1. Scott E. Fraser

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    1. Mentioned In 34 Articles

    2. 3D in vivo imaging with extended-focus optical coherence microscopy

      3D in vivo imaging with extended-focus optical coherence microscopy
      Optical coherence microscopy (OCM) has unique advantages of non-invasive 3D imaging without the need of exogenous labels for studying biological samples. However, the imaging depth of this technique is limited by the tradeoff between the depth of focus (DOF) and high lateral resolution in Gaussian optics. To overcome this limitation, we have developed an extended-focus OCM (xf-OCM) imaging system using quasi-Bessel beam illumination to extend the DOF to 100 m ...
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    3. Optical coherence microscopy with extended focus for in vivo embryonic imaging

      Optical coherence microscopy with extended focus for in vivo embryonic imaging
      Optical coherence microscopy (OCM) has unique advantages of high-resolution volumetric imaging without relying on exogenous labels or dyes. It combines the coherence-gated depth discrimination of optical coherence tomography (OCT) with the high lateral resolution of confocal microscopy, offering an excellent balance between the resolutions and imaging depth. However, as the lateral resolution becomes higher, the imaging depth of OCM decreases and its three-dimensional imaging capability is greatly degraded. To overcome ...
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    4. Phase variance optical coherence microscopy for label-free imaging of the developing vasculature in zebrafish embryos

      Phase variance optical coherence microscopy for label-free imaging of the developing vasculature in zebrafish embryos
      A phase variance optical coherence microscope (pvOCM) has been created to image blood flow in the microvasculature of zebrafish embryos, without the use of exogenous labels. The pvOCM imaging system has axial and lateral resolutions of 2.8 m 2.8m in tissue and imaging depth of more than 100 m 100m . Images of 2 to 5 days postfertilization zebrafish embryos identified the detailed anatomical structure based on OCM intensity ...
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    5. Label-free imaging of developing vasculature in zebrafish with phase variance optical coherence microscopy

      Label-free imaging of developing vasculature in zebrafish with phase variance optical coherence microscopy
      A phase variance optical coherence microscope (pvOCM) has been created to visualize blood flow in the vasculature of zebrafish embryos, without using exogenous labels. The pvOCM imaging system has axial and lateral resolutions of 2 m in tissue, and imaging depth of more than 100 m. Imaging of 25 days post-fertilization zebrafish embryos identified the detailed structures of somites, spinal cord, gut and notochord based on intensity contrast. Visualization of ...
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    6. Extended Duration Optical Coherence Tomography (OCT) System

      Extended Duration Optical Coherence Tomography (OCT) System
      This disclosure relates to the field of Optical Coherence Tomography (OCT). This disclosure particularly relates to methods and systems for providing larger field of view OCT images. This disclosure also particularly relates to methods and systems for OCT angiography. These systems may allow OCT scanning for an extended duration and generation of large field OCT images suitable for the OCT angiography.
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    7. Optical Coherence Tomography System For Health Characterization Of An Eye

      Optical Coherence Tomography System For Health Characterization Of An Eye
      This disclosure relates to the field of Optical Coherence Tomography (OCT). This disclosure particularly relates to methods and systems for providing larger field of view OCT images. This disclosure also particularly relates to methods and systems for OCT angiography. This disclosure further relates to systems for health characterization of an eye by OCT angiography.
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    8. Optical Coherence Tomography (OCT) System With Improved Motion Contrast

      Optical Coherence Tomography (OCT) System With Improved Motion Contrast
      This disclosure relates to the field of Optical Coherence Tomography (OCT). This disclosure particularly relates to an OCT system with improved motion contrast. This disclosure particularly relates to motion contrast methods for such OCT systems.
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    9. Optical Coherence Tomography (OCT) System With PHASE-SENSITIVE B-SCAN Registration

      Optical Coherence Tomography (OCT) System With PHASE-SENSITIVE B-SCAN Registration
      This disclosure relates to the field of Optical Coherence Tomography (OCT). This disclosure particularly relates to an OCT system having a configuration that uses a phase sensitive B-scan registration method. In this disclosure, an OCT system may have a configuration that scans a physical object, acquires OCT signals to form B-scans, uses these B-scans to determine an optimal shift in an axial direction by using total phase error between B-scans ...
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    10. Clinical application of optical coherence tomography in combination with functional diagnostics: advantages and limitations for diagnosis and assessment of therapy outcome in central serous chorioretinopathy

      Clinical application of optical coherence tomography in combination with functional diagnostics: advantages and limitations for diagnosis and assessment of therapy outcome in central serous chorioretinopathy
      ...23 August 2014, Accepted 16 September 2014, Published 21 November 2014 Approved for publication by Professor Scott Fraser Joshua A Schliesser, Gary Gallimore, Nancy Kunjukunju, Nelson R Sabates, Peter Koulen, Felix N S...
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    11. Visdex Corporation Receives 2013 NIH Grant for Phase Contrast OCT for Non-Invasive Imaging of Retinovascular Disease

      Visdex Corporation Receives 2013 NIH Grant for Phase Contrast OCT for Non-Invasive Imaging of Retinovascular Disease
      ...$404,061 Phase Contrast OCT for Non-Invasive Imaging of Retinovascular Disease. The principal investigator is Scott Fraser. The program started in 2010 and ends in 2015. Below is a summary of the proposed work. Since it...
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  2. About Scott E. Fraser

    Scott E. Fraser

    Scott E. Fraser is the Anna L. Rosen Professor of Biology and Professor of Bioengineering and Professor of Applied Physics and Director of the Biological Imaging Center at the California Institute of Technology.