1. Robert A. McLaughlin

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    1. Mentioned In 76 Articles

    2. Two-photon polymerisation 3D printed freeform micro-optics for optical coherence tomography fibre probes

      Two-photon polymerisation 3D printed freeform micro-optics for optical coherence tomography fibre probes
      Miniaturised optical coherence tomography (OCT) fibre-optic probes have enabled high-resolution cross-sectional imaging deep within the body. However, existing OCT fibre-optic probe fabrication methods cannot generate miniaturised freeform optics, which limits our ability to fabricate probes with both complex optical function and dimensions comparable to the optical fibre diameter. Recently, major advances in two-photon direct laser writing have enabled 3D printing of arbitrary three-dimensional micro/nanostructures with a surface roughness acceptable ...
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    3. Feature of The Week 04/27/2018: Miniaturized single-fiber-based needle probe for combined imaging and sensing in deep tissue

      Feature of The Week 04/27/2018: Miniaturized single-fiber-based needle probe for combined imaging and sensing in deep tissue
      The ability to visualize structure while simultaneously measuring chemical or physical properties of a biological tissue has the potential to improve our understanding of complex biological processes. We report the first miniaturized single-fiber-based imaging+sensing probe capable of simultaneous optical coherence tomography (OCT) imaging and temperature sensing. An OCT lens is fabricated at the distal end of a double-clad fiber, including a thin layer of rare-earth-doped tellurite glass to enable ...
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    4. Miniaturized single-fiber-based needle probe for combined imaging and sensing in deep tissue

      Miniaturized single-fiber-based needle probe for combined imaging and sensing in deep tissue
      The ability to visualize structure while simultaneously measuring chemical or physical properties of a biological tissue has the potential to improve our understanding of complex biological processes. We report the first miniaturized single-fiber-based imaging + sensing imaging+sensing probe capable of simultaneous optical coherence tomography (OCT) imaging and temperature sensing. An OCT lens is fabricated at the distal end of a double-clad fiber, including a thin layer of rare-earth-doped tellurite glass ...
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    5. A study of the effects of supine position and fluid intake on normal airway geometry using anatomical optical coherence tomography

      A study of the effects of supine position and fluid intake on normal airway geometry using anatomical optical coherence tomography
      Airway inhalation injuries are present in up to a third of all major burns patients and are the leading cause of mortality among this population. Understanding the mechanism of injury could minimise oedema (swelling) and airway damage. In this study, we present an anatomical OCT (aOCT) imaging system, based on a 1300-nm wavelength, high-speed, long-range MEMS-VCSEL swept laser source, for real-time volumetric imaging and assessment of inhalation injuries in airways ...
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    6. Linear-regression convolutional neural network for fully automated coronary lumen segmentation in intravascular optical coherence tomography

      Linear-regression convolutional neural network for fully automated coronary lumen segmentation in intravascular optical coherence tomography
      Intravascular optical coherence tomography (OCT) is an optical imaging modality commonly used in the assessment of coronary artery diseases during percutaneous coronary intervention. Manual segmentation to assess luminal stenosis from OCT pullback scans is challenging and time consuming. We propose a linear-regression convolutional neural network to automatically perform vessel lumen segmentation, parameterized in terms of radial distances from the catheter centroid in polar space. Benchmarked against gold-standard manual segmentation, our ...
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    7. Flexible needle with integrated optical coherence tomography probe for imaging during transbronchial tissue aspiration

      Flexible needle with integrated optical coherence tomography probe for imaging during transbronchial tissue aspiration
      Transbronchial needle aspiration (TBNA) of small lesions or lymph nodes in the lung may result in nondiagnostic tissue samples. We demonstrate the integration of an optical coherence tomography (OCT) probe into a 19-gauge flexible needle for lung tissue aspiration. This probe allows simultaneous visualization and aspiration of the tissue. By eliminating the need for insertion and withdrawal of a separate imaging probe, this integrated design minimizes the risk of dislodging ...
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    8. OncoRes Medical backed by MRCF to develop innovative imaging technology for breast cancer surgery

      OncoRes Medical backed by MRCF to develop innovative imaging technology for breast cancer surgery
      ...ccurately delineate malignant tissue at the microscopic level. The engineers include Dr. Brendan Kennedy, Dr. Robert McLaughlin, Dr. Kelsey Kennedy and Professor David Sampson from the School of Electrical, Electronic an...
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    9. Investigation of optical coherence micro-elastography as a method to visualize micro-architecture in human axillary lymph nodes

