1. Ruikang K. Wang

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    1. Mentioned In 237 Articles

    2. Association between OCT-based microangiography perfusion indices and diabetic retinopathy severity

      Association between OCT-based microangiography perfusion indices and diabetic retinopathy severity
      Aim To evaluate the association between retinal capillary non-perfusion and diabetic retinopathy (DR) severity using optical coherence tomography-based microangiography (OMAG). Methods 33 patients (51 eyes) with a history of diabetes underwent imaging with a 68 kHz Cirrus-5000 spectral domain OMAG prototype. Demographic and clinical characteristics were collected. The perfusion index (PI) was defined as per cent coverage of area by retinal vessels with flow, measured within a minimum of 6 ...
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    3. Projection Artifact Removal Improves Visualization and Quantitation of Macular Neovascularization Imaged by Optical Coherence Tomography Angiography

      Projection Artifact Removal Improves Visualization and Quantitation of Macular Neovascularization Imaged by Optical Coherence Tomography Angiography
      Purpose To visualize and quantify the size and vessel density of macular neovascularization (MNV) using optical coherence tomography angiography (OCTA) with a projection artifact removal algorithm. Design Multicenter, observational study. Participants Subjects with MNV in 1 eye. Methods Patients were imaged using either a swept-source OCTA prototype system or a spectral-domain OCTA prototype system. The optical microangiography (OMAG) algorithm was used to generate the OCTA images. Projection artifacts from the ...
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    4. Cerebral capillary velocimetry based on temporal OCT speckle contrast

      Cerebral capillary velocimetry based on temporal OCT speckle contrast
      We propose a new optical coherence tomography (OCT) based method to measure red blood cell (RBC) velocities of single capillaries in the cortex of rodent brain. This OCT capillary velocimetry exploits quantitative laser speckle contrast analysis to estimate speckle decorrelation rate from the measured temporal OCT speckle signals, which is related to microcirculatory flow velocity. We hypothesize that OCT signal due to sub-surface capillary flow can be treated as the ...
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    5. Evaluation of bilateral central retinal artery occlusions with optical coherence tomography-based microangiography

      Evaluation of bilateral central retinal artery occlusions with optical coherence tomography-based microangiography
      Background We report a case of bilateral central retinal artery occlusion and the evaluation of retinal vasculature and capillaries by using optical coherence tomography angiography. Case presentation A 75-year-old white man presented with central retinal artery occlusion in one eye and underwent a carotid angioplasty. Upon discontinuing anticoagulant, he had a subsequent central retinal artery occlusion in the other eye. Optical coherence tomography angiography images were obtained to compare the ...
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    6. Long-range and wide field of view optical coherence tomography for in vivo 3D imaging of large volume object based on akinetic programmable swept source

      Long-range and wide field of view optical coherence tomography for in vivo 3D imaging of large volume object based on akinetic programmable swept source
      ... 036005 (2016). [Crossref] [PubMed] S. Song, W. Wei, B.-Y. Hsieh, I. Pelivanov, T. T. Shen, M. O’Donnell, and R. K. Wang, “Strategies to improve phase-stability of ultrafast swept source optical coherence tomography for ...
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    7. Optical coherence tomography based microangiography provides an ability to longitudinally image arteriogenesis in vivo

      Optical coherence tomography based microangiography provides an ability to longitudinally image arteriogenesis in vivo
      Purpose : To perform an analysis of optical coherence tomography (OCT) abnormalities in patients with MEWDS, during the acute and recovery stages, using enhanced depth imaging-OCT (EDI-OCT). Methods : A retrospective case series of five patients with MEWDS was included. EDI-OCT imaging was evaluated to detect retinal and choroidal features. Results : In the acute phase, focal impairment of the ellipsoid zone and external limiting membrane, hyperreflective dots in the inner choroid, and ...
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    8. Depth-resolved 3D visualization of coronary microvasculature with optical microangiography

      Depth-resolved 3D visualization of coronary microvasculature with optical microangiography
      In this study, we propose a novel implementation of optical coherence tomography-based angiography combined with ex vivo perfusion of fixed hearts to visualize coronary microvascular structure and function. The extracorporeal perfusion of Intralipid solution allows depth-resolved angiographic imaging, control of perfusion pressure, and high-resolution optical microangiography. The imaging technique offers new opportunities for microcirculation research in the heart, which has been challenging due to motion artifacts and the lack of ...
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    9. Tail artifact removal in OCT angiography images of rodent cortex

      Tail artifact removal in OCT angiography images of rodent cortex
      Optical coherence tomography angiography (OCTA) is a surging non-invasive, label-free, in vivo volumetric imaging method, currently being translated to clinical ophthalmology and becoming popular in neuroscience. Despite its attractiveness, there is an inherent issue of using OCT angiograms for quantitative cerebrovascular studies: The dynamic scattering of moving erythrocytes within pial vasculature creates tail-like artifacts that shadow the capillary vessels in the deeper layers of cortex. This false flow effect is ...
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    10. Quantifying Retinal Microvascular Changes in Uveitis Using Spectral-Domain Optical Coherence Tomography Angiography

