1. Roberto Reif

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    1. Mentioned In 16 Articles

    2. Platform to investigate aqueous outflow system structure and pressure-dependent motion using high-resolution spectral domain optical coherence tomography

      Platform to investigate aqueous outflow system structure and pressure-dependent motion using high-resolution spectral domain optical coherence tomography
      The aqueous outflow system (AOS) is responsible for maintaining normal intraocular pressure (IOP) in the eye. Structures of the AOS have an active role in regulating IOP in healthy eyes and these structures become abnormal in the eyes with glaucoma. We describe a newly developed system platform to obtain high-resolution images of the AOS structures. By incorporating spectral domain optical coherence tomography (SD-OCT), the platform allows us to systematically control ...
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    3. Improved microcirculation imaging of human skin in vivo using optical microangiography with a correlation mapping mask

      Improved microcirculation imaging of human skin in vivo using optical microangiography with a correlation mapping mask
      Optical microangiography based on optical coherence tomography (OCT) is prone to noise that arises from a static tissue region. Here, we propose a method that can significantly reduce this noise. The method is developed based on an approach that uses the magnitude information of OCT signals to produce tissue microangiograms, especially suitable for the case where a swept-source OCT system is deployed. By combined use of two existing OCT microangiography ...
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    4. Changes in cochlear blood flow in mice due to loud sound exposure measured with Doppler optical microangiography and laser Doppler flowmetry

      Changes in cochlear blood flow in mice due to loud sound exposure measured with Doppler optical microangiography and laser Doppler flowmetry
      ... to loud sound exposure measured with Doppler optical microangiography and laser Doppler flowmetry Authors: Roberto Reif, Zhongwei Zhi, Suzan Dziennis, Alfred L. Nuttall, Ruikang K. Wang Abstract In this work we d...
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    5. Label-free imaging of blood vessel morphology with capillary resolution using optical microangiography

      Label-free imaging of blood vessel morphology with capillary resolution using optical microangiography
      Several tissue pathologies are correlated with changes in the blood vessel morphology and microcirculation that supplies the tissue. Optical coherence tomography (OCT) is an imaging technique that enables acquiring non-invasive three-dimensional images of biological structures with micrometer resolution. Optical microangiography (OMAG) is a method of processing OCT data which enables visualizing the three-dimensional blood vessel morphology within biological tissues. OMAG has high spatial resolution which allows visualizing single capillary vessels ...
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    6. Phase-sensitive optical coherence tomography characterization of pulse-induced trabecular meshwork displacement in ex vivo nonhuman primate eyes

      Phase-sensitive optical coherence tomography characterization of pulse-induced trabecular meshwork displacement in ex vivo nonhuman primate eyes
      Glaucoma is a blinding disease for which intraocular pressure (IOP) is the only treatable risk factor. The mean IOP is regulated through the aqueous outflow system, which contains the trabecular meshwork (TM). Considerable evidence indicates that trabecular tissue movement regulates the aqueous outflow and becomes abnormal during glaucoma; however, such motion has thus far escaped detection. The purpose of this study is to describe anovel use of a phase-sensitive optical ...
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    7. Quantifying Optical Microangiography Images Obtained from a Spectral Domain Optical Coherence Tomography System

      Quantifying Optical Microangiography Images Obtained from a Spectral Domain Optical Coherence Tomography System
      The blood vessel morphology is known to correlate with several diseases, such as cancer, and is important for describing several tissue physiological processes, like angiogenesis. Therefore, a quantitative method for characterizing the angiography obtained from medical images would have several clinical applications. Optical microangiography (OMAG) is a method for obtaining three-dimensional images of blood vessels within a volume of tissue. In this study we propose to quantify OMAG images obtained ...
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    8. Multifunctional nanoprobe to enhance the utility of optical based imaging techniques

      Multifunctional nanoprobe to enhance the utility of optical based imaging techniques
      Several imaging modalities such as optical coherence tomography, photothermal, photoacoustic and magnetic resonance imaging, are sensitive to different physical properties (i.e. scattering, absorption and magnetic) that can provide contrast within biological tissues. Usually exogenous agents are designed with specific properties to provide contrast for these imaging methods. In nano-biotechnology there is a need to combine several of these properties into a single contrast agent. This multifunctional contrast agent can ...
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    9. Depth profile absorber concentration reconstruction using photothermal optical coherence tomography

      Depth profile absorber concentration reconstruction using photothermal optical coherence tomography
      The concentration of photothermal (light-to-heat converters) compounds as a function of depth is determined in solid agar gel phantoms. The system contains an 808nm pump laser, which excites the photothermal compound, and a phase sensitive spectral domain optical coherence tomography system, which detects the changes in the optical pathlength of the sample induced by the temperature increase. The derivation of the model is described, and its parameters are empirically determined ...
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    10. Determining elastic properties of skin by measuring surface waves from an impulse mechanical stimulus using phase-sensitive optical coherence tomography

      Determining elastic properties of skin by measuring surface waves from an impulse mechanical stimulus using phase-sensitive optical coherence tomography
      The mechanical properties of skin are important tissue parameters that are useful for understanding skin patho-physiology, which can aid disease diagnosis and treatment. This paper presents an innovative method that employs phase-sensitive spectral-domain optical coherence tomography (PhS-OCT) to characterize the biomechanical properties of skin by measuring surface waves induced by short impulses from a home-made shaker. Experiments are carried out on single and double-layer agaragar phantoms, of different concentrations and ...
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    11. Three-Dimensional High-Resolution Imaging of Gold Nanorods Uptake in Sentinel Lymph Nodes

      Three-Dimensional High-Resolution Imaging of Gold Nanorods Uptake in Sentinel Lymph Nodes
      n this paper, we demonstrate an application of a noninvasive imaging modality, photothermal optical coherence tomography (PT-OCT), for imaging gold nanorods (GNRs) uptake in sentinel lymph node (SLN) of mice in situ. This application enables us to obtain higher quality images of SLN structures due to the photothermal contrast properties of the GNRs. It is also demonstrated that GNRs accumulate differently within several SLN structures, and this uptake is time ...
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    12. 1-16 of 16
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  2. About Roberto Reif

    Roberto Reif

    Roberto Reif is a Research Associate in the Biophotonics And Imaging Laboratory at the University of Washington.