1. Saba H. Syed

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    1. Mentioned In 17 Articles

    2. Quantification of Mouse Embryonic Eye Development with Optical Coherence Tomography In Utero

      Quantification	of	Mouse	Embryonic	Eye	Development	with	 Optical	Coherence	Tomography	In	Utero
      Mouse models are commonly used as research tools to understand regulatory pathways affected by human diseases and disorders. Live imaging tools for visualization of mouse embryonic ocular tissues would be beneficial in research associated with developmental ocular defects. In this study, in utero quantitative assessment of ocular structures in mouse embryos was performed with a swept-source optical coherence tomography (SSOCT). To define developmental changes in eye morphology in live embryos ...
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    3. Optical coherence tomography guided microinjections in live mouse embryos: high-resolution targeted manipulation for mouse embryonic research

      Optical coherence tomography guided microinjections in live mouse embryos: high-resolution targeted manipulation for mouse embryonic research
      ...ed. Our results indicate that OCT-guided microinjection could be a useful tool for mouse embryonic research. Saba H. Syed ; Andrew J. Coughlin ; Monica D. Garcia ; Shang Wang ; Jennifer L. West, et al. "Optical coheren...
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    4. Optical coherence tomography for live phenotypic analysis of embryonic ocular structures in mouse models

      Optical coherence tomography for live phenotypic analysis of embryonic ocular structures in mouse models
      Mouse models of ocular diseases provide a powerful resource for exploration of molecular regulation of eye development and pre-clinical studies. Availability of a live high-resolution imaging method for mouse embryonic eyes would significantly enhance longitudinal analyses and high-throughput morphological screening. We demonstrate that optical coherence tomography (OCT) can be used for live embryonic ocular imaging throughout gestation. At all studied stages, the whole eye is within the imaging distance of ...
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    5. Prenatal imaging of distal limb abnormalities using OCT in mice

      Prenatal imaging of distal limb abnormalities using OCT in mice
      Congenital abnormalities of the limbs are common birth defects. These include missing or extra fingers or toes, abnormal limb length, and abnormalities in patterning of bones, cartilage or muscles. Optical Coherence Tomography (OCT) is a 3-D imaging modality, which can produce high-resolution (~8 μm) images of developing embryos with an imaging depth of a few millimeters. Here we demonstrate the capability of OCT to perform 3D imaging of limb development ...
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    6. Feature Of The Week 5/22/11: Using OCT to Assess The Efficacy of Tissue Preservation Techniques

      Feature Of The Week 5/22/11: Using OCT to Assess The Efficacy of Tissue Preservation Techniques
      Feature Of The Week 5/22/11: A group of researchers at the University of Houston and Baylor College of Medicine, under direction of Dr. Kirill Larin, are currently performing studies that might help to understand the requirements needed for proper cryopreservation of vascular tissues. As reported in recent manuscript published in  Biochimica et Biophysica Acta, they assessed stability of aortic tissue in phosphate buffer saline (PBS) at 4°C ...
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    7. Permeation of human plasma lipoproteins in human carotid endarterectomy tissues: Measurement by optical Coherence tomography

      Permeation of human plasma lipoproteins in human carotid endarterectomy tissues: Measurement by optical Coherence tomography
      Atherosclerosis is an inflammatory process occurring in arterial tissue, involving the subintimal accumulation of low-density lipoproteins (LDL). Measurement of the rate at which LDL and other lipoproteins such as high-density lipoprotein (HDL) and very low-density lipoprotein (VLDL) enter and exit the tissue can provide insight into the mechanisms involved in the development of atherosclerotic lesions. Permeation of VLDL, LDL, HDL, and glucose was measured for normal and atherosclerotic human carotid ...
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    8. Feature Of The Week 4/10/11: Dr. Kirill Larin Narrates a Presentation on OCT Imaging of In Utero Embryonic Development

      Feature Of The Week 4/10/11: Dr. Kirill Larin Narrates a Presentation on OCT Imaging of In Utero Embryonic Development
      Feature Of The Week 4/10/11: Dr. Kirill Larin narrates a presentation of execptional work from researchers at the Baylor College of Medicine and University of Houston on the use of Optical Coherence Tomography for high resolution imaging of mouse development in utero.   Understanding of the genetic basis of human birth defects heavily relies on analysis of mouse embryos. The success of these efforts depends on the ability to ...
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    9. Time Dependent Changes in Aortic Tissue during Cold Storage in Physiological Solution

      Time Dependent Changes in Aortic Tissue during Cold Storage in Physiological Solution
      Background Stored vascular tissues are employed in biomedical research for studies in imaging, in biomechanics, and/or assessing vessel diseases. In the present study, the stability of aortic tissue in phosphate buffer saline (PBS) at 4 °C was monitored over a course of 10 days as determined by the rate of glucose permeation measured by Optical Coherence Tomography (OCT) and validated by histology. Methods and Results The initial mean permeability ...
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    10. Speckle variance OCT imaging of the vasculature in live mammalian embryos

      Speckle variance OCT imaging of the vasculature in live mammalian embryos
      Live imaging of normal and abnormal vascular development in mammalian embryos is important tool in embryonic research, which can potentially contribute to understanding, prevention and treatment of cardiovascular birth defects. Here, we used speckle variance analysis of swept source optical coherence tomography (OCT) data sets acquired from live mouse embryos to reconstruct the 3-D structure of the embryonic vasculature. Both Doppler OCT and speckle variance algorithms were used to reconstruct ...
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    11. Real-Time Imaging of Circulating Individual Blood Cells in Mammalian Embryos with Doppler SS-OCT

      Real-Time Imaging of Circulating Individual Blood Cells in Mammalian Embryos with Doppler SS-OCT
      Congenital cardiovascular (CV) defects are present in approximately 1% of live births. Moreover, among deaths due to birth defects, cardiovascular failures are the most likely. Therefore, characterization of mammalian embryonic cardio dynamics and understanding of the hemodynamic changes that occur during embryonic development is crucial for improving diagnostics, prevention, and treatment of cardiovascular defects and diseases. In this work, we combined Swept Source Optical Coherence Tomography (SSOCT) with live mouse ...
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    12. Hemodynamic measurements from individual blood cells in early mammalian embryos with Doppler swept source OCT

      Hemodynamic measurements from individual blood cells in early mammalian embryos with Doppler swept source OCT
      ...er Doppler velocimetry * (180.1655) Microscopy : Coherence tomography Citation Irina V. Larina, Steven Ivers, Saba Syed, Mary E. Dickinson, and Kirill V. Larin, "Hemodynamic measurements from individual blood cells in e...
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    13. 1-17 of 17
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  2. About Saba H. Syed

    Saba H. Syed

    Saba Syed is a graduate student at the University of Houston seeking a Ph.D. degree in Biomedical Engineering.  She received her B.S. degree in Biology from the University of Texas at Arlington and M.S. in BME from University of Houston. She has recently received a scholarship from the UH AGEP (Alliance for Graduate Education and the Professoriate) summer research program. The focus of her studies is embryonic imaging of mice with Optical Coherence Tomography.