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    1. Mentioned In 66 Articles

    2. Prognostic irrelevance of plaque vulnerability following plaque sealing in high-risk patients with type 2 diabetes: an optical coherence tomography study

      Explore Cardiovascular Diabetology Cardiology
      Prognostic irrelevance of plaque vulnerability following plaque sealing in high-risk patients with type 2 diabetes: an optical coherence tomography study
      Background Type 2 diabetes mellitus (T2DM) is associated with an increased cardiovascular risk related at least in part to a more vulnerable plaque phenotype. However, patients with T2DM exhibit also an increased risk following percutaneous coronary intervention (PCI). It is unknown if plaque vulnerability of a treated lesion influences cardiovascular outcomes in patients with T2DM. In this study, we aimed to assess the association of plaque morphology as determined by ...
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      Mentions: University of Cologne RWTH Aachen University Mathias Burgmaier

    3. Intrinsic calcification angle: a novel feature of the vulnerable coronary plaque in patients with type 2 diabetes: an optical coherence tomography study

      Explore Cardiovascular Diabetology Cardiology
      Intrinsic calcification angle: a novel feature of the vulnerable coronary plaque in patients with type 2 diabetes: an optical coherence tomography study
      Background Coronary calcification is associated with high risk for cardiovascular events. However, its impact on plaque vulnerability is incompletely understood. In the present study we defined the intrinsic calcification angle (ICA) as the angle externally projected by a vascular calcification and analyzed its role as novel feature of coronary plaque vulnerability in patients with type 2 diabetes. Methods Optical coherence tomography was used to determine ICA in 219 calcifications from ...
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      Mentions: RWTH Aachen University Mathias Burgmaier

    4. Quantitative Articular Cartilage Sub-Surface Defect Assessment Using Optical Coherence Tomography: An In-Vitro Study

      Explore ScienceDirect
      Quantitative Articular Cartilage Sub-Surface Defect Assessment Using Optical Coherence Tomography: An In-Vitro Study
      Assessment of structural cartilage damage is of high scientific and clinical interest. Optical Coherence Tomography (OCT) is a light-based cross-sectional imaging modality that allows the real-time assessment of articular cartilage at near-histological resolution. Algorithm routines for the detection, parameterization and quantification of sub-surface defects as assessed by OCT were implemented and validated in this study. Standard defects of 0.9 mm, 1.1 mm and 1.3 mm diameter were ...
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      Mentions: RWTH Aachen University Nicolai Brill Sven Nebelung

    5. Predictors for target lesion microcalcifications in patients with stable coronary artery disease: an optical coherence tomography study

      Explore Home - Springer Cardiology
      Predictors for target lesion microcalcifications in patients with stable coronary artery disease: an optical coherence tomography study
      Background The minimal fibrous cap thickness overlying the necrotic lipid core as well as the presence of macrophages are established characteristics of coronary plaque vulnerability. Recently, the presence of microcalcifications has emerged as a novel feature of vulnerable lesions. However, clinical and plaque morphological predictors of microcalcifications are unknown. Methods In patients with stable coronary artery disease, analysis of plaque morphology ( n =112) was performed using optical coherence tomography prior ...
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      Mentions: RWTH Aachen University Mathias Burgmaier

    6. Type 2 diabetes mellitus is associated with a lower fibrous cap thickness but has no impact on calcification morphology: an intracoronary optical coherence tomography study

      Explore Cardiovascular Diabetology Cardiology
      Type 2 diabetes mellitus is associated with a lower fibrous cap thickness but has no impact on calcification morphology: an intracoronary optical coherence tomography study
      Background Patients with type 2 diabetes (T2DM) are at high risk for cardiovascular events, which usually arise from the rupture of a vulnerable coronary plaque. The minimal fibrous cap thickness (FCT) overlying a necrotic lipid core is an established predictor for plaque rupture. Recently, coronary calcification has emerged as a relevant feature of plaque vulnerability. However, the impact of T2DM on these morphological plaque parameters is largely unexplored. Therefore, this ...
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      Mentions: RWTH Aachen University Mathias Burgmaier

