1. Saratov State University

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    1. Mentioned In 63 Articles

    2. Photodynamic opening of the blood-brain barrier and pathways of brain clearing

      Photodynamic opening of the blood-brain barrier and pathways of brain clearing
      A new application of the photodynamic treatment (PDT) is presented for the opening of blood-brain barrier (BBB) and the brain clearing activation that is associated with it, including the use of gold nanoparticles as emerging photosensitizer carriers in PDT. The obtained results clearly demonstrate two pathways for the brain clearing: 1) using PDT-opening of BBB and intravenous injection of FITC-dextran we showed a clearance of this tracer via the meningeal ...
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    3. Monitoring of temperature-mediated phase transitions of adipose tissue by combined optical coherence tomography and Abbe refractometry

      Monitoring of temperature-mediated phase transitions of adipose tissue by combined optical coherence tomography and Abbe refractometry
      Observation of temperature-mediated phase transitions between lipid components of the adipose tissues has been performed by combined use of the Abbe refractometry and optical coherence tomography. The phase transitions of the lipid components were clearly observed in the range of temperatures from 24C to 60C, and assessed by quantitatively monitoring the changes of the refractive index of 1- to 2-mm-thick porcine fat tissue slices. The developed approach has a great ...
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    4. Application of optical coherence tomography for in vivo monitoring of the meningeal lymphatic vessels during opening of blood–brain barrier: mechanisms of brain clearing

      Application of optical coherence tomography for in vivo monitoring of the meningeal lymphatic vessels during opening of blood–brain barrier: mechanisms of brain clearing
      The meningeal lymphatic vessels were discovered 2 years ago as the drainage system involved in the mechanisms underlying the clearance of waste products from the brain. The bloodbrain barrier (BBB) is a gatekeeper that strongly controls the movement of different molecules from the blood into the brain. We know the scenarios during the opening of the BBB, but there is extremely limited information on how the brain clears the substances ...
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    5. Collaborative effects of wavefront shaping and optical clearing agent in optical coherence tomography

      Collaborative effects of wavefront shaping and optical clearing agent in optical coherence tomography
      Developing a deep-tissue imaging tool with good optical resolution is one of the important goals of biophotonics because medical diagnosis usually requires imaging of fine details of whole tissue structures. Optical coherence tomography (OCT) is an extensively developed imaging tool for biological tissues. Based on low-coherence interferometry, OCT provides micrometer scale resolution and enables non-invasive high-speed imaging1 . OCT is widely used in ophthalmology because it can fully access retina, choroid ...
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    6. Imaging of subchondral bone by optical coherence tomography upon optical clearing of articular cartilage

      Imaging of subchondral bone by optical coherence tomography upon optical clearing of articular cartilage
      Optical clearing is an effective method to reduce light scattering of biological tissues that provides significant enhancement of light penetration into the biological tissues making non-invasive diagnosis more feasible. In current report Optical Coherence Tomography (OCT) in conjunction with optical clearing is applied for assessment of deep cartilage layers and cartilage-bone interface. The solution of Iohexol in water has been used as an optical clearing agent. The cartilage-bone boundary becomes ...
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    7. OCT/LCT monitoring the drug effect on the human cornea structure in vivo

      OCT/LCT	monitoring	the	drug 	effect	on	the	human	cornea	 structure	in	vivo
      The effect of anti-glaucoma drugs on the structure components of human eye cornea are studied. The eye drops Timolol-AKOS 0.5% and Kosopt were used as the object of study. 10 voluntary patients of the Eye Disease Clinic aged from 70 to 75 suffering from glaucoma took part in the studies. The study of cornea in vivo was carried out using the methods of laser scanning confocal tomography (LCT) and ...
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    8. Line-scan Raman microscopy complements optical coherence tomography for tumor boundary detection

      Line-scan Raman microscopy complements optical coherence tomography for tumor boundary detection
      Current technique for tumor resection requires biopsy of the tumor region and histological confirmation before the surgeon can be certain that the entire tumor has been resected. This confirmation process is time consuming both for the surgeon and the patient and also requires sacrifice of healthy tissue, motivating the development of novel technologies which can enable real-time detection of tumor-healthy tissue boundary for faster and more efficient surgeries. In this ...
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    9. Optical imaging of intracranial hemorrhages in newborns: modern strategies in diagnostics and direction for future research

      Optical imaging of intracranial hemorrhages in newborns: modern strategies in diagnostics and direction for future research
      Using Doppler optical coherence tomography (DOCT) we study stress-related intracranial hemorrhages (ICHs) in newborn rats. We investigate a masked stage of ICH development that corresponds to the first 4 h after the stress. We show that this period is characterized by significant changes in the diameter of the sagittal vein and the velocity of the cerebral venous blood flow (CVBF). We discuss diagnostic abilities of wavelet-based methods and consider an ...
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    10. Diffusing low-coherence interferometry of turbid media: an approach to transport parameters evaluation

      Diffusing low-coherence interferometry of turbid media: an approach to transport parameters evaluation
      The features of formation of interferometer output in the case of a broadband light source and random medium as a retro-reflector in the interferometer object arm are considered. It is shown for the large values of the pathlength difference the interferometer output decays exponentially with the decay rate dependent on the transport parameters of a probed random medium. This allows us to determine the transport mean free path of light ...
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    11. Photoinduced cell morphology alterations quantified within adipose tissues by spectral optical coherence tomography

      Photoinduced cell morphology alterations quantified within adipose tissues by spectral optical coherence tomography
      Morphological changes of the adipose tissue at phototreatment are studied in vitro using optical coherence tomography. The 200 to 600 m fat tissue slices are used in the experiments. The observed change in the tissue structure was associated with fat cell lipolysis and destruction caused by the photodynamic effect. It is found that overall heating of a sample from room to physiological temperature leads to deeper and faster morphology tissue ...
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  2. About Saratov State University

    Saratov State University

    Saratov State University is one of the oldest Higher Educational Institutions in Russia with rich history. It was founded on December 6, 1909 as the Imperial Saratov University & has been developing dynamically ever since that day. New departments were set up & new buildings were constructed which added to the SSU growth and development. Currently SSU is one of the biggest educational, scientific and cultural centers in Russia. As a result of 1998 integration process, several new institutions became parts of SSU structure.