1. San Carlos University Hospital

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    1. Mentioned In 70 Articles

    2. Thin-Cap Fibroatheroma Rather Than Any Lipid Plaques Increases the Risk of Cardiovascular Events in Diabetic Patients: Insights From the COMBINE OCT–FFR Trial

      Thin-Cap Fibroatheroma Rather Than Any Lipid Plaques Increases the Risk of Cardiovascular Events in Diabetic Patients: Insights From the COMBINE OCT–FFR Trial
      Background: Autopsy studies have established that thin-cap fibroatheromas (TCFAs) are the most frequent cause of fatal coronary events. In living patients, optical coherence tomography (OCT) has sufficient resolution to accurately differentiate TCFA from thick-cap fibroatheroma (ThCFA) and not lipid rich plaque (non-LRP). However, the impact of OCT-detected plaque phenotype of nonischemic lesions on future adverse events remains unknown. Therefore, we studied the natural history of OCT-detected TCFA, ThCFA, and non-LRP ...
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    3. Optical coherence tomography in coronary atherosclerosis assessment and intervention

      Optical coherence tomography in coronary atherosclerosis assessment and intervention
      Since optical coherence tomography (OCT) was first performed in humans two decades ago, this imaging modality has been widely adopted in research on coronary atherosclerosis and adopted clinically for the optimization of percutaneous coronary intervention. In the past 10 years, substantial advances have been made in the understanding of in vivo vascular biology using OCT. Identification by OCT of culprit plaque pathology could potentially lead to a major shift in ...
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    4. Thin-cap fibroatheroma predicts clinical events in diabetic patients with normal fractional flow reserve: the COMBINE OCT–FFR trial

      Thin-cap fibroatheroma predicts clinical events in diabetic patients with normal fractional flow reserve: the COMBINE OCT–FFR trial
      Aims The aim of this study was to understand the impact of optical coherence tomography (OCT)-detected thin-cap fibroatheroma (TCFA) on clinical outcomes of diabetes mellitus (DM) patients with fractional flow reserve (FFR)-negative lesions. Methods and results COMBINE OCT-FFR study was a prospective, double-blind, international, natural history study. After FFR assessment, and revascularization of FFR-positive lesions, patients with 1 FFR-negative lesions (target lesions) were classified in two groups based ...
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    5. Reproducibility of SD-OCT inner macular layer thickness measurements in children with primary congenital glaucoma

      Reproducibility of SD-OCT inner macular layer thickness measurements in children with primary congenital glaucoma
      Purpose To examine the reproducibility of spectral domain optical coherence tomography (SD-OCT) segmented ganglion cell complex and circumpapillary retinal nerve fiber layer (cpRNFL) measurements in children with primary congenital glaucoma (PCG) in comparison with healthy children. Methods 12 children with PCG (G1) and 24 healthy children (G2) were recruited. The following SD-OCT measurements (Spectralis, Heidelberg Engineering) were made in one eye per child: total macular thickness (MT), thicknesses in several ...
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    6. Optical coherence tomography angiography of choroidal nodules in neurofibromatosis type-1: A case series

      Optical coherence tomography angiography of choroidal nodules in neurofibromatosis type-1: A case series
      Purpose: To describe optical coherence tomography angiography (OCTA) findings in the retina and choroid of patients with neurofibromatosis type 1 (NF1). Methods: We describe a series of four patients diagnosed with NF1 and choroidal nodules who underwent a comprehensive ophthalmic evaluation including a retinal multimodal imaging study based on retinography, near-infrared reflectance imaging (NIR), enhanced depth imaging (EDI) optical coherence tomography (OCT) and OCTA. Results: Patients were three women and ...
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    7. Online Co-Registration Of IVUS and OCT

      Online Co-Registration Of IVUS and OCT
      Intravascular imaging using both intravascular ultrasound (IVUS) and optical coherence tomography (OCT) have become important tools in the Interventional Cardiologists armamentarium. However, in some centers, intravascular imaging is not widely employed. A number of reasons for this may exist, including lack of training in the use of intravascular imaging. Co-registration with angiography may be a helpful tool for those beginning to use both IVUS and OCT in the cath lab ...
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    8. Reduced macular vessel density in COVID-19 patients with and without associated thrombotic events using optical coherence tomography angiography

      Reduced macular vessel density in COVID-19 patients with and without associated thrombotic events using optical coherence tomography angiography
      Purpose: Thrombotic events (TE) represent one of the major complications of SARS-CoV-2 infection. The objective is to evaluate vessel density (VD) and perfusion density (PD) by optical coherence tomography angiography (OCTA) in COVID-19 patients, and compare the findings with healthy controls. The secondary objective is to evaluate if there are differences in OCTA parameters between COVID-19 patients with and without associated TE. Methods: Cross-sectional case-control study that included patients with ...
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    9. Retinal Nerve Fiber Layer Analysis in Children with Migraine with and without Aura using Optical Coherence Tomography: A Case-Control Study

      Retinal Nerve Fiber Layer Analysis in Children with Migraine with and without Aura using Optical Coherence Tomography: A Case-Control Study
      Purpose To evaluate retinal nerve fiber layer (RNFL) thickness in children with migraine, with and without aura, compared to healthy controls using optical coherence tomography (OCT). Methods Cross-sectional case-control study. Peripapillary RNFL thickness was measured using optical coherence tomography (OCT) in a group of children diagnosed with migraine with aura (MwA) (n=9) and migraine without aura (MwoA) (n=11), and in a group of healthy controls (n=20). Age ...
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    10. Longitudinal neointimal distribution pattern after Everolimus-eluting stent implantation: Insights from optical coherence tomography study

