1. Ruikang K. Wang

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    1. Mentioned In 260 Articles

    2. Methods and systems for integrated imaging using optical coherence tomography and photoacoustic imaging

      Methods and systems for integrated imaging using optical coherence tomography and photoacoustic imaging
      Systems and methods for photoacoustic imaging are provided. Photoacoustic signals are excited from a body and the excited photoacoustic signals are detected with a low coherence interferometer system serving as a photoacoustic detector. Cross-sectional images of the body are then reconstructed by the system from the detected photoacoustic signals.
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    3. Long ranging swept-source optical coherence tomography-based angiography outperforms its spectral-domain counterpart in imaging human skin microcirculations

      Long ranging swept-source optical coherence tomography-based angiography outperforms its spectral-domain counterpart in imaging human skin microcirculations
      There is an increasing demand for imaging tools in clinical dermatology that can perform in vivo wide-field morphological and functional examination from surface to deep tissue regions at various skin sites of the human body. The conventional spectral-domain optical coherence tomography-based angiography (SD-OCTA) system is difficult to meet these requirements due to its fundamental limitations of the sensitivity roll-off, imaging range as well as imaging speed. To mitigate these issues ...
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    4. Multifunctional in vivo imaging for monitoring wound healing using swept-source polarization-sensitive optical coherence tomography

      Multifunctional in vivo imaging for monitoring wound healing using swept-source polarization-sensitive optical coherence tomography
      Background and Objective Wound healing involves a complex and dynamic biological process in response to tissue injury. Monitoring of the cascade of cellular events is useful for wound management and treatment. The aim of this study is to demonstrate the potential of multifunctional polarization-sensitive optical coherence tomography (PS-OCT) to longitudinally monitor the self-healing process in a murine cutaneous wound model. Materials and Methods A multi-functional PS-OCT system based on swept ...
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    5. Complex signal-based optical coherence tomography angiography enables in vivo visualization of choriocapillaris in human choroid

      Complex signal-based optical coherence tomography angiography enables in vivo visualization of choriocapillaris in human choroid
      The choriocapillaris (CC) plays an essential role in maintaining the normal functions of the human eye. There is increasing interest in the community to develop an imaging technique for visualizing the CC, yet this remains underexplored due to technical limitations. We propose an approach for the visualization of the CC in humans via a complex signal-based optical microangiography (OMAG) algorithm, based on commercially available spectral domain optical coherence tomography (SD-OCT ...
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    6. Utility of optical coherence tomography angiography in detecting glaucomatous damage in a uveitic patient with disc congestion: A case report

      Utility of optical coherence tomography angiography in detecting glaucomatous damage in a uveitic patient with disc congestion: A case report
      Purpose To report a case of uveitic glaucoma with congested optic disc where optical coherence tomography angiography (OCT-A) provided diagnostic utility in assessing glaucomatous damage but optical coherence tomography (OCT) alone had limited utility. Observations We report a case of a 33-year-old Caucasian female referred to the USC Roski Eye Institute for uncontrolled intraocular pressure (IOP) in the left eye. She was managed by an outside provider for 6 months ...
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    7. Flexible wide-field optical micro-angiography based on Fourier-domain multiplexed dual-beam swept source optical coherence tomography

      Flexible wide-field optical micro-angiography based on Fourier-domain multiplexed dual-beam swept source optical coherence tomography
      Wide-field optical coherence tomography angiography (OCTA) is gaining interest in clinical imaging applications. In this pursuit, it is challenging to maintain the imaging resolution and sensitivity throughout the wide field of view (FoV). Here, we propose a novel method/system of dual-beam arrangement and Fourier domain multiplexing to achieve wide field OCTA when imaging the uneven surface samples. The proposed system provides two separate FoVs, with flexibility that the imaging ...
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    8. Methods of reducing motion artifacts for optical coherence tomography angiography

      Methods of reducing motion artifacts for optical coherence tomography angiography
      A method for reducing motion artifacts in optical coherence tomography (OCT) angiography images is disclosed. The method is applied to the intensity or complex OCT data prior to applying the motion contrast analysis and involves determining sub-pixel level shifts between at least two B-scans repeated approximately at the same location and applying the sub-pixel level shifts to the B-scans to be able to correct for motion and accurately determine motion ...
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    9. Optical coherence tomography imaging of cranial meninges post brain injury in vivo

      Optical coherence tomography imaging of cranial meninges post brain injury in vivo
      We report a new application of optical coherence tomography (OCT) to investigate the cranial meninges in an animal model of brain injury in vivo. The injury is induced in a mouse due to skull thinning, in which the repeated and excessive drilling exerts mechanical stress on the mouse brain through the skull, resulting in acute and mild brain injury. Transcranial OCT imaging reveals an interesting virtual space between the cranial ...
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    10. The effect of age on the response of retinal capillary filling to changes in intraocular pressure measured by optical coherence tomography angiography

