1. Ruikang K. Wang

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    1. Mentioned In 300 Articles

    2. Systems and methods for in vivo visualization of lymphatic vessels with optical coherence tomography

      Systems and methods for in vivo visualization of lymphatic vessels with optical coherence tomography
      The present technology relates generally to systems and methods for in vivo visualization of lymphatic vessels. A system includes an optical coherence tomography (OCT) device and a computing device coupled to the OCT device configured to cause the OCT device to perform an OCT scan, generate image data in response to the OCT scan, and apply an eigendecomposition filter to the image data to produce processed image data. Alternatively or ...
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    3. Quantifying choriocapillaris hypoperfusion in patients with choroidal neovascularization using swept-source OCT angiography

      Quantifying choriocapillaris hypoperfusion in patients with choroidal neovascularization using swept-source OCT angiography
      Purpose: To compare choriocapillaris flow voids (FV) in patients with neovascular age-related macular degeneration (AMD) with age-matched normal controls using swept-source optical coherence tomography angiography (SS-OCTA). Patients and methods: Eleven eyes of 11 subjects with neovascular AMD and 11 eyes of 11 age-similar normal subjects were imaged using SS-OCTA with a 6x6mm scanning pattern. Choriocapillaris FV, defined as a percentage of regions determined to have flow deficits divided by the ...
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    4. Quantification of choriocapillaris with OCTA: a comparison study

      Quantification of choriocapillaris with OCTA: a comparison study
      Purpose To demonstrate the variation in quantitative choriocapillaris (CC) metrics with various binarization approaches using optical coherence tomography angiography (OCTA). Design Retrospective, observational, cross-sectional case series. Methods 3x3 mm and 6x6 mm macular OCTA scans were obtained from normal eyes and from eyes with drusen secondary to AMD. The CC slab was extracted and the CC flow deficits (FDs) were segmented with two previously published algorithms: fuzzy C-means approach (FCM ...
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    5. Systems and methods for quantitative assessment of microvasculature using optical coherence tomography angiography

      Systems and methods for quantitative assessment of microvasculature using optical coherence tomography angiography
      A five-index quantitative analysis of OCT angiograms is disclosed. One method of analyzing an anatomical region of interest of a subject includes acquiring vascular image data from the region of interest and generating a binary vasculature map from the vascular image data. A vessel skeleton map and vessel perimeter map are generated from the binary vasculature map. Based on the three generated maps, a vessel area density, vessel skeleton density ...
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    6. Impaired Retinal Vascular Reactivity in Diabetic Retinopathy as Assessed by Optical Coherence Tomography Angiography

      Impaired Retinal Vascular Reactivity in Diabetic Retinopathy as Assessed by Optical Coherence Tomography Angiography
      Purpose : To assess retinal vascular reactivity in healthy controls and subjects with diabetic retinopathy (DR). Methods : A total of 22 healthy control eyes and 16 eyes with DR were enrolled. Images were acquired using a commercially available swept-source optical coherence tomography angiography (SS-OCTA) system. Three conditions were tested for each patient (hyperoxia, hypercapnia, and room-air) by employing a non-rebreathing apparatus that delivered appropriate gas mixtures (100% O 2 , 5% CO ...
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    7. Two-Year Risk of Exudation in Eyes with Non-Exudative AMD and Subclinical Neovascularization Detected with Swept Source OCT Angiography

      Two-Year Risk of Exudation in Eyes with Non-Exudative AMD and Subclinical Neovascularization Detected with Swept Source OCT Angiography
      Purpose Swept source optical coherence tomography angiography (SS-OCTA) was used to study the prevalence, incidence, and natural history of subclinical macular neovascularization (MNV) in eyes with unilateral non-exudative age-related macular degeneration (AMD). Design Prospective cohort study. Methods Patients were imaged using 3x3 mm and 6x6 mm SS-OCTA scan patterns. MNV was detected using the outer retina to choriocapillaris en face slab. Prevalence and incidence of subclinical MNV, Kaplan-Meier cumulative estimates ...
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    8. Optical coherence tomography correlates multiple measures of tissue damage following acute burn injury

      Optical coherence tomography correlates multiple measures of tissue damage following acute burn injury
      Background: The visual assessment of burned skin is inherently subjective, and whilst a number of imaging modalities have identified quantifiable parameters to characterize vascular and structural changes following burn damage, none have become common place in the assessment protocol. Here, we use optical coherence tomography (OCT)-based angiography (OCTA) to introduce novel correlations between vessel depth, i.e., the depth of functional blood vessels beneath the tissue surface, edema depth ...
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    9. Revealing the morphology and function of the cochlea and middle ear with optical coherence tomography

