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1. Mentioned In 65 Articles
2. Intrinsic calcification angle: a novel feature of the vulnerable coronary plaque in patients with type 2 diabetes: an optical coherence tomography study
  
  Explore Cardiovascular Diabetology Sep 28 2019 Cardiology
  
  Background Coronary calcification is associated with high risk for cardiovascular events. However, its impact on plaque vulnerability is incompletely understood. In the present study we defined the intrinsic calcification angle (ICA) as the angle externally projected by a vascular calcification and analyzed its role as novel feature of coronary plaque vulnerability in patients with type 2 diabetes. Methods Optical coherence tomography was used to determine ICA in 219 calcifications from ...
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  Mentions: RWTH Aachen University Mathias Burgmaier
3. Quantitative Articular Cartilage Sub-Surface Defect Assessment Using Optical Coherence Tomography: An In-Vitro Study
  
  Explore ScienceDirect Oct 13 2018
  
  Assessment of structural cartilage damage is of high scientific and clinical interest. Optical Coherence Tomography (OCT) is a light-based cross-sectional imaging modality that allows the real-time assessment of articular cartilage at near-histological resolution. Algorithm routines for the detection, parameterization and quantification of sub-surface defects as assessed by OCT were implemented and validated in this study. Standard defects of 0.9 mm, 1.1 mm and 1.3 mm diameter were ...
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  Mentions: RWTH Aachen University Nicolai Brill Sven Nebelung
4. Predictors for target lesion microcalcifications in patients with stable coronary artery disease: an optical coherence tomography study
  
  Explore Home - Springer Apr 17 2018 Cardiology
  
  Background The minimal fibrous cap thickness overlying the necrotic lipid core as well as the presence of macrophages are established characteristics of coronary plaque vulnerability. Recently, the presence of microcalcifications has emerged as a novel feature of vulnerable lesions. However, clinical and plaque morphological predictors of microcalcifications are unknown. Methods In patients with stable coronary artery disease, analysis of plaque morphology ( n =112) was performed using optical coherence tomography prior ...
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  Mentions: RWTH Aachen University Mathias Burgmaier
5. Type 2 diabetes mellitus is associated with a lower fibrous cap thickness but has no impact on calcification morphology: an intracoronary optical coherence tomography study
  
  Explore Cardiovascular Diabetology Dec 5 2017 Cardiology
  
  Background Patients with type 2 diabetes (T2DM) are at high risk for cardiovascular events, which usually arise from the rupture of a vulnerable coronary plaque. The minimal fibrous cap thickness (FCT) overlying a necrotic lipid core is an established predictor for plaque rupture. Recently, coronary calcification has emerged as a relevant feature of plaque vulnerability. However, the impact of T2DM on these morphological plaque parameters is largely unexplored. Therefore, this ...
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  Mentions: RWTH Aachen University Mathias Burgmaier
6. Evaluation of Long-term Anatomic Changes Following Canaloplasty With Anterior Segment Spectral-domain Optical Coherence Tomography and Ultrasound Biomicroscopy
  
  Explore LWW Online Dec 5 2017 Ophthalmology
  
  Background: To analyze long-term structural changes in conjunctiva, sclera and Schlemm canal (SC) with anterior segment optical coherence tomography (AS-OCT) and ultrasound biomicroscopy (UBM) following uncomplicated canaloplasty. Materials and Methods: Fifteen patients with planned canaloplasty and no intraoperative complications were included in this prospective study. AS-OCT images were acquired at 1, 3, 6 months and at a long-term time point (204.9mo) postsurgery. UBM images were acquired at 3, 6 ...
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  Mentions: RWTH Aachen University
7. Feature Of The Week 07/07/2017: Tomographical process monitoring of laser transmission welding with OCT
  
  Explore Optical Coherence Tomography News Jul 7 2017 NDE/NDT
  
  ...iable weld process and a safe product. For more information see recent Article . Courtesy Robert Schmitt from RWTH Aachen University and Philippe Ackermann from Fraunhofer-Institut fr Produktionstechnologie . Laser trans...
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  Mentions: RWTH Aachen University Robert Schmitt Philippe Ackermann
8. Biomedical Optics in Otorhinolaryngology (Textbook)
  
  Explore Springer US Sep 1 2016 Otolaryngology , Textbooks
  
  Biomedical Optics in Otorhinolaryngology: Head and Neck Surgery gives an overview of current technology in biomedical optics relevant to the field of Otorhinolaryngology and head and neck surgery. It provides a comprehensive source of knowledge for researchers and active clinicians seeking information on the principles and practical use of novel diagnostic and therapeutic technology. While most books focus exclusively on laser surgery, which has been largely unchanged for the past ...
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  Mentions: UC Irvine RWTH Aachen University Brian J. F. Wong
9. Polarization-sensitive optical coherence tomography-based imaging, parameterization, and quantification of human cartilage degeneration
  
  Explore SPIE | Journal Jul 27 2016
  
  Polarization-sensitive optical coherence tomography (PS-OCT) is a light-based, high-resolution, real-time, noninvasive, and nondestructive imaging modality yielding quasimicroscopic cross-sectional images of cartilage. As yet, comprehensive parameterization and quantification of birefringence and tissue properties have not been performed on human cartilage. PS-OCT and algorithm-based image analysis were used to objectively grade human cartilage degeneration in terms of surface irregularity, tissue homogeneity, signal attenuation, as well as birefringence coefficient and band width, height ...
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  Mentions: RWTH Aachen University Robert Schmitt Nicolai Brill
10. Detecting early stage osteoarthritis by optical coherence tomography?
  
