1. Ruikang K. Wang

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    1. Mentioned In 198 Articles

    2. Minimally invasive surgical method to detect sound processing in the cochlear apex by optical coherence tomography

      Minimally invasive surgical method to detect sound processing in the cochlear apex by optical coherence tomography
      Sound processing in the inner ear involves separation of the constituent frequencies along the length of the cochlea. Frequencies relevant to human speech (100 to 500 Hz) are processed in the apex region. Among mammals, the guinea pig cochlear apex processes similar frequencies and is thus relevant for the study of speech processing in the cochlea. However, the requirement for extensive surgery has challenged the optical accessibility of this area ...
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    3. Review of optical coherence tomography based angiography in neuroscience

      Review of optical coherence tomography based angiography in neuroscience
      The brain is a complex ecosystem, consisting of multiple layers and tissue compartments. To facilitate the understanding of its function and its response to neurological insults, a fast in vivo imaging tool with a micron-level resolution, which can provide a field of view at a few millimeters, is desirable. Optical coherence tomography (OCT) is a noninvasive method for imaging three-dimensional biological tissues with high resolution ( 10 m 10m ) and without ...
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    4. Development of a phase-sensitive Fourier domain optical coherence tomography system to measure mouse organ of Corti vibrations in two cochlear turns

      Development of a phase-sensitive Fourier domain optical coherence tomography system to measure mouse organ of Corti vibrations in two cochlear turns
      In this study, we have developed a phase-sensitive Fourier-domain optical coherence tomography system to simultaneously measure the in vivo inner ear vibrations in the hook area and second turn of the mouse cochlea. This technical development will enable measurement of intra-cochlear distortion products at ideal locations such as the distortion product generation site and reflection site. This information is necessary to un-mix the complex mixture of intra-cochlear waves comprising the ...
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    5. Multifunctional 1050 nm Spectral Domain OCT System at 147 kHz for Posterior Eye Imaging

      Multifunctional 1050 nm Spectral Domain OCT System at 147 kHz for Posterior Eye Imaging
      The recent development of optical coherence tomography in ophthalmology has shown great interests in using the system in 1 m in contrast to 800 nm wavelength range due to the less reflection and absorption of retinal pigment epithelium and pigmented choroidal melanocytes in 1 m wavelength. The clinical value of using 1 m system has been demonstrated in choroid imaging, retinal and choroidal microcirculation, etc. By examining different aspects of ...
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    6. Moving beam shear wave reconstruction for both ultrasound and optical coherence tomography applications

      Moving beam shear wave reconstruction for both ultrasound and optical coherence tomography applications
      Shear wave elasticity imaging can quantitatively estimate a stiffness map of biological tissues based on speckle-tracking shear wave propagation. However, current approaches cannot directly reconstruct elasticity properties in speckle-less or speckle-free regions, for example within the crystalline lens in ophthalmology. We propose an imaging sequence to reconstruct the elastic properties in speckle-free regions by sequentially launching shear waves with a laterally moving acoustic radiation force, and then detecting the displacement ...
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    7. Quantitative shear-wave optical coherence elastography with a programmable phased array ultrasound as the wave source

      Quantitative shear-wave optical coherence elastography with a programmable phased array ultrasound as the wave source
      The purpose of this study is to implement a beam-steering ultrasound as the wave source for shear-wave optical coherence elastography (SW-OCE) to achieve an extended range of elastic imaging of the tissue sample. We introduce a linear phased array ultrasound transducer (LPAUT) as the remote and programmable wave source and a phase-sensitive optical coherence tomography (OCT) as the sensitive shear-wave detector. The LPAUT is programmed to launch acoustic radiation force ...
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    8. Methods and algorithms for optical coherence tomography-based angiography: a review and comparison

