1. Seok-Hyun Yun

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    1. Mentioned In 30 Articles

    2. Numerical model of optical coherence tomographic vibrography imaging to estimate corneal biomechanical properties

      Numerical model of optical coherence tomographic vibrography imaging to estimate corneal biomechanical properties

      Most techniques measuring corneal biomechanics in vivo are biased by side factors. We demonstrate the ability of optical coherence tomographic (OCT) vibrography to determine corneal material parameters, while reducing current prevalent restrictions of other techniques (such as intraocular pressure (IOP) and thickness dependency). Modal analysis was performed in a finite-element (FE) model to study the oscillation response in isolated thin corneal flaps/eye globes and to analyse the dependency of the frequency response function on: corneal elasticity, viscoelasticity, geometry (thickness and curvature), IOP and density. The model was verified experimentally in flaps from three bovine corneas and in two enucleated ...

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    3. Research Fellow (or Research assistant) Massachusetts General Hospital / Harvard Medical School , Cambridge, MA

      Research Fellow (or Research assistant) Massachusetts General Hospital / Harvard Medical School , Cambridge, MA

      Research Fellow (or Research assistant) Massachusetts General Hospital / Harvard Medical School , Cambridge, MA, United States Employer Description The Wellman Center for Photomedicine Job Description Yun Lab at Harvard Medical School and the Wellman Center for Photomedicine at MGH has one open position for postdoctoral fellow with PhD in the field of optical coherence tomography. More information, visit http://www2.massgeneral.org/wellman/faculty-yun-pi.htm or http:// www.intelon.org (Applications for technical assistantship will also be received.) To apply, send a full CV and a cover letter to Prof. Yun at syun@hms.harvard.edu. Job Requirements Solid understanding of ...

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    4. Fast and accurate metrology of multi-layered ceramic materials by an automated boundary detection algorithm developed for optical coherence tomography data

      Fast and accurate metrology of multi-layered ceramic materials by an automated boundary detection algorithm developed for optical coherence tomography data

      Optical coherence tomography (OCT) is useful for materials defect analysis and inspection with the additional possibility of quantitative dimensional metrology. Here, we present an automated image-processing algorithm for OCT analysis of roll-to-roll multilayers in 3D manufacturing of advanced ceramics. It has the advantage of avoiding filtering and preset modeling, and will, thus, introduce a simplification. The algorithm is validated for its capability of measuring the thickness of ceramic layers, extracting the boundaries of embedded features with irregular shapes, and detecting the geometric deformations. The accuracy of the algorithm is very high, and the reliability is better than 1 μm when ...

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    5. Simultaneous 3D imaging of sound-induced motions of the tympanic membrane and middle ear ossicles

      Simultaneous 3D imaging of sound-induced motions of the tympanic membrane and middle ear ossicles

      Efficient transfer of sound by the middle ear ossicles is essential for hearing. Various pathologies can impede the transmission of sound and thereby cause conductive hearing loss. Differential diagnosis of ossicular disorders can be challenging since the ossicles are normally hidden behind the tympanic membrane (TM). Here we describe the use of a technique termed optical coherence tomography (OCT) vibrography to view the sound-induced motion of the TM and ossicles simultaneously. With this method, we were able to capture three-dimensional motion of the intact TM and ossicles of the chinchilla ear with nanometer-scale sensitivity at sound frequencies from 0.5 ...

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    6. CBORT 2013 OCT Symposium July 29th at Harvard Medical School Cambridge MA, USA

      CBORT 2013 OCT Symposium July 29th at Harvard Medical School Cambridge MA, USA

      OCT2013 – the first international symposium hosted by the Center for Biomedical OCT Research and Translation at Harvard Medical School and Massachusetts General Hospital, will focus on the latest and greatest technical capabilities of OCT, provide an overview of the commercially available OCT systems, discuss advancements in numerous clinical application areas, and introduce emerging preclinical optical imaging techniques. The unique emphasis of technology and clinical utility presented in the symposium will bring together an interdisciplinary group of expert clinicians, engineers, physicists, biologists, businesspersons, and trainees from around the world to foster the realization of OCT technology and implementation in the clinic ...

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    7. Methodist Hospital Research Institute receives NIH Grant for Multi-Scale Optical Imaging of the Cancer Vasculature and Tumor Microenvironment

      Methodist Hospital Research Institute receives NIH Grant for Multi-Scale Optical Imaging of the Cancer Vasculature and Tumor Microenvironment

      Methodist Hospital Research Institute receives a $301,316 NIH grant for Multi-Scale Optical Imaging of the Cancer Vasculature and Tumor Microenvironment. The principal investigator is Seok-Hyun (Andy) Yun. The program is part of a multi-year program that started in 2012 and ends in 2014. Below is a summary of the work. Core 2 will provide the five projects with a number of unique advanced optical systems; collaborate with the project investigators in the design, execution, and analysis of animal experiments; and develop new instrumentation and methodology as needs arise. The Core will be established in Boston within the Wellman Center ...

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    8. CBORT OCT Technical Foundations and Systematic Implementation Summer Workshop 2012 July 30-31st, Cambridge MA, USA.

      CBORT OCT Technical Foundations and Systematic Implementation Summer Workshop 2012 July 30-31st, Cambridge MA, USA.

