1. RWTH Aachen University

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    1. Mentioned In 64 Articles

    2. Quantitative Articular Cartilage Sub-Surface Defect Assessment Using Optical Coherence Tomography: An In-Vitro Study

      Quantitative Articular Cartilage Sub-Surface Defect Assessment Using Optical Coherence Tomography: An In-Vitro Study
      Assessment of structural cartilage damage is of high scientific and clinical interest. Optical Coherence Tomography (OCT) is a light-based cross-sectional imaging modality that allows the real-time assessment of articular cartilage at near-histological resolution. Algorithm routines for the detection, parameterization and quantification of sub-surface defects as assessed by OCT were implemented and validated in this study. Standard defects of 0.9 mm, 1.1 mm and 1.3 mm diameter were ...
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    3. Predictors for target lesion microcalcifications in patients with stable coronary artery disease: an optical coherence tomography study

      Predictors for target lesion microcalcifications in patients with stable coronary artery disease: an optical coherence tomography study
      Background The minimal fibrous cap thickness overlying the necrotic lipid core as well as the presence of macrophages are established characteristics of coronary plaque vulnerability. Recently, the presence of microcalcifications has emerged as a novel feature of vulnerable lesions. However, clinical and plaque morphological predictors of microcalcifications are unknown. Methods In patients with stable coronary artery disease, analysis of plaque morphology ( n =112) was performed using optical coherence tomography prior ...
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    4. Type 2 diabetes mellitus is associated with a lower fibrous cap thickness but has no impact on calcification morphology: an intracoronary optical coherence tomography study

      Type 2 diabetes mellitus is associated with a lower fibrous cap thickness but has no impact on calcification morphology: an intracoronary optical coherence tomography study
      Background Patients with type 2 diabetes (T2DM) are at high risk for cardiovascular events, which usually arise from the rupture of a vulnerable coronary plaque. The minimal fibrous cap thickness (FCT) overlying a necrotic lipid core is an established predictor for plaque rupture. Recently, coronary calcification has emerged as a relevant feature of plaque vulnerability. However, the impact of T2DM on these morphological plaque parameters is largely unexplored. Therefore, this ...
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    5. Evaluation of Long-term Anatomic Changes Following Canaloplasty With Anterior Segment Spectral-domain Optical Coherence Tomography and Ultrasound Biomicroscopy

      Evaluation of Long-term Anatomic Changes Following Canaloplasty With Anterior Segment Spectral-domain Optical Coherence Tomography and Ultrasound Biomicroscopy
      Background: To analyze long-term structural changes in conjunctiva, sclera and Schlemm canal (SC) with anterior segment optical coherence tomography (AS-OCT) and ultrasound biomicroscopy (UBM) following uncomplicated canaloplasty. Materials and Methods: Fifteen patients with planned canaloplasty and no intraoperative complications were included in this prospective study. AS-OCT images were acquired at 1, 3, 6 months and at a long-term time point (204.9mo) postsurgery. UBM images were acquired at 3, 6 ...
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    6. Biomedical Optics in Otorhinolaryngology (Textbook)

      Biomedical Optics in Otorhinolaryngology (Textbook)
      Biomedical Optics in Otorhinolaryngology: Head and Neck Surgery gives an overview of current technology in biomedical optics relevant to the field of Otorhinolaryngology and head and neck surgery. It provides a comprehensive source of knowledge for researchers and active clinicians seeking information on the principles and practical use of novel diagnostic and therapeutic technology. While most books focus exclusively on laser surgery, which has been largely unchanged for the past ...
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    7. Polarization-sensitive optical coherence tomography-based imaging, parameterization, and quantification of human cartilage degeneration

      Polarization-sensitive optical coherence tomography-based imaging, parameterization, and quantification of human cartilage degeneration
      Polarization-sensitive optical coherence tomography (PS-OCT) is a light-based, high-resolution, real-time, noninvasive, and nondestructive imaging modality yielding quasimicroscopic cross-sectional images of cartilage. As yet, comprehensive parameterization and quantification of birefringence and tissue properties have not been performed on human cartilage. PS-OCT and algorithm-based image analysis were used to objectively grade human cartilage degeneration in terms of surface irregularity, tissue homogeneity, signal attenuation, as well as birefringence coefficient and band width, height ...
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    8. Detecting early stage osteoarthritis by optical coherence tomography?

