolved and en face angiograms and a ...

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    5. Three-dimensional retinal and choroidal capillary imaging by power Doppler optical coherence angiography with adaptive optics

      Three-dimensional retinal and choroidal capillary imaging by power Doppler optical coherence angiography with adaptive optics

      Retinal and choroidal vascular imaging is a key to the better understanding and diagnosis of eye diseases. To achieve comprehensive three-dimensional capillary imaging, we used an enhanced vascular imaging technique, so called adaptive optics optical coherence angiography (AO-OCA). AO-OCA enables in vivo high-resolution and high-contrast micro-vascular imaging by detecting Doppler frequency shifts. Using this technique, the retinal and choroidal vasculatures of healthy subjects were imaged. The results show that both intensity and Doppler power images have sufficient contrast to discriminate almost all vasculatures from the static tissue. However, the choriocapillaris, pre-arterioles, and post-venules in the Sattler layer were more contrasted ...

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    6. Extended depth of focus adaptive optics spectral domain optical coherence tomography

      Extended depth of focus adaptive optics spectral domain optical coherence tomography
      We present an adaptive optics spectral domain optical coherence tomography (AO-SDOCT) with a long focal range by active phase modulation of the pupil. A long focal range is achieved by introducing AO-controlled third-order spherical aberration (SA). The property of SA and its effects on focal range are investigated in detail using the Huygens-Fresnel principle, beam profile measurement and OCT imaging of a phantom. The results indicate that the focal range is extended by applying SA, and the direction of extension can be controlled by the sign of applied SA. Finally, we demonstrated in vivo human retinal imaging by altering the ...
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    7. An approach to measure blood flow in single choroidal vessel using Doppler optical coherence tomography

      An approach to measure blood flow in single choroidal vessel using Doppler optical coherence tomography

      Purpose:To evaluate the absolute blood flow rate in a single choroidal vessel using Doppler optical coherence tomography (OCT). Methods:Three choroidal vessels were selected in the right eye of three normal subjects, and were measured with Doppler OCT at a 1,020-nm probe wavelength. The pulsatile change of the blood flow was obtained from synchronized measurement of Doppler OCT and plethysmography. Absolute blood flow rates in choroidal vessels were calculated from Doppler OCT volume data. Results:The cyclic change of the blood flow was quantitatively obtained. Absolute blood flow velocities and blood flow rates at peak systole [mean (SD ...

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    8. Optical Rheology of Porcine Sclera by Birefringence Imaging

      Optical Rheology of Porcine Sclera by Birefringence Imaging

      Purpose To investigate a relationship between birefringence and elasticity of porcine sclera ex vivo using polarization-sensitive optical coherence tomography (PS-OCT). Methods Elastic parameters and birefringence of 19 porcine eyes were measured. Four pieces of scleral strips which were parallel to the limbus, with a width of 4 mm, were dissected from the optic nerve head to the temporal side of each porcine eye. Birefringence of the sclera was measured with a prototype PS-OCT. The strain and force were measured with a uniaxial material tester as the sample was stretched with a speed of 1.8 mm/min after preconditioning. A ...

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    9. Office based multi-functional anterior eye segment optical coherence tomography

      Office based multi-functional anterior eye segment optical coherence tomography

      An office based Doppler and polarization sensitive swept-source optical coherence tomography (Doppler-PS-SS-OCT) was developed for diagnosis and evaluation of abnormalities of anterior eye segment in clinic. A healthy eye was measured in vivo by the Doppler PS-OCT. The results showed that the Doppler PS-OCT may have potential to identify blood vessels and discriminate fibrous tissues in abnormalities, such as scarring in bleb, and scleral inflammation.

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  2. About Shuichi Makita

    Shuichi Makita is a Researcher in the Computational Optics Group in the Institute of Applied Physics, University of Tsukuba in Japan.