1. Ruikang K. Wang

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    1. Mentioned In 271 Articles

    2. Multiple Research Scientist and Post-Doctoral Positions in OCT Available at the University of Washington, Seattle.

      Multiple Research Scientist and Post-Doctoral Positions in OCT Available at the University of Washington, Seattle.
      ...required. Competitive salary and benefits offered. Please send resume and names of 3 references via email to: Ruikang Wang, PhD Professor, Bioengineering, University of Washington wangrk@uw.edu There are multiple researc...
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    3. Automated three‐dimensional cell counting method for grading uveitis of rodent eye in vivo with optical coherence tomography

      Automated three‐dimensional cell counting method for grading uveitis of rodent eye in vivo with optical coherence tomography
      In preclinical vision research, cell grading in small animal models is essential for the quantitative evaluation of intraocular inflammation. Here, we present a new and practical optical coherence tomography (OCT) image analysis method for the automated detection and counting of aqueous cells in the anterior chamber (AC) of a rodent model of uveitis. Anterior segment OCT images are acquired with a 100kHz swept‐source OCT system. The proposed method consists ...
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    4. OCT‐based angiography of human dermal microvascular reactions to local stimuli: Implications for increasing capillary blood collection volumes

      OCT‐based angiography of human dermal microvascular reactions to local stimuli: Implications for increasing capillary blood collection volumes
      Objectives To measure and compare microvascular responses within the skin of the upper arm to local stimuli, such as heating or rubbing, through the use of optical coherence tomography angiography (OCTA), and to investigate its impact on blood volume collection. Materials and Methods With the use of heat packs or rubbing, local stimulation was applied to the skin of either the left or right upper arm. Data from the stimulated ...
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    5. Optical coherence tomography angiography monitors human cutaneous wound healing over time

      Optical coherence tomography angiography monitors human cutaneous wound healing over time
      Background: In vivo imaging of the complex cascade of events known to be pivotal elements in the healing of cutaneous wounds is a difficult but essential task. Current techniques are highly invasive, or lack the level of vascular and structural detail required for accurate evaluation, monitoring and treatment. We aimed to use an advanced optical coherence tomography (OCT)-based angiography (OCTA) technique for the non-invasive, high resolution imaging of cutaneous ...
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    6. Generating​ ​retinal​ ​flow​ ​maps​ ​from​ ​structural​ ​optical​ ​coherence​ ​tomography​ ​with​ ​artificial intelligence

      Generating​ ​retinal​ ​flow​ ​maps​ ​from​ ​structural​ ​optical​ ​coherence​ ​tomography​ ​with​ ​artificial intelligence
      Despite advances in artificial intelligence (AI), its application in medical imaging has been burdened and limited by expert-generated labels. We used images from optical coherence tomography angiography (OCTA), a relatively new imaging modality that measures retinal blood flow, to train an AI algorithm to generate flow maps from standard optical coherence tomography (OCT) images, exceeding the ability and bypassing the need for expert labeling. Deep learning was able to infer ...
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    7. Generating perfusion maps from structural optical coherence tomography with artificial intelligence

      Generating perfusion maps from structural optical coherence tomography with artificial intelligence
      Despite significant advances in artificial intelligence (AI) for computer vision, its application in medical imaging has been limited by the burden and limits of expert-generated labels. We used images from optical coherence tomography angiography (OCTA), a relatively new imaging modality that measures perfusion of the retinal vasculature, to train an AI algorithm to generate vasculature maps from standard structural optical coherence tomography (OCT) images of the same retinae, both exceeding ...
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    8. Optical coherence tomography angiography and cutaneous wound healing

      Optical coherence tomography angiography and cutaneous wound healing
      Background: Examination of the skins vascular and structural features is essential in clinical, medical, and research dermatology. However, there is a lack of comprehensive imaging tools that clearly and accurately evaluates the skins vascular and structural features. Current techniques are invasive and have inherent preparatory drawbacks. Aim: To use optical coherence tomography angiography (OCTA) for a more accurate depiction of vessels in the skin without the use of a dye ...
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    9. Optical Coherence Tomography Microangiography Imaging of Circumscribed Choroidal Hemangioma

      Optical Coherence Tomography Microangiography Imaging of Circumscribed Choroidal Hemangioma
      Optical coherence tomography angiography (OCTA) is a new imaging technology capable of providing three-dimensional (3-D) retinal and choroidal microvascular maps without a need for exogenous dye. In this study, the authors evaluate the retinal and choroidal microvascular architecture of the macula in a patient with choroidal hemangioma using OCTA. Widefield OCTA with tracking capability and segmentation was performed to provide images with a field of view at 9 9 mm ...
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    10. Structural and Functional Associations of Macular Microcirculation in the Ganglion Cell-inner Plexiform Layer in Glaucoma Using Optical Coherence Tomography Angiography

