1. Sebastian Wolf

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    1. Mentioned In 32 Articles

    2. Evaluation of different Swept’Source optical coherence tomography angiography (SS‐OCTA) slabs for the detection of features of diabetic retinopathy

      Evaluation of different Swept’Source optical coherence tomography angiography (SS‐OCTA) slabs for the detection of features of diabetic retinopathy
      Purpose To compare different Swept‐Source optical coherence tomography angiography (SS‐OCTA) slabs for the detection of features of diabetic retinopathy (DR), to find the most suitable slab for grading. Methods Retrospective cross‐sectional study. Consecutive patients with DR were evaluated using SS‐OCTA. The central 12 12 mm scan was used to generate the retinal, superficial and deep slab. The grading results of the slabs were then compared to ...
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      Mentions: Sebastian Wolf
    3. Expert-level Automated Biomarker Identification in Optical Coherence Tomography Scans

      Expert-level Automated Biomarker Identification in Optical Coherence Tomography Scans
      In ophthalmology, retinal biological markers, or biomarkers , play a critical role in the management of chronic eye conditions and in the development of new therapeutics. While many imaging technologies used today can visualize these, Optical Coherence Tomography (OCT) is often the tool of choice due to its ability to image retinal structures in three dimensions at micrometer resolution. But with widespread use in clinical routine, and growing prevalence in chronic ...
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    4. Comparison of Choroidal Thickness Measurements Using Spectral Domain Optical Coherence Tomography in Six Different Settings and With Customized Automated Segmentation Software

      Comparison of Choroidal Thickness Measurements Using Spectral Domain Optical Coherence Tomography in Six Different Settings and With Customized Automated Segmentation Software
      Purpose : We investigate which spectral domain-optical coherence tomography (SD-OCT) setting is superior when measuring subfoveal choroidal thickness (CT) and compared results to an automated segmentation software. Methods : Thirty patients underwent enhanced depth imaging (EDI)-OCT. B-scans were extracted in six different settings (W+N = white background/normal contrast 9; W+H = white background/maximum contrast 16; B+N = black background/normal contrast 12; B+H = black background/maximum contrast 16 ...
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    5. Swept‐source optical coherence tomography angiography reveals vascular changes in intermediate uveitis

      Swept‐source optical coherence tomography angiography reveals vascular changes in intermediate uveitis
      Purpose To evaluate retinal and choroidal vascular changes in patients with intermediate uveitis with/without concomitant retinal vasculitis using wide field swept‐source optical coherence tomography angiography (OCTA). Methods In this study consecutive patients with intermediate uveitis vasculitis and healthy age‐matched controls were evaluated using central 3 3 mm OCTA scans and montage scans. Differences among the groups as well as the association between central changes assessed by 3 ...
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    6. Vascular Abnormalities In Diabetic Retinopathy Assessed With SWEPT-SOURCE Optical Coherence Tomography Angiography Widefield Imaging

      Vascular Abnormalities In Diabetic Retinopathy Assessed With SWEPT-SOURCE Optical Coherence Tomography Angiography Widefield Imaging
      Purpose: To detect vascular abnormalities in diabetic retinopathy using swept-source optical coherence tomography angiography (SS-OCTA) widefield images, and to compare the findings with color fundus photographs (CFPs) using Early Treatment Diabetic Retinopathy Study severity grading. Methods: 3 mm 3 mm and 12 mm 12 mm scans were acquired to cover 70 to 80 of the posterior pole using a 100-kHz SS-OCTA instrument. Two masked graders assessed the presence of vascular ...
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    7. Cataract significantly influences quantitative measurements on swept-source optical coherence tomography angiography imaging

      Cataract significantly influences quantitative measurements on swept-source optical coherence tomography angiography imaging
      Purpose To analyze retinal blood flow before and after cataract surgery using swept-source optical coherence tomography angiography (SS-OCTA). Methods Prospective observational study. Consecutive patients were recruited and scanned using SS-OCTA before and after cataract surgery. Laser flare photometry were performed post-surgery. Perfusion and vessel density of superficial (SCP) and deep capillary plexuses (DCP) of the 3 3 mm images as well as foveal avascular zone (FAZ) measurements were assessed. Vessel ...
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    8. Spectral-Domain Optical Coherence Tomography Associations of Neovascular Conversion in Age-Related Macular Degeneration

      Spectral-Domain Optical Coherence Tomography Associations of Neovascular Conversion in Age-Related Macular Degeneration
      Purpose: To identify spectral-domain optical coherence tomography (SD-OCT) features associated with exudative conversion in fellow eyes of patients treated for neovascular age-related macular degeneration (nAMD) in their first eye. Methods: Retrospective observational study. Spectral-domain optical coherence tomography images of converting fellow eyes (study eyes) from 83 patients with nAMD were compared to fellow eyes of age- and sex-matched patients with nAMD who did not convert (control eyes). Parameters related to ...
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    9. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FEATURES OF TORPEDO MACULOPATHY

      OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FEATURES OF TORPEDO MACULOPATHY
      Background/Purpose: To investigate the retinal and choroidal vasculature in patients with torpedo maculopathy with optical coherence tomography-angiography (OCT-A). Methods: Retrospective case series of four patients who were examined at the department of Ophthalmology at the University Hospital Bern. Main Outcome was the lesion size over time in OCT-A and fundus autofluorescence. Results: Three patients had Type I and 1 patient had Type II torpedo maculopathy. Torpedo maculopathy lesion size ...
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    10. Optical Coherence Tomography Angiography in Mice: Comparison with Confocal Scanning Laser Microscopy and Fluorescein Angiography

      Optical Coherence Tomography Angiography in Mice: Comparison with Confocal Scanning Laser Microscopy and Fluorescein Angiography
      Purpose : Optical coherence tomography angiography (OCT-A) allows noninvasive visualization of retinal vessels in vivo. OCT-A was used to characterize the vascular network of the mouse retina and was compared with fluorescein angiography (FA) and histology. Methods : In the present study, OCT-A based on a Heidelberg Engineering Spectralis system was used to investigate the vascular network in mice. Data was compared with FA and confocal microscopy of flat-mount histology stained with ...
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    11. Relationship Between Presumptive Inner Nuclear Layer Thickness and Geographic Atrophy Progression in Age-Related Macular Degeneration

      Relationship Between Presumptive Inner Nuclear Layer Thickness and Geographic Atrophy Progression in Age-Related Macular Degeneration
      Purpose : To analyze inner retinal changes in patients with geographic atrophy (GA) secondary to age-related macular degeneration and identify morphological cues for progression. Methods : A total of 100 eyes with GA were assessed in this longitudinal, observational case series. Patients with GA and absent confounding pathology were compared with age-matched controls. The retinal layers on spectral-domain optical coherence tomography, acquired in tracking mode, were segmented manually on central scans through ...
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    12. Automatic assessment of time-resolved OCT images for selective retina therapy

      Automatic assessment of time-resolved OCT images for selective retina therapy
      Purpose In recent years, selective retina laser treatment (SRT), a sub-threshold therapy method, avoids widespread damage to all retinal layers by targeting only a few. While these methods facilitate faster healing, their lack of visual feedback during treatment represents a considerable shortcoming as induced lesions remain invisible with conventional imaging and make clinical use challenging. To overcome this, we present a new strategy to provide location-specific and contact-free automatic feedback ...
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    13. Time-Resolved Ultra–High Resolution Optical Coherence Tomography for Real-Time Monitoring of Selective Retina Therapy

      Time-Resolved Ultra–High Resolution Optical Coherence Tomography for Real-Time Monitoring of Selective Retina Therapy
      Purpose : Selective retina therapy (SRT) is a novel treatment for retinal pathologies, solely targeting the RPE. During SRT, the detection of an immediate tissue reaction is challenging, as tissue effects remain limited to intracellular RPE photodisruption. Time-resolved ultra-high axial resolution optical coherence tomography (OCT) is thus evaluated for the monitoring of dynamic optical changes at and around the RPE during SRT. Methods : An experimental OCT system with an ultra-high axial ...
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    14. The Presence of Intra- or Subretinal Fluid during the Loading Phase in the Treatment of Exudative Age-Related Macular Degeneration with Intravitreal Ranibizumab Assessed by Optical Coherence Tomography

      The Presence of Intra- or Subretinal Fluid during the Loading Phase in the Treatment of Exudative Age-Related Macular Degeneration with Intravitreal Ranibizumab Assessed by Optical Coherence Tomography
      Purpose: To assess intra- and subretinal fluid during the loading phase with intravitreal ranibizumab in exudative age-related macular degeneration and to quantify the accuracy of crosshair scan spectral-domain optical coherence tomography with regard to retinal fluid. Methods: This is a retrospective study of 31 treatment-naive patients who received 3 monthly intravitreal ranibizumab injections. Visual acuity and the presence of retinal fluid were assessed at each visit using volume and crosshair ...
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    15. Assessment of ultra-high resolution optical coherence tomography for monitoring tissue effects caused by laser photocoagulation of ex-vivo porcine retina

      Assessment of ultra-high resolution optical coherence tomography for monitoring tissue effects caused by laser photocoagulation of ex-vivo porcine retina
      ...tissue effects caused by laser photocoagulation of ex-vivo porcine retina Patrick Steiner ; Volker Enzmann ; Sebastian Wolf ; Anke Bossen ; Christoph Meier ; Raphael Sznitman; Assessment of ultra-high resolution optical...
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  2. About Sebastian Wolf

    Sebastian Wolf is with the Universitätsklinik für Augenheilkunde, Inselspital, University Bern, Bern, Switzerland and with the Bern Photographic Reading Center, Universitätsklinik für Augenheilkunde, Inselspital, University Bern, Bern, Switzerland.