1. Ryerson University

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    1. Mentioned In 95 Articles

    2. Differential standard deviation of log-scale intensity based optical coherence tomography angiography

      Differential standard deviation of log-scale intensity based optical coherence tomography angiography
      In this paper, a differential standard deviation of log-scale intensity (DSDLI) based optical coherence tomography angiography (OCTA) is presented for calculating microvascular images of human skin. The DSDLI algorithm calculates the variance in difference images of two consecutive log-scale intensity based structural images from the same position along depth direction to contrast blood flow. The en face microvascular images were then generated by calculating the standard deviation of the differential ...
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    3. Microvascular contrast enhancement in optical coherence tomography using microbubbles

      Microvascular contrast enhancement in optical coherence tomography using microbubbles
      Gas microbubbles (MBs) are investigated as intravascular optical coherence tomography (OCT) contrast agents. Agar + intralipid scattering tissue phantoms with two embedded microtubes were fabricated to model vascular blood flow. One was filled with human blood, and the other with a mixture of human blood + MB. Swept-source structural and speckle variance (sv) OCT images, as well as speckle decorrelation times, were evaluated under both no-flow and varying flow conditions. Faster decorrelation ...
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    4. Measuring intracellular motion in cancer cell using optical coherence tomography

      Measuring intracellular motion in cancer cell using optical coherence tomography
      In this study, we demonstrate that OCT speckle decorrelation techniques can be used to probe intracellular motion in cancer cells. Spheroids and cell pellets were used as a model to probe intracellular motion. ZnCl 2 was used to inhibit mitochondrial motion within the cells. The results reveal the changes in intracellular motion during the spheroid growth phase. Moreover, to modify the motion of mitochondria, cell pellet were exposed to ZnCl ...
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    5. Blood flow contrast enhancement in optical coherence tomography using microbubbles: a phantom study

      Blood flow contrast enhancement in optical coherence tomography using microbubbles: a phantom study
      In this study gas microbubbles are investigated as intravascular OCT contrast agents. Agar+Intralipid scattering tissue-like phantoms with two embedded microtubes were fabricated to model vascular blood flow. One was filled with human blood, and the other with a mixture of human blood and microbubbles. Swept-source structural and speckle variance OCT images, as well as speckle decorrelation times, were evaluated under both stationary and flow conditions. Faster decorrelation times and ...
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    6. Optical coherence tomography spectral analysis for detecting apoptosis in vitro and in vivo

      Optical coherence tomography spectral analysis for detecting apoptosis in vitro and in vivo
      Apoptosis is a form of programmed cell death characterized by a series of predictable morphological changes at the subcellular level, which modify the light-scattering properties of cells. We present a spectroscopic optical coherence tomography (OCT) technique to detect changes in subcellular morphology related to apoptosis in vitro and in vivo . OCT data were acquired from acute myeloid leukemia (AML) cells treated with cisplatin over a 48-h period. The backscatter spectrum ...
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    7. Cadaveric in-situ testing of optical coherence tomography system-based skull base surgery guidance

      Cadaveric in-situ testing of optical coherence tomography system-based skull base surgery guidance
      Optical Coherence Tomography (OCT) has extensive potential for producing clinical impact in the field of neurological diseases. A neurosurgical OCT hand-held forward viewing probe in Bayonet shape has been developed. In this study, we test the feasibility of integrating this imaging probe with modern navigation technology for guidance and monitoring of skull base surgery. Cadaver heads were used to simulate relevant surgical approaches for treatment of sellar, parasellar and skull ...
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    8. Vascular wall stress during intravascular optical coherence tomography imaging

      Vascular wall stress during intravascular optical coherence tomography imaging
      Biomechanical properties of arterial wall is crucial for understanding the changes in the cardiovascular system. Catheters are used during intravascular optical coherence tomography (IVOCT) imaging. The presence of a catheter alters the flow field, pressure distribution and frictional resistance to flow in an artery. In this paper, we first study the transmural stress distribution of the catheterized vessel. COMSOL (COMSOL 4.4) was used to simulate the blood flow induced ...
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    9. Evaluation of hemodynamics changes during interventional stent placement using Doppler optical coherence tomography

      Evaluation of hemodynamics changes during interventional stent placement using Doppler optical coherence tomography
      Carotid atherosclerosis is a critical medical concern that can lead to ischemic stroke. Local hemodynamic patterns have also been associated with the development of atherosclerosis, particularly in regions with disturbed flow patterns such as bifurcations. Traditionally, this disease was treated using carotid endarterectomy, however recently there is an increasing trend of carotid artery stenting due to its minimally invasive nature. It is well known that this interventional technique creates changes ...
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    10. Spinal cord deformation due to nozzle gas flow effects using optical coherence tomography

