1. Ruikang K. Wang

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    1. Mentioned In 142 Articles

    2. In vivo imaging of functional microvasculature within tissue beds of oral and nasal cavities by swept-source optical coherence tomography with a forward/side-viewing probe

      In vivo imaging of functional microvasculature within tissue beds of oral and nasal cavities by swept-source optical coherence tomography with a forward/side-viewing probe
      ...a forward/side-viewing probe Woo June Choi and Ruikang K. Wang »View Author Affiliations Woo June Choi and Ruikang K. Wang^* ^Department of Bioengineering, University of Washington, 3720 15th NE, Seattle, WA 98195, ...
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    3. Method and apparatus for quantitative imaging of blood perfusion in living tissue

      Method and apparatus for quantitative imaging of blood perfusion in living tissue

      Embodiments provide methods and systems for quantitative imaging of blood perfusion in living tissue. A method provides for obtaining an optical microangiography (OMAG) image of a sample, wherein the image has an OMAG background sample; digitally reconstructing a homogeneous ideal static background tissue; replacing the OMAG background sample with the digitally reconstructed homogeneous ideal static background tissue; correlating two or more neighboring A-lines with the digitally reconstructed homogeneous ideal static background tissue; and measuring a phase difference between the two or more neighboring A-lines to quantify blood perfusion in the sample. Methods using digital reconstruction to reduce random phase noise ...

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    4. Optical coherence tomography microangiography for monitoring the response of vascular perfusion to external pressure on human skin tissue

      Optical coherence tomography microangiography for monitoring the response of vascular perfusion to external pressure on human skin tissue
      ...vely assessing tissue microcirculation in the locally pressed tissue in vivo. Woo June Choi ; Hequn Wang and Ruikang K. Wang "Optical coherence tomography microangiography for monitoring the response of vascular perfus...
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    5. Full anterior segment biometry with extended imaging range spectral domain optical coherence tomography at 1340 nm

      Full anterior segment biometry with extended imaging range spectral domain optical coherence tomography at 1340 nm

      We demonstrate an extended-imaging-range anterior-segment optical coherence tomography (eAS-OCT) system for the biometric assessment of full AS in human eye. This newly developed eAS-OCT operating at 1340-nm wavelength band is simultaneously capable of an imaging speed of 120 kHz A-line scan rate, an axial resolution of 7.2 μ m, and an extended imaging range of up to 16 mm in air. Imaging results from three healthy subjects and one subject with a narrow-angle demonstrate the instrument’s utility. With this system, it can provide anatomical dimensions of AS, including central corneal thickness, anterior chamber width, anterior chamber depth, crystalline lens ...

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      Mentions: Ruikang K. Wang
    6. Laser induced surface acoustic wave combined with phase sensitive optical coherence tomography for superficial tissue characterization: a solution for practical application

      Laser induced surface acoustic wave combined with phase sensitive optical coherence tomography for superficial tissue characterization: a solution for practical application
      ..., and Zhihong Huang »View Author Affiliations Chunhui Li,^1 Guangying Guan,^2,^3 Fan Zhang,^2 Ghulam Nabi,^1 Ruikang K. Wang,^2,^3 and Zhihong Huang^2 ^1Division of Imaging Technology, School of Medicine, University o...
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    7. Improved microcirculation imaging of human skin in vivo using optical microangiography with a correlation mapping mask

      Improved microcirculation imaging of human skin in vivo using optical microangiography with a correlation mapping mask

      Optical microangiography based on optical coherence tomography (OCT) is prone to noise that arises from a static tissue region. Here, we propose a method that can significantly reduce this noise. The method is developed based on an approach that uses the magnitude information of OCT signals to produce tissue microangiograms, especially suitable for the case where a swept-source OCT system is deployed. By combined use of two existing OCT microangiography methods—ultrahigh-sensitive optical microangiography (UHS-OMAG) and correlation mapping OCT (cmOCT)—the final tissue microangiogram is generated by masking UHS-OMAG image using the binary representation of cmOCT image. We find that ...

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    8. University of Washington Receives NIH Grant for Studying Non-Invasive Real-Time Label-Free 3D Imaging of Retinal Microcircuation

      University of Washington Receives NIH Grant for Studying Non-Invasive Real-Time Label-Free 3D Imaging of Retinal Microcircuation
      ...udying Non-Invasive Real-Time Label-Free 3D Imaging of Retinal Microcircuation. The principal investigator is Ruikang Wang. The program began in 2014 and ends in 2018. Below is a summary of the proposed work. Non-invasi...
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    9. Noninvasive Imaging of Retinal Morphology and Microvasculature in Obese Mice using Optical Coherence Tomography and Optical Microangiography

      Noninvasive Imaging of Retinal Morphology and Microvasculature in Obese Mice using Optical Coherence Tomography and Optical Microangiography

      Purpose:To evaluate early diabetes-induced changes in retinal thickness and microvasculature in a type II diabetic mouse model using OCT/OMAG. Methods:22 week old obese BTBR mice (OB, n=10) and wild type control mice (WT, n=10) were imaged. Three-dimensional data were captured with OCT using an ultrahigh sensitive OMAG scanning protocol for 3D angiography of the retina and dense A-scan protocol for measurement of the total retinal blood flow (RBF) rate. The thickness of the nerve fiber layer (NFL) and NFL to inner plexiform layer (IPL) were measured and compared between OB and WT mice. The linear ...

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  2. About Ruikang K. Wang

    Ruikang K. Wang

    Ruikang K. Wang is a professor in the biomedical engineering department at Washington University. He interests include: High resolution functional optical imaging using coherence gating and confocal gating techniques as applied to healthcare, Optical biopsy and functional imaging in tissue engineering, Photoacoustic imaging, and Light propagation in biological tissue.