      The Center for Biomedical OCT Research and Translation (CBORT), at Massachusetts General Hospital and Harvard Medical School is hosting its first annual OCT workshop, OCT: Technical Foundations and Systematic Implementation. The event will bring a highly select group of OCT engineers and researchers from academia and industry to Boston for intense theoretical and practical training of OCT principles and functionality. Lectures and hands on laboratory demos will be held by leaders in the field including: Professors Brett Bouma, Guillermo (Gary) Tearney, S.H. (Andy) Yun, and Ben Vakoc. Topics will include light source development, signal processing & system calibration, system integration ...

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    9. SPIE Photonics West is set to grow -- again -- in 2012

      SPIE Photonics West is set to grow -- again -- in 2012

      BELLINGHAM, Washington, USA -- New biomedical optics treatments for cancer and other diseases and for restoring sight, the latest green photonics enabling sustainable energy solutions, and laser innovations for manufacturing, communications, and much more are on the program at SPIE Photonics West next January in San Francisco, California. Photonics West -- already the world's largest international conference and exhibition on industrial and medical applications of optics, lasers, and photonics -- will be larger than ever in 2012, with more papers and expanded exhibition space. Dates are 21-26 January at the Moscone Center. More than 19,000 attendees are expected for technical sessions ...

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    10. Methods And Arrangements For Analysis, Diagnosis, And Treatment Monitoring Of Vocal Folds By Optical Coherence Tomography

      Methods And Arrangements For Analysis, Diagnosis, And Treatment Monitoring Of Vocal Folds By Optical Coherence Tomography
      Exemplary embodiments of an apparatus and a method can be provided. For example, a first information can be obtained for at least one signal that is (i) at least partially periodic and (ii) associated with at least one structure. In addition, a second information associated with the structure can be generated at multiple time points within a single cycle of the at least one signal. The second information can include information for the structure below a surface thereof. Further, it is possible to generate a third information based on the first information and the second information, where the third information ...
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    11. System, method and arrangement which can use spectral encoding heterodyne interferometry techniques for imaging

      System, method and arrangement which can use spectral encoding heterodyne interferometry techniques for imaging
      Systems, arrangements and methods for obtaining three-dimensional imaging data are provided. For example, a broadband light source can provide a particular radiation. A first electro-magnetic radiation can be focused and diffracted, and then provided to at least one sample to generate a spectrally-encoded line. A second electro-magnetic radiation may be provided to a reference, which may include a double-pass rapidly-scanning optical delay, where the first and second electro-magnetic radiations can be based on the particular radiation. An interference between a third electro-magnetic radiation (associated with the first electro-magnetic radiation) and a fourth electro-magnetic radiation (associated with the second electro-magnetic radiation ...
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    12. Systems and methods for generating data based on one or more spectrally-encoded endoscopy techniques

      Systems and methods for generating data based on one or more spectrally-encoded endoscopy techniques
      Exemplary systems and methods for generating data associated with at least one portion of a sample can be provided. For example, according to one exemplary embodiment of such systems and methods, it is possible to provide a particular radiation using at least one first arrangement. The particular radiation can include at least one first electro-magnetic radiation directed to at least one sample and at least one second electro-magnetic radiation directed to a reference arrangement. The first radiation and/or the second radiation can comprise a plurality of wavelengths. The first electro-magnetic radiation can be spectrally dispersed along at least one ...
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    13. Methods, arrangements and systems for polarization-sensitive optical frequency domain imaging of a sample

      Methods, arrangements and systems for polarization-sensitive optical frequency domain imaging of a sample
      Arrangements and methods are provided for obtaining data associated with a sample. For example, at least one first electro-magnetic radiation can be provided to a sample and at least one second electro-magnetic radiation can be provided to a reference (e.g., a non-reflective reference). A frequency of such radiation(s) can repetitively vary over time with a first characteristic period. In addition, a polarization state of the first electro-magnetic radiation, the second electro-magnetic radiation, a third electro-magnetic radiation (associated with the first radiation) or a fourth electro-magnetic radiation (associated with the second radiation) can repetitively vary over time with a ...
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  2. About Seok-Hyun Yun

    Seok-Hyun Yun

    Seok Hyun Yun received his Ph.D. degree in physics (optics) from KAIST, Korea, in 1997. He was a Chevening Scholar and visiting student at Optoelectronics Research Centre in University of Southampton, UK, in 1996. His PhD thesis research has led to a $68M-funded startup company in San Jose, CA, which was later acquired by LG-Nortel. In 1999-2003, he worked there as a founding member and manager. In 2003, moving his career to biomedical optics, he joined the Wellman Center for Photomedicine at Massachusetts General Hospital and HarvardMedical School. Currently, he is an Associate Professor at Harvard and affiliated faculty member at MIT (Health Sciences and Technology).

    Dr. Yun's primary research interest is developing novel light-based technologies for biomedical applications. Dr. Yun wrote more than 50 U.S. patents, many of which have been licensed, commercialized, and FDA approved. In particular, Dr. Yun has co-invented Fourier-domain optical coherence tomography (OCT). Besides problem- solving, Dr. Yun's research also embraces curiosity-driven projects without specific applications in mind. An example is biological cell lasers, which received accolades from the general public as well as the scientific community (see the Figure above)