1. Ruikang K. Wang

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    1. Mentioned In 183 Articles

    2. Lymphatic response to depilation-induced inflammation in mouse ear assessed with label-free optical lymphangiography

      Lymphatic response to depilation-induced inflammation in mouse ear assessed with label-free optical lymphangiography
      Background and Objectives Optical microangiography (OMAG) is a noninvasive technique capable of imaging 3D microvasculature. OMAG-based optical lymphangiography has been developed for 3D visualization of lymphatic vessels without the need for exogenous contrast agents. In this study, we utilize the optical lymphangiography to investigate dynamic changes in lymphatic response within skin tissue to depilation-induced inflammation by using mouse ear as a simple tissue model. Materials and Methods A spectral-domain optical ...
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    3. Polarization sensitive spectral domain OCT using an interference signal modulated at a constant frequency and a two-path reference arm with a single reference mirror

      Polarization sensitive spectral domain OCT using an interference signal modulated at a constant frequency and a two-path reference arm with a single reference mirror
      Embodiments include apparatuses and methods for spectral domain polarization sensitive optical coherence tomography including a reference assembly for detection of the polarization sensitive spectral interferograms formed by vertically and horizontally polarized beam components. Interference signals between the reference and sample beams may be modulated at a constant frequency.
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    4. Evaluation of the effect of elevated intraocular pressure and reduced ocular perfusion pressure on retinal capillary bed filling and total retinal blood flow in rats by OMAG/OCT

      Evaluation of the effect of elevated intraocular pressure and reduced ocular perfusion pressure on retinal capillary bed filling and total retinal blood flow in rats by OMAG/OCT
      Purpose To determine if retinal capillary filling is preserved in the face of acutely elevated intraocular pressure (IOP) in anesthetized rats, despite a reduction in total retinal blood flow (RBF), using optical microangiography/optical coherence tomography (OMAG/OCT). Methods OMAG provided the capability of depth-resolved imaging of the retinal microvasculature down to the capillary level. Doppler OCT was applied to measure the total RBF using an enface integration approach. The ...
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    5. Vasodynamics of pial and penetrating arterioles in relation to arteriolo-arteriolar anastomosis after focal stroke

      Vasodynamics of pial and penetrating arterioles in relation to arteriolo-arteriolar anastomosis after focal stroke
      Changes in blood perfusion in highly interconnected pial arterioles provide important insights about the vascular response to ischemia within brain. The functional role of arteriolo-arteriolar anastomosis (AAA) in regulating blood perfusion through penetrating arterioles is yet to be discovered. We apply a label-free optical microangiography (OMAG) technique to evaluate the changes in vessel lumen diameter and red blood cell velocity among a large number of pial and penetrating arterioles within ...
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    6. Wide-field imaging of retinal vasculature using optical coherence tomography-based microangiography provided by motion tracking.

      Wide-field imaging of retinal vasculature using optical coherence tomography-based microangiography provided by motion tracking.
      Optical coherence tomography (OCT)-based optical microangiography (OMAG) is a high-resolution, noninvasive imaging technique capable of providing three-dimensionalin vivoblood flow visualization within microcirculatory tissue beds in the eye. Although the technique has demonstrated early clinical utility by imaging diseased eyes, its limited field of view (FOV) and the sensitivity to eye motion remain the two biggest challenges for the widespread clinical use of the technology. Here, we report the results ...
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    7. Method and apparatus for ultrahigh sensitive optical microangiography

      Method and apparatus for ultrahigh sensitive optical microangiography
      Embodiments herein provide an ultrahigh sensitive optical microangiography (OMAG) system that provides high sensitivity to slow flow information, such as that found in blood flow in capillaries, while also providing a relatively low data acquisition time. The system performs a plurality of fast scans (i.e., B-scans) on a fast scan axis, where each fast scan includes a plurality of A-scans. At the same time, the system performs a slow ...
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    8. In vivo blood flow imaging of inflammatory human skin induced by tape stripping using optical microangiography

      In vivo blood flow imaging of inflammatory human skin induced by tape stripping using optical microangiography
      Vasculature response is a hallmark for most inflammatory skin disorders. Tape stripping on human skin causes a minor inflammation which leads to changes in microvasculature. In this study, optical microangiography (OMAG), noninvasive volumetric microvasculature in vivo imaging method, has been used to track the vascular responses after tape stripping. Vessel density has been quantified and used to correlate with the degree of skin irritation. The proved capability of OMAG technique ...
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    9. Quantitative shear wave optical coherence elastography (SW-OCE) with acoustic radiation force impulses (ARFI) induced by phase array transducer

      Quantitative shear wave optical coherence elastography (SW-OCE) with acoustic radiation force impulses (ARFI) induced by phase array transducer
      ...th acoustic radiation force impulses (ARFI) induced by phase array transducer Shaozhen Song ; Nhan Minh Le ; Ruikang K. Wang ; Zhihong Huang; Quantitative shear wave optical coherence elastography (SW-OCE) with acoustic...
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  2. About Ruikang K. Wang

    Ruikang K. Wang

    Ruikang K. Wang is a professor in the biomedical engineering department at Washington University. He interests include: High resolution functional optical imaging using coherence gating and confocal gating techniques as applied to healthcare, Optical biopsy and functional imaging in tissue engineering, Photoacoustic imaging, and Light propagation in biological tissue.