1. Robert A. McLaughlin

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    1. Mentioned In 71 Articles

    2. Flexible needle with integrated optical coherence tomography probe for imaging during transbronchial tissue aspiration

      Flexible needle with integrated optical coherence tomography probe for imaging during transbronchial tissue aspiration
      Transbronchial needle aspiration (TBNA) of small lesions or lymph nodes in the lung may result in nondiagnostic tissue samples. We demonstrate the integration of an optical coherence tomography (OCT) probe into a 19-gauge flexible needle for lung tissue aspiration. This probe allows simultaneous visualization and aspiration of the tissue. By eliminating the need for insertion and withdrawal of a separate imaging probe, this integrated design minimizes the risk of dislodging ...
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    3. OncoRes Medical backed by MRCF to develop innovative imaging technology for breast cancer surgery

      OncoRes Medical backed by MRCF to develop innovative imaging technology for breast cancer surgery
      ...ccurately delineate malignant tissue at the microscopic level. The engineers include Dr. Brendan Kennedy, Dr. Robert McLaughlin, Dr. Kelsey Kennedy and Professor David Sampson from the School of Electrical, Electronic an...
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    4. Investigation of optical coherence micro-elastography as a method to visualize micro-architecture in human axillary lymph nodes

      Investigation of optical coherence micro-elastography as a method to visualize micro-architecture in human axillary lymph nodes
      Background Evaluation of lymph node involvement is an important factor in detecting metastasis and deciding whether to perform axillary lymph node dissection (ALND) in breast cancer surgery. As ALND is associated with potentially severe long term morbidity, the accuracy of lymph node assessment is imperative in avoiding unnecessary ALND. The mechanical properties of malignant lymph nodes are often distinct from those of normal nodes. A method to image the micro-scale ...
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    5. In vivo label-free lymphangiography of cutaneous lymphatic vessels in human burn scars using optical coherence tomography

      In vivo label-free lymphangiography of cutaneous lymphatic vessels in human burn scars using optical coherence tomography
      We present an automated, label-free method for lymphangiography of cutaneous lymphatic vessels in humans in vivo using optical coherence tomography (OCT). This method corrects for the variation in OCT signal due to the confocal function and sensitivity fall-off of a spectral-domain OCT system and utilizes a single-scattering model to compensate for A-scan signal attenuation to enable reliable thresholding of lymphatic vessels. A segment-joining algorithm is then incorporated into the method ...
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    6. Optical coherence tomography in the assessment of acute changes in cutaneous vascular diameter induced by heat stress

      Optical coherence tomography in the assessment of acute changes in cutaneous vascular diameter induced by heat stress
      There are limited imaging technologies available that can accurately assess or provide surrogate markers of the in vivo cutaneous microvessel network in humans. In this study, we establish the use of optical coherence tomography (OCT) as a novel imaging technique to assess acute changes in cutaneous microvessel area density and diameter in humans. OCT speckle decorrelation images of the skin on the ventral side of the forearm up to a ...
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    7. Deep tissue volume imaging of birefringence through fibre-optic needle probes for the delineation of breast tumour

      Deep tissue volume imaging of birefringence through fibre-optic needle probes for the delineation of breast tumour
      Identifying tumour margins during breast-conserving surgeries is a persistent challenge. We have previously developed miniature needle probes that could enable intraoperative volume imaging with optical coherence tomography. In many situations, however, scattering contrast alone is insufficient to clearly identify and delineate malignant regions. Additional polarization-sensitive measurements provide the means to assess birefringence, which is elevated in oriented collagen fibres and may offer an intrinsic biomarker to differentiate tumour from benign ...
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    8. Investigation of optical attenuation imaging using optical coherence tomography for monitoring of scars undergoing fractional laser treatment

      Investigation of optical attenuation imaging using optical coherence tomography for monitoring of scars undergoing fractional laser treatment
      En face 2D OCT attenuation coefficient map of a treated immature scar derived from the pre-treatment (top) and the post-treatment (bottom) scans. (Vasculature (black) is masked out.) The scale bars are 0.5 mm. We demonstrate the use of the near-infrared attenuation coefficient, measured using optical coherence tomography (OCT), in longitudinal assessment of hypertrophic burn scars undergoing fractional laser treatment. The measurement method incorporates blood vessel detection by speckle decorrelation ...
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    9. Optical coherence tomography for longitudinal monitoring of vasculature in scars treated with laser fractionation - Gong - 2015 - Journal of Biophotonics - Wiley Online Library