      Investigation of optical coherence micro-elastography as a method to visualize micro-architecture in human axillary lymph nodes
      Background Evaluation of lymph node involvement is an important factor in detecting metastasis and deciding whether to perform axillary lymph node dissection (ALND) in breast cancer surgery. As ALND is associated with potentially severe long term morbidity, the accuracy of lymph node assessment is imperative in avoiding unnecessary ALND. The mechanical properties of malignant lymph nodes are often distinct from those of normal nodes. A method to image the micro-scale ...
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    10. In vivo label-free lymphangiography of cutaneous lymphatic vessels in human burn scars using optical coherence tomography

      In vivo label-free lymphangiography of cutaneous lymphatic vessels in human burn scars using optical coherence tomography
      We present an automated, label-free method for lymphangiography of cutaneous lymphatic vessels in humans in vivo using optical coherence tomography (OCT). This method corrects for the variation in OCT signal due to the confocal function and sensitivity fall-off of a spectral-domain OCT system and utilizes a single-scattering model to compensate for A-scan signal attenuation to enable reliable thresholding of lymphatic vessels. A segment-joining algorithm is then incorporated into the method ...
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    11. Optical coherence tomography in the assessment of acute changes in cutaneous vascular diameter induced by heat stress

      Optical coherence tomography in the assessment of acute changes in cutaneous vascular diameter induced by heat stress
      There are limited imaging technologies available that can accurately assess or provide surrogate markers of the in vivo cutaneous microvessel network in humans. In this study, we establish the use of optical coherence tomography (OCT) as a novel imaging technique to assess acute changes in cutaneous microvessel area density and diameter in humans. OCT speckle decorrelation images of the skin on the ventral side of the forearm up to a ...
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    12. Deep tissue volume imaging of birefringence through fibre-optic needle probes for the delineation of breast tumour

      Deep tissue volume imaging of birefringence through fibre-optic needle probes for the delineation of breast tumour
      Identifying tumour margins during breast-conserving surgeries is a persistent challenge. We have previously developed miniature needle probes that could enable intraoperative volume imaging with optical coherence tomography. In many situations, however, scattering contrast alone is insufficient to clearly identify and delineate malignant regions. Additional polarization-sensitive measurements provide the means to assess birefringence, which is elevated in oriented collagen fibres and may offer an intrinsic biomarker to differentiate tumour from benign ...
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    13. Investigation of optical attenuation imaging using optical coherence tomography for monitoring of scars undergoing fractional laser treatment

      Investigation of optical attenuation imaging using optical coherence tomography for monitoring of scars undergoing fractional laser treatment
      En face 2D OCT attenuation coefficient map of a treated immature scar derived from the pre-treatment (top) and the post-treatment (bottom) scans. (Vasculature (black) is masked out.) The scale bars are 0.5 mm. We demonstrate the use of the near-infrared attenuation coefficient, measured using optical coherence tomography (OCT), in longitudinal assessment of hypertrophic burn scars undergoing fractional laser treatment. The measurement method incorporates blood vessel detection by speckle decorrelation ...
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    14. Optical coherence tomography for longitudinal monitoring of vasculature in scars treated with laser fractionation - Gong - 2015 - Journal of Biophotonics - Wiley Online Library

      Optical coherence tomography for longitudinal monitoring of vasculature in scars treated with laser fractionation - Gong - 2015 - Journal of Biophotonics - Wiley Online Library
      En face optical coherence tomography vasculature images pre-treatment (top) and 20 weeks after the first laser treatment (bottom) of a mature burn scar. Arrows mark the same vessel pattern. This study presents the first in vivo longitudinal assessment of scar vasculature in ablative fractional laser treatment using optical coherence tomography (OCT). A method based on OCT speckle decorrelation was developed to visualize and quantify the scar vasculature over the treatment ...
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    15. 1-15 of 76 1 2 3 4 5 »
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  2. About Robert A. McLaughlin

    Robert A. McLaughlin

    Robert A. McLaughlin is with the Optical and Biomedical Engineering Laboratory at the University of Western Australia. Prior to joining OBEL, Dr Robert McLaughlin was a research scientist with Siemens Molecular Imaging in Oxford, UK. He was responsible for development of new image processing algorithms for use in oncology. He has also held a number of management positions in industry over several years, and has managed the development cycle of three commercial medical products. These include a software application currently used clinically in the USA and Europe for the diagnosis of Alzheimer's disease. Previously, he was a postdoctoral researcher at the University of Oxford, developing image processing algorithms for MRI and CT images for use in minimally invasive brain surgery

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