1. Ruikang K. Wang

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    1. Mentioned In 220 Articles

    2. Automated segmentation and enhancement of optical coherence tomography-acquired images of rodent brain

      Automated segmentation and enhancement of optical coherence tomography-acquired images of rodent brain
      Background Optical coherence tomography (OCT) is a non-invasive optical imaging method that has proven useful in various fields such as ophthalmology, dermatology and neuroscience. In ophthalmology, significant progress has been made in retinal layer segmentation and enhancement of OCT images. There are also segmentation algorithms to separate epidermal and dermal layers in OCT-acquired images of human skin. New Method We describe simple image processing methods that allow automatic segmentation and ...
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    3. Aqueous outflow regulation: Optical coherence tomography (OCT) imaging implicates pressure-dependent tissue motion

      Aqueous outflow regulation: Optical coherence tomography (OCT) imaging implicates pressure-dependent tissue motion
      Glaucoma is a leading cause of blindness worldwide and results from damage to the optic nerve. Currently, intraocular pressure is the only treatable risk factor. Changes in aqueous outflow regulate pressure; regulation becomes abnormal in glaucoma. From inside the eye aqueous flows out through the trabecular meshwork into a venous sinus called Schlemm's canal, next into collector channels and finally returns to the episcleral vessels of the venous system ...
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    4. Quantitative assessment of the retinal microvasculature using optical coherence tomography angiography

      Quantitative assessment of the retinal microvasculature using optical coherence tomography angiography
      Optical coherence tomography angiography (OCTA) is clinically useful for the qualitative assessment of the macular microvasculature. However, there is a need for comprehensive quantitative tools to help objectively analyze the OCT angiograms. Few studies have reported the use of a single quantitative index to describe vessel density in OCT angiograms. In this study, we introduce a five-index quantitative analysis of OCT angiograms in an attempt to detect and assess vascular ...
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    5. Assessment of edema volume in skin upon injury in a mouse ear model with optical coherence tomography

      Assessment of edema volume in skin upon injury in a mouse ear model with optical coherence tomography
      Accurate measurement of edema volume is essential for the investigation of tissue response and recovery following a traumatic injury. The measurements must be noninvasive and repetitive over time so as to monitor tissue response throughout the healing process. Such techniques are particularly necessary for the evaluation of therapeutics that are currently in development to suppress or prevent edema formation. In this study, we propose to use optical coherence tomography (OCT ...
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    6. Repeatability and reproducibility of optic nerve head perfusion measurements using optical coherence tomography angiography

      Repeatability and reproducibility of optic nerve head perfusion measurements using optical coherence tomography angiography
      Optical coherence tomography angiography (OCTA) has increasingly become a clinically useful technique in ophthalmic imaging. We evaluate the repeatability and reproducibility of blood perfusion in the optic nerve head (ONH) measured using optical microangiography (OMAG)-based OCTA. Ten eyes from 10 healthy volunteers are recruited and scanned three times with a 68-kHz Cirrus HD-OCT 5000-based OMAG prototype system (Carl Zeiss Meditec Inc., Dublin, California) centered at the ONH involving two ...
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    7. Strategies to improve phase-stability of ultrafast swept source optical coherence tomography for single shot imaging of transient mechanical waves at 16 kHz frame rate

      Strategies to improve phase-stability of ultrafast swept source optical coherence tomography for single shot imaging of transient mechanical waves at 16 kHz frame rate
      We present single-shot phase-sensitive imaging of propagating mechanical waves within tissue, enabled by an ultrafast optical coherence tomography (OCT) system powered by a 1.628MHz Fourier domain mode-locked (FDML) swept laser source. We propose a practical strategy for phase-sensitive measurement by comparing the phases between adjacent OCT B-scans, where the B-scan contains a number of A-scans equaling an integer number of FDML buffers. With this approach, we show that micro-strain ...
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    8. Optic Disc Perfusion in Primary Open Angle and Normal Tension Glaucoma Eyes Using Optical Coherence Tomography-Based Microangiography

