1. Semmelweis University

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    1. Mentioned In 54 Articles

    2. Long-term outcomes of patients with normal fractional flow reserve and thin-cap fibroatheroma

      Long-term outcomes of patients with normal fractional flow reserve and thin-cap fibroatheroma
      Background: The long-term prognostic implications of fractional flow reserve (FFR)-negative lesions hosting vulnerable plaques remain unsettled. Aims: The aim of this study was to evaluate the association of non-ischaemic lesions hosting optical coherence tomography (OCT)-detected thin-cap fibroatheromas (TCFA) with first and recurrent cardiovascular events during follow-up up to 5 years in a diabetes mellitus (DM) patient population. Methods: COMBINE OCT-FFR is a prospective, international, double-blind, natural history study ...
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    3. Thin-Cap Fibroatheroma Rather Than Any Lipid Plaques Increases the Risk of Cardiovascular Events in Diabetic Patients: Insights From the COMBINE OCT–FFR Trial

      Thin-Cap Fibroatheroma Rather Than Any Lipid Plaques Increases the Risk of Cardiovascular Events in Diabetic Patients: Insights From the COMBINE OCT–FFR Trial
      Background: Autopsy studies have established that thin-cap fibroatheromas (TCFAs) are the most frequent cause of fatal coronary events. In living patients, optical coherence tomography (OCT) has sufficient resolution to accurately differentiate TCFA from thick-cap fibroatheroma (ThCFA) and not lipid rich plaque (non-LRP). However, the impact of OCT-detected plaque phenotype of nonischemic lesions on future adverse events remains unknown. Therefore, we studied the natural history of OCT-detected TCFA, ThCFA, and non-LRP ...
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    4. Effect of Evolocumab on Coronary Plaque Phenotype and Burden in Statin-Treated Patients Following Myocardial Infarction

      Effect of Evolocumab on Coronary Plaque Phenotype and Burden in Statin-Treated Patients Following Myocardial Infarction
      Objectives The purpose of this study was to determine the effect of evolocumab on optical coherence tomography (OCT) measures of plaque composition. Background The proprotein convertase subtilisin kexin type-9 inhibitor evolocumab produced coronary atheroma regression in statin-treated patients. Methods Patients with a nonST-segment elevation myocardial infarction were treated with monthly evolocumab 420 mg (n = 80) or placebo (n = 81) for 52 weeks. Patients underwent serial OCT and intravascular ultrasound imaging ...
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    5. Non-malignant conjunctival epithelial masses with ocular surface squamous neoplasia-like optical coherence tomography features

      Non-malignant conjunctival epithelial masses with ocular surface squamous neoplasia-like optical coherence tomography features
      Purpose: To observe and describe the anterior segment optical coherence tomography features of limbally localised non-malignant epithelial mass lesions METHODS: Thirteen patients (age: 66.9 16.3 years) with conjunctival mass suggesting ocular surface squamous neoplasia with biomicroscopic examination were imaged using anterior segment ocular coherence tomography (anterior segment optical coherence tomography)/Cirrus HD-OCT, Model 4000, Carl Zeiss Meditec, Inc., Dublin, CA, and Spectralis HRA + OCT system, Heidelberg Engineering, Vista ...
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    6. Optical coherence tomography angiography in glaucoma: analysis of the vessel density-visual field sensitivity relationship

      Optical coherence tomography angiography in glaucoma: analysis of the vessel density-visual field sensitivity relationship
      Glaucoma, a well-defined group of progressive optic neuropathies is one of the leading causes of irreversible blindness worldwide. In order to stop or slow down the progression of glaucomatous vision deterioration, intraocular pressure reduction by medical, laser or surgical treatment is needed. To ensure that treatment is efficient and tailored to the actual needs both cross sectional evaluation of disease severity and measurement of rate of progression are essential. Currently ...
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    7. The Impact of Deterministic Signal Loss on OCT Angiography Measurements

      The Impact of Deterministic Signal Loss on OCT Angiography Measurements
      Purpose : In this study, we aimed at investigating the impact of deterministic signal loss on image quality and, thus, on optical coherence tomography angiography (OCTA) measurements performed by the RTVue-XR Avanti System. Methods : Absorptive filters with different optical densities (ODs) were used to simulate signal loss in a controlled way in 30 eyes from 15 healthy subjects. Scan Quality (SQ), provided by the AngioVue software, was applied as a measure ...
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    8. Examination of corneal deposits in nephropathic cystinosis using in vivo confocal microscopy and anterior segment optical coherence tomography: an age-dependent cross sectional study

      Examination of corneal deposits in nephropathic cystinosis using in vivo confocal microscopy and anterior segment optical coherence tomography: an age-dependent cross sectional study
      Background Presence of corneal cystine crystals is the main ocular manifestation of cystinosis, although controversial findings concerning the corneal layer with the highest density have been reported. The aim of this study was the analysis of the characteristics of crystal arrangement in different corneal layers and the assessment of corneal morphological changes with age. Methods A cross sectional study was carried out in three children and three adults who had ...
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    9. SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY, FLUORESCEIN ANGIOGRAPHY, AND INDOCYANINE GREEN ANGIOGRAPHY COMPARISONS REVISITED

      SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY, FLUORESCEIN ANGIOGRAPHY, AND INDOCYANINE GREEN ANGIOGRAPHY COMPARISONS REVISITED
      Purpose: To compare area measurements between swept source optical coherence tomography angiography ( SSOCTA ), fluorescein angiography ( FA ), and indocyanine green angiography ( ICGA ) after applying a novel deep-learning-assisted algorithm for accurate image registration. Methods: We applied an algorithm for the segmentation of blood vessels in FA , ICGA , and SSOCTA images of 24 eyes with treatment-naive neovascular age-related macular degeneration. We trained a model based on U-Net and Mask R-CNN for each imaging ...
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    10. The effect of image quality on the reliability of OCT angiography measurements in patients with diabetes

      The effect of image quality on the reliability of OCT angiography measurements in patients with diabetes
      Background This study aimed to determine the relationship between image quality and measurement repeatability of optical coherence tomography angiography (OCTA) parameters in patients with non-proliferative diabetic retinopathy. Methods A total of 100 eyes of 50 patients were included in the study. Three OCTA images were obtained consecutively during one session of imaging in all patients using the RTVue AngioVue OCTA device. We applied the signal strength index (SSI) provided by ...
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    11. What’s New in Optical Coherence Tomography Angiography for Glaucoma (Book Chapter)

      What’s New in Optical Coherence Tomography Angiography for Glaucoma (Book Chapter)
      Glaucoma is one of the main clinical areas where OCT angiography is used. In contrast to medical retinal application, where qualitative image analysis and semiquantitative measurements are frequently satisfactory for clinical decision-making, in glaucoma the exact quantitative measurements provide the useful information. Therefore both general ophthalmologists who treat glaucoma patients and glaucoma subspecialists need to be familiar with the measurement details of OCT angiography, the types of complementary structural information ...
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    12. Enhanced depth imaging and swept-source optical coherence tomography findings in choroidal osteoma: a case report

      Enhanced depth imaging and swept-source optical coherence tomography findings in choroidal osteoma: a case report
      Purpose The aim of this study was to report the findings from enhanced depth imaging (EDI) and swept-source optical coherence tomography (OCT) in a choroidal osteoma. Methods A case study of a patient with choroidal osteoma is presented and discussed. Results A 25-year-old woman presented with an asymptomatic peripapillary mass. Fundus examination revealed a yelloworange, well-defined geographical lesion. B‑scan ultrasonography, corroborated by fundus autofluorescence (FAF) and OCT findings, pointed ...
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    13. Influence of Posterior Subcapsular Cataract on Structural OCT and OCT Angiography Vessel Density Measurements in the Peripapillary Retina

      Influence of Posterior Subcapsular Cataract on Structural OCT and OCT Angiography Vessel Density Measurements in the Peripapillary Retina
      Purpose: To investigate the influence of posterior subcapsular cataract (PSC) on structural optical coherence tomography (OCT) and OCT angiography vessel density (VD) measurements. Methods: One eye each of 10 consecutive participants with PSC were imaged using the Angiovue/RTvue-XR OCT via undilated pupil, and 30 minutes later via dilated pupil. Peripapillary retinal nerve fiber layer thickness (RNFLT), peripapillary capillaries and all-vessels VD, ganglion cell complex thickness (GCC), parafoveal VD and ...
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    14. Semi-manual Vessel Density Analysis on Optical Coherence Tomography Angiography Images of Healthy Adults

      Semi-manual Vessel Density Analysis on Optical Coherence Tomography Angiography Images of Healthy Adults
      Optical coherence tomography angiography (OCTA) is a software upgrade on conventional spectral-domain or swept-source optical coherence tomography devices that enables non-invasive, dye-free, three dimensional analysis of the retinal vessels. Vessel density is a very important parameter almost in all retinal disorders. In the recent past, automated quantification software was built into some OCTA devices which can automatically calculate the retinal vessel density as well. In this study two semi-manual techniques ...
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    15. Valsalva Maneuver and Peripapillary OCT Angiography Vessel Density

      Valsalva Maneuver and Peripapillary OCT Angiography Vessel Density
      Purpose: To investigate the potential influence of breath holding on the results of peripapillary vessel density (VD) measurement with optical coherence tomography angiography. Materials and Methods: Three peripapillary VD measurements were made at 2-minute intervals on the right eye of 12 healthy young volunteers using the Angiovue/RTvue-XR OCT (software version 2017.1, Phase 7 update) without changing the head and body positions. During the first 2 measurements the volunteers ...
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  2. About Semmelweis University

    Semmelweis University

    Semmelweis University was founded in 1769 and is the oldest medical school in Hungary. The faculty became an independent medical school after the Second World War and developed into a university that teaches medicine, dentistry, pharmacy, health sciences, health management, and physical education and sport sciences.  The University is named after Ignác Semmelweis (1818-1865), the revolutionary obstetrician who discovered the cause of puerperal fever in the 1840s, and is therefore also known as “the savior of mothers”.   Today, Semmelweis University is widely recognized as one of Europe’s leading centers of medicine and health sciences, combining innovation and a time-tested tradition in three main areas: education, research and health care.