      Methods and algorithms for optical coherence tomography-based angiography: a review and comparison
      Optical coherence tomography (OCT)-based angiography is increasingly becoming a clinically useful and important imaging technique due to its ability to provide volumetric microvascular networks innervating tissue beds in vivo without a need for exogenous contrast agent. Numerous OCT angiography algorithms have recently been proposed for the purpose of contrasting microvascular networks. A general literature review is provided on the recent progress of OCT angiography methods and algorithms. The basic ...
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    9. SWEPT SOURCE OCT ANGIOGRAPHY OF NEOVASCULAR MACULAR TELANGIECTASIA TYPE 2

      SWEPT SOURCE OCT ANGIOGRAPHY OF NEOVASCULAR MACULAR TELANGIECTASIA TYPE 2
      Background/Purpose: To image subretinal neovascularization in proliferative macular telangiectasia Type 2 (MacTel2) using swept source optical coherence tomography based microangiography (OMAG). Methods: Patients with macular telangiectasia Type 2 were enrolled in a prospective, observational study known as the MacTel Project and evaluated using a high-speed 1,050 nm swept-source OCT prototype system. The OMAG algorithm generated en face flow images from three retinal layers, and the region bounded by ...
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    10. Swept-source optical coherence tomography powered by a 1.3-μm vertical cavity surface emitting laser enables 2.3-mm-deep brain imaging in mice in vivo

      Swept-source optical coherence tomography powered by a 1.3-μm vertical cavity surface emitting laser enables 2.3-mm-deep brain imaging in mice in vivo
      We report noninvasive, in vivo optical imaging deep within a mouse brain by swept-source optical coherence tomography (SS-OCT), enabled by a 1.3 - m vertical cavity surface emitting laser (VCSEL). VCSEL SS-OCT offers a constant signal sensitivity of 105 dB throughout an entire depth of 4.25 mm in air, ensuring an extended usable imaging depth range of more than 2 mm in turbid biological tissue. Using this approach, we ...
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    11. Minimizing projection artifacts for accurate presentation of choroidal neovascularization in OCT micro-angiography

      Minimizing projection artifacts for accurate presentation of choroidal neovascularization in OCT micro-angiography
      Current optical coherence tomography (OCT) based micro-angiography is prone to a projection (or tailing) effect due to the high scattering property of blood within overlying patent vessels, creating artifacts that interfere with the interpretation of retinal angiographic results. In this work, the projection effect in OCT micro-angiography is examined and its causality is explained by strong light scattering and photon propagation within blood. A simple practical approach is then introduced ...
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    12. Geographic mapping of choroidal thickness in myopic eyes using 1050-nm spectral domain optical coherence tomography Read More: http://www.worldscientific.com/doi/10.1142/S1793545815500121

      Geographic mapping of choroidal thickness in myopic eyes using 1050-nm spectral domain optical coherence tomography   Read More: http://www.worldscientific.com/doi/10.1142/S1793545815500121
      Purpose: To provide a geographical map of choroidal thickness (CT) around the macular region among subjects with low, moderate and high myopia. Methods: 20 myopic subjects (n = 40 eyes) without other identified pathologies participated in this study: 20 eyes of 3 diopters (D) (low myopic), 10 eyes between -3 and -6D (moderate myopic), and 10 eyes of 6D (high myopic). The mean age of subjects was 30.2 years ( 7 ...
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    13. Potential use of OCT-based microangiography in clinical dermatology

      Potential use of OCT-based microangiography in clinical dermatology
      Background Optical coherence tomography (OCT) is a revolutionary imaging technique used commonly in ophthalmology, and on the way to become clinically viable alternative in dermatology due to its capability of acquiring histopathology level details of in vivo tissue, non-invasively. In this study, we demonstrate the capabilities of OCT-based microangiography in detecting high resolution, three-dimensional structural, and microvascular features of in vivo human skin with various conditions. Methods A swept-source OCT ...
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    14. 1-15 of 198 1 2 3 4 ... 12 13 14 »
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  2. About Ruikang K. Wang

    Ruikang K. Wang

    Ruikang K. Wang is a professor in the biomedical engineering department at Washington University. He interests include: High resolution functional optical imaging using coherence gating and confocal gating techniques as applied to healthcare, Optical biopsy and functional imaging in tissue engineering, Photoacoustic imaging, and Light propagation in biological tissue.