    7. Evaluation of Long-term Anatomic Changes Following Canaloplasty With Anterior Segment Spectral-domain Optical Coherence Tomography and Ultrasound Biomicroscopy

      Explore LWW Online Ophthalmology
      Evaluation of Long-term Anatomic Changes Following Canaloplasty With Anterior Segment Spectral-domain Optical Coherence Tomography and Ultrasound Biomicroscopy
      Background: To analyze long-term structural changes in conjunctiva, sclera and Schlemm canal (SC) with anterior segment optical coherence tomography (AS-OCT) and ultrasound biomicroscopy (UBM) following uncomplicated canaloplasty. Materials and Methods: Fifteen patients with planned canaloplasty and no intraoperative complications were included in this prospective study. AS-OCT images were acquired at 1, 3, 6 months and at a long-term time point (204.9mo) postsurgery. UBM images were acquired at 3, 6 ...
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      Mentions: RWTH Aachen University

    9. Biomedical Optics in Otorhinolaryngology (Textbook)

      Explore Springer US Otolaryngology , Textbooks
      Biomedical Optics in Otorhinolaryngology (Textbook)
      Biomedical Optics in Otorhinolaryngology: Head and Neck Surgery gives an overview of current technology in biomedical optics relevant to the field of Otorhinolaryngology and head and neck surgery. It provides a comprehensive source of knowledge for researchers and active clinicians seeking information on the principles and practical use of novel diagnostic and therapeutic technology. While most books focus exclusively on laser surgery, which has been largely unchanged for the past ...
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      Mentions: UC Irvine RWTH Aachen University Brian J. F. Wong

    10. Polarization-sensitive optical coherence tomography-based imaging, parameterization, and quantification of human cartilage degeneration

      Explore SPIE | Journal
      Polarization-sensitive optical coherence tomography-based imaging, parameterization, and quantification of human cartilage degeneration
      Polarization-sensitive optical coherence tomography (PS-OCT) is a light-based, high-resolution, real-time, noninvasive, and nondestructive imaging modality yielding quasimicroscopic cross-sectional images of cartilage. As yet, comprehensive parameterization and quantification of birefringence and tissue properties have not been performed on human cartilage. PS-OCT and algorithm-based image analysis were used to objectively grade human cartilage degeneration in terms of surface irregularity, tissue homogeneity, signal attenuation, as well as birefringence coefficient and band width, height ...
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      Mentions: RWTH Aachen University Robert Schmitt Nicolai Brill

    11. Detecting early stage osteoarthritis by optical coherence tomography?

      Explore Taylor & Francis Online
      Detecting early stage osteoarthritis by optical coherence tomography?
      Osteoarthritis (OA) is the most common chronic disease of our joints, manifested by a dynamically increasing degeneration of hyaline articular cartilage (AC). While currently no therapy can reverse this process, the few available treatment options are hampered by the inability of early diagnosis. Loss of cartilage surface, or extracellular matrix (ECM), integrity is considered the earliest sign of OA. Despite the increasing number of imaging modalities surprisingly few imaging biomarkers ...
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      Mentions: RWTH Aachen University Nicolai Brill Sven Nebelung

    12. Quantitative OCT and MRI biomarkers for the differentiation of cartilage degeneration

      Explore Home - Springer
      Quantitative OCT and MRI biomarkers for the differentiation of cartilage degeneration
      Objective To evaluate the usefulness of quantitative parameters obtained by optical coherence tomography (OCT) and magnetic resonance imaging (MRI) in the comprehensive assessment of human articular cartilage degeneration. Materials and methods Human osteochondral samples of variable degeneration ( n =45) were obtained from total knee replacements and assessed by MRI sequences measuring T1, T1, T2 and T2* relaxivity and by OCT-based quantification of irregularity (OII, optical irregularity index), homogeneity (OHI, optical ...
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      Mentions: RWTH Aachen University Nicolai Brill Sven Nebelung