      Longitudinal neointimal distribution pattern after Everolimus-eluting stent implantation: Insights from optical coherence tomography study
      Background/purpose: Everolimus-eluting stents (EES) are established as latest generation drug eluting stents. However, optical coherence tomography (OCT) assessment of neointimal distribution after EES implantation is lacking. We aimed to assess the longitudinal neointimal distribution pattern after EES implantation using OCT. Methods: Data from 3 prospective studies (HEAL-EES, REVER and RESERVOIR), including patients with EES implantation and OCT follow-up study, were merged. Analyzed stents were divided into 3 segments of ...
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    11. Multimodal imaging in optic nerve melanocytoma: Optical coherence tomography angiography and other findings

      Multimodal imaging in optic nerve melanocytoma: Optical coherence tomography angiography and other findings
      Purpose To evaluate optical coherence tomography (OCT), fundus autofluorescence (FAF) imaging and optical coherence tomography angiography (OCTA) as diagnostic tools in optic disc melanocytoma (ODM) and study the differences in peripapillary and macular vascular density in eyes with ODM using OCTA. Methods Patients with ODM were enrolled in this case series. Each patient underwent evaluation of best-corrected visual acuity, slit-lamp biomicroscopy, fundus examination, fundus photography, standard visual field testing, spectral ...
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    12. Influence of neoatherosclerosis on prognosis and treatment response in patients with in-stent restenosis

      Influence of neoatherosclerosis on prognosis and treatment response in patients with in-stent restenosis
      Introduction and objectives Neoatherosclerosis is one of the causes of in-stent restenosis (ISR). Our objective was to evaluate the influence of neoatherosclerosis on prognosis and treatment response in patients with ISR. Methods This is a pooled analysis of the optical coherence tomography (OCT)-substudies of 2 multicenter, randomized clinical trials , RIBS IV and V, comparing treatment with paclitaxel-coated balloon vs everolimus-eluting stent in patients with ISR. OCT evaluation was performed ...
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    13. Characteristic findings of acute spontaneous coronary artery dissection by cardiac computed tomography

      Characteristic findings of acute spontaneous coronary artery dissection by cardiac computed tomography
      Background: Spontaneous coronary artery dissection (SCAD) is an infrequent cause of acute coronary syndrome (ACS); however, its detection carries relevant clinical implications. Cardiac computed tomography (CCT) has been found to be useful for follow-up, but data during the acute phase are scarce. Thus, our aim was to evaluate the early diagnostic ability of CCT to detect SCAD. Methods: We retrospectively analyzed all the in-hospital CCT performed in a prospective cohort ...
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    14. Normative database of peripapillary vessel density measured by optical coherence tomography angiography and correlation study

      Normative database of peripapillary vessel density measured by optical coherence tomography angiography and correlation study
      Purpose: To provide a normative data set of swept-source optical coherence tomography angiography (SS-OCTA) peripapillary vessel density (VD) measurements and assess correlations with age, gender, disc area and axial length (AL). Material and Methods: This was an observational cross-sectional study conducted on 346 right eyes of healthy subjects. Peripapillary SS-OCTA VD measurements were obtained in the retinal superficial capillary plexus (SCP), deep capillary plexus (DCP), and choriocapillaris (CC) in all ...
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    15. Correlation Between Optical Coherence Tomography and Magnetic Resonance Imaging of Rectus Muscle Thickness Measurements in Graves' Ophthalmopathy

      Correlation Between Optical Coherence Tomography and Magnetic Resonance Imaging of Rectus Muscle Thickness Measurements in Graves' Ophthalmopathy
      PURPOSE: To assess the correlation between optical coherence tomography (OCT) and magnetic resonance imaging (MRI) measurements of extraocular rectus muscle thickness in patients with Graves' ophthalmopathy. METHODS: This was a cross-sectional observational study conducted in 62 eyes of 31 patients with Graves' ophthalmopathy. The disease phase was inactive in 20 patients and active in the remaining 11. The OCT measurements obtained were: medial rectus thickness at 7.2 and 9 ...
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    16. Spatial analysis of thickness changes in ten retinal layers of Alzheimer’s disease patients based on optical coherence tomography

      Spatial analysis of thickness changes in ten retinal layers of Alzheimer’s disease patients based on optical coherence tomography
      The retina is an attractive source of biomarkers since it shares many features with the brain. Thickness differences in 10 retinal layers between 19 patients with mild Alzheimers disease (AD) and a control group of 24 volunteers were investigated. Retinal layers were automatically segmented and their thickness at each scanned point was measured, corrected for tilt and spatially normalized. When the mean thickness of entire layers was compared between patients ...
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  2. About San Carlos University Hospital

    San Carlos University Hospital

    Clinico San Carlos University Hospital.  The San Carlos Hospital is a health center since its establishment in 1787 has among its objectives the improvement of care, teaching and research. Rebuilt in the 60's, reaching its present location has been changing and adapting to the demands of Madrid society, is a reference to national and international level facilities and professionals.