1. Rice University

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    1. Mentioned In 33 Articles

    2. Spectropathology-corroborated multimodal quantitative imaging biomarkers for neuroretinal degeneration in diabetic retinopathy

      Spectropathology-corroborated multimodal quantitative imaging biomarkers for neuroretinal degeneration in diabetic retinopathy
      ...e of Technology-Kharagpur, Kharagpur, West Bengal, India; 4Department of Computer and Electrical Engineering, Rice University, Houston, TX, USA; 5Department of Biotechnology, National Institute of Technology Sikkim, Rava...
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    3. Image mapped optical coherence tomography

      Image mapped optical coherence tomography
      A method for imaging a sample. The method includes, during a single acquisition event, receiving depth-encoded electromagnetic (EM) fields from points on a sample that includes a first depth-encoded EM field for a first point and a second depth-encoded EM field for a second point, and redirecting the first depth-encoded EM field along a first predetermined direction to a first location on a dispersing re-imager and the second depthencoded EM ...
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      Mentions: Rice University
    4. Miniature, minimally invasive, tunable endoscope for investigation of the middle ear

      Miniature, minimally invasive, tunable endoscope for investigation of the middle ear
      We demonstrate a miniature, tunable, minimally invasive endoscope for diagnosis of the auditory system. The probe is designed to sharply image anatomical details of the middle ear without the need for physically adjusting the position of the distal end of the endoscope. This is achieved through the addition of an electrowetted, tunable, electronically-controlled lens to the optical train. Morphological imaging is enabled by scanning light emanating from an optical coherence ...
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    5. The use of time-lapse optical coherence tomography to image the effects of microapplied toxins on the retina

      The use of time-lapse optical coherence tomography to image the effects of microapplied toxins on the retina
      Purpose: We developed a novel technique using a drug microperfusion device and time-lapse optical coherence tomography (OCT) for accelerated drug screening and retinotoxin characterization. Methods: Using an ex vivo rabbit eyecup preparation, we studied retinotoxin effects in real-time by microperfusing small retinal areas under a transparent fluoropolymer tube. Known retinotoxic agents were applied to the retina for 5 minute periods while changes in retinal structure, thickness, and reflectance were monitored ...
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    6. Snapshot 3D optical coherence tomography system using image mapping spectrometry

      Snapshot 3D optical coherence tomography system using image mapping spectrometry
      A snapshot 3-Dimensional Optical Coherence Tomography system was developed using Image Mapping Spectrometry. This system can give depth information (Z) at different spatial positions (XY) within one camera integration time to potentially reduce motion artifact and enhance throughput. The current (x,y, ) datacube of (85356117) provides a 3D visualization of sample with 400 m depth and 13.4 m in transverse resolution. Axial resolution of 16.0 m can also ...
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    7. OCT guided microinjections for mouse embryonic research

      OCT guided microinjections for mouse embryonic research
      Optical coherence tomography (OCT) is gaining popularity as live imaging tool for embryonic research in animal models. Recently we have demonstrated that OCT can be used for live imaging of cultured early mouse embryos (E7.5-E10) as well as later stage mouse embryos in utero (E12.5 to the end of gestation). Targeted delivery of signaling molecules, drugs, and cells is a powerful approach to study normal and abnormal development ...
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    8. Multi-system comparison of optical coherence tomography performance with point spread function phantoms

      Multi-system comparison of optical coherence tomography performance with point spread function phantoms
      Point spread function (PSF) phantoms based on unstructured distributions of sub-resolution particles in a transparent matrix have proven effective for evaluating resolution and its spatial variation in optical coherence tomography (OCT) systems. Measurements based on PSF phantoms have the potential to become a standard test method for consistent, objective and quantitative inter-comparison of OCT system performance. Towards this end, we have evaluated three PSF phantoms and investigated their ability to ...
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  2. About Rice University

    Rice University

    Rice University is a private, comprehensive research university located in Houston, Texas, and adjacent to the Texas Medical Center. Rice is noted for its strength in the applied sciences. The university has been a pioneer in the fields of nanotechnology, artificial heart research, structural chemical analysis, and space science.

    Optical Spectroscopy and Imaging Laboratory at Rice University.  We are developing novel screening and detection modalities for in situ detection of pre-cancer.  These devices are based on quantitative optical imaging and spectroscopy and use low power light sources, fiber optics and semiconductor detectors to provide painless, instantaneous diagnosis. We collaborate with the UT MD Anderson Cancer Center to conduct clinical trials to develop and evaluate automated diagnostic algorithms and their impact on health care costs. We seek to optimize these systems by understanding the interaction between light and tissue at the microscopic and biochemical levels.