1. RWTH Aachen University

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    1. Mentioned In 72 Articles

    2. Optical coherence tomography and convolutional neural networks can differentiate colorectal liver metastases from liver parenchyma ex vivo

      Optical coherence tomography and convolutional neural networks can differentiate colorectal liver metastases from liver parenchyma ex vivo
      Purpose: Optical coherence tomography (OCT) is an imaging technology based on low-coherence interferometry, which provides non-invasive, high-resolution cross-sectional images of biological tissues. A potential clinical application is the intraoperative examination of resection margins, as a real-time adjunct to histological examination. In this ex vivo study, we investigated the ability of OCT to differentiate colorectal liver metastases (CRLM) from healthy liver parenchyma, when combined with convolutional neural networks (CNN). Methods: Between ...
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    3. Thin-Cap Fibroatheroma Rather Than Any Lipid Plaques Increases the Risk of Cardiovascular Events in Diabetic Patients: Insights From the COMBINE OCT–FFR Trial

      Thin-Cap Fibroatheroma Rather Than Any Lipid Plaques Increases the Risk of Cardiovascular Events in Diabetic Patients: Insights From the COMBINE OCT–FFR Trial
      Background: Autopsy studies have established that thin-cap fibroatheromas (TCFAs) are the most frequent cause of fatal coronary events. In living patients, optical coherence tomography (OCT) has sufficient resolution to accurately differentiate TCFA from thick-cap fibroatheroma (ThCFA) and not lipid rich plaque (non-LRP). However, the impact of OCT-detected plaque phenotype of nonischemic lesions on future adverse events remains unknown. Therefore, we studied the natural history of OCT-detected TCFA, ThCFA, and non-LRP ...
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    4. Detecting early osteoarthritis through changes in biomechanical properties – A review of recent advances in indentation technologies in a clinical arthroscopic setup

      Detecting early osteoarthritis through changes in biomechanical properties – A review of recent advances in indentation technologies in a clinical arthroscopic setup
      Osteoarthritis (OA) is a degenerative joint disease currently affecting half of all women and one-third of all men aged over 65 and it is predicted to even increase in the next decades. In the variety of causes leading to OA, the first common denominator are changes in the extracellular matrix of the cartilage. In later stages, OA affects the whole joint spreading to higher levels of tissue architecture causing irreversible ...
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    5. Lesion Geometry as Assessed by Optical Coherence Tomography Is Related to Myocardial Ischemia as Determined by Cardiac Magnetic Resonance Imaging

      Lesion Geometry as Assessed by Optical Coherence Tomography Is Related to Myocardial Ischemia as Determined by Cardiac Magnetic Resonance Imaging
      Introduction: Although the relationship between the geometry of coronary stenosis and the presence of myocardial ischemia is well known, the association between stenosis geometry and severity and/or extent of ischemia is still unexplored. Thus, we investigated this relationship using optical coherence tomography (OCT) to assess stenosis parameters and cardiac magnetic resonance imaging (CMR) to determine both extent and severity of ischemia. Methods: We analyzed 55 lesions from 51 patients ...
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    6. Quantitative Flow Ratio Is Related to Intraluminal Coronary Stenosis Parameters as Assessed with Optical Coherence Tomography

      Quantitative Flow Ratio Is Related to Intraluminal Coronary Stenosis Parameters as Assessed with Optical Coherence Tomography
      Background: Quantitative flow ratio (QFR) is a novel method for assessing hemodynamic relevance of a coronary lesion based on angiographic projections without the need of a pressure wire. Various studies demonstrated that QFR consistently related to fractional flow reserve (FFR); however, it is still unclear to what extent QFR reflects intraluminal stenosis parameters. Given that optical coherence tomography (OCT) is currently the gold standard to assess intraluminal stenosis parameters, we ...
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    7. Prognostic irrelevance of plaque vulnerability following plaque sealing in high-risk patients with type 2 diabetes: an optical coherence tomography study

      Prognostic irrelevance of plaque vulnerability following plaque sealing in high-risk patients with type 2 diabetes: an optical coherence tomography study
      Background Type 2 diabetes mellitus (T2DM) is associated with an increased cardiovascular risk related at least in part to a more vulnerable plaque phenotype. However, patients with T2DM exhibit also an increased risk following percutaneous coronary intervention (PCI). It is unknown if plaque vulnerability of a treated lesion influences cardiovascular outcomes in patients with T2DM. In this study, we aimed to assess the association of plaque morphology as determined by ...
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    8. Intrinsic calcification angle: a novel feature of the vulnerable coronary plaque in patients with type 2 diabetes: an optical coherence tomography study

