A system and method for measuring tissue motion within a living tissue of the anterior segment and aqueous outflow system of the eye in a subject are provided. Tissue movements are extracted from a plurality of images acquired from the living tissue using an optical coherence tomography system. The images may be corrected using motion compensation. To extract the tissue movements from the images, waves from a cardiac pulse or other externally induced pulses from the subject are acquired, and a pulse wave is defined for a given time, which is then correlated with a velocity wave defined for a ...

We present an optical vibrometer based on delay-encoded, dual-beamlet phase-sensitive Fourier domain interferometric system to provide depth-resolved subnanometer scale vibration information from scattering biological specimens. System characterization, calibration, and preliminary vibrometry with biological specimens were performed. The proposed system has the potential to provide both amplitude and direction of vibration of tissue microstructures on a single two-dimensional plane.

Systems and methods for photoacoustic imaging are provided. Photoacoustic signals are excited from a body and the excited photoacoustic signals are detected with a low coherence interferometer system serving as a photoacoustic detector. Cross-sectional images of the body are then reconstructed by the system from the detected photoacoustic signals.

We report a newly developed high speed 1050nm spectral domain optical coherence tomography (SD-OCT) system for imaging posterior segment of human eye. The system is capable of an axial resolution at ~10 µm in air, an imaging depth of 6.1 mm in air, a system sensitivity fall-off at ~6 dB/3mm and an imaging speed of 120,000 A-scans per second. We experimentally demonstrate the system’s capability to perform phase-resolved imaging of dynamic blood flow within retina, indicating high phase stability of the SDOCT system. Finally, we show an example that uses this newly developed system to image ...

We demonstrate a 1050-nm spectral domain optical coherence tomography (OCT) system with a 12 mm imaging depth in air, a 120 kHz A-scan rate and a 10 μm axial resolution for anterior-segment imaging of human eye, in which a new prototype InGaAs linescan camera with 2048 active-pixel photodiodes is employed to record OCT spectral interferograms in parallel. Combined with the full-range complex technique, we show that the system delivers comparable imaging performance to that of a swept-source OCT with similar system specifications.