      Structural and Functional Associations of Macular Microcirculation in the Ganglion Cell-inner Plexiform Layer in Glaucoma Using Optical Coherence Tomography Angiography
      Purpose: To quantify retinal microvasculature within the macular ganglion cell-inner plexiform layer (GCIPL) in primary open angle glaucoma (POAG) and normal eyes, determine association of vessel parameters with structural and functional measures, and report diagnostic accuracy of vessel parameters. Methods: POAG and normal patients underwent 6▒mm6▒mm macula scans (Angioplex TM optical coherence tomography angiography [OCTA]; Cirrus TM HD-OCT 5000); and Humphrey Field Analyzer II-i 24-2 visual field (VF ...
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    11. Optical coherence tomography angiography of normal skin and inflammatory dermatologic conditions

      Optical coherence tomography angiography of normal skin and inflammatory dermatologic conditions
      Background In clinical dermatology, the identification of subsurface vascular and structural features known to be associated with numerous cutaneous pathologies remains challenging without the use of invasive diagnostic tools. Objective To present an advanced optical coherence tomography angiography (OCTA) method to directly visualize capillary-level vascular and structural features within skin in vivo . Methods An advanced OCTA system with a 1310nm wavelength was used to image the microvascular and structural features ...
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    12. Special Section Guest Editorial: Commemorating 25 Years of Optical Coherence Tomography: a Perspective on Biomedical Applications

      Special Section Guest Editorial: Commemorating 25 Years of Optical Coherence Tomography: a Perspective on Biomedical Applications
      ptical coherence tomography (OCT) has become a major medical imaging technology in the time since its inception now more than 25 years ago. During this time, OCT has become very well established in ophthalmology, and this application area largely dominates the field. Next in importance and stage of development is cardiovascular medicine, also a strongly commercial technology, but at an earlier stage and a slower pace of uptake than ophthalmology ...
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    13. Methods and systems for integrated imaging using optical coherence tomography and photoacoustic imaging

      Methods and systems for integrated imaging using optical coherence tomography and photoacoustic imaging
      Systems and methods for photoacoustic imaging are provided. Photoacoustic signals are excited from a body and the excited photoacoustic signals are detected with a low coherence interferometer system serving as a photoacoustic detector. Cross-sectional images of the body are then reconstructed by the system from the detected photoacoustic signals.
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    14. Long ranging swept-source optical coherence tomography-based angiography outperforms its spectral-domain counterpart in imaging human skin microcirculations

      Long ranging swept-source optical coherence tomography-based angiography outperforms its spectral-domain counterpart in imaging human skin microcirculations
      There is an increasing demand for imaging tools in clinical dermatology that can perform in vivo wide-field morphological and functional examination from surface to deep tissue regions at various skin sites of the human body. The conventional spectral-domain optical coherence tomography-based angiography (SD-OCTA) system is difficult to meet these requirements due to its fundamental limitations of the sensitivity roll-off, imaging range as well as imaging speed. To mitigate these issues ...
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    15. Multifunctional in vivo imaging for monitoring wound healing using swept-source polarization-sensitive optical coherence tomography

      Multifunctional in vivo imaging for monitoring wound healing using swept-source polarization-sensitive optical coherence tomography
      Background and Objective Wound healing involves a complex and dynamic biological process in response to tissue injury. Monitoring of the cascade of cellular events is useful for wound management and treatment. The aim of this study is to demonstrate the potential of multifunctional polarization-sensitive optical coherence tomography (PS-OCT) to longitudinally monitor the self-healing process in a murine cutaneous wound model. Materials and Methods A multi-functional PS-OCT system based on swept ...
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    16. Complex signal-based optical coherence tomography angiography enables in vivo visualization of choriocapillaris in human choroid

      Complex signal-based optical coherence tomography angiography enables in vivo visualization of choriocapillaris in human choroid
      The choriocapillaris (CC) plays an essential role in maintaining the normal functions of the human eye. There is increasing interest in the community to develop an imaging technique for visualizing the CC, yet this remains underexplored due to technical limitations. We propose an approach for the visualization of the CC in humans via a complex signal-based optical microangiography (OMAG) algorithm, based on commercially available spectral domain optical coherence tomography (SD-OCT ...
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  2. About Ruikang K. Wang

    Ruikang K. Wang

    Ruikang K. Wang is a professor in the biomedical engineering department at Washington University. He interests include: High resolution functional optical imaging using coherence gating and confocal gating techniques as applied to healthcare, Optical biopsy and functional imaging in tissue engineering, Photoacoustic imaging, and Light propagation in biological tissue.