1. Shang Wang

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    1. Mentioned In 41 Articles

    2. Speckle variance optical coherence tomography of blood flow in the beating mouse embryonic heart

      Speckle variance optical coherence tomography of blood flow in the beating mouse embryonic heart
      Efficient separation of blood and cardiac wall in the beating embryonic heart is essential and critical for experiment-based computational modelling and analysis of early-stage cardiac biomechanics. Although speckle variance optical coherence tomography (SV-OCT) relying on calculation of intensity variance over consecutively acquired frames is a powerful approach for segmentation of fluid flow from static tissue, application of this method in the beating embryonic heart remains challenging because moving structures generate ...
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    3. Evaluation of dermal fillers with noncontact optical coherence elastography

      Evaluation of dermal fillers with noncontact optical coherence elastography
      Over 2 million dermal filler procedures are performed each year in the USA alone, and this figure is only expected to increase as the aging population continues to grow. Dermal filler treatments can last from a few months to years depending on the type of filler and its placement. Although adverse reactions are rare, they can be quite severe due to ischemic events and filler migration. Previously, techniques such as ...
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    4. Live dynamic analysis of the developing cardiovascular system in mice

      Live dynamic analysis of the developing cardiovascular system in mice
      The study of the developing cardiovascular system in mice is important for understanding human cardiogenesis and congenital heart defects. Our research focuses on imaging early development in the mouse embryo to specifically understand cardiovascular development under the regulation of dynamic factors like contractile force and blood flow using optical coherence tomography (OCT). We have previously developed an OCT based approach that combines static embryo culture and advanced image processing with ...
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    5. Optical coherence tomography for image-guided dermal filler injection and biomechanical evaluation

      Optical coherence tomography for image-guided dermal filler injection and biomechanical evaluation
      Dermal fillers are a very popular anti-aging treatment with estimated sales in the billions of dollars and millions of procedures performed. As the aging population continues to grow, these figures are only expected to increase. Dermal fillers have various compositions depending on their intended application. Reactions to dermal fillers can be severe, such as ischemic events and filler migration to the eyes. However, these adverse reactions are rare. Nevertheless, the ...
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    6. Dynamic imaging and quantitative analysis of cranial neural tube closure in the mouse embryo using optical coherence tomography

      Dynamic imaging and quantitative analysis of cranial neural tube closure in the mouse embryo using optical coherence tomography
      Neural tube closure is a critical feature of central nervous system morphogenesis during embryonic development. Failure of this process leads to neural tube defects, one of the most common forms of human congenital defects. Although molecular and genetic studies in model organisms have provided insights into the genes and proteins that are required for normal neural tube development, complications associated with live imaging of neural tube closure in mammals limit ...
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    7. Optical Modalities for Embryonic Imaging

      Optical Modalities for Embryonic Imaging
      tudies of disease etiology often rely on the murine (mouse) model, which provides valuable genotypic information. Yet associated phenotypic information from murine embryos is often lacking. Of the various techniques that have been proposed for imaging such embryos, optical modalities may provide the best compromise among speed, penetration depth and resolution. This year, we developed approaches to improve embryonic imaging with optical coherence tomography (OCT), 1 and also provided a ...
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    8. Live four-dimensional optical coherence tomography reveals embryonic cardiac phenotype in mouse mutant

      Live four-dimensional optical coherence tomography reveals embryonic cardiac phenotype in mouse mutant
      Efficient phenotyping of developmental defects in model organisms is critical for understanding the genetic specification of normal development and congenital abnormalities in humans. We previously reported that optical coherence tomography (OCT) combined with live embryo culture is a valuable tool for mouse embryo imaging and four-dimensional (4-D) cardiodynamic analysis; however, its capability for analysis of mouse mutants with cardiac phenotypes has not been previously explored. Here, we report 4-D (three-dimensional ...
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    9. Four-dimensional live imaging of hemodynamics in mammalian embryonic heart with Doppler optical coherence tomography

      Four-dimensional live imaging of hemodynamics in mammalian embryonic heart with Doppler optical coherence tomography
      Four-dimensional live hemodynamic imaging of the mouse embryonic heart at embryonic day 9.0 using Doppler optical coherence tomography, showing directional blood flows in the sinus venosus, primitive atrium, atrioventricular region and vitelline vein. Hemodynamic analysis of the mouse embryonic heart is essential for understanding the functional aspects of early cardiogenesis and advancing the research in congenital heart defects. However, high-resolution imaging of cardiac hemodynamics in mammalian models remains challenging ...
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    10. Live 4D optical coherence tomography for early embryonic mouse cardiac phenotyping