      Intrinsic calcification angle: a novel feature of the vulnerable coronary plaque in patients with type 2 diabetes: an optical coherence tomography study
      Background Coronary calcification is associated with high risk for cardiovascular events. However, its impact on plaque vulnerability is incompletely understood. In the present study we defined the intrinsic calcification angle (ICA) as the angle externally projected by a vascular calcification and analyzed its role as novel feature of coronary plaque vulnerability in patients with type 2 diabetes. Methods Optical coherence tomography was used to determine ICA in 219 calcifications from ...
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    9. Quantitative Articular Cartilage Sub-Surface Defect Assessment Using Optical Coherence Tomography: An In-Vitro Study

      Quantitative Articular Cartilage Sub-Surface Defect Assessment Using Optical Coherence Tomography: An In-Vitro Study
      Assessment of structural cartilage damage is of high scientific and clinical interest. Optical Coherence Tomography (OCT) is a light-based cross-sectional imaging modality that allows the real-time assessment of articular cartilage at near-histological resolution. Algorithm routines for the detection, parameterization and quantification of sub-surface defects as assessed by OCT were implemented and validated in this study. Standard defects of 0.9 mm, 1.1 mm and 1.3 mm diameter were ...
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    10. Predictors for target lesion microcalcifications in patients with stable coronary artery disease: an optical coherence tomography study

      Predictors for target lesion microcalcifications in patients with stable coronary artery disease: an optical coherence tomography study
      Background The minimal fibrous cap thickness overlying the necrotic lipid core as well as the presence of macrophages are established characteristics of coronary plaque vulnerability. Recently, the presence of microcalcifications has emerged as a novel feature of vulnerable lesions. However, clinical and plaque morphological predictors of microcalcifications are unknown. Methods In patients with stable coronary artery disease, analysis of plaque morphology ( n =112) was performed using optical coherence tomography prior ...
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    11. Type 2 diabetes mellitus is associated with a lower fibrous cap thickness but has no impact on calcification morphology: an intracoronary optical coherence tomography study

      Type 2 diabetes mellitus is associated with a lower fibrous cap thickness but has no impact on calcification morphology: an intracoronary optical coherence tomography study
      Background Patients with type 2 diabetes (T2DM) are at high risk for cardiovascular events, which usually arise from the rupture of a vulnerable coronary plaque. The minimal fibrous cap thickness (FCT) overlying a necrotic lipid core is an established predictor for plaque rupture. Recently, coronary calcification has emerged as a relevant feature of plaque vulnerability. However, the impact of T2DM on these morphological plaque parameters is largely unexplored. Therefore, this ...
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    12. Evaluation of Long-term Anatomic Changes Following Canaloplasty With Anterior Segment Spectral-domain Optical Coherence Tomography and Ultrasound Biomicroscopy

      Evaluation of Long-term Anatomic Changes Following Canaloplasty With Anterior Segment Spectral-domain Optical Coherence Tomography and Ultrasound Biomicroscopy
      Background: To analyze long-term structural changes in conjunctiva, sclera and Schlemm canal (SC) with anterior segment optical coherence tomography (AS-OCT) and ultrasound biomicroscopy (UBM) following uncomplicated canaloplasty. Materials and Methods: Fifteen patients with planned canaloplasty and no intraoperative complications were included in this prospective study. AS-OCT images were acquired at 1, 3, 6 months and at a long-term time point (204.9mo) postsurgery. UBM images were acquired at 3, 6 ...
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    13. Biomedical Optics in Otorhinolaryngology (Textbook)

      Biomedical Optics in Otorhinolaryngology (Textbook)
      Biomedical Optics in Otorhinolaryngology: Head and Neck Surgery gives an overview of current technology in biomedical optics relevant to the field of Otorhinolaryngology and head and neck surgery. It provides a comprehensive source of knowledge for researchers and active clinicians seeking information on the principles and practical use of novel diagnostic and therapeutic technology. While most books focus exclusively on laser surgery, which has been largely unchanged for the past ...
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    14. Polarization-sensitive optical coherence tomography-based imaging, parameterization, and quantification of human cartilage degeneration

      Polarization-sensitive optical coherence tomography-based imaging, parameterization, and quantification of human cartilage degeneration
      Polarization-sensitive optical coherence tomography (PS-OCT) is a light-based, high-resolution, real-time, noninvasive, and nondestructive imaging modality yielding quasimicroscopic cross-sectional images of cartilage. As yet, comprehensive parameterization and quantification of birefringence and tissue properties have not been performed on human cartilage. PS-OCT and algorithm-based image analysis were used to objectively grade human cartilage degeneration in terms of surface irregularity, tissue homogeneity, signal attenuation, as well as birefringence coefficient and band width, height ...
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  2. About RWTH Aachen University

    RWTH Aachen University

    RWTH Aachen University is the largest university of technology in Germany and one of the most renowned technical universities in Europe.   Institute of Semiconductor Electronics of the RWTH Aachen is one of the leading research institutes in the field of nanotechnology and femtosecond technology. The primary field of the developed technologies can be found in applications for information technology (data processing and data communication) while important applications in the field of life science (genetic analysis) and renewable energies (Photovoltaics) are established, too.