      Optic Disc Perfusion in Primary Open Angle and Normal Tension Glaucoma Eyes Using Optical Coherence Tomography-Based Microangiography
      Purpose To investigate optic disc perfusion differences in normal, primary open-angle glaucoma (POAG), and normal tension glaucoma (NTG) eyes using optical microangiography (OMAG) based optical coherence tomography (OCT) angiography technique. Design Cross-sectional, observational study. Subjects Twenty-eight normal, 30 POAG, and 31 NTG subjects. Methods One eye from each subject was scanned with a 68 kHz Cirrus HD-OCT 5,000-based OMAG prototype system centered at the optic nerve head (ONH) (Carl ...
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    9. Intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow

      Intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow
      We demonstrate in vivo volumetric optical microangiography at 200 volumes / s 200volumes/s by the use of 1.6 MHz Fourier domain mode-locking swept source optical coherence tomography and an effective 36 kHz microelectromechanical system (MEMS) scanner. We propose an intervolume analysis strategy to contrast the dynamic blood flow signal from the static tissue background. The proposed system is demonstrated by imaging cerebral blood flow in mice in vivo . For ...
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    10. Video-rate volumetric optical coherence tomography-based microangiography

      Video-rate volumetric optical coherence tomography-based microangiography
      Video-rate volumetric optical coherence tomography (vOCT) is relatively young in the field of OCT imaging but has great potential in biomedical applications. Due to the recent development of the MHz range swept laser sources, vOCT has started to gain attention in the community. Here, we report the first in vivo video-rate volumetric OCT-based microangiography (vOMAG) system by integrating an 18-kHz resonant microelectromechanical system (MEMS) mirror with a 1.6-MHz FDML ...
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    11. Optic nerve head perfusion in normal eyes and eyes with glaucoma using optical coherence tomography-based microangiography

      Optic nerve head perfusion in normal eyes and eyes with glaucoma using optical coherence tomography-based microangiography
      Background: To investigate the differences of perfusion in the optic nerve head (ONH) between normal and glaucomatous eyes using optical microangiography (OMAG) based optical coherence tomography (OCT) angiography technique. Methods: One eye from each subject was scanned with a 68 kHz Cirrus 5000 HD-OCT-based OMAG prototype system centered at the ONH (Carl Zeiss Meditec Inc, Dublin, CA, USA). Microvascular images were generated from the OMAG dataset by detecting the differences ...
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    12. Blood flow changes after unilateral carotid artery ligation monitored by optical coherence tomography

      Blood flow changes after unilateral carotid artery ligation monitored by optical coherence tomography
      Unilateral carotid artery ligation which could induce adaptive improvement is a classic model that has been widely used to study pathology of ischemic disease. In those studies, blood flow is an important parameter to characterize the ischemia. Optical coherence tomography (OCT) is a powerful imaging modality which can provide depth resolved images in biological tissue with high spatial and temporal resolution. SPF rats was anesthetized with isoflurane and divided into ...
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    13. Application of optical coherence tomography based microangiography for cerebral imaging

      Application of optical coherence tomography based microangiography for cerebral imaging
      Requirements of in vivo rodent brain imaging are hard to satisfy using traditional technologies such as magnetic resonance imaging and two-photon microscopy. Optical coherence tomography (OCT) is an emerging tool that can easily reach at high speeds and provide high resolution volumetric images with a relatively large field of view for rodent brain imaging. Here, we provide the overview of recent developments of functional OCT based imaging techniques for neuroscience ...
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    14. Automated detection of inflammatory cells in whole anterior chamber of a uveitis mouse from swept-source optical coherence tomography images

      Automated detection of inflammatory cells in whole anterior chamber of a uveitis mouse from swept-source optical coherence tomography images
      Cell grading in a rodent anterior chamber is essential for anterior inflammation evaluation in preclinical vision research. This paper describes a computerized method for detection and counting of the anterior chamber cells from swept-source optical coherence tomography (SS-OCT) images of a experimental rodent model of uveitis. The volumetric anterior segment OCT data is obtained from 100 kHz SS-OCT imaging of mouse eye in vivo. For the OCT cross-sections, each OCT ...
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    15. 1-15 of 220 1 2 3 4 ... 13 14 15 »
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  2. About Ruikang K. Wang

    Ruikang K. Wang

    Ruikang K. Wang is a professor in the biomedical engineering department at Washington University. He interests include: High resolution functional optical imaging using coherence gating and confocal gating techniques as applied to healthcare, Optical biopsy and functional imaging in tissue engineering, Photoacoustic imaging, and Light propagation in biological tissue.