1. Seok-Hyun Yun

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    1. Mentioned In 28 Articles

    2. Fast and accurate metrology of multi-layered ceramic materials by an automated boundary detection algorithm developed for optical coherence tomography data

      Fast and accurate metrology of multi-layered ceramic materials by an automated boundary detection algorithm developed for optical coherence tomography data

      Optical coherence tomography (OCT) is useful for materials defect analysis and inspection with the additional possibility of quantitative dimensional metrology. Here, we present an automated image-processing algorithm for OCT analysis of roll-to-roll multilayers in 3D manufacturing of advanced ceramics. It has the advantage of avoiding filtering and preset modeling, and will, thus, introduce a simplification. The algorithm is validated for its capability of measuring the thickness of ceramic layers, extracting the boundaries of embedded features with irregular shapes, and detecting the geometric deformations. The accuracy of the algorithm is very high, and the reliability is better than 1 μm when ...

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    3. Simultaneous 3D imaging of sound-induced motions of the tympanic membrane and middle ear ossicles

      Simultaneous 3D imaging of sound-induced motions of the tympanic membrane and middle ear ossicles

      Efficient transfer of sound by the middle ear ossicles is essential for hearing. Various pathologies can impede the transmission of sound and thereby cause conductive hearing loss. Differential diagnosis of ossicular disorders can be challenging since the ossicles are normally hidden behind the tympanic membrane (TM). Here we describe the use of a technique termed optical coherence tomography (OCT) vibrography to view the sound-induced motion of the TM and ossicles simultaneously. With this method, we were able to capture three-dimensional motion of the intact TM and ossicles of the chinchilla ear with nanometer-scale sensitivity at sound frequencies from 0.5 ...

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    4. CBORT 2013 OCT Symposium July 29th at Harvard Medical School Cambridge MA, USA

      CBORT 2013 OCT Symposium July 29th at Harvard Medical School Cambridge MA, USA

      OCT2013 – the first international symposium hosted by the Center for Biomedical OCT Research and Translation at Harvard Medical School and Massachusetts General Hospital, will focus on the latest and greatest technical capabilities of OCT, provide an overview of the commercially available OCT systems, discuss advancements in numerous clinical application areas, and introduce emerging preclinical optical imaging techniques. The unique emphasis of technology and clinical utility presented in the symposium will bring together an interdisciplinary group of expert clinicians, engineers, physicists, biologists, businesspersons, and trainees from around the world to foster the realization of OCT technology and implementation in the clinic ...

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    5. Methodist Hospital Research Institute receives NIH Grant for Multi-Scale Optical Imaging of the Cancer Vasculature and Tumor Microenvironment

      Methodist Hospital Research Institute receives NIH Grant for Multi-Scale Optical Imaging of the Cancer Vasculature and Tumor Microenvironment

      Methodist Hospital Research Institute receives a $301,316 NIH grant for Multi-Scale Optical Imaging of the Cancer Vasculature and Tumor Microenvironment. The principal investigator is Seok-Hyun (Andy) Yun. The program is part of a multi-year program that started in 2012 and ends in 2014. Below is a summary of the work. Core 2 will provide the five projects with a number of unique advanced optical systems; collaborate with the project investigators in the design, execution, and analysis of animal experiments; and develop new instrumentation and methodology as needs arise. The Core will be established in Boston within the Wellman Center ...

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    6. Subnanometer optical coherence tomographic vibrography

      Subnanometer optical coherence tomographic vibrography

      The ability to quantify and visualize submicrometer-scale oscillatory motions of objects in three dimensions has a wide range of application in acoustics, materials sciences, and medical imaging. Here we demonstrate that volumetric snapshots of rapid periodic motion can be captured using optical coherence tomography (OCT) with subnanometer-scale motion sensitivity and microsecond-scale temporal resolution. This technique, termed OCT vibrography, was applied to generate time-resolved volumetric vibrographs of a miniature drum driven acoustically at several kilohertz.

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    7. CBORT OCT Technical Foundations and Systematic Implementation Summer Workshop 2012 July 30-31st, Cambridge MA, USA.

      CBORT OCT Technical Foundations and Systematic Implementation Summer Workshop 2012 July 30-31st, Cambridge MA, USA.

      The Center for Biomedical OCT Research and Translation (CBORT), at Massachusetts General Hospital and Harvard Medical School is hosting its first annual OCT workshop, OCT: Technical Foundations and Systematic Implementation. The event will bring a highly select group of OCT engineers and researchers from academia and industry to Boston for intense theoretical and practical training of OCT principles and functionality. Lectures and hands on laboratory demos will be held by leaders in the field including: Professors Brett Bouma, Guillermo (Gary) Tearney, S.H. (Andy) Yun, and Ben Vakoc. Topics will include light source development, signal processing & system calibration, system integration ...

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    8. SPIE Photonics West is set to grow -- again -- in 2012

      SPIE Photonics West is set to grow -- again -- in 2012

      BELLINGHAM, Washington, USA -- New biomedical optics treatments for cancer and other diseases and for restoring sight, the latest green photonics enabling sustainable energy solutions, and laser innovations for manufacturing, communications, and much more are on the program at SPIE Photonics West next January in San Francisco, California. Photonics West -- already the world's largest international conference and exhibition on industrial and medical applications of optics, lasers, and photonics -- will be larger than ever in 2012, with more papers and expanded exhibition space. Dates are 21-26 January at the Moscone Center. More than 19,000 attendees are expected for technical sessions ...