      Detecting early stage osteoarthritis by optical coherence tomography?
      Osteoarthritis (OA) is the most common chronic disease of our joints, manifested by a dynamically increasing degeneration of hyaline articular cartilage (AC). While currently no therapy can reverse this process, the few available treatment options are hampered by the inability of early diagnosis. Loss of cartilage surface, or extracellular matrix (ECM), integrity is considered the earliest sign of OA. Despite the increasing number of imaging modalities surprisingly few imaging biomarkers ...
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    9. Quantitative OCT and MRI biomarkers for the differentiation of cartilage degeneration

      Quantitative OCT and MRI biomarkers for the differentiation of cartilage degeneration
      Objective To evaluate the usefulness of quantitative parameters obtained by optical coherence tomography (OCT) and magnetic resonance imaging (MRI) in the comprehensive assessment of human articular cartilage degeneration. Materials and methods Human osteochondral samples of variable degeneration ( n =45) were obtained from total knee replacements and assessed by MRI sequences measuring T1, T1, T2 and T2* relaxivity and by OCT-based quantification of irregularity (OII, optical irregularity index), homogeneity (OHI, optical ...
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    10. Towards Optical Coherence Tomography-Based Elastographic Evaluation of Human Cartilage

      Towards Optical Coherence Tomography-Based Elastographic Evaluation of Human Cartilage
      Optical Coherence Tomography (OCT) is an imaging technique that allows the surface and subsurface evaluation of semitransparent tissues by generating microscopic cross-sectional images in real time, to millimeter depths and at micrometer resolutions. As the differentiation of cartilage degeneration remains diagnostically challenging to standard imaging modalities, an OCT- and MRI-compatible indentation device for the assessment of cartilage functional properties was developed and validated in the present study. After describing the ...
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    11. Evaluation of early anatomical changes following canaloplasty with anterior segment spectral-domain optical coherence tomography and ultrasound biomicroscopy

      Evaluation of early anatomical changes following canaloplasty with anterior segment spectral-domain optical coherence tomography and ultrasound biomicroscopy
      Purpose To analyse structural changes in conjunctiva, sclera and Schlemm's canal (SC) following canaloplasty with optical coherence tomography (AS-OCT) and ultrasound biomicroscopy (UBM). Methods Fifteen patients undergoing canaloplasty were included in this prospective study. AS-OCT images were acquired pre- and 1, 7, 30 and 90 days postoperatively. UBM was performed 3 months postoperatively. The surgical site was evaluated for the presence of SC, transscleral filtration, a scleral lake and ...
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    12. 3D Human cartilage surface characterization by optical coherence tomography

      3D Human cartilage surface characterization by optical coherence tomography
      Early diagnosis and treatment of cartilage degeneration is of high clinical interest. Loss of surface integrity is considered one of the earliest and most reliable signs of degeneration, but cannot currently be evaluated objectively. Optical Coherence Tomography (OCT) is an arthroscopically available light-based non-destructive real-time imaging technology that allows imaging at micrometre resolutions to millimetre depths. As OCT-based surface evaluation standards remain to be defined, the present study investigated the ...
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    13. Evaluation of Single-Impact-Induced Cartilage Degeneration by Optical Coherence Tomography

      Evaluation of Single-Impact-Induced Cartilage Degeneration by Optical Coherence Tomography
      Posttraumatic osteoarthritis constitutes a major cause of disability in our increasingly elderly population. Unfortunately, current imaging modalities are too insensitive to detect early degenerative changes of this disease. Optical coherence tomography (OCT) is a promising nondestructive imaging technique that allows surface and subsurface imaging of cartilage, at near-histological resolution, and is principally applicable in vivo during arthroscopy. Thirty-four macroscopically normal human cartilage-bone samples obtained from total joint replacements were subjected ...
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    14. Optical coherence tomography-based parameterization and quantification of articular cartilage surface integrity

      Optical coherence tomography-based parameterization and quantification of articular cartilage surface integrity
      Loss of articular cartilage surface integrity is considered the earliest sign of osteoarthritis; however, its reliable detection has not been established by clinical routine diagnostics. This study comprehensively assesses a set of 11 algorithm-based 2-D Optical Coherence Tomography roughness parameters and investigates their clinical impact. Histology and manual irregularity quantification of 105 human cartilage samples with variable degeneration served as reference. The majority of parameters revealed a close-to-linear correlation with ...
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    15. Correlation Between OCT-Derived Intrastent Dimensions and Fractional Flow Reserve Measurements After Coronary Stent Implantation and Impact on Clinical Outcome

      Correlation Between OCT-Derived Intrastent Dimensions and Fractional Flow Reserve Measurements After Coronary Stent Implantation and Impact on Clinical Outcome
      Background. Insufficient stent expansion, vessel wall injury, and tissue prolapse, all frequently unrecognized by coronary angiography, are predictors of future major adverse cardiac event (MACE) after percutaneous coronary intervention (PCI). Optical coherence tomography (OCT) provides accurate visualization of these features of inadequate stent deployment, whereas reduced fractional flow reserve (FFR) values after PCI indicate functional significance of a residual intrastent stenosis. Objective. To investigate the relationship of OCT-derived intrastent lumen ...
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  2. About RWTH Aachen University

    RWTH Aachen University

    RWTH Aachen University is the largest university of technology in Germany and one of the most renowned technical universities in Europe.   Institute of Semiconductor Electronics of the RWTH Aachen is one of the leading research institutes in the field of nanotechnology and femtosecond technology. The primary field of the developed technologies can be found in applications for information technology (data processing and data communication) while important applications in the field of life science (genetic analysis) and renewable energies (Photovoltaics) are established, too.