      The effect of age on the response of retinal capillary filling to changes in intraocular pressure measured by optical coherence tomography angiography
      Purpose To compare the effect of elevated intraocular pressure (IOP) on retinal capillary filling in elderly vs adult rats using optical coherence tomography angiography (OCTA). Methods The IOP of elderly (24-month-old, N = 12) and adult (68 month-old, N = 10) Brown Norway rats was elevated in 10 mmHg increments from 10 to 100 mmHg. At each IOP level, 3D OCT data were captured using an optical microangiography (OMAG) scanning protocol and ...
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    11. Optical coherence tomography angiography: A comprehensive review of current methods and clinical applications

      Optical coherence tomography angiography: A comprehensive review of current methods and clinical applications
      OCT has revolutionized the practice of ophthalmology over the past 1020 years. Advances in OCT technology have allowed for the creation of novel OCT-based methods. OCT-Angiography (OCTA) is one such method that has rapidly gained clinical acceptance since it was approved by the FDA in late 2016. OCTA images are based on the variable backscattering of light from the vascular and neurosensory tissue in the retina. Since the intensity and ...
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    12. Automatic motion correction for in vivo human skin optical coherence tomography angiography through combined rigid and nonrigid registration

      Automatic motion correction for in vivo human skin optical coherence tomography angiography through combined rigid and nonrigid registration
      When using optical coherence tomography angiography (OCTA), the development of artifacts due to involuntary movements can severely compromise the visualization and subsequent quantitation of tissue microvasculatures. To correct such an occurrence, we propose a motion compensation method to eliminate artifacts from human skin OCTA by means of step-by-step rigid affine registration, rigid subpixel registration, and nonrigid B-spline registration. To accommodate this remedial process, OCTA is conducted using two matching all-depth ...
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    13. Optical coherence tomography angiography-based capillary velocimetry

      Optical coherence tomography angiography-based capillary velocimetry
      Challenge persists in the field of optical coherence tomography (OCT) when it is required to quantify capillary blood flow within tissue beds in vivo . We propose a useful approach to statistically estimate the mean capillary flow velocity using a model-based statistical method of eigendecomposition (ED) analysis of the complex OCT signals obtained with the OCT angiography (OCTA) scanning protocol. ED-based analysis is achieved by the covariance matrix of the ensemble ...
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    14. USC ReceivesNIH Grant for Defining the Relationship of Retinal MIcrocirculation with Glaucoma, Systemic Disease, and Ocular Anatomic Factors in African Americans

      USC ReceivesNIH Grant for Defining the Relationship of Retinal MIcrocirculation with Glaucoma, Systemic Disease, and Ocular Anatomic Factors in African Americans
      ...coursework, training will be greatly enhanced by regular meetings with renowned mentors (Dr. Rohit Varma, Dr. Ruikang Wang, Dr. James Gauderman, and Dr. Roberta McKean-Cowdin), as well as participation in local and inter...
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    15. Robust numerical phase stabilization for long-range swept-source optical coherence tomography

      Robust numerical phase stabilization for long-range swept-source optical coherence tomography
      A novel phase stabilization technique is demonstrated with significant improvement in the phase stability of a micro-electromechanical (MEMS) vertical cavity surface-emitting laser (VCSEL) based swept-source optical coherence tomography (SS-OCT) system. Without any requirements of hardware modifications, the new fully numerical phase stabilization technique features high tolerance to acquisition jitter, and significantly reduced budget in computational effort. We demonstrate that when measured with biological tissue, this technique enables a phase sensitivity ...
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    16. Imaging collector channel entrance with a new intraocular micro-probe swept-source optical coherence tomography

      Imaging collector channel entrance with a new intraocular micro-probe swept-source optical coherence tomography
      Purpose To describe the use of a newly developed side-viewing catheter probe to provide the cross-sectional images of collector channel entrance (CCE), achieved by swept-source optical coherence tomography (SS-OCT). Methods A side-viewing SS-OCT catheter probe was developed that has a core probe diameter of 0.15 mm and an outer diameter of 0.25 mm, for the purpose of imaging CCEs within eye globe. Cadaver eyes harvested from swine and ...
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    17. 1-15 of 260 1 2 3 4 ... 16 17 18 »
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  2. About Ruikang K. Wang

    Ruikang K. Wang

    Ruikang K. Wang is a professor in the biomedical engineering department at Washington University. He interests include: High resolution functional optical imaging using coherence gating and confocal gating techniques as applied to healthcare, Optical biopsy and functional imaging in tissue engineering, Photoacoustic imaging, and Light propagation in biological tissue.