      Optical coherence tomography for longitudinal monitoring of vasculature in scars treated with laser fractionation - Gong - 2015 - Journal of Biophotonics - Wiley Online Library
      En face optical coherence tomography vasculature images pre-treatment (top) and 20 weeks after the first laser treatment (bottom) of a mature burn scar. Arrows mark the same vessel pattern. This study presents the first in vivo longitudinal assessment of scar vasculature in ablative fractional laser treatment using optical coherence tomography (OCT). A method based on OCT speckle decorrelation was developed to visualize and quantify the scar vasculature over the treatment ...
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    10. Molecular imaging needles: dual-modality optical coherence tomography and fluorescence imaging of labeled antibodies deep in tissue

      Molecular imaging needles: dual-modality optical coherence tomography and fluorescence imaging of labeled antibodies deep in tissue
      ...Kirk,^1 Anne S. Kramer,^3 George C. Yeoh,^3 Nicolas Godbout,^2 David D. Sampson,^1,^4 Caroline Boudoux,^2 and Robert A. McLaughlin^1 ^1Optical + Biomedical Engineering Laboratory, School of Electrical, Electronic, & Co...
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    11. Near video-rate optical coherence elastography by acceleration with a graphics processing unit

      Near video-rate optical coherence elastography by acceleration with a graphics processing unit
      We present a graphics processing unit (GPU)- accelerated optical coherence elastography (OCE) system capable of generating strain images (elastograms) of soft tissue at near video-rates. The system implements phase-sensitive compression OCE using a pipeline of GPU kernel functions to enable a highly parallel implementation of OCE processing using the OpenCL framework. Developed on a commercial-grade GPU and desktop computer, the system achieves a processing rate of 21 elastograms per second ...
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    12. Does smooth muscle in an intact airway undergo length adaptation during a sustained change in transmural pressure?

      Does smooth muscle in an intact airway undergo length adaptation during a sustained change in transmural pressure?
      ...go length adaptation during a sustained change in transmural pressure? Thomas K. Ansell , Peter K. McFawn , Robert A. McLaughlin , David D. Sampson , Peter R. Eastwood , David R. Hillman , Howard W. Mitchell , Peter B....
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    13. Parametric imaging of viscoelasticity using optical coherence elastography

      Parametric imaging of viscoelasticity using optical coherence elastography
      We demonstrate imaging of soft tissue viscoelasticity using optical coherence elastography. Viscoelastic creep deformation is induced in tissue using step-like compressive loading and the resulting time-varying deformation is measured using phase-sensitive optical coherence tomography. From a series of co-located B-scans, we estimate the local strain rate as a function of time, and parameterize it using a four-parameter KelvinVoigt model of viscoelastic creep. The estimated viscoelastic strain and time constant are ...
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    14. Research Associate / Research Fellow Microscope In A Needle at the University of Western Australia

      Research Associate / Research Fellow Microscope In A Needle at the University of Western Australia
      ...for its relaxed outdoor lifestyle. For more information: see http://www.obel.ee.uwa.edu.au or email A/Prof. Robert McLaughlin Robert.McLaughlin@uwa.edu.au Note that a second position is also currently being advertise...
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  2. About Robert A. McLaughlin

    Robert A. McLaughlin

    Robert A. McLaughlin is with the Optical and Biomedical Engineering Laboratory at the University of Western Australia. Prior to joining OBEL, Dr Robert McLaughlin was a research scientist with Siemens Molecular Imaging in Oxford, UK. He was responsible for development of new image processing algorithms for use in oncology. He has also held a number of management positions in industry over several years, and has managed the development cycle of three commercial medical products. These include a software application currently used clinically in the USA and Europe for the diagnosis of Alzheimer's disease. Previously, he was a postdoctoral researcher at the University of Oxford, developing image processing algorithms for MRI and CT images for use in minimally invasive brain surgery

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