      Revealing the morphology and function of the cochlea and middle ear with optical coherence tomography
      Optical coherence tomography (OCT) has revolutionized physiological studies of the hearing organ, the vibration and morphology of which can now be measured without opening the surrounding bone. In this review, we provide an overview of OCT as used in the otological research, describing advances and different techniques in vibrometry, angiography, and structural imaging.
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    10. Visualizing choriocapillaris using swept-source optical coherence tomography angiography with various probe beam sizes

      Visualizing choriocapillaris using swept-source optical coherence tomography angiography with various probe beam sizes
      ... human choroid,” J. Biomed. Opt. 22(12), 1–10 (2017). [Crossref] [PubMed] A. Zhang, Q. Zhang, C.-L. Chen, and R. K. Wang, “Methods and algorithms for optical coherence tomography-based angiography: a review and compariso...
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    11. Effect of Scan Size on Glaucoma Diagnostic Performance Using OCT Angiography En Face Images of the Radial Peripapillary Capillaries

      Effect of Scan Size on Glaucoma Diagnostic Performance Using OCT Angiography En Face Images of the Radial Peripapillary Capillaries
      Precis: When comparing 4.54.5mm to 6.06.0mm optical coherence tomography angiography scans of the radial peripapillary capillaries (RPCs) for glaucoma diagnostic capability, there was a trend of 4.5 scans outperforming 6.0 scans, especially for inferior, nasal, and superior quadrants. Objectives: The main purpose of this study was to compare diagnostic ability of peripapillary vessel parameters from 4.54.5mm (4.5) and 6.06.0mm ...
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    12. Development of a clinical prototype of a miniature hand-held optical coherence tomography probe for prematurity and pediatric ophthalmic imaging

      Development of a clinical prototype of a miniature hand-held optical coherence tomography probe for prematurity and pediatric ophthalmic imaging
      We report a novel design and operation of a highly integrated miniature handheld OCT probe, with high-speed angiography function that can be used in clinical settings for young children and infants, providing rapid, non-invasive structural and angiographic imaging of the retina and choroid. The imaging system is operated at 200 kHz, with 3D OCT and OCTA scan time of 0.8 and 3.2 seconds, respectively, and the scanning angle ...
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    13. The evaluation of spontaneous Descemet’s membrane reattachment using swept-source optical coherence tomography: a case report

      The evaluation of spontaneous Descemet’s membrane reattachment using swept-source optical coherence tomography: a case report
      A 29-year old man presented with a history of facial burn in August of 2017. Slit lamp examination revealed significant central corneal stromal scarring in the right eye. The patient received deep anterior lamellar keratoplasty (DALK) in the right eye. Three weeks post operatively, the patient was found to have recurrent corneal edema on slit lamp exam, and standard anterior segment optical coherence tomography (OCT) revealed a central detachment of ...
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    14. Optic Nerve Head Perfusion Before and After Intravitreal Antivascular Growth Factor Injections Using Optical Coherence Tomography-based Microangiography

      Optic Nerve Head Perfusion Before and After Intravitreal Antivascular Growth Factor Injections Using Optical Coherence Tomography-based Microangiography
      Purpose: To use optical coherence tomography angiography (OCTA) to evaluate the changes in optic nerve head perfusion following intravitreal antivascular endothelial growth factor injections. Methods: Preinjection and postinjection intraocular pressure (IOP) and OCTA images were taken of both the injected and uninjected fellow eyes. Results: Mean preinjection IOP was 16.64.7mmHg, which increased to a mean of 40.313.0mmHg ( P 0.0001) during the first postinjection image and ...
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    15. Correlations Between Choriocapillaris Flow Deficits Around Geographic Atrophy and Enlargement Rates Based on Swept Source OCT Imaging

      Correlations Between Choriocapillaris Flow Deficits Around Geographic Atrophy and Enlargement Rates Based on Swept Source OCT Imaging
      Purpose To determine the possible correlation between the annual enlargement rates (ERs) of geographic atrophy (GA) with the percentage and size of the choriocapillaris (CC) flow deficits (FDs) surrounding GA, measured with swept source optical coherence tomography angiography (SS-OCTA) images. Design Prospective, observational case series. Participants Patients with GA secondary to non-exudative AMD. Methods Patients were imaged with a 100-kHz SS-OCTA instrument (PLEX Elite 9000, Carl Zeiss Meditec) using a ...
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    16. 1-15 of 300 1 2 3 4 ... 18 19 20 »
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  2. About Ruikang K. Wang

    Ruikang K. Wang

    Ruikang K. Wang is a professor in the biomedical engineering department at Washington University. He interests include: High resolution functional optical imaging using coherence gating and confocal gating techniques as applied to healthcare, Optical biopsy and functional imaging in tissue engineering, Photoacoustic imaging, and Light propagation in biological tissue.