1. Robert A. McLaughlin

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    1. Mentioned In 77 Articles

    2. Distribution of airway narrowing responses across generations and at branching points, assessed in vitro by anatomical optical coherence tomography

      Distribution of airway narrowing responses across generations and at branching points, assessed in vitro by anatomical optical coherence tomography
      Background Previous histological and imaging studies have shown the presence of variability in the degree of bronchoconstriction of airways sampled at different locations in the lung (i.e., heterogeneity). Heterogeneity can occur at different airway generations and at branching points in the bronchial tree. Whilst heterogeneity has been detected by previous experimental approaches its spatial relationship either within or between airways is unknown. Methods In this study, distribution of airway ...
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    3. Airway Narrowing Assessed by Anatomical Optical Coherence Tomography In Vitro: Dynamic Airway Wall Morphology and Function

      Airway Narrowing Assessed by Anatomical Optical Coherence Tomography In Vitro: Dynamic Airway Wall Morphology and Function
      Regulation of airway caliber by lung volume or bronchoconstrictor stimulation is dependent on physiological, structural and mechanical events within the airway wall, including airway smooth muscle (ASM) contraction, deformation of the mucosa and cartilage, and tensioning of elastic matrices linking wall components. Despite close association between events in the airway wall and the resulting airway caliber these have typically been studied separately: the former primarily using histological approaches, the latter ...
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    4. Lymph node micro-architecture can be imaged using optical coherence tomography

      Lymph node micro-architecture can be imaged using optical coherence tomography
      Background: Histological assessment is the gold standard technique for identification of lymph node involvement in breast cancer. However, this may only be performed ex vivo and will often result in the unnecessary excision of healthy lymph nodes. In axillary clearance, this will result in lymphedema in approximately 26% of patients. Optical Coherence Tomography (OCT) is a real-time imaging modality with the potential to perform in vivo optical biopsy of lymph ...
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    5. Anatomical optical coherence tomography: a safe and effective tool for quantitative long-term monitoring of upper airway size and shape

      ...J. J. Armstrong, S. Becker, R. A. McLaughlin et al. Anatomical optical coherence tomography (aOCT) is an endoscopic optical technique that enables continuous, quantitative assessment of hollow organ size and s...
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  2. About Robert A. McLaughlin

    Robert A. McLaughlin

    Robert A. McLaughlin is with the Optical and Biomedical Engineering Laboratory at the University of Western Australia. Prior to joining OBEL, Dr Robert McLaughlin was a research scientist with Siemens Molecular Imaging in Oxford, UK. He was responsible for development of new image processing algorithms for use in oncology. He has also held a number of management positions in industry over several years, and has managed the development cycle of three commercial medical products. These include a software application currently used clinically in the USA and Europe for the diagnosis of Alzheimer's disease. Previously, he was a postdoctoral researcher at the University of Oxford, developing image processing algorithms for MRI and CT images for use in minimally invasive brain surgery

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