1. Robert W. Knighton

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    1. Mentioned In 20 Articles

    2. Methods to reduce variance in OCT analysis of the macula

      Methods to reduce variance in OCT analysis of the macula
      Methods for analyzing optical coherence tomography (OCT) images of the macula to reduce variance and improve disease diagnosis are presented. One embodiment of the invention is directed towards selecting analysis locations and data segmentation techniques to take advantage of structural homogeneities. Another embodiment is directed towards reducing the variance in a collection of normative data by transforming the individual members of the database to correspond to a Standard Macula. Variations ...
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    3. Enhanced optical coherence tomography for anatomical mapping

      Enhanced optical coherence tomography for anatomical mapping
      A system, method and apparatus for anatomical mapping utilizing optical coherence tomography. In the present invention, 3-dimensional fundus intensity imagery can be acquired from a scanning of light back-reflected from an eye. The scanning can include spectral domain scanning, as an example. A fundus intensity image can be acquired in real-time. The 3-dimensional data set can be reduced to generate an anatomical mapping, such as an edema mapping and a ...
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    4. Visible light optical coherence tomography for in vivo imaging the spectral contrasts of the retinal nerve fiber layer

      Visible light optical coherence tomography for in vivo imaging the spectral contrasts of the retinal nerve fiber layer
      The ultimate goal of the study is to provide an imaging tool to detect the earliest signs of glaucoma before clinically visible damage occurs to the retinal nerve fiber layer (RNFL). Studies have shown that the optical reflectance of the damaged RNFL at short wavelength ( reduced much more than that at long wavelength, which provides spectral contrasts for imaging the earliest damage to the RNFL. To image the spectral contrasts ...
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    5. Dual-band spectral-domain optical coherence tomography for in vivo imaging the spectral contrasts of the retinal nerve fiber layer

      Dual-band spectral-domain optical coherence tomography for in vivo imaging the spectral contrasts of the retinal nerve fiber layer
      ...logy : Optical diagnostics for medicine ToC Category: Category Pending Citation Xiangyang Zhang, Jianming Hu, Robert W. Knighton, Xiang-Run Huang, Carmen A. Puliafito, and Shuliang Jiao, "Dual-band spectral-domain optica...
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    6. Revealing Henle's Fiber Layer using Spectral Domain Optical Coherence Tomography

      Revealing Henle's Fiber Layer using Spectral Domain Optical Coherence Tomography
      Purpose. Spectral domain optical coherence tomography (SD OCT) uses infrared light to visualize reflectivity of structures of differing optical properties within the retina. Despite their presence on histological studies, traditionally acquired SD OCT images are unable to delineate the axons of photoreceptor nuclei, Henle's fiber layer (HFL). We present a new method to reliably identify HFL by varying the entry position of the SD OCT beam through the pupil ...
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    7. Feature Of The Week 7/18/10: Ultra-High Resolution Imaging of Retinal Structure of Birds of Prey using Optical Coherence Tomography

      Feature Of The Week 7/18/10: Ultra-High Resolution Imaging of Retinal Structure of Birds of Prey using Optical Coherence Tomography
      Feature Of The Week 7/18/10: Birds and particularly birds of prey are known for their unique retinal structures. And while optical coherence tomography (OCT) has been used to image retinas in a variety of animals before, including birds, high resolution spectral domain OCT imaging has not been reported in avian species. The work of imaging the retina of birds of prey was done at Dr. Shuliang Jiao’s ...
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    8. Retinal Structure of Birds of Prey Revealed by Ultra-High Resolution Spectral-Domain Optical Coherence Tomography

      Retinal Structure of Birds of Prey Revealed by Ultra-High Resolution Spectral-Domain Optical Coherence Tomography
      PURPOSE. To reveal three-dimensional (3D) information about the retinal structures of birds of prey in vivo METHODS. An ultra-high resolution spectral-domain optical coherence tomography (SDOCT) system was built for in vivo imaging of bird of prey retina. The calibrated imaging depth and axial resolution of the system were 3.1 mm and 2.8 µm (in tissue), respectively. 3D segmentation was performed for calculation of the retinal nerve fiber layer ...
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    9. Characteristics of Optic Nerve Head Drusen on Optical Coherence Tomography Images

      BACKGROUND AND OBJECTIVE To describe the characteristics of optic nerve head drusen in optical coherence tomography (OCT) images. PATIENTS AND METHODS Cross-sectional images of the optic nerve were obtained in seven patients with optic nerve head drusen with Stratus and spectral-domain OCT (Carl Zeiss Meditec, Dublin, CA). These were compared to optic disc photographs, autofluorescence, and echography images. For comparison, these tests were performed on four patients with papilledema and ...
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    10. Spectral Domain Optical Coherence Tomographic Imaging of Geographic Atrophy

      BACKGROUND AND OBJECTIVE To compare images of geographic atrophy (GA) obtained using spectral domain optical coherence tomography (SD-OCT) with images obtained using fundus autofluorescence (FAF). PATIENTS AND METHODS Five eyes from patients with dry AMD were imaged using SD-OCT and FAF, and the size and shape of the GA were compared. RESULTS GA appears bright on SD-OCT compared with the surrounding areas with an intact retinal pigment epithelium because of ...
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    11. Spectral Domain Optical Coherence Tomography for Proliferative Diabetic Retinopathy With Subhyaloid Hemorrhage

      A prototype 6-µm axial resolution spectral domain optical coherence tomography (SD-OCT) device was used to image the retina of a patient with uncontrolled diabetes mellitus who had proliferative diabetic retinopathy with subhyaloid hemorrhage. A raster scan pattern with 128 B-scans covering a 6 × 6 × 2-mm volume of the retina was obtained. SD-...
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    12. Macular Thickness Measurements in Normal Eyes Using Spectral Domain Optical Coherence Tomography

      BACKGROUND AND OBJECTIVE Knowledge of the macular thickness in a normal population is important for the evaluation of pathological macular change. The purpose of this study was to define and measure macular thickness in normal eyes using spectral domain optical coherence tomography (OCT). PATIENTS AND METHODS Fifty eyes from 50 normal subjects (29 men and 21 women, aged 22 to 68 years) were scanned with a prototype Cirrus HD-OCT system ...
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  2. About Robert W. Knighton

    Robert W. Knighton

    Robert W. Knighton is an Research Professor at the Bascom Palmer Eye Institute at the University of Miami.

  3. Quotes

    1. Previous anatomical studies of raptor foveae required examination of the retina with a microscope, limiting the number of birds that could be studied.
      In High-Res Imaging Expands Vision Research of Live Birds of Prey: Study Produces First-Time Images of Retinal Structure of Hawks and Owls
    2. One can imagine that obtaining data with an SD-OCT scanner could become a routine procedure at the many bird observatories in the world.
      In High-Res Imaging Expands Vision Research of Live Birds of Prey: Study Produces First-Time Images of Retinal Structure of Hawks and Owls