      Spinal cord deformation due to nozzle gas flow effects using optical coherence tomography
      The use of gas assistance in laser machining hard materials is well established in manufacturing but not in the context of surgery. Laser cutting of osseous tissue in the context of neurosurgery can benefit from gas-assist but requires an understanding of flow and pressure effects to minimize neural tissue damage. In this study we acquire volumetric flow rates through a gas nozzle on the spinal cord, with dura and without ...
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    11. Application of optical coherence tomography attenuation imaging for quantification of optical properties in medulloblastoma

      Application of optical coherence tomography attenuation imaging for quantification of optical properties in medulloblastoma
      The hemodynamic environment is known to play a crucial role in the progression, rupture, and treatment of intracranial aneurysms. Currently there is difficulty assessing and measuring blood flow profiles in vivo. An emerging high resolution imaging modality known as split spectrum Doppler optical coherence tomography (ssDOCT) has demonstrated the capability to quantify hemodynamic patterns as well as arterial microstructural changes. In this study, we present a novel in vitro method ...
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    12. Feature Of The Week 01/18/15: An Integrated Optical Coherence Tomography-Gas Nozzle System for Surgical Laser Ablation Applications

      Comment "Dear Ms. Kumar. Thank you for your comment. Please note all three articles you mentioned above are already on OCT ..." - Eric Swanson
      Feature Of The Week 01/18/15: An Integrated Optical Coherence Tomography-Gas Nozzle System for Surgical Laser Ablation Applications
      ... site of gas delivery. For more information see recent Article . Courtesy of Ronnie Wong and Victor Yang from Ryerson University . Gas assisted laser machining of materials is a common practice in the manufacturing indus...
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    13. Development of an integrated optical coherence tomography-gas nozzle system for surgical laser ablation applications: preliminary findings of in situ spinal cord deformation due to gas flow effects

      Development of an integrated optical coherence tomography-gas nozzle system for surgical laser ablation applications: preliminary findings of in situ spinal cord deformation due to gas flow effects
      ... Ryerson University, Toronto, Ontario, M5B 2K3, Canada ^2Department of Electrical and Computer Engineering, Ryerson University, Toronto, Ontario, M5B 2K3, Canada ^3Department of Surgical Neuromonitoring, Sunnybrook H...
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    14. Evaluation of flow velocities after carotid artery stenting through split spectrum Doppler optical coherence tomography and computational fluid dynamics modeling

      Evaluation of flow velocities after carotid artery stenting through split spectrum Doppler optical coherence tomography and computational fluid dynamics modeling
      ...Yang^1,^2,^3,^4,^* ^1Biophotonics and Bioengineering Laboratory, Dept. Electrical and Computer Engineering, Ryerson University, 350 Victoria Street, Toronto, ON, M5B 2K3, Canada ^2Physical Science - Brain Sciences Re...
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    15. Histogram flow mapping with optical coherence tomography for in vivo skin angiography of hereditary hemorrhagic telangiectasia

      Histogram flow mapping with optical coherence tomography for in vivo skin angiography of hereditary hemorrhagic telangiectasia
      ...Timothy W. H. Luk Ryerson University, Biophotonics and Bioengineering Laboratory, Toronto M5B 2K3, Canada Ryerson University, Department of Electrical and Computer Engineering, Toronto M5B 2K3, Canada Joel Ramjist ...
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  2. About Ryerson University

    Ryerson University

    Ryerson University is Canada’s leader in innovative, career-focused education and a university clearly on the move. It is a distinctly urban university with a mission to serve societal need, and a long-standing commitment to engaging its community. Guided by a bold new Academic Plan, an ambitious research agenda, and a recently-completed Master Plan to revitalize the campus and surrounding neighbourhood, Ryerson is now the most applied-to university in Ontario relative to available spaces, and its reputation with business and community leaders continues to rise. In just a few years since the introduction of its first master's program, Ryerson has grown to host 2,000 graduate students in 34 programs, including nine at the doctoral level. The University now ranks third in Canada - and first in Ontario - in terms of research growth. And Ryerson is reshaping the downtown core of Toronto with two new buildings: a Photography Gallery and Research Centre in the heart of campus, and a Student Learning Centre on the site of the iconic Sam the Record Man property on Yonge Street, in the heart of the city. Since 1948, Ryerson has built its reputation on the strength of its academic curriculum, and offers close to 100 PhD, master's, and undergraduate programs, with a total enrolment of 25,000 and more than 65,000 registrations annually in The G. Raymond Chang School of Continuing Education.