1. Saratov State University

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    1. Mentioned In 56 Articles

    2. Line-scan Raman microscopy complements optical coherence tomography for tumor boundary detection

      Line-scan Raman microscopy complements optical coherence tomography for tumor boundary detection

      Current technique for tumor resection requires biopsy of the tumor region and histological confirmation before the surgeon can be certain that the entire tumor has been resected. This confirmation process is time consuming both for the surgeon and the patient and also requires sacrifice of healthy tissue, motivating the development of novel technologies which can enable real-time detection of tumor-healthy tissue boundary for faster and more efficient surgeries. In this study, the potential of combining structural information from optical coherence tomography (OCT) and molecular information from line-scan Raman microscopy (LSRM) for such an application is presented. The results show a ...

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    3. Optical imaging of intracranial hemorrhages in newborns: modern strategies in diagnostics and direction for future research

      Optical imaging of intracranial hemorrhages in newborns: modern strategies in diagnostics and direction for future research

      Using Doppler optical coherence tomography (DOCT) we study stress-related intracranial hemorrhages (ICHs) in newborn rats. We investigate a masked stage of ICH development that corresponds to the first 4 h after the stress. We show that this period is characterized by significant changes in the diameter of the sagittal vein and the velocity of the cerebral venous blood flow (CVBF). We discuss diagnostic abilities of wavelet-based methods and consider an adaptive technique allowing us to reveal clearest distinctions in the dynamics of CVBF between normal and stressed newborn rats. Finally, we conclude that the venous insufficiency in newborns and a ...

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    4. Diffusing low-coherence interferometry of turbid media: an approach to transport parameters evaluation

      Diffusing low-coherence interferometry of turbid media: an approach to transport parameters evaluation

      The features of formation of interferometer output in the case of a broadband light source and random medium as a retro-reflector in the interferometer object arm are considered. It is shown for the large values of the pathlength difference the interferometer output decays exponentially with the decay rate dependent on the transport parameters of a probed random medium. This allows us to determine the transport mean free path of light propagation in the medium. This approach can e applied not only for the strongly scattering media, but also for scattering samples characterized by non-diffusive regime of light propagation.

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    5. Photoinduced cell morphology alterations quantified within adipose tissues by spectral optical coherence tomography

      Photoinduced cell morphology alterations quantified within adipose tissues by spectral optical coherence tomography

      Morphological changes of the adipose tissue at phototreatment are studied in vitro using optical coherence tomography. The 200 to 600 μ m fat tissue slices are used in the experiments. The observed change in the tissue structure was associated with fat cell lipolysis and destruction caused by the photodynamic effect. It is found that overall heating of a sample from room to physiological temperature leads to deeper and faster morphology tissue changes if other processing conditions are kept constant. These data support the hypothesis that photodynamic/photothermal treatment induces fat cell lipolysis during some period after treatment.

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    6. A focused air-pulse system for optical-coherence-tomography-based measurements of tissue elasticity

      A focused air-pulse system for optical-coherence-tomography-based measurements of tissue elasticity

      Accurate non-invasive assessment of tissue elasticity in vivo is required for early diagnostics of many tissue abnormalities. We have developed a focused air-pulse system that produces a low-pressure and short-duration air stream, which can be used to excite transient surface waves (SWs) in soft tissues. System characteristics were studied using a high-resolution analog pressure transducer to describe the excitation pressure. Results indicate that the excitation pressure provided by the air-pulse system can be easily controlled by the air source pressure, the angle of delivery, and the distance between the tissue surface and the port of the air-pulse system. Furthermore, we ...

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    7. Handbook of Coherent-Domain Optical Methods - Second Addition (Book)

      Handbook of Coherent-Domain Optical Methods - Second Addition (Book)

      This handbook deals with laser and coherent-domain methods as applied to biomedical diagnostics, environmental monitoring, and materials inspection. It is a second edition of the two-volume Handbook of Coherent-Domain Optical Methods for Biomedical Diagnostics, Environmental and Material Science published by Kluwer Academic Publishers in 2004. The appearance of this book was stimulated by the recent rapid progress in novel photonics technologies on the basis of diode lasers, broadband femtosecond lasers (Ti: Sapphire or Cr: F€orsterite), light-emitting diodes (LEDs), and superluminescence diodes (SLDs). Such technologies are applicable in many fields, namely, biomedical, environmental, and material diagnostics and monitoring. The main ...

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    8. Estimation of shear wave velocity in gelatin phantoms utilizing PhS-SSOCT

      Estimation of shear wave velocity in gelatin phantoms utilizing PhS-SSOCT

      We report a method for measuring shear wave velocity in soft materials using phase stabilized swept source optical coherence tomography (PhS-SSOCT). Wave velocity was measured in phantoms with various concentrations of gelatin and therefore different stiffness. Mechanical waves of small amplitudes (∼10 μm) were induced by applying local mechanical excitation at the surface of the phantom. Using the phase-resolved method for displacement measurement described here, the wave velocity was measured at various spatially distributed points on the surface of the tissue-mimicking gelatin-based phantom. The measurements confirmed an anticipated increase in the shear wave velocity with an increase in the gelatin ...

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    9. Visualization of magnetic microcapsules in liquid by optical coherent tomography and control of their arrangement via external magnetic field

      Visualization of magnetic microcapsules in liquid by optical coherent tomography and control of their arrangement via external magnetic field

      Optical coherence tomography (OCT) is a new, non-invasive, noncontact in vivo imaging technology. We demonstrated that the OCT can be used as a sufficient technique for nanocomposite microcapsule visualization in a liquid medium. As a model system we choose a water/glycerol mixture with viscosity in a variable range from 1.01 to 1.41×103 mPa s, including viscosity of a blood plasma. We have found that tomography spatial resolution is enough to visualize capsules and their aggregates in liquids and to estimate their concentration via two-dimensional (2D) tomography scan analysis. In our experimental conditions microcapsule concentration measured by ...

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    10. Use of fractional laser microablation and ultrasound to facilitate the delivery of gold nanoparticles into skin in vivo

      Use of fractional laser microablation and ultrasound to facilitate the delivery of gold nanoparticles into skin in vivo
      ...iversity, Saratov, Russia 5 Research and Educational Institute of Optics and Biophotonics, N.G. Chernyshevsky Saratov State University, Saratov, Russian Federation 6 Iinstitute for Problems of Precise Mechanics and Contr...
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  2. About Saratov State University

    Saratov State University

    Saratov State University is one of the oldest Higher Educational Institutions in Russia with rich history. It was founded on December 6, 1909 as the Imperial Saratov University & has been developing dynamically ever since that day. New departments were set up & new buildings were constructed which added to the SSU growth and development. Currently SSU is one of the biggest educational, scientific and cultural centers in Russia. As a result of 1998 integration process, several new institutions became parts of SSU structure.