      Live 4D optical coherence tomography for early embryonic mouse cardiac phenotyping
      Studying embryonic mouse development is important for our understanding of normal human embryogenesis and the underlying causes of congenital defects. Our research focuses on imaging early development in the mouse embryo to specifically understand cardiovascular development using optical coherence tomography (OCT). We have previously developed imaging approaches that combine static embryo culture, OCT imaging and advanced image processing to visualize the whole live mouse embryos and obtain 4D (3D+time ...
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    11. Three-dimensional imaging of the developing mouse female reproductive organs with optical coherence tomography

      Three-dimensional imaging of the developing mouse female reproductive organs with optical coherence tomography
      Infertility is a known major health concern and is estimated to impact ~15% of couples in the U.S. The majority of failed pregnancies occur before or during implantation of the fertilized embryo into the uterus. Understanding the mechanisms regulating development by studying mouse reproductive organs could significantly contribute to an improved understanding of normal development of reproductive organs and developmental causes of infertility in humans. Towards this goal, we ...
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    12. Functional optical coherence tomography for high-resolution mapping of cilia beat frequency in the mouse oviduct in vivo

      Functional optical coherence tomography for high-resolution mapping of cilia beat frequency in the mouse oviduct in vivo
      Since mouse is a superior model for genetic analysis of human disorders, reproductive studies in mice have significant implications on further understanding of fertility and infertility in humans. Fertilized oocytes are transported through the reproductive tract by motile cilia lining the lumen of the oviduct as well as by oviduct contractions. While the role of cilia is well recognized, ciliary dynamics in the oviduct is not well understood, largely owing ...
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    13. Optical Coherence Tomography as a Tool for Real-Time Visual Feedback and Biomechanical Assessment of Dermal Filler Injections: Preliminary Results in a Pig Skin Model

      Optical Coherence Tomography as a Tool for Real-Time Visual Feedback and Biomechanical Assessment of Dermal Filler Injections: Preliminary Results in a Pig Skin Model
      Dermal fillers are a popular anti-aging treatment with over 2 million procedures performed in the USA in 2013, and this figure will only increase as the aging population grows. Most FDA approved fillers last 3 to 24 months, depending on composition and injection site. There are numerous FDA-approved dermal fillers of varying compositions, with the most common being hyaluronic acid. Various fillers have optimal uses in specific skin layers corresponding ...
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    14. Direct four-dimensional structural and functional imaging of cardiovascular dynamics in mouse embryos with 1.5  MHz optical coherence tomography

      Direct four-dimensional structural and functional imaging of cardiovascular dynamics in mouse embryos with 1.5  MHz optical coherence tomography
      High-resolution three-dimensional (3D) imaging of cardiovascular dynamics in mouse embryos is greatly desired to study mammalian congenital cardiac defects. Here, we demonstrate direct four-dimensional (4D) imaging of the cardiovascular structure and function in live mouse embryos at a 43 Hz volume rate using an optical coherence tomography (OCT) system with a 1.5 MHz Fourier domain mode-locking swept laser source. Combining ultrafast OCT imaging with live mouse embryo culture protocols ...
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    15. High-resolution three-dimensional in vivo imaging of mouse oviduct using optical coherence tomography

      High-resolution three-dimensional in vivo imaging of mouse oviduct using optical coherence tomography
      The understanding of the reproductive events and the molecular mechanisms regulating fertility and infertility in humans relies heavily on the analysis of the corresponding phenotypes in mouse models. While molecular genetic approaches provide significant insight into the molecular regulation of these processes, the lack of live imaging methods that allow for detailed visualization of the mouse reproductive organs limits our investigations of dynamic events taking place during the ovulation, the ...
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    16. Feature Of The Week 03/22/15: Assessing Age-Related Changes in the Biomechanical Properties of Rabbit Lens using a Co-Focused Ultrasound and Optical Coherence Elastography System

      Feature Of The Week 03/22/15: Assessing Age-Related Changes in the Biomechanical Properties of Rabbit Lens using a Co-Focused Ultrasound and Optical Coherence Elastography System
      Presbyopia, the progressive, age-related loss of accommodation power of the eye, is closely related to the viscoelastic properties of the crystalline lens and their alterations by aging. The increase in lens stiffness is generally believed to be responsible for the progressive loss of the ability of the lens to change shape, leading to presbyopia. Noninvasive measurements of mechanical properties of the lens in vivo will promote the comprehensive understandings of ...
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  2. About Shang Wang

    Shang Wang

    Shang Wang is a graduate student at the university of Houston seeking a Ph.D. degree in Biomedical Engineering. His research focuses on Optical Coherence Tomography (OCT) system development and OCT based biosensors developme .