1. Rodney W. Kirk

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    1. Mentioned In 24 Articles

    2. Miniaturized single-fiber-based needle probe for combined imaging and sensing in deep tissue

      Miniaturized single-fiber-based needle probe for combined imaging and sensing in deep tissue
      The ability to visualize structure while simultaneously measuring chemical or physical properties of a biological tissue has the potential to improve our understanding of complex biological processes. We report the first miniaturized single-fiber-based imaging + sensing imaging+sensing probe capable of simultaneous optical coherence tomography (OCT) imaging and temperature sensing. An OCT lens is fabricated at the distal end of a double-clad fiber, including a thin layer of rare-earth-doped tellurite glass ...
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    3. Flexible needle with integrated optical coherence tomography probe for imaging during transbronchial tissue aspiration

      Flexible needle with integrated optical coherence tomography probe for imaging during transbronchial tissue aspiration
      Transbronchial needle aspiration (TBNA) of small lesions or lymph nodes in the lung may result in nondiagnostic tissue samples. We demonstrate the integration of an optical coherence tomography (OCT) probe into a 19-gauge flexible needle for lung tissue aspiration. This probe allows simultaneous visualization and aspiration of the tissue. By eliminating the need for insertion and withdrawal of a separate imaging probe, this integrated design minimizes the risk of dislodging ...
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    4. Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins

      Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins
      Incomplete excision of malignant tissue is a major issue in breast-conserving surgery, with typically 20 - 30% of cases requiring a second surgical procedure arising from postoperative detection of an involved margin. We report advances in the development of a new intraoperative tool, optical coherence micro-elastography, for the assessment of tumor margins on the micro-scale. We demonstrate an important step by conducting whole specimen imaging in intraoperative time frames with a ...
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    5. Promising New Imaging Tool Allows Surgeons to Detect Malignant Tissue During Breast-Conserving Surgery for Breast Cancer

      Promising New Imaging Tool Allows Surgeons to Detect Malignant Tissue During Breast-Conserving Surgery for Breast Cancer
      ...eons tell us about, they’re not going to make an impact.” Paper: Wes M. Allen, Lixin Chin, Philip Wijesinghe, Rodney W. Kirk, Bruce Latham, David D. Sampson, Christobel M. Saunders, and Brendan F. Kennedy, "Wide-field op...
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    6. Optical coherence tomography in the assessment of acute changes in cutaneous vascular diameter induced by heat stress

      Optical coherence tomography in the assessment of acute changes in cutaneous vascular diameter induced by heat stress
      There are limited imaging technologies available that can accurately assess or provide surrogate markers of the in vivo cutaneous microvessel network in humans. In this study, we establish the use of optical coherence tomography (OCT) as a novel imaging technique to assess acute changes in cutaneous microvessel area density and diameter in humans. OCT speckle decorrelation images of the skin on the ventral side of the forearm up to a ...
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    7. Deep tissue volume imaging of birefringence through fibre-optic needle probes for the delineation of breast tumour

      Deep tissue volume imaging of birefringence through fibre-optic needle probes for the delineation of breast tumour
      Identifying tumour margins during breast-conserving surgeries is a persistent challenge. We have previously developed miniature needle probes that could enable intraoperative volume imaging with optical coherence tomography. In many situations, however, scattering contrast alone is insufficient to clearly identify and delineate malignant regions. Additional polarization-sensitive measurements provide the means to assess birefringence, which is elevated in oriented collagen fibres and may offer an intrinsic biomarker to differentiate tumour from benign ...
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    8. Molecular imaging needles: dual-modality optical coherence tomography and fluorescence imaging of labeled antibodies deep in tissue

      Molecular imaging needles: dual-modality optical coherence tomography and fluorescence imaging of labeled antibodies deep in tissue
      ... Robert A. McLaughlin »View Author Affiliations Loretta Scolaro,^1,^* Dirk Lorenser,^1 Wendy-Julie Madore,^2 Rodney W. Kirk,^1 Anne S. Kramer,^3 George C. Yeoh,^3 Nicolas Godbout,^2 David D. Sampson,^1,^4 Caroline Boudo...
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    9. Near video-rate optical coherence elastography by acceleration with a graphics processing unit

      Near video-rate optical coherence elastography by acceleration with a graphics processing unit
      We present a graphics processing unit (GPU)- accelerated optical coherence elastography (OCE) system capable of generating strain images (elastograms) of soft tissue at near video-rates. The system implements phase-sensitive compression OCE using a pipeline of GPU kernel functions to enable a highly parallel implementation of OCE processing using the OpenCL framework. Developed on a commercial-grade GPU and desktop computer, the system achieves a processing rate of 21 elastograms per second ...
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    10. Imaging deep skeletal muscle structure using a high-sensitivity ultrathin side-viewing optical coherence tomography needle probe

      Imaging deep skeletal muscle structure using a high-sensitivity ultrathin side-viewing optical coherence tomography needle probe
      We have developed an extremely miniaturized optical coherence tomography (OCT) needle probe (outer diameter 310 m) with high sensitivity (108 dB) to enable minimally invasive imaging of cellular structure deep within skeletal muscle. Three-dimensional volumetric images were acquired from ex vivo mouse tissue, examining both healthy and pathological dystrophic muscle. Individual myofibers were visualized as striations in the images. Degradation of cellular structure in necrotic regions was seen as a ...
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    11. Automated quantification of lung structures from optical coherence tomography images

      Automated quantification of lung structures from optical coherence tomography images
      Characterization of the size of lung structures can aid in the assessment of a range of respiratory diseases. In this paper, we present a fully automated segmentation and quantification algorithm for the delineation of large numbers of lung structures in optical coherence tomography images, and the characterization of their size using the stereological measure of median chord length. We demonstrate this algorithm on scans acquired with OCT needle probes in ...
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    12. Ultrasound-Guided Optical Coherence Tomography Needle Probe for the Assessment of Breast Cancer Tumor Margins

      Ultrasound-Guided Optical Coherence Tomography Needle Probe for the Assessment of Breast Cancer Tumor Margins
      OBJECTIVE.The purpose of this study was to evaluate a new imaging technique for the assessment of breast cancer tumor margins. The technique entails deployment of a high-resolution optical imaging needle under ultrasound guidance. Assessment was performed on fresh ex vivo tissue samples. CONCLUSION. Use of the ultrasound-guided optical needle probe allowed in situ assessment of fresh tissue margins. The imaging findings corresponded to the histologic findings.
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    13. 3D imaging of internal structures of skeletal muscle with an ultrathin side-viewing optical needle probe

      3D imaging of internal structures of skeletal muscle with an ultrathin side-viewing optical needle probe
      Evaluation of degradation in the structure of skeletal muscle is important for the assessment or diagnosis of many myopathies, such as Duchenne muscular dystrophy. Histological analysis is the gold standard to evaluate such degradation but requires excision and fixation of the tissue. This is undesirably invasive in patients and precludes longitudinal study of disease progression in patients or animal models. Optical coherence tomography (OCT) is a high-resolution (10m) imaging modality ...
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    14. 1-15 of 24 1 2 »
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  2. About Rodney W. Kirk

    Rodney W. Kirk

    Rodney Kirk is a research assistant professor in the Optical+Biomedical Engineering Laboratory is in the School of Electrical, Electronic and Computer Engineering at the University of Western Australia in Perth, Western Australia.