    13. Towards Optical Coherence Tomography-Based Elastographic Evaluation of Human Cartilage

      Explore ScienceDirect
      Towards Optical Coherence Tomography-Based Elastographic Evaluation of Human Cartilage
      Optical Coherence Tomography (OCT) is an imaging technique that allows the surface and subsurface evaluation of semitransparent tissues by generating microscopic cross-sectional images in real time, to millimeter depths and at micrometer resolutions. As the differentiation of cartilage degeneration remains diagnostically challenging to standard imaging modalities, an OCT- and MRI-compatible indentation device for the assessment of cartilage functional properties was developed and validated in the present study. After describing the ...
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      Mentions: RWTH Aachen University Robert Schmitt Nicolai Brill

    14. Evaluation of early anatomical changes following canaloplasty with anterior segment spectral-domain optical coherence tomography and ultrasound biomicroscopy

      Explore Wiley Online Library Ophthalmology
      Evaluation of early anatomical changes following canaloplasty with anterior segment spectral-domain optical coherence tomography and ultrasound biomicroscopy
      Purpose To analyse structural changes in conjunctiva, sclera and Schlemm's canal (SC) following canaloplasty with optical coherence tomography (AS-OCT) and ultrasound biomicroscopy (UBM). Methods Fifteen patients undergoing canaloplasty were included in this prospective study. AS-OCT images were acquired pre- and 1, 7, 30 and 90 days postoperatively. UBM was performed 3 months postoperatively. The surgical site was evaluated for the presence of SC, transscleral filtration, a scleral lake and ...
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      Mentions: RWTH Aachen University

    15. 3D Human cartilage surface characterization by optical coherence tomography

      Explore IOPscience
      3D Human cartilage surface characterization by optical coherence tomography
      Early diagnosis and treatment of cartilage degeneration is of high clinical interest. Loss of surface integrity is considered one of the earliest and most reliable signs of degeneration, but cannot currently be evaluated objectively. Optical Coherence Tomography (OCT) is an arthroscopically available light-based non-destructive real-time imaging technology that allows imaging at micrometre resolutions to millimetre depths. As OCT-based surface evaluation standards remain to be defined, the present study investigated the ...
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      Mentions: Thorlabs RWTH Aachen University Robert Schmitt

    16. Evaluation of Single-Impact-Induced Cartilage Degeneration by Optical Coherence Tomography

      Explore Hindawi Publishing Corporation Ophthalmology
      Evaluation of Single-Impact-Induced Cartilage Degeneration by Optical Coherence Tomography
      Posttraumatic osteoarthritis constitutes a major cause of disability in our increasingly elderly population. Unfortunately, current imaging modalities are too insensitive to detect early degenerative changes of this disease. Optical coherence tomography (OCT) is a promising nondestructive imaging technique that allows surface and subsurface imaging of cartilage, at near-histological resolution, and is principally applicable in vivo during arthroscopy. Thirty-four macroscopically normal human cartilage-bone samples obtained from total joint replacements were subjected ...
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      Mentions: Thorlabs RWTH Aachen University Robert Schmitt
    17. 1-15 of 66 1 2 3 4 5 »
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  4. About RWTH Aachen University

    RWTH Aachen University

    RWTH Aachen University is the largest university of technology in Germany and one of the most renowned technical universities in Europe.   Institute of Semiconductor Electronics of the RWTH Aachen is one of the leading research institutes in the field of nanotechnology and femtosecond technology. The primary field of the developed technologies can be found in applications for information technology (data processing and data communication) while important applications in the field of life science (genetic analysis) and renewable energies (Photovoltaics) are established, too.

  5. Related Topics

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    4. Relationship between optical coherence tomography derived intraluminal and intramural criteria and haemodynamic relevance as determined by fractional flow reserve in intermediate coronary stenoses of patients with type 2 diabetes
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    5. Morphometric grading of osteoarthritis by optical coherence tomography - An ex vivo study
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