      Quantifying Retinal Microvascular Changes in Uveitis Using Spectral-Domain Optical Coherence Tomography Angiography
      Purpose To quantify retinal capillary density and morphology in uveitis using SD-OCTA. Design Cross-sectional, observational study Methods Healthy and uveitic subjects were recruited from two tertiary care eye centers. Prototype SD-OCTA devices (Cirrus, Carl Zeiss Meditec, Inc., Dublin, CA) were used to generate 3x3 mm 2 OCTA images centered on the fovea. Subjects were placed into 3 groups based on the type of optical microangiography (OMAG) algorithm used for image ...
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    11. Post-doctoral Positions Available in Biophotonics and Imaging Lab, University of Washington, Seattle

      Post-doctoral Positions Available in Biophotonics and Imaging Lab, University of Washington, Seattle
      There are a number of postdoctoral positions immediately available in Wang Lab [Biophotonics and Imaging Laboratory (BAIL)], Department of Bioengineering, University of Washington, Seattle, WA. These positions are associated with research grants sponsored by the National Institutes of Health, Coulter foundation, Carl Zeiss Meditec, etc. The research areas in BAIL include volumetric optical coherence tomography (vOCT), volumetric optical micro-angiography (vOMAG), photoacoustic imaging (PAI), multiphoton microscopy, laser speckle imaging, and their ...
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    12. Peripapillary Retinal Nerve Fiber Layer Vascular Microcirculation in Glaucoma Using Optical Coherence Tomography–Based Microangiography

      Peripapillary Retinal Nerve Fiber Layer Vascular Microcirculation in Glaucoma Using Optical Coherence Tomography–Based Microangiography
      Purpose : To investigate the vascular microcirculation changes in the retinal nerve fiber layer (RNFL) in normal, glaucoma suspect, and open-angle glaucoma (OAG) groups using optical coherence tomographybased microangiography (OMAG). Methods : One eye from each subject was scanned with a Cirrus HD-OCT 5000based OMAG prototype system montage scanning protocol centered at the optic nerve head (ONH). Blood flow signals were extracted using OMAG algorithm. Retinal nerve fiber layer vascular microcirculation was ...
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    13. Quantifying Microvascular Density and Morphology in Diabetic Retinopathy Using Spectral-Domain Optical Coherence Tomography Angiography

      Quantifying Microvascular Density and Morphology in Diabetic Retinopathy Using Spectral-Domain Optical Coherence Tomography Angiography
      Purpose : To quantify changes in retinal microvasculature in diabetic retinopathy (DR) by using spectral-domain optical coherence tomography angiography (SD-OCTA). Methods : Retrospective, cross-sectional, observational study of healthy and diabetic adult subjects with and without DR. Retinal microvascular changes were assessed by using SD-OCTA images and an intensity-based optical microangiography algorithm. A semiautomated program was used to calculate indices of microvascular density and morphology in nonsegmented and segmented SD-OCTA images. Microvascular density ...
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    14. Minimal basilar membrane motion in low-frequency hearing

      Minimal basilar membrane motion in low-frequency hearing
      To perceive speech, the brain relies on inputs from sensory cells located near the top of the spiral-shaped cochlea. This low-frequency region of the inner ear is anatomically difficult to access, and it has not previously been possible to study its mechanical response to sound in intact preparations. Here, we used optical coherence tomography to image sound-evoked vibration inside the intact cochlea. We show that low-frequency sound moves a small ...
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    15. Quantitative Assessment of Anterior Segment Inflammation in a Rat Model of Uveitis Using Spectral-Domain Optical Coherence Tomography

      Quantitative Assessment of Anterior Segment Inflammation in a Rat Model of Uveitis Using Spectral-Domain Optical Coherence Tomography
      Purpose : To develop anterior segment spectral-domain optical coherence tomography (SD-OCT) and quantitative image analysis for use in experimental uveitis in rats. Methods : Acute anterior uveitis was generated in Lewis rats. A spectral domain anterior segment OCT system was used to image the anterior chamber (AC) and ciliary body at baseline and during peak inflammation 2 days later. Customized MatLab image analysis algorithms were developed to segment the AC, count AC ...
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  2. About Ruikang K. Wang

    Ruikang K. Wang

    Ruikang K. Wang is a professor in the biomedical engineering department at Washington University. He interests include: High resolution functional optical imaging using coherence gating and confocal gating techniques as applied to healthcare, Optical biopsy and functional imaging in tissue engineering, Photoacoustic imaging, and Light propagation in biological tissue.