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    9. Triggered optical coherence tomography for capturing rapid periodic motion

      Triggered optical coherence tomography for capturing rapid periodic motion
      Quantitative cross-sectional imaging of vocal folds during phonation is potentially useful for diagnosis and treatments of laryngeal disorders. Optical coherence tomography (OCT) is a powerful technique, but its relatively low frame rates makes it challenging to visualize rapidly vibrating tissues. Here, we demonstrate a novel method based on triggered laser scanning to capture 4-dimensional (4D) images of samples in motu at audio frequencies over 100 Hz. As proof-of-concept experiments, we applied this technique to imaging the oscillations of biopolymer gels on acoustic vibrators and aerodynamically driven vibrations of the vocal fold in an ex vivo calf larynx model. Our results ...
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    10. Methods And Arrangements For Analysis, Diagnosis, And Treatment Monitoring Of Vocal Folds By Optical Coherence Tomography

      Methods And Arrangements For Analysis, Diagnosis, And Treatment Monitoring Of Vocal Folds By Optical Coherence Tomography
      Exemplary embodiments of an apparatus and a method can be provided. For example, a first information can be obtained for at least one signal that is (i) at least partially periodic and (ii) associated with at least one structure. In addition, a second information associated with the structure can be generated at multiple time points within a single cycle of the at least one signal. The second information can include information for the structure below a surface thereof. Further, it is possible to generate a third information based on the first information and the second information, where the third information ...
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    11. System, method and arrangement which can use spectral encoding heterodyne interferometry techniques for imaging

      System, method and arrangement which can use spectral encoding heterodyne interferometry techniques for imaging
      Systems, arrangements and methods for obtaining three-dimensional imaging data are provided. For example, a broadband light source can provide a particular radiation. A first electro-magnetic radiation can be focused and diffracted, and then provided to at least one sample to generate a spectrally-encoded line. A second electro-magnetic radiation may be provided to a reference, which may include a double-pass rapidly-scanning optical delay, where the first and second electro-magnetic radiations can be based on the particular radiation. An interference between a third electro-magnetic radiation (associated with the first electro-magnetic radiation) and a fourth electro-magnetic radiation (associated with the second electro-magnetic radiation ...
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    12. Systems and methods for generating data based on one or more spectrally-encoded endoscopy techniques

      Systems and methods for generating data based on one or more spectrally-encoded endoscopy techniques
      Exemplary systems and methods for generating data associated with at least one portion of a sample can be provided. For example, according to one exemplary embodiment of such systems and methods, it is possible to provide a particular radiation using at least one first arrangement. The particular radiation can include at least one first electro-magnetic radiation directed to at least one sample and at least one second electro-magnetic radiation directed to a reference arrangement. The first radiation and/or the second radiation can comprise a plurality of wavelengths. The first electro-magnetic radiation can be spectrally dispersed along at least one ...
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    13. Methods, arrangements and systems for polarization-sensitive optical frequency domain imaging of a sample

      Methods, arrangements and systems for polarization-sensitive optical frequency domain imaging of a sample
      Arrangements and methods are provided for obtaining data associated with a sample. For example, at least one first electro-magnetic radiation can be provided to a sample and at least one second electro-magnetic radiation can be provided to a reference (e.g., a non-reflective reference). A frequency of such radiation(s) can repetitively vary over time with a first characteristic period. In addition, a polarization state of the first electro-magnetic radiation, the second electro-magnetic radiation, a third electro-magnetic radiation (associated with the first radiation) or a fourth electro-magnetic radiation (associated with the second radiation) can repetitively vary over time with a ...
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    14. Dynamic imaging of vocal fold oscillation with four-dimensional optical coherence tomography

      Dynamic imaging of vocal fold oscillation with four-dimensional optical coherence tomography

      Optical coherence tomography (OCT) can provide high-resolution ([sim]10-15 [mu]m/pixel) images of vocal fold microanatomy, as demonstrated previously. We explored physiologically triggered Fourier-domain OCT for imaging vocal folds during phonation. The goal is to visualize dynamic histological cross sections and four-dimensional data sets where multiple planes are displayed in synchronized motion. If feasible, this approach could be a useful research tool and spur development of new clinical instrumentation.A Fourier-domain, triggered OCT system was created and tested in experiments on excised calf larynges to obtain preliminary observations and characterize important factors affecting image quality.Larynges were imaged during ...

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    15. Method and apparatus for performing optical imaging using frequency-domain interferometry

      Method and apparatus for performing optical imaging using frequency-domain interferometry
      An apparatus and method are provided. In particular, at least one first electro-magnetic radiation may be provided to a sample and at least one second electro-magnetic radiation can be provided to a non-reflective reference. A frequency of the first and/or second radiations varies over time. An interference is detected between at least one third radiation associated with the first radiation and at least one fourth radiation associated with the second radiation. Alternatively, the first electro-magnetic radiation and/or second electro-magnetic radiation have a spectrum which changes over time. The spectrum may contain multiple frequencies at a particular time. In ...
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    16. 1-15 of 28 1 2 »
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  2. About Seok-Hyun Yun

    Seok-Hyun Yun

    Seok-Hyun Yun, Ph.D, is an Assistant Professor in the Wellman Center for Photomedicine at the Massachusetts General Hospital. Research Interests My lab focuses on developing new optical technologies and applying them to solve biological questions and medical problems. To realize this goal, we integrate our expertise in physics, photonics, and various engineering disciplines with biomedical needs and curiosities. Our research activities therefore include multidisciplinary collaboration particularly with biologists and clinicians. Also we sometimes jointly pursue collaboration with industrial partners to enhance the practical impacts of research.