  Explore Taylor & Francis Online Feb 11 2016
  
  Osteoarthritis (OA) is the most common chronic disease of our joints, manifested by a dynamically increasing degeneration of hyaline articular cartilage (AC). While currently no therapy can reverse this process, the few available treatment options are hampered by the inability of early diagnosis. Loss of cartilage surface, or extracellular matrix (ECM), integrity is considered the earliest sign of OA. Despite the increasing number of imaging modalities surprisingly few imaging biomarkers ...
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  Mentions: RWTH Aachen University Nicolai Brill Sven Nebelung
11. Quantitative OCT and MRI biomarkers for the differentiation of cartilage degeneration
  
  Explore Home - Springer Jan 20 2016
  
  Objective To evaluate the usefulness of quantitative parameters obtained by optical coherence tomography (OCT) and magnetic resonance imaging (MRI) in the comprehensive assessment of human articular cartilage degeneration. Materials and methods Human osteochondral samples of variable degeneration ( n =45) were obtained from total knee replacements and assessed by MRI sequences measuring T1, T1, T2 and T2* relaxivity and by OCT-based quantification of irregularity (OII, optical irregularity index), homogeneity (OHI, optical ...
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  Mentions: RWTH Aachen University Nicolai Brill Sven Nebelung
12. Towards Optical Coherence Tomography-Based Elastographic Evaluation of Human Cartilage
  
  Explore ScienceDirect Dec 10 2015
  
  Optical Coherence Tomography (OCT) is an imaging technique that allows the surface and subsurface evaluation of semitransparent tissues by generating microscopic cross-sectional images in real time, to millimeter depths and at micrometer resolutions. As the differentiation of cartilage degeneration remains diagnostically challenging to standard imaging modalities, an OCT- and MRI-compatible indentation device for the assessment of cartilage functional properties was developed and validated in the present study. After describing the ...
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  Mentions: RWTH Aachen University Robert Schmitt Nicolai Brill
13. Evaluation of early anatomical changes following canaloplasty with anterior segment spectral-domain optical coherence tomography and ultrasound biomicroscopy
  
  Explore Wiley Online Library Dec 9 2015 Ophthalmology
  
  Purpose To analyse structural changes in conjunctiva, sclera and Schlemm's canal (SC) following canaloplasty with optical coherence tomography (AS-OCT) and ultrasound biomicroscopy (UBM). Methods Fifteen patients undergoing canaloplasty were included in this prospective study. AS-OCT images were acquired pre- and 1, 7, 30 and 90 days postoperatively. UBM was performed 3 months postoperatively. The surgical site was evaluated for the presence of SC, transscleral filtration, a scleral lake and ...
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  Mentions: RWTH Aachen University
14. 3D Human cartilage surface characterization by optical coherence tomography
  
  Explore IOPscience Sep 24 2015
  
  Early diagnosis and treatment of cartilage degeneration is of high clinical interest. Loss of surface integrity is considered one of the earliest and most reliable signs of degeneration, but cannot currently be evaluated objectively. Optical Coherence Tomography (OCT) is an arthroscopically available light-based non-destructive real-time imaging technology that allows imaging at micrometre resolutions to millimetre depths. As OCT-based surface evaluation standards remain to be defined, the present study investigated the ...
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  Mentions: Thorlabs RWTH Aachen University Robert Schmitt
15. Evaluation of Single-Impact-Induced Cartilage Degeneration by Optical Coherence Tomography
  
  Explore Hindawi Publishing Corporation Jul 7 2015 Ophthalmology
  
  Posttraumatic osteoarthritis constitutes a major cause of disability in our increasingly elderly population. Unfortunately, current imaging modalities are too insensitive to detect early degenerative changes of this disease. Optical coherence tomography (OCT) is a promising nondestructive imaging technique that allows surface and subsurface imaging of cartilage, at near-histological resolution, and is principally applicable in vivo during arthroscopy. Thirty-four macroscopically normal human cartilage-bone samples obtained from total joint replacements were subjected ...
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  Mentions: Thorlabs RWTH Aachen University Robert Schmitt
16. Optical coherence tomography-based parameterization and quantification of articular cartilage surface integrity
  
  Explore OSA | OSA Publishing Jun 8 2015
  
  Loss of articular cartilage surface integrity is considered the earliest sign of osteoarthritis; however, its reliable detection has not been established by clinical routine diagnostics. This study comprehensively assesses a set of 11 algorithm-based 2-D Optical Coherence Tomography roughness parameters and investigates their clinical impact. Histology and manual irregularity quantification of 105 human cartilage samples with variable degeneration served as reference. The majority of parameters revealed a close-to-linear correlation with ...
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  Mentions: RWTH Aachen University Robert Schmitt Nicolai Brill
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